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Aldactone (Spironolactone)

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Aldactone is a diuretic (water pill) used to treat a number of different problems including primary aldosteronism (an imbalance in hormones that causes high blood pressure), heart failure, high blood pressure, and swelling due to certain liver or kidney problems. Unlike other diuretics, it doesn't lower your body's potassium levels.

Other names for this medication:
Aldostix, Amifru, Aquamide, Dyamide, Dytor, Fruselac, Frusis, Lactone, Lasilactone, Metolactone, Spilactone, Spiromide, Spironolactone, Spirotic, Torlactone, Tormax, Torsid, Zator

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Also known as: Spironolactone


Generic Aldactone is a perfect remedy, which helps to fight with hyperaldosteronism, hypokalemia, edema, ascites, hirsutism, alopecia (baldness), acne. It can also be used together with other medicines to treat myasthenia gravis, precocious puberty, high blood pressure. Generic Aldactone acts by controlling the level of water and salt and by decreasing the potassium loss from your body. Aldactone is also known as Spironolactone, Spirotone, Spiractin, Osyrol, Spiroctan, Spirolon, Verospiron. It is aldosterone receptor antagonists. Generic name of Generic Aldactone is Spironolactone. Brand names of Generic Aldactone are Aldactone, Spiractin, Spirotone, Spironol, Berlactone, Novo-Spiroton.


You can feel the effects of Generic Aldactone after 2 weeks of treatment. It depends on the health state and other factors of the patient. Take Generic Aldactone tablets orally with water, at the same time every day. Do not crush or chew it. Take Generic Aldactone once (in the morning) or twice a day. If you want to achieve most effective results do not stop taking Generic Aldactone suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store below 25 degrees C (77 degrees F). Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Aldactone are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Aldactone if you are allergic to spironolactone, or if you have:

Addison's disease (an adrenal gland disorder); high levels of potassium in your blood (hyperkalemia); if you are unable to urinate; or if you are also taking eplerenone.

To make sure Aldactone is safe for you, tell your doctor if you have:

an electrolyte imbalance (such as low levels of calcium, magnesium, or sodium in your blood); kidney disease; liver disease; or heart disease.

Tell your doctor if you are pregnant or plan to become pregnant. Having congestive heart failure, cirrhosis, or uncontrolled high blood pressure during pregnancy may lead to medical problems in the mother or the baby. Your doctor should decide whether you take Aldactone if you are pregnant.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

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To obtain detailed structural information for spider dragline spidroin (MaSp1), we prepared three versions of the consensus peptide GGLGGQGAGAAAAAAGGAGQGGYGGLGSQGAGR labeled with 13C at six different sites. We have investigated the effect of lead on nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells and the role in this process of extracellular signal regulated protein kinase (ERK), a key component of NGF-induced differentiation. A simple method of evaluating actual patient dependency is presented and a suggestion made as to how this dependency can be correlated with nursing staff levels. This is the first study to report that its incidence is significantly related to the extent of sympathectomy or the location of primary hyperhidrosis. Such a marked decrease in RNA content coincided with high values of the G1a X G1b ratio in the G1 phase.

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Intermittent androgen ablation in patients with biochemical failure after pelvic radiotherapy for localized prostate cancer. Main physiopathologic mechanisms involved in hepatic drug reactions. Thirty-two women received hyperbaric oxygen therapy in a multiplace chamber for a median of 25 sessions (range, 7-60). Wnt3a may also modulate the symmetry-breaking activity of mechanosensory cilia in the node. Mutations in the Pendred syndrome gene have been observed in patients with deafness and vestibular aqueduct dilatation, in the absence of other Pendred syndrome features. Also, the ideal suturing technique (interrupted v continuous) according to the physical characteristics of the suture material and the optimal length for laparoscopic sutures were determined. Reducing infant mortality in rural America: evaluation of the Rural Infant Care Program.

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Alterations in the non-coding displacement (D) loop of mitochondrial DNA are present in many cancers. A model of patient migration is specified and estimated using panel observations covering mobility and other main regional quality indicators over the period 1996-1999. One hundred six patients with abdominal pain were prospectively enrolled in this study. The spectrum of secreted enzymes comprised various types of hydrolases and lignolytic enzymes of the manganese peroxidase/versatile peroxidase family. The PC-ANNs approach with SNV preprocessing spectra was found to provide the best results. Our findings suggest that alterations on this protein might imply changes in microtubule-involved function such as cell division, which in the testes might lead to damage in the spermatogenesis, leading probably to infertility. This equivalent circuit contains a minimum number of components necessary for understanding and quantifying the detuning and losses caused by electric and magnetic field coupling with the sample. Current medical therapy includes dopamine receptor antagonists and atypical antipsychotics. FH-B-hTERT can induce hESCs differentiation into hematopoietic cells more efficiently than S17. Twenty-five compounds were identified from the dichloromethane and methanol extracts of royal jelly from Greece.

