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Acupain (Tramadol)

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Acupain is used for the management of pain in adults. Although it's a little weaker than other opioids, it can still be addictive and habit-forming. Acupain is available as both an immediate-acting tablet and an extended-release tablet.

Other names for this medication:
Acuvin, Anazac, Antram, Atdol, Didol, Dolmeri, Dolomed, Jpdol, Lagesic, Muzox, Nobligan, Opigesic, Orchidol, Ospidol, Paxmax, Radol, Tramafen, Tramaflam, Tramakind, Tramasol, Tramatas, Transic, Trazac, Ultrazac, Xtram

Similar Products:
Deltasone, Glucophage, Fosamax, Lasix, Persantine, Kemadrin, Detrol

Also known as: Tramadol


{name} (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

{name} is used to treat moderate to severe pain in adults.

The extended-release form of tramadol ({name} ER) is for around-the-clock treatment of pain. {name} ER is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Acupain: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Acupain is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Acupain dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Acupain are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

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Thermodynamic and correlation properties of living polymers are studied both in the mean-field and in the critical scaling regimes. The differential diagnosis of life-threatening microangiopathic disorders in a postpartum female includes severe preeclampsia-eclampsia, hemolysis, elevated liver functions tests, low platelets syndrome and thrombotic thrombocytopenic purpura. Opioids affect motor and sensory function throughout the gastrointestinal tract, and are frequently associated with a number of gastrointestinal symptoms including constipation, which impairs the quality of life and may limit the dose of opioid or result in discontinuation altogether. To investigate the cholinergic specificity of these effects, the muscarinic cholinergic antagonist pirenzepine was centrally administered before carbachol. We present a case of a patient with cerebral sinuvenous thrombosis who was first treated for neuroborreliosis.

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Pituitary response to growth hormone-releasing factor in rats with functional or anatomical lesions of the central nervous system that inhibit endogenous growth hormone secretion. Numerous difficulties remain associated with pediatric heart transplantation. An algorithm for determining satellite track end points with subpixel resolution in spaced-based images is presented. In contrast, addition of the activator ATP in the presence of PALA causes a significant increase in the scattering amplitude, indicating a large quaternary structural change, although the mutant does not entirely convert to the wild-type R structure. We have used a statistical scheme based on a Hidden Markov Model (HMM) to classify all heavy atoms of a protein into a small number of burial atomic types depending on sequence context.

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Early stimulation of the handicapped and potentially handicapped children--breakthrough of a concept. Natural course of insomnia comorbid with cancer: an 18-month longitudinal study. Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation. Fungal pneumonias are most frequently caused by Aspergillus spp., dimorphic fungi and Cryptococcus neoformans. Standardized NanoArray PCR (SNAP) is a recently developed gene profiling technology that enables the measurement of transcripts from samples containing reduced quantities or degraded nucleic acids. This study evaluated the effects of obesity on health-related quality of life (HRQOL) measures in juvenile-onset systemic lupus erythematosus (jSLE). The incorporation of rifampicin into multilayer and monolayer vesicles (liposomes) of different phosholipid composition. Therefore, characterizing 15q11.2-13.3 chromatin structure is important for understanding the regulation of this locus during normal neuronal development.

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Incidence of cancer and mortality among employees in the asbestos cement industry in Denmark. Variability in dosing and costs of biologics among patients with rheumatoid arthritis (RA) is of interest to healthcare descision-makers. In the classical Hartmann test the wave front is obtained by integration of the transverse aberrations, joining the sampled points by small straight segments, in the so-called Newton integration. Furthermore, an effect of image scale factor on SS was not revealed. Treatment of cells with a cytoskeleton-disrupting agent decreased receptor activity, as did overexpression of actin, particularly a mutant actin that does not polymerize. The incidence of the onset of ROP and severe ROP requiring laser treatment were assessed. Investigate the effect of a yoga intervention on alcohol and drug abuse behaviors in women with PTSD. Top-down signals from the dorsal parietal areas to primary visual cortex serially highlight cortical locations representing successive letters in a text before they can be recognized and concatenated into a word. These patients should be evaluated after surgery for HPV infections to prevent HPV-related diseases and cancers. By contrast, MCPP responses of BALB mice were most sensitive to morphine conditioning when subjects experienced a change in their social environment between housing and conditioning (Ih-Sc or Sh-Ic).

