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Alpram (Alprazolam)
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Alpram

Alpram is used to treat anxiety and panic disorders. It belongs to a class of medications called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body (GABA). Alpram is mostly used to treat anxiety disorders, panic disorders, and nausea due to chemotherapy. Alpram may also be indicated for the treatment of generalized anxiety disorder, as well as for the treatment of anxiety conditions with co-morbid depression. The FDA label advises that the physician should periodically reassess the usefulness of the drug.

Other names for this medication:
Alpradol, Alprazolam, Alprine, Alprogard, Alprop, Alzin, Alzotime, Ambusyn, Anxizam, Balmusa, Depoxit, Dizeral, Emlol, Fledore, Kaprolam, Oclam, Parazolam, Paxor, Pecalm, Plaxid, Setlan, Silam, Sozox, Tagat, Trazopin, Viprax, Zoltweet

Similar Products:
Calan, Vantin, Theolair, Combivent, Lexapro, Duphaston, Actos

Also known as: Alprazolam

Description

{name} XR (alprazolam) is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Alprazolam affects chemicals in the brain that may become unbalanced and cause anxiety.

{name} XR is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

{name} XR may also be used for other purposes not listed in this medication guide.

Dosage

This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alpram XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of alprazolam can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alpram dosage information

Side effects

The most common side effects associated with Alpram are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Alpram XR if you have:

narrow-angle glaucoma; if you are also taking itraconazole (Sporanox) or ketoconazole (Nizoral); or if you are allergic to alprazolam or to other benzodiazepines, such as chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

Before taking Alpram XR, tell your doctor if you are allergic to any drugs, or if you have:

asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems; glaucoma; kidney or liver disease (especially alcoholic liver disease); a history of depression or suicidal thoughts or behavior; or a history of drug or alcohol addiction.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

It is dangerous to try and purchase Alpram XR on the Internet or from vendors outside of the United States. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of alprazolam purchased on the Internet have been found to contain haloperidol (Haldol), a potent antipsychotic drug with dangerous side effects. For more information, contact the U.S. Food and Drug Administration (FDA) or visit www.fda.gov/buyonlineguide

FDA pregnancy category D. Alpram XR can cause birth defects in an unborn baby. Do not use Alpram XR without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. Alprazolam can pass into breast milk and may harm a nursing baby. Do not use Alpram XR without telling your doctor if you are breast-feeding a baby.

The sedative effects of Alpram XR may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking Alpram XR. Do not give this medication to anyone under 18 years old.

Alpram XR pregnancy and breastfeeding warnings (more detail)

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Because this form of cerebrovascular disease is potentially preventable, interventions that address risk factors for the development of cerebral microangiopathy may go a long way in preventing disability for the next generation of elderly persons. Two basic mechanisms have been proposed as being potentially responsible for c9FTD/ALS: loss-of-function of the protein encoded by this gene (associated with aberrant DNA methylation) and gain of function through the formation of RNA foci or protein aggregates. A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis, resection rate, mortality and morbidity. The aim of the current survey was to provide an updated overview of anesthetic management of Caesarean sections in Germany. ctxB gene was amplified by PCR method and sequenced for further analysis. Lack of standards in informed consent in complementary and alternative medicine.

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We report here a study on the environmental dependence of the occurrence, at low temperature, of ultra-sharp field induced avalanches in phase separated manganites. As MAD4 is a member of the MAD family, which antagonizes the functions of MYC and promotes cell differentiation, the biological function of the interaction between TCP10L and MAD4 may be to maintain the differentiation state in liver cells. This is one of the first reports indicating the pharmacogenetic role of Cyp2C19 and ABCB1 in teratogenesis of AED in pregnant WWE. A diagnostic strategy guided by keen clinical judgment should focus on positive symptom criteria and on the absence of alarm symptoms. Relationship between the expressions of mitofusin-2 and procollagen in uterosacral ligament fibroblasts of postmenopausal patients with pelvic organ prolapse. Demand for improved capability has resulted in a drive to maximise the efficiency of the solver whilst maintaining a reliable solution.

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We embed the fixed brain hemisphere with reference markers in agar. All 4 subjects with apperceptive prosopagnosia due to lesions limited to fusiform cortex had intact voice discrimination and recognition. To determine the efficacy of proton-pump inhibitor (PPI) therapy for chronic laryngo-pharyngitis treated with lifestyle modification. Measurement of Dmax/MU values with either solid or nontilting scanning water systems may give rise to inaccuracies due to the difficulty in locating an accurate position for dmax, since the ionization chamber usually cannot be scanned along the central axis of the beveled intraoperative applicator. 11 of these patients are alive at least 6 months after grafting, 5 of them after more than 2 years. Based on that, we performed molecular assays for the identification of E542K, E545G/K and H1047R mutations in the PIK3CA gene and of the R248C mutation in the FGFR3 gene. We therefore suggest that dysspondyloenchondromatosis is a genetically heterogeneous condition. It is also made likely that the shed elicitors are of peptidoglycan nature. Influence of liposomal local anesthetics on platelet aggregation in vitro. Multiple system atrophy (MSA) is an adult-onset and rapidly progressive, neurodegenerative condition that presents with autonomic dysfunction, parkinsonism, cerebellar ataxia and corticospinal deficits.

