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Alendronate is used to prevent and treat certain types of bone loss (osteoporosis) in adults. Osteoporosis causes bones to become thinner and break more easily. Your chance of developing osteoporosis increases as you age, after menopause, or if you are taking corticosteroid medications (such as prednisone) for a long time.

Other names for this medication:
Alant, Alendix, Alendronate, Alenost, Bifosa, Denfos, Osteofos, Ostogee, Poronil, Ralenost, Restofos, Zophost

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Intagra, Mellaril, Tricor, Periactin, Valium, Casodex


{name} (alendronate) is a bisphosphonate (bis FOS fo nayt) medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures.

{name} is used in women to treat or prevent osteoporosis caused by menopause and in men and women to treat osteoporosis caused by taking steroids.

{name} is also used to increase bone mass in men who have osteoporosis, and to treat Paget's disease of bone in men and women.


Generic Alendronate should be taken orally. It is recommended to take Generic Alendronate in liquid form once a week in the morning without food. It is recommended to take Generic Alendronate in tablets of 5-mg and 10-mg once a day in the morning without food. It is recommended to take Generic Alendronate in tablets of 30-mg and 70-mg once a week in the morning without food. It is recommended to take Generic Alendronate in tablets of 40-mg once a day in the morning for six months to treat Paget's disease of bone. If you want to achieve most effective results do not stop taking Generic Alendronate suddenly.


Drink a full glass of milk and seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Do not make yourself vomit and do not lie down.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alendronate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Alendronate if you are allergic to alendronate, or if you have:

low levels of calcium in your blood (hypocalcemia); or problems with the muscles in your esophagus (the tube that connects your mouth and stomach).

Do not take Alendronate if you cannot sit upright or stand for at least 30 minutes. Alendronate can cause serious problems in the stomach or esophagus. You must stay upright for at least 30 minutes after taking this medicine.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

trouble swallowing; problems with your stomach or digestion; low levels of calcium in your blood; a dental problem (you may need a dental exam before you begin taking Alendronate); kidney disease; or any condition that makes it hard for your body to absorb nutrients from food (malabsorption).

In rare cases, this medicine may cause bone loss (osteonecrosis) in the jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work. The longer you use Alendronate, the more likely you are to develop this condition.

Osteonecrosis of the jaw may be more likely if you have cancer or received chemotherapy, radiation, or steroids. Other risk factors include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem.

Alendronate has also been reported to cause fractures, or broken bones, in the large bones of the leg. Tell your doctor if you have any leg or groin pain while using Alendronate.

Talk with your doctor about the risks and benefits of using this medication.

It is not known whether Alendronate will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Stop using the medicine and tell your doctor right away if you become pregnant.

It is not known whether alendronate passes into breast milk or if it could harm a nursing baby. Ask your doctor about any risk.

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The subunit structures of placental Hex A and B have previously been assigned as alpha beta 2 and 2 beta 2, respectively. To investigate whether the globules or bridges observed are caused by fibrinogen, platelets were washed and treated first with thrombin (1 U thrombin/ml) in order to remove fibrinogen from platelet storage organelles and then with plasmin (0.5-2 U/ml) in order to dissolve remnants of fibrinogen from the platelet surface. Skin cancer is the most common neoplasm in Brazil, with increasing incidence in recent decades. An iterative type I polyketide synthase PKSN catalyzes synthesis of the decaketide alternapyrone with regio-specific octa-methylation. The antagonistic action of metallic cations to the enhancing activity of phoscolic acid, a tetracycline adjuvant. Disease-specific health status (SGRQ) and generic health status (EQ-5D, AQoL, SF-36) were assessed at baseline, four, eight, and 12 months. This changes the ribosome-binding sequence GAGG of gene E to GAAG without affecting the amino acid, glutamine, encoded by the overlapping gene D. The relaxation of electronic spins S of paramagnetic species is studied by the field-dependence of the longitudinal, transverse, and longitudinal in the rotating frame relaxation rates R1, R2, and R1rho of nuclear spins I carried by dissolved probe solutes.