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Additionally, the spectra of phenotypes, genes, and telomeres affected in yaf9Delta and htz1Delta strains are significantly similar, further supporting a role for Yaf9 in Htz1 deposition. Our objective was to experimentally evaluate whether antioxidant consumption is associated with decreased intestinal damage in intestinal surgical procedures. Differential expression of the ASGM1 antigen on anti-reovirus and alloreactive cytotoxic T lymphocytes (CTL). Retrospective case note analysis of all patients who underwent EOAS from 1998 to 2002, recording in-hospital morbidity and mortality. Even though most respondents avoided eating unpasteurized dairy products, they were unaware of the risk associated with ready-to-eat foods. The alignment was either homeotropic or planar, depending on the time during which the film was cooling from the isotropic state to the liquid crystal one. In the presence of an intact (collateralized) COW, this was achieved by enhanced flow in the contralateral (normal) carotid artery. After incubation with taxol, the Golgi apparatus is fragmented and is conspicuously present in areas of the cytoplasm enriched in microtubules. Its significance in increased serum gamma GTP activity after ethanol feeding.

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Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity. Odds ratios were calculated using logistic and ordinal regression. Solvent effect on the relative quantum yield and fluorescence quenching of a newly synthesized coumarin derivative. To investigate the Toxoplasma gondii (TOX) infection in males with sterility and the effect of the infection on the reproductive function of males. Feature-based classification of amino acid substitutions outside conserved functional protein domains. Mechanisms of injury and diagnosis pitfalls are specified, and treatment options are discussed. Jaundice, digestive tract symptoms, increase of bilirubin and thrombinogen activity were the main manifestations. To maximize the chances of success for new EHR implementations from a behavioral point of view, general doubts about the rationale for such systems must be mitigated through improving design, stressing how EHRs are relevant to physician jobs, and providing substantiating evidence that EHRs are easier to use and more effective than nonusers might expect. Comparative study of the upper and lower limb skin blood flow control mechanisms in patients with essential hypertension.

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2010, 15 cases with soft tissue defects at 15 fingers tip were treated with this island flaps. 31 species of mosquitoes have been found in an investigation of the mosquito fauna in the district of Schwerin, German Democratic Republic. This can be improved by prescribing drugs at shorter intervals to reflect their pharmacokinetics and using newer techniques of drug administration. TAs also play important roles in bacterial persistence, biofilm formation and multidrug tolerance, and have considerable potential both as new components of the genetic toolbox and as targets for novel antibacterial drugs. The replacement therapy with triiodothyronin (T3) reduced the level of flagyl pills price depressed behavior to the initial value. Molecular dynamics simulations of the formation of 1D spin-valves from stretched Au-Co and Pt-Co nanowires.

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GnRH II as a possible cytostatic regulator in the development of endometriosis. Can increasing adult vaccination rates reduce lost time and protonix 20mg tab increase productivity?. Diagnosis and monitoring of coagulopathy is problematic, particularly in resource-poor countries where further research is required to develop more reliable, cheap clotting tests. Upon stimulation of ephrin-B pathways in IEC-6 cells with recombinant rat EphB1-Fc, gene expression was analyzed by Affymetrix(R) rat genome 230 high density arrays at different time points. Even more striking changes occur in the dermis, i.e., massive elastosis (deposition of abnormal elastic fibers), collagen degeneration, and twisted, dilated microvasculature. Animal experiments showed that preventing the diffusion of sulfur-containing compounds had a pronounced antitumour effect. With speech and noise both in front of the patient, two patients performed better with both devices than with either device alone. Effects of macromolecular crowding on amyloid beta (16-22) aggregation using coarse-grained simulations. The capillary filtration of albumin (CFA) is often increased in diabetic patients.