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By knowing in extreme detail the exact anatomy of the complex post-surgical coronary system, a successful treatment can be planned for the patient. However, these weights increased more significantly in KO mice compared to WT mice, suggesting a greater inflammatory response in KO mice. The abnormalities consist mainly of bile duct compression, stenoses, fibrotic strictures and dilation of both extrahepatic and intrahepatic bile ducts, as well as gallbladder varices. However, a single device incorporating all the perceived improvements should still be pursued. EGCG upregulated the expression of tissue inhibitor of MMP-2 (TIMP-2) protein. Thus, although BRUCE is broadly expressed in embryonic, extraembryonic, and adult mouse tissues, this bifunctional protein might play a unique role in normal trophoblast differentiation and embryonic survival. Cases were derived from two prospective trials and a retrospective cohort to comprise an evenly distributed case mix of patients. In bursts, the LFA power was lower in periods of burst suppression as compared to those of trace alternant.

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Perceptions of the impact of depression and anxiety and the medication for these conditions on safety in the workplace. This review summarises epidemiology, pathogenesis, difficult clinical problems and management issues in SSc-ILD. The concentrations of Irgarol and M1 in the test water were determined by HPLC after solid-phase extraction. Analysis of a dataset with missing data with a dichotomous outcome variable showed unpredictable results for both GEE and random coefficient analysis. It is difficult to reduce unstable fracture of the distal end of the radius in the way of close reduction. In the modified group, there was fine granular proteinaceous membrane on the surface of the IOLs, but in the non-modified group there was fibrinous reticular proteinaceous membrane. Two related owl species (barred owl and great horned owl) were used as surrogates to validate hormone assays for fecal metabolites of progesterone, 17beta-estradiol, testosterone, and corticosterone. The mouse model of mycobacterial infection provides an excellent tool with which to examine the inter-relationship between protective cell-mediated immunity and tissue-damaging hypersensitivity.

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Preliminary observations on valproate and cystic ovaries: letter to editor. A total of 404 Chinese adults who grew up in rural Yongnian County, Handan City, Northern China, were included. Early and intensive pharmacological treatment not only may reduce gastrointestinal symptoms but also reverse malignant bowel obstruction. Further, workday mornings may be a time of reduced mother-child cortisol attunement. This unusual phenomenon, known as reentrance, has been observed before in a limited number of colloidal and micellar systems, but it has not yet been observed in active glass mixtures. Transgenic mice were generated by microinjecting HBV genome into fertilized eggs. A prospective study comparing infection risk and disease activity in children with juvenile idiopathic arthritis treated with and without tumor necrosis factor-alpha inhibitors. This paper presents the need to improve existing digital human models (DHMs) so they are better able to serve as effective ergonomics analysis and design tools. Transcranial direct current stimulation is a novel therapeutic option for treating depression during pregnancy.

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Eleven cases of necrotizing fasciitis of the posterior neck are reviewed to demonstrate the advantage of using a bilobed fasciocutaneous flap for repair following surgical debridement. One hundred participants were randomized to this parallel, double-blind, placebo-controlled study, which 86 of them completed. The use of orphan G protein-coupled receptors (GPCRs) as targets to identify new transmitters has led over the last decade to the discovery of 12 novel neuropeptide families. Specific drug use for rate or rhythm control, as well as drug use for stroke prevention, was surveyed. Phaoniaamicula Villeneuve, 1922 is noted from Finland for the first time. They completed the POCS as well as the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Also, it was characterized by the high positive and negative prognostic values. Thus, Jab1 constitutes a regulatory molecule that integrates laminin211 signals in Schwann cells to govern cell cycle, cell number, and differentiation.

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Following left pneumonectomy, alveolar and airway epithelial cells underwent compensatory DNA synthesis, reaching maximal levels 5 d after the surgery. Population genetic structure, genetic diversity, and natural history of the South American species of Nothofagus subgenus Lophozonia (Nothofagaceae) inferred from nuclear microsatellite data. Employment discrimination--Americans with Disabilities Act--Ninth Circuit holds that the direct threat defense is not available when an employee poses a threat to his own health or safety--Echazabal v. Suppression of severe achondroplasia with developmental delay and acanthosis nigricans by the p.Thr651Pro mutation. The correlation of survival with antibodies to HPV16, to oncoproteins E6 and E7, and to type of HPV DNA was evaluated using multivariate Cox regression analysis, including stage, age, histology, and hospital in the model.

