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Acupain (Tramadol)
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Acupain

Acupain is used for the management of pain in adults. Although it's a little weaker than other opioids, it can still be addictive and habit-forming. Acupain is available as both an immediate-acting tablet and an extended-release tablet.

Other names for this medication:
Acuvin, Anazac, Antram, Atdol, Didol, Dolmeri, Dolomed, Jpdol, Lagesic, Muzox, Nobligan, Opigesic, Orchidol, Ospidol, Paxmax, Radol, Tramafen, Tramaflam, Tramakind, Tramasol, Tramatas, Transic, Trazac, Ultrazac, Xtram

Similar Products:
Deltasone, Glucophage, Fosamax, Lasix, Persantine, Kemadrin, Detrol

Also known as: Tramadol

Description

{name} (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

{name} is used to treat moderate to severe pain in adults.

The extended-release form of tramadol ({name} ER) is for around-the-clock treatment of pain. {name} ER is not for use on an as-needed basis for pain.

Dosage

Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Acupain: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Acupain is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Acupain dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Acupain are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

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Thermodynamic and correlation properties of living polymers are studied both in the mean-field and in the critical scaling regimes. The differential diagnosis of life-threatening microangiopathic disorders in a postpartum female includes severe preeclampsia-eclampsia, hemolysis, elevated liver functions tests, low platelets syndrome and thrombotic thrombocytopenic purpura. Opioids affect motor and sensory function throughout the gastrointestinal tract, and are frequently associated with a number of gastrointestinal symptoms including constipation, which impairs the quality of life and may limit the dose of opioid or result in discontinuation altogether. To investigate the cholinergic specificity of these effects, the muscarinic cholinergic antagonist pirenzepine was centrally administered before carbachol. We present a case of a patient with cerebral sinuvenous thrombosis who was first treated for neuroborreliosis.

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Pituitary response to growth hormone-releasing factor in rats with functional or anatomical lesions of the central nervous system that inhibit endogenous growth hormone secretion. Numerous difficulties remain associated with pediatric heart transplantation. An algorithm for determining satellite track end points with subpixel resolution in spaced-based images is presented. In contrast, addition of the activator ATP in the presence of PALA causes a significant increase in the scattering amplitude, indicating a large quaternary structural change, although the mutant does not entirely convert to the wild-type R structure. We have used a statistical scheme based on a Hidden Markov Model (HMM) to classify all heavy atoms of a protein into a small number of burial atomic types depending on sequence context.

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Early stimulation of the handicapped and potentially handicapped children--breakthrough of a concept. Natural course of insomnia comorbid with cancer: an 18-month longitudinal study. Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation. Fungal pneumonias are most frequently caused by Aspergillus spp., dimorphic fungi and Cryptococcus neoformans. Standardized NanoArray PCR (SNAP) is a recently developed gene profiling technology that enables the measurement of transcripts from samples containing reduced quantities or degraded nucleic acids. This study evaluated the effects of obesity on health-related quality of life (HRQOL) measures in juvenile-onset systemic lupus erythematosus (jSLE). The incorporation of rifampicin into multilayer and monolayer vesicles (liposomes) of different phosholipid composition. Therefore, characterizing 15q11.2-13.3 chromatin structure is important for understanding the regulation of this locus during normal neuronal development.

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Several members of the glycoside hydrolase 61 (GH61) family of proteins have recently been shown to dramatically increase the breakdown of lignocellulosic biomass by microbial hydrolytic cellulases. Total hospital charge, length of stay, mortality, pneumonia, respiratory failure, urinary tract infection, urinary retention, anastomotic leak, and postoperative ileus. The STIR with water suppression provided the highest contrast between silicone and the surrounding adipose tissue. These results suggest that monosaccharides may play a role in the inhibitory effect of these fungi on endothelial tube formation. Univariate and multivariate regression analyses of relevant outcome variables were performed. The current study investigates a possible role for durational differences alongside spectral changes. In 2000, 2 143 individuals 60 years of age or older were interviewed, using the standardized SABE questionnaire. Signals that emanate from the GPCR superfamily converge on the small TRP family, leading to channel sensitization and activation, which amplify pain, itch, cough, and neurogenic inflammation. Fetal and maternal dose estimates for computed tomographic pelvimetry have been obtained from phantom measurements.

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Rates of obesity among black African and black Caribbean women in the UK are consistently higher than among white women. In addition, the peak flow velocity during atrial contraction and the ratio of atrial peak flow velocity to rapid diastolic peak flow velocity were significantly greater in patients than in controls. In this work vibrational spectra of mixtures of two glass-forming bioprotectant systems, i.e., trehalose and glycerol, are collected at very low temperature by using the indirect geometry time-of-flight (t.o.f.) TOSCA spectrometer at the ISIS Pulse Neutron Facility (Rutherford Appleton Laboratory, Oxford, U.K.). Indomethacin, a cyclo-oxygenase inhibitor, had no significant influence on both isoprenaline- and acetylcholine-induced relaxations in both control and hyperthyroid rats. In 1998, a pre-validated questionnaire was sent to all women who had a cruciate fascial sling between 1979 and 1996 under the care of the senior author at a District General Hospital and in private practice. Sixty-five articles were identified covering both vitamin K antagonist-anticoagulation reversal and treatment of bleeding/coagulopathy in non-anticoagulated patients. An on-going double-blind study is presented in which pregnant women with hypertension are randomly allocated to either metoprolol or placebo treatment. It effectively restored renal protein level alterations of urate transport-related molecular proteins urate transporter 1, glucose transporter 9, organic anion transporter 1, and ATP-binding cassette subfamily G member 2 in this model, possibly resulting in the enhancement of kidney urate excretion. A sample of 28 nurses from seven teaching hospitals in Taiwan, Republic of China was selected through theoretical sampling. Rearrangement of the BCL6 locus at 3q27 is an independent poor prognostic factor in nodal diffuse large B-cell lymphoma.

