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Amantadine

Amantadine is a medication used to treat dyskinesia associated with parkinsonism and influenza caused by type A influenzavirus, though its use for the latter is no longer recommended due to widespread drug resistance.

Other names for this medication:
Amantadine, Amantral, Amantrel, Comantrel, Neaman

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Description

Amantadine is an antidyskinetic medicine. It is used to treat Parkinson's disease (sometimes called "paralysis agitans" or "shaking palsy") and its symptoms, including dyskinesia (sudden uncontrolled movements). It may be given alone or in combination with other medicines (eg, levodopa) for Parkinson's disease. By improving muscle control and reducing stiffness, this medicine allows more normal movements of the body as the disease symptoms are reduced. Amantadine is also used to treat stiffness and shakiness caused by certain medicines that are used to treat nervous, mental, and emotional conditions.

Amantadine is also an antiviral medicine. It is used to prevent or treat certain influenza (flu) infections (type A). It may be given alone or together with flu shots. Amantadine will not work for colds, other types of flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain amantadine. It may not be specific to Amantadine. Please read with care.

For patients taking amantadine for Parkinson's disease or movement problems (including dyskinesia) caused by certain medicines used to treat nervous, mental, and emotional conditions:

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine comes with a Medication Guide or patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions. Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely. Improvement in the symptoms of Parkinson's disease usually occurs in about 2 days. However, in some patients, this medicine must be taken for up to 2 weeks before the full benefit is seen.

For patients taking amantadine to prevent or treat flu infections:

Talk to your doctor about the possibility of getting a flu shot if you have not had one yet. This medicine is best taken before exposure or right away after exposure to people who have the flu. To help keep yourself from getting the flu, keep taking this medicine for the full time of treatment. Or if you already have the flu, continue taking this medicine for the full time of treatment even if you begin to feel better after a few days. This will help clear up your infection completely. If you stop taking this medicine too soon, your symptoms may return. This medicine should be taken for at least 2 days after all your flu symptoms have disappeared. This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times at day and night. For example, if you are to take two doses a day, the doses should be spaced about 12 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your doctor. If you are using the oral liquid form of amantadine, use a marked measuring spoon, oral syringe, or medicine cup to measure each dose correctly. The average household teaspoon may not hold the right amount of liquid.

Take Gocovri® extended-release capsule at bedtime. Swallow whole. Do not crush, break, or chew it. You may also open and sprinkle the extended-release capsules on a teaspoonful of soft food, including applesauce. Take all of the medicine right away without chewing. You may take this medicine with or without food.

Take Osmolex ER™ extended-release tablet in the morning. Swallow whole. Do not crush, open, or chew it.

Do not receive the nasal flu vaccine (live attenuated influenza vaccine) while taking this medicine.

Do not drink alcohol while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of Parkinson's disease or movement problems (including dyskinesia): For oral dosage forms (extended-release capsules): Adults—137 milligrams (mg) once a day at bedtime. Your doctor may increase your dose to 274 mg (two 137 mg capsules) once a day at bedtime after one week. Children—Use and dose must be determined by your doctor. For oral dosage forms (extended-release tablets): Adults—129 milligrams (mg) once a day in the morning. Your doctor may increase your dose each week to a maximum dose of 322 mg (one 129 mg tablet and one 193 mg tablet) once a day taken in the morning. Children—Use and dose must be determined by your doctor. For oral dosage forms (liquid-filled capsules, syrup, and tablets): Adults—100 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed. Older adults—At first, 100 milligrams (mg) once a day as a single dose. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor. For the treatment or prevention of flu: For oral dosage forms (capsules, syrup, and tablets): Adults—200 milligrams (mg) or 4 teaspoonfuls once a day as a single dose. Older adults—100 milligrams (mg) once a day as a single dose. Children 9 to 12 years of age—100 milligrams (mg) or 2 teaspoonfuls 2 times a day. Children 1 to 9 years of age—Dose is based on body weight and must be determined by your doctor. The usual dose is 4.4 to 8.8 milligrams (mg) per kilogram (kg) of body weight per day. The dose is divided evenly and given 2 times a day. However, the dose is usually not more than 150 mg per day. Children younger than 1 year of age—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Amantadine and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Amantadine dosage information