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In this paper the potential use of hematoporphyrin-derivative (HpD) phototherapy in the local treatment of bronchogenic carcinoma is discussed. However, only a few organogels are currently being studied as drug/vaccine delivery vehicles as most of the existing organogels are composed of pharmaceutically unacceptable organic liquids and/or unacceptable/untested gelators. The molarless condition enhanced an age-dependent decrease in both learning ability and the number of neurons in the hippocampal CA1 subfield and the age-dependent increase in the number and hypertrophy of GFAP-labeled astrocytes in the same subfield. The yeast two-hybrid assay revealed that Bacillus subtilis DnaD, a possible component of the primosome and required for replication initiation, interacted with DnaA and DnaD itself. Divergent effects of BMP-2 on gene expression in pulmonary artery smooth muscle cells from normal subjects and patients with idiopathic pulmonary arterial hypertension. Six hundred and fifty one cases of acute myocardial infarction were retrospectively recorded in the Emergency County Hospital of Baia Mare from 1.01.1999 till 30.09.2003. These data suggest that IL-6 may be involved in the progression of subclinical LV dysfunction to clinical CHF. A synchronized molecular clock was also demonstrated in equine adipose tissue although oscillation of Bmal1 was less robust than that of Per2 and Cry1. This paper summarizes the BRAVO Study extinction budget assessment and interprets the attribution results in the context of annual and multiyear causes of haze by drawing on long-term aerosol monitoring data and regional transport climatology, as well as results from other investigations. Exceptional total and functional yields of the human adenosine (A2a) receptor expressed in the yeast Saccharomyces cerevisiae.

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To develop a set of items to supplement the Consumer Assessment of Healthcare Providers and Systems (CAHPS) Hospital Survey (HCAHPS) to assess how well hospitals communicate health information to inpatients. Diagnostic value of single-photon-emission computed tomography in severe central nervous system involvement of systemic lupus erythematosus: a case-control study. The use of modern, minimal invasive methods and tension free mesh implants for the reconstruction is widely used in rectocele repair as well. On the copies the lenght of contact between the different juxtaglomerular structures and the basement membrane of the macula densa was measured. Before the third postnatal week no difference was observed in the laminar or topographic organization of the ipsilateral retinotectal projection between vehicle and treated rats in either normal or lesion conditions. It is suggested that the failure of anterograde conduction at relatively late atrial coupling intervals was caused by a short AH functional refractoriness produced by the pre-excitation of the lower AV junction by a partial AV nodal bypass. Among the amino acids tested, the most stimulatory compounds for both the ros and rp were L-alanine and L-arginine, having estimated electrophysiological thresholds of approximately 10(-9) M. The molecular weight of the biochemically purified HSS was found identically to that of the recombined HSS as expressed in the prokaryotic cells. The presence of blood-borne hunger and satiety factors in domestic fowls was investigated in two experiments.

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DPSCs were challenged at MAO and smooth titanium surface separately for different durations, and the bone marrow mesenchymal stem cells (BMSCs) served as the positive controls. The transesophageal approach has been shown to provide additional diagnostic information over conventional transthoracic imaging for specific structural cardiac anomalies and in the perioperative setting, the opportunity for confirmation of preoperative diagnoses, and modification of the surgical plan if new or different pathology is identified. A modest but significant improvement in ascorbic acid status occurred in response to supplement and the riboflavin supplement enhanced the overall improvement in riboflavin status observed. Physical activity in the prevention of cardiovascular disease: an epidemiological perspective. Experimental control periods were of 60min duration in all cases. Elements are collected from the column by using a mixture adjusted to a pH range of 4-7 and 6-12 by ammonia or ammonium chloride for Ga and In, respectively.

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The concentration of LH in plasma, particularly at 7 to 9 weeks of age, before gonadal growth, or during the prepubertal peak of LH secretion, at about 2 to 4 weeks before the onset of lay, may be a useful criterion in the selection of laying strains. Localization of a flavonoid biosynthetic polyphenol oxidase in vacuoles. However, these IS are also detected in the genomes of various Bordetella species, such that they are not specific for either B. In contrast, FCGR2A 131H/R and FCGR3A 158V/F polymorphisms could not predict treatment outcomes. All the patients were treated initially conservatively with rest and antibiotic therapy after diagnosis and those who did not respond to conservative treatment of at least 4 weeks were treated surgically. Observations on amniotic fluid bilirubin levels in relation to gestational age. Many elderly patients developed new functional impairment following hospitalisation. Absence of device-device interaction (DDI) in a patient with cardiac and diaphragmatic pacemakers for congenital central hypoventilation syndrome. Our results show a striking heterogeneity in patients WB clotting profiles, each patient having a particular pattern and an individual type of response to bypassing agents. In contrast, control Profilin I, without the PTD4 domain, was unable to cross the cell membrane.