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Loss of function mutations of Kif7, the vertebrate orthologue of the Drosophila Hh pathway component Costal2, cause defects in the limbs and neural tubes of mice, attributable to ectopic expression of Hh target genes. It may provide a method of great promise in cases where delayed bone formation during distraction osteogenesis occurs. Early ambulation in the ventilated patient is gaining wider acceptance. This case-control study demonstrated no significant effect of CYP2D6 genotype on risk of recurrence in breast cancer patients who received adjuvant tamoxifen therapy. Overall, macromolecular LMWH could be delivered deeply into the skin by topical application of cFlexosome for the treatment is albendazole generic of superficial thrombosis, subcutaneous wounds, bruise, and burns. We study the individualization of therapy by simultaneously taking into account the design of sampling schedule and optimal therapeutic drug monitoring. Animals were sacrificed and their brains were removed for biochemical estimation after performing behavioural tests. Examination of the affected dog revealed generalized alopecia, patchy erythema, and superficial erosions with histological evidence of mural folliculitis. Cassava geminivirus-induced RNA silencing increased by raising the temperature from 25 degrees C to 30 degrees C, with the appearance of less symptomatic newly developed leaves, irrespective of the nature of the virus. According to the semiempirical method for hardness based on the Mulliken overlap population, the hardnesses for hexagonal forms have been evaluated and compared to diamond.

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Wiskott-Aldrich syndrome (WAS) is an X-linked disorder characterized by eczema, thrombocytopenia and increased susceptibility of infections, with mutations of the WAS gene being responsible for WAS and X-linked thrombocytopenia. There is growing evidence that activation of the Notch pathway can result in consequences on cell morphogenesis and behaviour, both during embryonic development and cancer progression. bieneusi type D, two were identical to type F (from a pig), and nine were previously unreported. A search of the Pubmed, MEDLINE, EMBASE, Cochrane and Ovid databases was performed to review literature on the efficacy and safety profile of anti-CD20 therapy in pSS patients. The predicted instabilities can advance our conceptual understanding of physical mechanisms behind collective phenomena in biological systems, in particular those with inherent anisotropy. Finally, evaluations of the impact of modifications to irrigation practices indicated that this approach warrants consideration as a supplemental control technique.

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Effect of orexin-A (hypocretin-1) on hyperalgesic and cachectic manifestations of experimentally induced rheumatoid arthritis in rats. Eisenmenger syndrome (ES) occurs as the most advanced form of pulmonary arterial hypertension (PAH) in patients with congenital heart disease. Complications from beta-adrenergic blockers also are relatively frequent in elderly persons. Our aim was to prospectively assess whether a successful IFN therapy modifies development and/or progression of EV in patients with HCV-related compensated cirrhosis. Discovery of quasispecies at position 222 (Q/L), in addition to the absence of the mutations in poultry/environmental samples, suggested that the mutations occurred during human infection and did not transmit further. The autonomic nervous system and related drugs in dental practice, Part II: Adrenergic agonists and antagonists. This action effectively shortens the cell apex and thus forces the apparatus to bend. Although a wealth of evidence supports the hypothesis that some functions of the nervous system may be altered during exposure to microgravity, the possible changes in basic neuronal physiology are not easy to assess. Our objective is to investigate if PE is diagnosed according to clinical practice guidelines. NF-kappaB in the lung was activated by injection of the lipoplex and its nuclear localization was observed.

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Increased hunger and speed of eating in obese children and adolescents. The IRS contents (0.7-22.5 ng) and concentrations (2.7-118.0 pg/mg wet weight tissue) both increased slightly with gestation. However, the candidacy of Atf2 was only weakly supported when we used a genetic network approach and by focused reanalysis of genome-wide association study data from European-American and African-American populations. Measuring and managing outcomes across the continuum of care has been a major task for healthcare organizations over the past decade. In this study, we measured therapeutic efficacy and determined if amniotic membranes could be used for facial nerve repair. The inhibitory influence is allegra drug mediated by the negative feed-back of adrenal corticosteroids and by the short loop feed-back of ACTH on its own secretion. However, the role of GM-CSF in advanced atherosclerotic plaque progression, the process that gives rise to clinically dangerous plaques, is unknown. Strategy for repetitive pinched injections on a microfluidic device. To evaluate the effects of interdental brushing in addition to toothbrushing, as compared with toothbrushing alone or toothbrushing and flossing for the prevention and control of periodontal diseases, dental plaque and dental caries. Influence of plasma proteins on the onset of hypnotic action of intravenous midazolam.

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