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Adaple (Adapalene)

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Adaple is an expensive drug used to treat mild to moderate acne. This drug is slightly more popular than comparable drugs. It is available in generic and brand versions. Over-the-counter Adaple is now available without a prescription.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Cenforce, Suprax, Combivent, Rulide, Detrol

Also known as: Adapalene


Adapalene is used to treat acne. It works partly by keeping skin pores clear.

Adapalene is available only with your doctor's prescription.


Usual Adult Dose for Acne:

Adaple 0.1% cream, 0.1% gel, 0.3% gel: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Lotion: Apply a thin film of lotion to the entire face and other affected areas of the skin once daily, after washing gently with a mild soapless cleanser. Dispense a nickel size amount of lotion (3 to 4 actuations of the pump) to cover the entire face. Avoid application to the areas of skin around eyes, lips and mucous membranes.

Usual Pediatric Dose for Acne:

Adaple 0.1% cream, 0.1% gel, 0.3% gel: 11 years or less: Safety and efficacy have not been established. 12 to 18 years: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Safety and effectiveness of the lotion formulation in pediatric patients under the age of 12 have not been established.

Detailed Adaple dosage information


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Adaple are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Adaple if you are allergic to Adaple components. It is not known whether Adaple will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant or breast-feeding. Do not get Adaple in your eyes or on the inside of your nose or mouth. For the first 2 to 3 weeks of treatment, your skin condition may appear to worsen. This is expected. Do not stop using the medicine during this time. Do not use other medicines on your skin without first discussing it with your doctor. While you are using Adaple, you may use cosmetics. After using cosmetics, thoroughly wash and dry the affected area before applying this medicine. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Adaple. Use a sunscreen if you must be outside. Do not apply it to sunburned skin. Do not stop taking Adaple suddenly.

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Laparoscopy has become a well-established alternative to open surgery for the management of many urologic tumors. The quantity and quality of fats consumed in the diet influence the risk of cardiovascular disease (CVD). The cell cycle of early mammalian embryos: lessons from genetic mouse models. Inflammations of the periphery of the fundus oculi (report of 3 cases). Survival rates of women with carcinoma of the esophagus exceed those of men. To compare the morphological difference of coronary atherosclerotic plaques in patients with stable angina(SA), unstable angina (UA) and acute myocardial infarction (AMI). Sensitivity analysis can be used to analyse the effects of uncertainties associated with the criteria weights. Genetic load in subdivided populations: interactions between the migration rate, the size and the number of subpopulations.

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Clinical progress after randomized on/off pacemaker treatment for hypertrophic obstructive cardiomyopathy. Based on these in vitro studies, we determined if the MVNP gene from either an Edmonston-related strain of MV or a MVNP gene sequence derived from a patient with PD (P-MVNP), when targeted to cells in the OCL lineage of transgenic mice with the TRACP promoter (TRACP/MVNP mice), induced changes in bone similar to those found in PD. Performance of normal males on the Halstead Tactual Performance Test under severe environmental stress. Amino acid precipitation from plasma was followed by gel filtration on Sepharose 4B and further purification was achieved by affinity chromatography on heparin-Sepharose. There were numerous instances of damage to the cutting teeth surfaces. The atrioventricular node-His bundle track was destroyed by means of a neodymium-yttrium-aluminium-garnet laser (Nd-YAG laser) used in continuous emission at 35 watts. This is the first description of the evolution of a gap junction disease over time and we note that follow-up of patients suffering from gap junction skin disorders is necessary to fully delineate the phenotypes caused by mutations in gap junction genes.

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This condition is not uncommon, often chronic in presentation, not excluded by pyrexia, and commonly associated with anaemia. Formation of the corneous layer in the epidermis of the tuatara (Sphenodon punctatus, Sphenodontida, Lepidosauria, Reptilia). Friction melanosis and striae distensa caused by stretch training on a bench press. Mothers of 100 children were interviewed while admitted or in the emergency room. Massive anterior capsule shrinkage after plate-haptic silicone lens implantation in uveitis. New methods of endoscopic diagnosis of digestive tract diseases in the Soviet Union. Previously vascular calcification was thought to be a passive process which involved the deposition of calcium and phosphate in arteries and cardiac valves. HIV-1 in female genital secretions has been measured using swabs, Sno Strips (Akorn, Inc., Buffalo Grove, IL), and cervicovaginal lavage (CVL), but little is known regarding the comparability of these collection techniques. The association of peroxidases to the glucan matrix is in favor of the role of the sheath as a supporting structure. Increased accumulation of radioactivity was observed in malignant pleural and ascitic effusion as to a patient with stomach cancer and in malignant pleural effusions as to 2 patients (1 with breast cancer and another with lung cancer) during the performance of routine whole-body bone scans with 99mTc methylene diphosphonate.