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Heme oxygenase-1 mediates the anti-inflammatory effect of mushroom Phellinus linteus in LPS-stimulated RAW264.7 macrophages. Emodin, not through open block mechanism, markedly reduced the amplitude of I(KA) and I(Kdr) and modulated the gating properties of K(V) channels in a reversible and dose-dependent manner. Reliable diagnosis (especially for BD-II) and/or instigation of recommended treatments is currently delayed by insufficient awareness of the early, polymorphous presentations of BD, lack of systematic screening and/or failure to follow established guidelines. These spindle-shaped cells expressed vimentin and ASMA but not cytokeratin (AE1/3). Under fluoroscopic guidance, we performed discography using indigocarmine mixed with radio-opaque dye. Stable osteochondritis dissecans lesions show no surrounding signal abnormality on T2-weighted images. To investigate the molecular phenotypes and senescent mechanism of NP cells, and to identify the method of alleviating senescence of NP cells. This study provides further empirical evidence that trauma, when sufficiently severe, is the most significant predictor of PTSD severity.

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Influence of cavity configuration on the adhesion of two resin-based composites to pulpal floor dentin. Explained variation from a multilevel model of appropriate care is partitioned across patient-, physician-, and clinic-level factors. Sodium arsenite-induced inhibition of eukaryotic translation initiation factor 4E (eIF4E) results in cytotoxicity and cell death. The CD11c-enriched dendritic cell population obtained from the spleen was transduced in vitro with recombinant hepatitis C virus core and nonstructural 5 proteins by using macromolecular-based protein delivery. Fibrochondrocytes from temporomandibular joint (TMJ) discs were exposed to dynamic tensile strain for various time intervals in the presence of interleukin (IL)-1beta. Furthermore, the possibility of perfusion abnormality due to these uncommon conditions must be remembered whenever trauma patients are evaluated for pulmonary thromboembolism with scintigraphy. Anaerobic Degradation of Chloroaromatic Compounds in Aquatic Sediments under a Variety of Enrichment Conditions.

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Promise and pitfalls of quantitative imaging in oncology clinical trials. Only those hips with a persisting deformity need undergo femoral osteotomy. An unusual presentation of mastocytosis: unilateral swelling of the vulva. The age/latency relationship in the total sample was significant, but contrary to the reports of some others was statistically better described at CZ by a linear and not a curvilinear age regression function. Headache, and migraine in particular, is the main neurological reason for consultation. There are no systematic screening programs and traditional platforms for newborn hearing screening, such as well-baby and intensive care nurseries, do not provide sufficient coverage due to the high incidence of births at home or in primary healthcare facilities. Adsorption of hydrogen sulfide onto activated carbon fibers: effect of pore structure and surface chemistry. The adherent and B cells from both infected and control animals failed to induce significant tolerance.

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Abundant degenerating axon terminals were observed to make axosomatic synaptic contacts with rubral neurons labeled with HRP retrogradely and also with unlabeled rubral neurons. The mechanism of formation of spinal SDHs after trauma has been heretofore relatively unclear. Such alterations may play a role in the pathogenesis of alcoholic liver disease. The authors recommend the integration of the method of ultrasonic diagnosis in the system of measures taken for tending the pregnant. Risk analysis is a widely used tool to understand problems in food safety policy, but it is seldom applied to nutrition policy. Quantitative analysis of human SAA and C-reactive protein (CRP) was performed by radial immune diffusion (RID) assay for all cases. The syrinx, the vocal organ in birds, shows sexual dimorphism in the duck, Anas platyrhynchos. This extensive aggregation process takes place not only in solution, but also on FbsA-functionalized colloidal particles, and leads to the formation of a thick layer on the bacterial cell wall itself, which becomes an efficient mask against phagocytosis. Taken together, these data identify ROR alpha1 as a potential target in the treatment of chronic inflammatory diseases, including atherosclerosis and rheumatoid arthritis. Interleukin-10 and Fas polymorphisms and susceptibility for (pre)neoplastic cervical disease.

