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Acnovate (Adapalene)

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Acnovate is a topical retinoid with FDA approval for the treatment of acne vulgaris. Clinicians use retinoids are used to treat a wide variety of skin disorders. Acnovate also has multiple off-label therapeutic applications.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Elocon, Zocor, Duricef, Wellbutrin, Symmetrel, Persantine, Valtrex

Also known as: Adapalene


Adapalene is used to treat acne. It works partly by keeping skin pores clear.

Adapalene is available only with your doctor's prescription.


Follow the directions for using this medicine provided by your doctor. Use Acnovate exactly as directed. Acnovate is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Acnovate. Acnovate should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Acnovate. Continue using Acnovate until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Acnovate promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

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The most common side effects associated with Acnovate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Studies of this medicine have been done only in adult patients, and there is no specific information comparing use of adapalene in children up to 12 years of age with use in other age groups. In teenagers, adapalene is not expected to cause different side effects or problems than it does in adults.

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Altered DNA repair capacity and bleomycin sensitivity as risk markers for non-small cell lung cancer. This article describes the adaptation of a model estimating the burden of postmenopausal osteoporosis (PMO) to the UK. Increased population size, reduced feeder space, and reduced floor area per hen resulted in a significant (P less than .01) decline in percent egg production. Such STDP was reversed when compared with those described so far in other mammalian brain structures. Besides being resistant to pitting and crevice attack, which can lead to corrosion fatigue and stress corrosion cracking failures, the implant material must be highly resistant to wear and abrasion. In Bradysia hygida, multiple amplification initiation sites are predicted to exist upstream of the BhC4-1 gene.

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Nutrition label use partially mediates the relationship between attitude toward healthy eating and overall dietary quality among college students. Elevation of cytokines contributes to the pathology of these diseases. The intent of this final rule is to expand the hospice benefit periods, improve documentation requirements to support certification and recertification of terminal illness, provide guidance on hospice admission procedures, clarify hospice discharge procedures, update coverage and payment requirements, and address the changing needs of beneficiaries, suppliers, and the Medicare program. Heat treatment, proteolysis and treatment with certain inorganic salts such as copper, and mercurous mercury, group specific reagents P-chloromercury benzoate and N-ethylmalemide (PCMB, NEM) and protein denaturants were found to have an adverse effect, while oxidizing agents had no effect. These results support the hypothesis that at least in some patients already at diagnosis or in the very first weeks, subclones have important differences in respect to resistance. Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. What can we expect from an anti-inflammatory agent after 3 years of experimentation and rheumatologic practice?. Indeed in PHA-stimulated lymphocytes, deoxycytidine caused significant although incomplete rescue from toxicity due to dCF and AdR.

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Genetic properties of linkage group XIX in Chlamydomonas reinhardtii. Heat-treated commercial lactulose syrups were most inhibitory, whereas non-heat-treated pure lactulose was only slightly more inhibitory than sucrose. Molecular cloning of TGF-alpha cDNA from human and rat has indicated that this factor is synthesized as part of a larger precursor, proTGF-alpha. The positive relationship between maternal PTH and measures of infant size may relate to increased mineral demands by larger babies, but warrants further moduretic drug investigation. Rho family Guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system. Continuous GH treatment also feminized the expression of endogenous murine Cyp2b and Cyp3a44 genes. A chiral, heterometallic metal-organic framework derived from a tris(chelate) coordination complex. Vein grafts and proximal carotid arteries were then harvested for morphological and biochemical studies at time points ranging from 1 to 14 days. Breath-hold three-dimensional (3D) steady-state free precession (SSFP) magnetic resonance (MR) angiography was compared with 3D contrast material-enhanced MR angiography in patients suspected of having renal artery stenosis.

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Assessing heterogeneity of peroxisomes: isolation of two subpopulations from rat liver. Phenotypically, adiponectin KO mice possessed smaller epididymal fat pads and showed reduced body weight compared with WT mice. Creatinine coefficient was computed per kg of body weight as well as per kg of lean body weight. Comparative study of iron mobilization from haemosiderin, ferritin and iron(III) precipitates by chelators. HSP90 mRNA was expressed at much higher levels in cancerous tissue than in non-cancerous tissues. Immunoblot analysis with betaF1 antiserum showed that all three forms are highly glycosylated and contain asparagine N-linked glycans commonly found in other plant glycoproteins. Diastereoselective allylation and crotylation of N metoclopramide drug fever -unsubstituted imines derived from ketones. Changes in acetoin dehydrogenase, acetate kinase, NADH oxidase, pyruvate oxidase, and acetate kinase activities correlated with changes in end product distribution.

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