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Electromyographic data were collected from seven hip, abdominal, and back muscle pairs. This article provides an overview of depression diagnosis in stroke, reviews the epidemiology of poststroke depression and its associated morbidity and mortality, and reviews existing evidence on the treatment and prevention of poststroke depression. Testicular adrenal rest tumors in a patient with congenital adrenal hyperplasia: sonographic and magnetic resonance imaging findings. In this study, genes encoding homologs of the Saccharomyces cerevisiae low- and high-affinity phosphodiesterases, PDE1 and PDE2, respectively, were deleted in serotype A strains of C. Understanding the human condition in this holistic manner prepares nurses to develop clinically relevant research questions. influenzae were then compared with blood levels attained after the usual dose regimens. The studies showed a substantial obstacle to volume flow in SE-disc valves while LK-valves are similar to normal mitral valves.

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To evaluate the safety and efficacy of transjugular intrahepatic portosystemic shunt (TIPS) in the control of bleeding from ectopic varices. Recent advances in understanding the role of metabolic, signaling, and inflammatory pathways in obesity have provided opportunities to better understand the pathophysiology of insulin resistance in the heart. The advantages of the Concise system as a bonding agent and our experiences with it over the past 10 years are discussed. In contrast to wild-type protein, they did not form gap junctions. The ASK1-GFP in a dominant negative fashion resulted in abnormal tetrads resembling those of the ask1-1 mutant, supporting that the expression timing of the ASK1-GFP in male meiocytes reflects the expression timing of the endogenous ASK1. coli and Pseudomonas fluorescens 701E1 is apparently driven by an S. Some features of the spatial organization of the central nucleus of the inferior colliculus of the cat. Hormones were measured to confirm ovulation and classify menstrual cycle phase among naturally cycling women and to monitor OC compliance among OC users. A pregnant woman presented for an emergency laparotomy under general anaesthesia. The study aimed to describe a case of vulvar angiomyxoma recurred almost 20 years after its initial surgery.

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Corpus callosum functioning in patients with normal pressure hydrocephalus before and after surgery. This method is based on the phenomenon that pathological blood under low pressure behaves like a solid body. Loads acting in an internal fixator measured in vitro under the application of pure moments such as those commonly used for implant testing and basic research were compared with loads measured in 10 patients in vivo. The diagnosis of PID was confirmed by laparoscopy in one patient who was later found to have a tubercular infection. The development of endobronchial stents provides a natural complement to techniques aimed at clearing bronchial obstruction by helping to maintain patency in the long term. Among several important and original contributions, this paper summarises his work on myxoedema, paraplegia and anorexia nervosa. atropine methonitrate, ipratropium bromide), 102 subjects tested with these drugs and with beta 2-adrenergic bronchodilators were classified into three groups, namely: a group with positive skin prick tests (group 1), a group with blood or sputum eosinophilia but negative skin prick tests (group 2), and a group with negative skin prick tests and neither blood nor sputum eosinophilia (group 3). Echocardiography in the evaluation of patients in chest pain units.

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The recommended approach to a child or adolescent with an endocrine emergency involves recognizing clinical disease, stabilizing the patient with basic and advanced life support intervention, and transferring the patient to a facility which can provide appropriate definitive care. GITR plays a pivotal role in controlling T cell-mediated responses in experimental models of organ-specific autoimmunity, chronic infection, and anti-tumor immunity. Changes in the number of DNA-protein cross links in spleen lymphocytes of mice exposed to low intensity low dose gamma irradiation. Screening patients admitted to a rehabilitation center has become important. This study was to establish a simple and easy method of immunoelectrophoresis to detect serum GPDA-F, and evaluate clinical value of GPDA-F in the diagnosis of hepatocelluar carcinoma. Efficacy and optimal dosing of short hairpin RNA against MUC1 was determined. Electrocardiographic bases for the diagnosis of left ventricular hypertrophy. Current trials lack long-term data required to assess safety as well as surgery for ALD. Mortality did not prove significantly different in the two groups. In the course of evolution, Gram-positive bacteria, defined here as prokaryotes from the domain Bacteria with a cell envelope composed of one biological membrane (monodermita) and a cell wall composed at least of peptidoglycan and covalently linked teichoic acids, have developed several mechanisms permitting to a cytoplasmic synthesized protein to be present on the bacterial cell surface.