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The methodology has wide-spread applicability for analyses of dynamic or static spinal or other ligament strains, and may be used to determine spinal canal and intervertebral foramen narrowing and area reduction. We show that gefitinib plus sirolimus can be safely coadministered on a continuous, daily dosing schedule, and established the recommended dose level of these agents in combination for future phase 2 clinical trials. Different outcomes of synergy between song production and song perception in the same subspecies (Molothrus ater ater). In addition, phosphorylation of the serine/threonine kinase AKT and of glycogen synthase kinase 3 was inhibited in T cells from lethal toxin-injected mice. The identity can a child take cough medicine and motrin of the sulfoxide was surmised from gas chromatography-mass spectrometry and gas chromatography- Fourier transform infrared spectroscopy results. The short- and long-term outcomes of the patients were evaluated with regard to stump salvage, wound healing rate, complications, and mortality rate.

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X-ray diffraction patterns of liquid crystalline solutions of poly-gamma-benzyl-L-glutamate. Enhancement of single-strand breaks by chemical radiosensitizers. Analytical and preparative isoelectric focusing were used to characterize xylanase multienzyme components. Influence of Fusarium and Myrothecium mycotoxins on dehydrogenase activity of Saccharomyces cerevisiae. Using genome-wide SNP data, we found the distribution of SNPs within each open reading frame (ORF) of MLST loci, which were not represented by the established B. The strong signature of positive Darwinian selection in a major part of D1 protein is testament to this. The usual potential complications associated with trauma to mature skeleton, as well as immature selection includes post-traumatic arthritis, stiffness, reflex sympathetic dystrophy, as well as those seen with physeal damage including leg length discrepancy, angular deformities, or a combination. This indicates that there was no increased resistance in the placenta, neither after the nicotine gum nor the placebo gum.(ABSTRACT TRUNCATED AT 250 WORDS).

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The PrP-Sc occurred within germinal centers of the affected nictitating membranes and tonsils and was located in the cytoplasm of the dendrite-like cells, lymphoid cells, and macrophages. The kinetic mechanism of a flavonol-ring-B O-glucosyltransferase from Chrysosplenium americanum was investigated. This effect was not secondary to a change in bronchomotor tone but was possibly related to changes in pulmonary haemodynamics. Paper chromatographic determination of free amino acids in the bone marrow of some animals during different seasons. In vivo and in vitro demonstration levaquin antibiotic sinusitis of epithelial cell-induced myofibroblast differentiation of keratocytes and an inhibitory effect by amniotic membrane. Osteoporosis and proximal femoral fractures in the female elderly of Jerusalem. We isolated cells from surgical resections of 21 prostate tumors and measured apoptosis and viability in these primary cells and 17 established cell lines from human prostate, bladder, renal cell and testicular carcinomas.

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Less widespread alterations were found concerning the glutamatergic neurotransmission system. Pediatric-specific antimicrobial susceptibility data and empiric antibiotic selection. We quantified the CHD burden and analysed trends from 1999 to 2007 in all adults aged over 25 years resident in England. The differentiation and localization of intraocular disorders (e.g. Degree of participation of exogenous thymidine in the overall deoxyribonucleic acid synthesis in Escherichia coli. Supplemental oxygen therapy and rehabilitation of the patient with chronic obstructive pulmonary disease. Combined laparoscopy in the diagnosis of diseases of the organs of the hepatopancreatoduodenal zone. This study directly addressed the issue of gene therapy of mitochondrial diseases by using nuclear transplantation of zygotes of transmitochondria mice (mito-mice). This study suggests that addition of RSG to submaximal doses of MET may be a suitable alternative to the maximal effective dose of MET monotherapy. Due, possibly, to an effect on the libido glucophage medicine exposure to 45 rad increased the fertility whereas the animals given 63 rad produced less offspring than the controls.

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