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Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity. Odds ratios were calculated using logistic and ordinal regression. Solvent effect on the relative quantum yield and fluorescence quenching of a newly synthesized coumarin derivative. To investigate the Toxoplasma gondii (TOX) infection in males with sterility and the effect of the infection on the reproductive function of males. Feature-based classification of amino acid substitutions outside conserved functional protein domains. Mechanisms of injury and diagnosis pitfalls are specified, and treatment options are discussed. Jaundice, digestive tract symptoms, increase of bilirubin and thrombinogen activity were the main manifestations. To maximize the chances of success for new EHR implementations from a behavioral point of view, general doubts about the rationale for such systems must be mitigated through improving design, stressing how EHRs are relevant to physician jobs, and providing substantiating evidence that EHRs are easier to use and more effective than nonusers might expect. Comparative study of the upper and lower limb skin blood flow control mechanisms in patients with essential hypertension.

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GnRH II as a possible cytostatic regulator in the development of endometriosis. Can increasing adult vaccination rates reduce lost time and protonix 20mg tab increase productivity?. Diagnosis and monitoring of coagulopathy is problematic, particularly in resource-poor countries where further research is required to develop more reliable, cheap clotting tests. Upon stimulation of ephrin-B pathways in IEC-6 cells with recombinant rat EphB1-Fc, gene expression was analyzed by Affymetrix(R) rat genome 230 high density arrays at different time points. Even more striking changes occur in the dermis, i.e., massive elastosis (deposition of abnormal elastic fibers), collagen degeneration, and twisted, dilated microvasculature. Animal experiments showed that preventing the diffusion of sulfur-containing compounds had a pronounced antitumour effect. With speech and noise both in front of the patient, two patients performed better with both devices than with either device alone. Effects of macromolecular crowding on amyloid beta (16-22) aggregation using coarse-grained simulations. The capillary filtration of albumin (CFA) is often increased in diabetic patients.

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Loss of function mutations of Kif7, the vertebrate orthologue of the Drosophila Hh pathway component Costal2, cause defects in the limbs and neural tubes of mice, attributable to ectopic expression of Hh target genes. It may provide a method of great promise in cases where delayed bone formation during distraction osteogenesis occurs. Early ambulation in the ventilated patient is gaining wider acceptance. This case-control study demonstrated no significant effect of CYP2D6 genotype on risk of recurrence in breast cancer patients who received adjuvant tamoxifen therapy. Overall, macromolecular LMWH could be delivered deeply into the skin by topical application of cFlexosome for the treatment is albendazole generic of superficial thrombosis, subcutaneous wounds, bruise, and burns. We study the individualization of therapy by simultaneously taking into account the design of sampling schedule and optimal therapeutic drug monitoring. Animals were sacrificed and their brains were removed for biochemical estimation after performing behavioural tests. Examination of the affected dog revealed generalized alopecia, patchy erythema, and superficial erosions with histological evidence of mural folliculitis. Cassava geminivirus-induced RNA silencing increased by raising the temperature from 25 degrees C to 30 degrees C, with the appearance of less symptomatic newly developed leaves, irrespective of the nature of the virus. According to the semiempirical method for hardness based on the Mulliken overlap population, the hardnesses for hexagonal forms have been evaluated and compared to diamond.

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Wiskott-Aldrich syndrome (WAS) is an X-linked disorder characterized by eczema, thrombocytopenia and increased susceptibility of infections, with mutations of the WAS gene being responsible for WAS and X-linked thrombocytopenia. There is growing evidence that activation of the Notch pathway can result in consequences on cell morphogenesis and behaviour, both during embryonic development and cancer progression. bieneusi type D, two were identical to type F (from a pig), and nine were previously unreported. A search of the Pubmed, MEDLINE, EMBASE, Cochrane and Ovid databases was performed to review literature on the efficacy and safety profile of anti-CD20 therapy in pSS patients. The predicted instabilities can advance our conceptual understanding of physical mechanisms behind collective phenomena in biological systems, in particular those with inherent anisotropy. Finally, evaluations of the impact of modifications to irrigation practices indicated that this approach warrants consideration as a supplemental control technique.

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Effect of orexin-A (hypocretin-1) on hyperalgesic and cachectic manifestations of experimentally induced rheumatoid arthritis in rats. Eisenmenger syndrome (ES) occurs as the most advanced form of pulmonary arterial hypertension (PAH) in patients with congenital heart disease. Complications from beta-adrenergic blockers also are relatively frequent in elderly persons. Our aim was to prospectively assess whether a successful IFN therapy modifies development and/or progression of EV in patients with HCV-related compensated cirrhosis. Discovery of quasispecies at position 222 (Q/L), in addition to the absence of the mutations in poultry/environmental samples, suggested that the mutations occurred during human infection and did not transmit further. The autonomic nervous system and related drugs in dental practice, Part II: Adrenergic agonists and antagonists. This action effectively shortens the cell apex and thus forces the apparatus to bend. Although a wealth of evidence supports the hypothesis that some functions of the nervous system may be altered during exposure to microgravity, the possible changes in basic neuronal physiology are not easy to assess. Our objective is to investigate if PE is diagnosed according to clinical practice guidelines. NF-kappaB in the lung was activated by injection of the lipoplex and its nuclear localization was observed.

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