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No negative effect on sensory quality was found in short-term stored products. Few children were given dexamethasone, but only 5/108 may have benefited. The complex and specific interplay between thrips, tospoviruses, and their shared plant hosts leads to outbreaks of crop disease epidemics of economic and social importance. The effectiveness of neuro-music therapy according to the Heidelberg model compared to a single session of educational counseling as treatment for tinnitus: a controlled trial. Gnotobiotic pigs dosed orally with filtrates (0.8 and 0.65 micron) of intestinal mucosa from a pig affected by proliferative haemorrhagic enteropathy developed lesions of proliferative enteritis, affecting mainly the ilea. The two-year graft and patients survival of LERT was compared with 22 living genetically related donor transplantation (LRT) performed in the same time.

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The second case was a patient evaluated by cone-beam CT, who presented with an extremely atrophic mandible with bilateral extramandibular courses of the IANs. Early identification of the neurotoxicity and alterations in dose or schedule for the medication could prevent the development of chronic symptoms, which, once established, may take cleocin medication classification many months or years to resolve or even persist throughout life with a substantial effect on quality of life. Recently, Hcy capability to generate NTD and modify neural crest cell migration has been demonstrated in chick embryos. This retrospective analysis evaluates the clinical efficacy and toxicity of second-line docetaxel-based chemotherapy after failure of fluorouracil-based first-line treatment for advanced esophageal squamous cell carcinoma (ESCC). The differential inhibition of COX-1 and COX-2 is not sufficient to explain the absence of a correlation between in vitro and in vivo effects, especially for 2-aryl-propionates, thus indicating the participation of metabolites.

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High prevalence of V37I genetic variant in the connexin-26 (GJB2) gene among non-syndromic hearing-impaired and control Thai individuals. The notable incidences of radiographic dysplasia after previous DDH normalization in our study cohort appear to outweigh the risks of radiation exposure. An attempt to assume absorption and excretion of lead in the healthy Japanese population. Texture coarseness responsive neurons and their mapping in layer 2-3 of the rat barrel cortex in vivo. The relationship between the phenomenon of the nonselective reinnervation and the functional recovery after section and repair of the highly organized third cranial nerve motor system in rats was studied. Effects of iron manipulation on trace elements level in a model of colitis in rats.

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Capitated payments for mental health patients: a comparison of potential approaches in a public sector population. Migratory potential was estimated by transwell chamber in vitro. All the tests were executed with a weight of 110 g on a tooth field with a multibracket appliance. A set of neurocognitive tests was also administered to all the participants. Previously published interpolation methods based on shift maps, non-uniform Fourier transformation and a b-spline interpolation were compared with the proposed method. Major endpoints for the trial were operative time, morbidity, retained stone rate, reoperation rate, and hospital stay. Models of bedside report incorporating the patient into the triad have been shown to increase patient engagement and enhance caregiver support and education. Transfection experiments expressing human FcgammaRIIbl or b2 in Raw 264.7 murine macrophage cells revealed that both isoforms are tyrosine phosphorylated and promote SHIP phosphorylation. Full-genome identification and characterization of NBS-encoding disease resistance genes in wheat. For this, a whole mount immunohistochemical method was used to locate cell bodies of neurons in the cockroach central nervous system immunoreactive to antibodies raised against the pentapeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH).

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Thus, apparent diffusion coefficient values and diffusion weighted imaging can be used to detect early diaschisis. crescentus, ftsH expression is transiently induced after temperature upshift and in stationary phase. Comparing practical measurements of mesophyll cells, calculations performed in a 3D model of a cell with chloroplasts as well as a theoretical analysis showed that the 2D approach yielded biased results, while the underestimation could be up to 10-fold. Low dose oral tacrolimus provides a valuable alternative treatment option for IBD patients with refractory pyoderma gangrenosum. Fibrin plays a major role in blood clotting and is important in wound healing. All patients underwent median sternotomy and received standard anesthesia and intensive care unit management for this institution. The results compare favorably with recent experiments carried out with turbulent soap films.

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We have compared our data to those found using histopathology and segmentation maps obtained by the mathematical processing of three-dimensional T2-weighted MRI data via a neural network. Group BS received levobupivacaine before trocar site incision and intraperitoneal levobupivacaine immediately after pneumoperitoneum. The SVM module based on human methylation patterns was used for genome-wide analysis of methylation sites. On the other hand, the effect produced by phosphatidic acid appeared to be different, since it did not change the optimal concentration of Triton X-100 for the two enzymes. Implications for designing DSSLT and decision support systems in general are discussed. The variables that had statistically significant correlation with prognosis were combined to build a model. By utilizing Ag-, Fe-, Au-, and TiO2-derived NPs, we have succeeded in visualizing various metabolites, including fatty acid and glycosphingolipids, with higher sensitivity and spatial resolution than conventional techniques. These results and depakote ec dosing others converge to suggest that masking spread from the first formant is not a significant factor in the identification of voiced stop consonants by listeners with sloping, mild-to-moderate hearing loss. Controlling the growth mode of para-sexiphenyl (6P) on ZnO by partial fluorination. Uterine epithelial cell estrogen receptor alpha-dependent and -independent genomic profiles that underlie estrogen responses in mice.

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