Side effects

The most common side effects associated with Amantadine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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Recent advances in neurochemistry and therapeutics of degenerative dementias. Two of these studies found a higher mean peak pressure during exercise than the criterion (50 mm Hg). An accurate diagnosis of GORD can aid effective treatment and have significant clinical impact. This article presents a summary of outcome and survival rates after unicompartmental knee arthroplasty in the lateral compartment. Dose-dependent character of effect of anti-plague vaccination on reaction of apudocytes in immunocompetent organs and duodenum biomodels was established, that indirectly reflects the direction of processes of immunogenesis in central and peripheral organs of immune system. A 71-year-old woman was diagnosed with rheumatoid arthritis in 2002. To present the recent advances in imaging for diagnosis, staging, and follow-up of bladder cancer. Although hatha yoga has frequently been recommended for patients with bipolar disorder (BD) and there is preliminary evidence that it alleviates depression, there are no published data on the benefits-and potential risks-of yoga for patients with BD. It is necessary to elucidate the molecular mechanism of SARS-CoV replication and rationalize the anti-SARS therapeutic intervention.

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The updated Nice classification for PH has been enhanced to include a greater depth of CHD and emphasizes persistent PH of the newborn and developmental lung diseases, such as bronchopulmonary dysplasia and congenital diaphragmatic hernia. Neuroepithelial bodies (NEB) and solitary endocrine cells in the hamster lung. Besides, it allows us to establish the relationship between the detailed configuration accounting and the average-atom methods. Physical inactivity as the culprit of metabolic inflexibility: evidence from bed-rest studies. Evaluation of the practical feasibility and acceptability of home monitoring in residential homes. To assure the responsiveness to odors of each inhalation, a rapid removal of odorants from the microenvironment of the receptor is essential. It is imperative that maternal and child survival programs become sensitized to the urgency of early identification of HIV in infants and their retention in care. Total ankle arthroplasty is available with fixed-bearing (FB) or mobile-bearing (MB) versions, and there is little consensus on the benefits and drawbacks of each type. Since polyunsaturated fatty acids are important constituents of synaptic membranes and since platelet MAO may reflect brain MAO, we consider these co-existing findings important in the interpretation of the psychiatric symptoms.

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Bone marrow morphology at diagnosis as a prognostic parameter in Philadelphia-positive chronic myelogenous leukaemia (CML). All skull-base fractures and related features, recorded by the consensus of two radiologists, were classified as anatomically significant or non-significant on the basis of eight criteria. However, no additive effects were noted when agonists were added in combination. Despite an aging population around the globe, older adults are largely excluded from RCTs evaluating management of LBP, and there is no evidence of change in this feldene practice over the last 2 decades. Susceptible males had a mating advantage when competing with any of the resistant males, suggesting a substantial cost of resistance genes to this trait.

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Goodness of fit of the recurrent event models is assessed using Cox-Snell residuals. However, in certain high-risk individuals, such as the obese, smokers, and irradiated patients, flap reliability is decreased, which leads to a higher rate of flap complications. Facilitating large-scale transitions to quality of care: an idea whose time has come. HFRS after a wild rodent bite in the Haute-Savoie--and risk of exposure to Hantaan-like virus in a Paris laboratory. A national cross sectional study was undertaken to explore the perceptions concerning the importance of, and progress in, aspects of clinical governance among board level and directorate managers in English acute, ambulance, and mental health/learning disabilities (MH/LD) trusts. Radiation sensitizing effect of estramustine is not dependent on apoptosis. Novel methods of automated structure elucidation based on 13C NMR spectroscopy. Moreover, silencing of CD91 (a common receptor for damage-associated molecular patterns, such as calreticulin and heat-shock protein-90/70) in immature DCs led to the inhibition of DC activation.

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