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Our analysis suggests that the observed increase in ectopic pregnancies in this area was partly real and partly due to better diagnosis. Gender differences in academic productivity and academic career choice among urology residents. These constraints coincide with those that appeared in the previous literature on this topic. Strain difference of mouse in susceptibility to Mycoplasma pulmonis infection. Current status of dynamic lymphoscintigraphy and sentinel lymph-node biopsy in urological malignancies. For example, in contrast to TH, DAT immunoreactivity in the cortex was localized predominantly to small-diameter profiles, whereas, in the dorsolateral caudate nucleus, DAT and TH immunoreactivities were present in both large-diameter and small-diameter profiles, which may represent varicose and intervaricose axon segments, respectively. Maternal and cord blood leptin were compared by the Wilcoxon signed rank test. Recently it was shown that chronic back pain (CBP) is associated with a specific pattern of brain atrophy. (3) cN1 patients who are not downstaged by induction therapy have a poor outcome. The procedures outlined in this study may be used to establish a genetic map of adenovirus type 2.

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Five of the test animals were lost between 16 and 25 days after irradiation. Splenic responses to thymus independent (TI) antigens TNP-Ficoll and TNP-LPS were not reduced when these antigens were administered one day after LPS. The isozyme-selective P-450 inhibitor alpha-naphthoflavone (ANF) potently inhibited the high-affinity component of caffeine N-demethylations, while 1-phenylimidazole (PI) was a more potent inhibitor of the low-affinity component. Alosetron improves quality of life in women with diarrhea-predominant irritable bowel syndrome. Individual antibody coated beads with hepatitis A virus bound to their surface were trapped by negative dielectrophoresis in a field cage and analysed by fluorescence microscopy. Patients with primary SS show signs of both sympathetic and parasympathetic dysfunction. As soon as the SM organizes into intimal and sub-intimal layers (6 days of life), the 2 intimal cell types can be identified by their macrophagic (A-cells) and secretory (B-cells) features. We determined outcomes and associated factors in this rare group. Good clinical improvement was achieved after treatment with steroids, sulfasalazine, and anticoagulation with enoxaparin followed by long-term warfarin.

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Methanol extract from cultured Scutellaria baicalensis cells inhibited the proliferation of human monocytic leukemia cell line THP-1 and human osteogenic sarcoma cell line HOS. Combined staining with cytochemical stains for myeloperoxidase or nonspecific esterase on the same slide is also possible when needed. Sera were tested urispas 200mg dosage for antibodies (IgM and IgG) to Orientia tsutsugamushi using ELISA kit. Its reduction was known to be correlated with the prevalence of cardiovascular complications. A patient with Sturge-Weber-Dimitri disease presented with intractable seizures and progressive intellectual deterioration. This is the first report showing an anti-inflammatory activity of estrogen in microglia. Two groups of animals were implanted with stimulating electrodes in the lateral hypothalamus for intracranial self-stimulation (ICSS). Based on ATP content and histomorphology, APAP was more toxic in mouse than in rat and human PCLS.

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Here, we demonstrate for the first time that mesenchymal stem (MS) cells can in fact be recovered from matrix material saturated with cells from bone marrow after microfracture. Direct counts with acridine orange showed no significant difference between glutaraldehyde- and Lugol iodine solution-preserved samples under any storage temperature when samples were counted within 1 week of collection. Absence of CD40 signaling is associated with an increase in intimal thickening after arterial injury. A 41-year-old woman suffering HGES, with positive staining for CD117 (c-kit) and large abdominal and retroperitoneal mass progressing after chemotherapy, vasotec tablet was treated with Imatinib Mesylate. When exercise interventions are supervised and energy expenditure is controlled, there are no sex-based differences in the measured compensatory response to exercise. Six patients had low-dose-rate brachytherapy, and 2 patients had high-dose-rate brachytherapy. hMPV may be the etiology of some cases previously categorized as idiopathic pneumonia syndrome. Alternate but do not swim: a test for executive motor dysfunction in Parkinson disease.

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This study investigates differences in femur midshaft shape, robusticity, and sexual dimorphism derived from external measurements between a broad range of prehistoric and historic North American populations with different subsistence strategies and inferred levels of mobility. We report two cases of idiopathic pulmonary haemosiderosis who responded well to treatment with oral glucocorticoids. The Sixteen Personality Factors Questionnaire (16PF) was administered to 69 subjects. Chronic aspecific respiratory disease: the gaps in our knowledge prilosec 30 mg and the aim for future work. podJ null mutants are unable to form holdfast or pili, have reduced swarming motility, and have difficulty ejecting the flagellum during the swarmer to stalked cell transition. Effects of activation on functional aster formation, microtubule assembly, and blastocyst development of goat oocytes injected with round spermatids. Long-term studies, to document anticipated improved safety with slow shock-wave rate, are needed. Many patients deemed inoperable for AVR have been treated successfully by TAVI. Observation on the cytology of tongue coating in common childhood diseases.