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Structure of the neuronal protein calexcitin suggests a mode of interaction in signalling pathways of learning and memory. The integration of viral cDNA into the host genome is an essential step in the HIV-1-life cycle and is mediated by the virally encoded enzyme, integrase (IN). Cubital tunnel release with excision of the distal half of the medial epicondyle was performed in 19 patients. Evaluation of prospective methods of obtaining desalinized water for a centralized domestic drinking water supply. The POC is a guiding catheter with an occlusion balloon attached on the outside of the catheter at its distal end. In 35 consecutive patients (median age, 62.3 years) with biopsy-proved prostate cancer, 3-T endorectal MR imaging was performed. Early repair seems to preserve postcoarctation arterial wall structure, but seems to have only limited effect on precoarctation vessel walls, which supports the theory of a developmental defect of the proximal aorta and its branches.

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The constraints of body size on aerodynamics and energetics in flying fruit flies: an integrative view. Contrast-enhanced cardiovascular magnetic resonance (CMR) is a useful adjunct in the diagnostic work up of patients with TTC. Similar results were obtained with alternative models, including a traditional univariate proband predictive model. APOE polymorphism does not affect the incidence of dementia in this age group. In this study, we demonstrate the involvement of DNAM-1-triggering receptor and its ligands, poliovirus receptor (PVR) and Nectin-2, in natural killer (NK) cell-mediated lysis of dendritic cells (DCs).

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Serological study of leptospiral infections and endogenous uveitis among horses and ponies in the United Kingdom. Molecular evolution and functionally important structures of molluscan Dermatopontin: implications for the origins of molluscan shell matrix proteins. We report a 1-y-old girl with cervicofacial nocardial infection who presented with acute suppurative otitis media and lymphadenitis. Here we show that the putative T-cell receptor mRNA is expressed at a relatively high level during intrathymic differentiation before decreasing about 10-20-fold in normal, mature peripheral blood T cells and that it can also be detected in T-cell clones with helper and cytotoxic functions, as well as in at least one clone with suppressor properties. Previous reports have suggested that the bladder epithelial zebeta drug barrier may be compromised in interstitial cystitis (IC). Effect of repeat acute injury on contractile function of the external anal sphincter in an animal model. Total mercury, organic mercury, copper, manganese, selenium, and zinc in Sarda sarda from the Gulf of Genoa. The low-temperature recombination of CO with myoglobin was studied using Fourier transform infrared spectroscopy.

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The aim of the study was to investigate the effects of level of neuroticism on electrophysiological event-related potentials (ERPs) to different kinds crestor dose equivalent to pravastatin of stimuli. We have also identified TSG-6 as a potential marker that could be used for early diagnosis and prognosis of cancerous or precancerous lesions. Valve replacement surgery in end-stage renal failure: mechanical prostheses versus bioprostheses. Fifty-five TKAs were performed with the only difference being whether an intramedullary (31) or extramedullary (24) cutting guide was used. Retrospective study of all patients that presented between 1992 and 1998 with congenital nystagmus not related to visual deprivation or acquired pathologies of the visual pathways. The location of the tumor with its benign course producing no demonstrable increase in visual loss over 14 years in such a young patient is quite unusual. Dermatosis papulosa nigra (DPN) is a disorder commonly encountered in the adult black population.

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In metallic alloys corrosions and electric currents can effect an irritation to the oral mucosa. The use of mathematical models to determine relapse and to predict response to chemotherapy in breast cancer. The biogenesis of these multisubunit enzymes, encoded by the ccoNOQP operon, depends on the ccoGHIS gene products, which are proposed to be specifically required for co-factor insertion and maturation of cbb3-type cytochrome c oxidases. These results indicate that DISC1 is involved in cerebral cortex development, and suggest that loss of DISC1 function may underlie neurodevelopmental dysfunction in schizophrenia. Mast cells modulate maintained neuronal activity in the thalamus in vivo. These results suggested that the cast joining could be potentially employed for electroformed copings. Results indicate that hepatic triglyceride (TG) and cholesterol ester content are greater and plasma levels of TG and cholesterol are lower in triolein-supplemented groups. SP protected neonatal brain from hypoxic-ischemic injury through maintaining cerebral metabolism and mitochondrial function. We explored the association between different types of childhood families with later alcohol-related problems of the offspring, in particular drunk driving.

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