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Localization of Cu, Zn-SOD in human gastric mucosa with monoclonal antibody. Filoviruses belong to the order of negative-stranded non-segmented RNA viruses and are classified zetia medication class into two genera, Ebola and Marburg viruses. Accuracy of predicting and controlling time-dependent aortic enhancement from a test bolus injection. The recombinant TK proteins containing the aa substitutions R41H or V348I had high phosphorylation activities suggesting most likely natural gene polymorphisms. Heavy metal intoxication not only inhibits transport of amino acids at the brush border, but also prolongs their TET and increases the size of S for a given reabsorbed load. The indices with the most significant diagnostic value in hyper- and hypothyroidism were derived on the base of a comprehensive analysis of the individual data. We here compare the efficacy of three different delivery strategies for antisense PNA: 1) conjugation to hydrophobic peptides, 2) adsorption onto polymeric microspheres and 3) encapsulation in autologous erythrocytes. The author describes a case of ankle valgus following an undiagnosed traumatic section of tibialis posterior tendon.

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Immunochemotherapy with schizophyllan (SPG) combined with chemotherapeutic agents was evaluated in two syngeneic tumor-C3H/He mouse systems. Damicoside from Axinella damicornis: the influence of a glycosylated galactose 4-OH group on the immunostimulatory activity of alpha-galactoglycosphingolipids. The North American Opossum (Didelphis marsupialis) is an excellent model for the study of hemoglobin ontogeny. The study systematically varied rigid lens parameters and corneal topography while monitoring the following key aspects of lens fit. Clinical effect of newly developed oral carbonaceous adsorbent (AST-120) in patients with advanced stages of chronic glomerulonephritis. At about 90 days of age, each male was given testosterone replacement therapy and tested over a period of 6 weeks for mounting. Complement (C3) receptor-mediated attachment of agarose beads to mouse peritoneal macrophages and human monocytes. Isomeric compounds of N alpha-arylsulfonylated amides of omega-amidinophenyl-alpha-aminoalkylcarboxylic acids--N levaquin antibiotics alpha-amidinophenylsulfonylated amides or N alpha-arylsulfonylated amidino anilides of omega-phenyl-alpha-aminoalkylcarboxylic acids, respectively--possess weak antithrombin activity as compared to the derivatives of the basic structure.

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Treatment of postoperative nausea and vomiting with dolasetron versus ondansetron: is there a conflict of interest?. Arterial embolization in the treatment of renal trauma of a horseshoe kidney. Modification of electrode for regional mucose blood flow measurements with the aid of hydrogen gas clearance. These results suggest that gibberellin modulates the activity of mtPDC by regulating OsPDK1 expression and subsequently controlling plant growth and development. We used reliable techniques to detect disease-related genes and confirmed downregulation of desmuslin in abnormal veins. Functional interaction between Pax3 and TAZ may provide a clue to clarifying the mechanism by which Pax3 serves as a transcriptional activator during embryogenesis. We propose an interlingua-based indexing approach to account for the particular challenges that arise in the design and implementation of cross-language document retrieval systems for the medical domain. Batch as well as dynamic adsorption studies were conducted with 10(-5) to 5 x 10(-3) M Cu(II) and Cd(II).

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By repeated biopsies, time-sequential changes of the injected colloidal carbon distribution were investigated in glomeruli of NZB/W F1 mice. However, currently available treatments for both these viruses are effective only in a limited number of patients, are costly, prolonged, associated with significant side effects and require a substantial commitment from the patients and healthcare providers. The results demonstrate that a successful employment of PTA depends on a normal contralateral renal plasma flow and a normalization of plasma flow of the post-stenotic kidney. The incidence of stroke in China is higher than that of coronary artery disease. Increased risk of exceeding entertainment-media guidelines in preschool children from low socioeconomic background: the Generation R Study.

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Campylobacter numbers recovered from the breast skin of carcasses treated with vinegar also increased during defeathering but to a significantly lesser extent. Spectroscopic and computational studies of the de novo designed protein DF2t: correlation to the biferrous active site of ribonucleotide reductase and factors that affect O2 reactivity. Glycemic reaction and state of the Islands of Langerhans in golden hamsters following dithizone administration. Inflammatory myofibroblastic tumor of renal pelvis presenting with prolonged fever and abdominal pain in children: report of 1 case and review of literature. The trajectories were analyzed by using principal component analysis. Small particle formation was the primary aggregate induced during and after cardiopulmonary bypass in both groups, and serial changes in particle formation up to 24 hours after cardiopulmonary bypass were similar in both groups. Plasmic digests of fibrinogen, produced at various enzyme-to-substrate ratios, and purified plasmic degradation products of fibrinogen reacted poorly with the absorbed antiserum. The gene ncgl2918 encodes a novel maleylpyruvate isomerase that needs mycothiol as cofactor and links mycothiol biosynthesis and gentisate assimilation in Corynebacterium glutamicum.

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