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Anastrocare (Anastrozole)
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Anastrocare

Anastrocare is an aromatase inhibitor, indicated primarily for the adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer, the first-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor-unknown locally advanced or metastatic breast cancer and the treatment of advanced breast cancer in postmenopausal women with disease progression, following tamoxifen therapy.

Other names for this medication:
Altraz, Altrol, Anabrez, Anastrocare, Anastrozole, Anatero, Anazol, Armilon, Armotraz, Femistra, Femitraz, Qubol, Redest, Rimidex, Stazonex, Xenosoul

Similar Products:
Klonopin, Coreg, Xenical, Intagra, Inderal

Also known as: Anastrozole

Description

{name} (anastrozole) lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.

{name} is used to treat breast cancer in postmenopausal women.

{name} is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox).

Dosage

The following information describes Anastrocare dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug forms and strengths

Anastrocare comes as 1-mg tablets that are taken by mouth.

Dosage for breast cancer

The usual dosage of Anastrocare for breast cancer is one tablet taken once a day. It’s best to take your dose at the same time each day.

What if I miss a dose?

If you forget to take a dose of Anastrocare, take the missed dose as soon as you remember. However, if it’s almost time for your next dose, just skip the missed dose and take your next dose as usual. Don’t take two doses together to make up for a missed dose.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

Anastrocare is meant to be used as a long-term treatment for breast cancer. If you and your doctor determine that Anastrocare is safe and effective for you, you’ll likely take it long term.

The length of time that you’ll take this drug depends on the type of cancer you’re using it to treat. Below we describe the typical length of time that Anastrocare is given. But to know for sure how long you should take Anastrocare, talk with your doctor.

For advanced breast cancer

If you’re taking Anastrocare to treat advanced breast cancer, you’ll usually take the drug for as long as your doctor feels this treatment is right for you. (With advanced breast cancer, the cancer has either spread to nearby areas or lymph nodes, called locally advanced breast cancer, or spread to other parts of your body, called metastatic breast cancer.)

For early breast cancer

If you’re taking Anastrocare as adjuvant treatment of early breast cancer, you’ll usually take the drug for at least 5 years. Adjuvant treatment is used to lower the risk of your breast cancer coming back or spreading after it’s already been treated with surgery. (With early breast cancer, the cancer hasn’t spread out of either your breast or the lymph nodes in your armpit.)

It’s not currently known if Anastrocare should be continued after these 5 years. And if so, it’s not known for how long after the first 5 years it should be taken.

Some studies found that breast cancer is less likely to come back if an aromatase inhibitor is taken for an additional 5 years after the first 5 years of adjuvant therapy. (Aromatase inhibitors are a class of medications.) With this approach to treatment, the drug would be taken for a total of 10 years. However, other studies didn’t show a benefit for extending the treatment beyond 5 the usual years.

In addition, one recent study found that taking Anastrocare for a total of 10 years didn’t provide any more benefit than taking it for a total of 7 years.

How long you take Anastrocare for early breast cancer will depend on how likely your breast cancer is to come back. It will also depend on your risk of side effects from treatment.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Anastrocare are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Anastrocare can interact with several other medications.

Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe.

Anastrocare and other medications

Below are lists of medications that can interact with Anastrocare. These lists do not contain all the drugs that may interact with Anastrocare.

Before taking Anastrocare, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Anastrocare and tamoxifen

Like Anastrocare, tamoxifen is a hormone therapy that’s used to treat breast cancer. But taking tamoxifen with Anastrocare can lower the amount of Anastrocare in your body. This can make Anastrocare less effective for you.

Because of this interaction, you shouldn’t take tamoxifen with Anastrocare. However, if recommended by your doctor, it’s fine to take Anastrocare after you’ve finished taking tamoxifen.

Anastrocare and drugs that contain estrogen

Taking Anastrocare with drugs that contain estrogen could make Anastrocare less effective for you. Because of this, you shouldn’t take these types of drugs while you’re using Anastrocare.

Examples of drugs that contain estrogen include:

  • hormone replacement therapy (HRT)
  • vaginal estrogen products, such as creams and tablets
  • birth control medications, such as pills, patches, and vaginal rings
If you have questions about using medications that contain estrogen with Anastrocare, talk with your doctor.

Anastrocare and herbs and supplements

There aren’t any herbs or supplements that have been specifically reported to interact with Anastrocare. However, you should still check with your doctor or pharmacist before using any of these products while taking Anastrocare.

For example, it’s possible that supplements such as red clover or wild yam could make Anastrocare less effective. (These supplements are used by some women to reduce menopausal symptoms, such as hot flashes.)

This interaction is possible because these supplements contain phytoestrogens, which are weak estrogen-like substances found in certain plants. There isn’t enough information available to say for sure whether taking phytoestrogens can affect your breast cancer treatment or not.

Be sure to talk with your doctor before taking any herbs or supplements with Anastrocare.

Anastrocare and foods

There aren’t any foods that are known to interact with Anastrocare. Talk with your doctor to find out if there are any foods you should avoid during Anastrocare treatment.

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Determination of purity of toluidine blue O by thin layer chromatography (TLC). Protective effect of sera from swine immunized with different fractions from broth culture of an attenuated strain of Erysipelothrix rhusiopathiae. From these data we conclude that activating c-KIT and PDGFR mutations are sporadic in human cancers known to overexpress these tyrosine kinase receptor genes and suggest that, except in GIST, this overexpression is not correlated with activating mutations. The cellular mechanism by which HS increases degranulation is unknown. The cells, which were round, oval or polygonal in shape, were arranged in a compact sheet. The aim of this paper is to analyse and summarize the main advances in experimental research on cerebral arteriovenous fistulas. Although each of these large intermediate filament proteins colocalized with desmin when coexpressed in SW-13 cells, expression of paranemin, but not synemin or nestin, led to the formation of an extended desmin network. This study was undertaken to describe changes in the incidence of diarrhea and prevalence of malnutrition among children in an urban Brazilian shantytown from 1989 to 1996.

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To determine whether there is an increased incidence of persistent pulmonary hypertension in neonates delivered by cesarean, with or without labor, compared with those delivered vaginally. Case of ascites and cachexia in a patient with chronic renal failure treated with repeated dialyses. Temperature was measured in the surrounding tissue at various distances from the stent, determining heat penetration. In this study we examined whether the effects of mental fatigue on behaviour are due to reduced action monitoring as indexed by the error related negativity (Ne/ERN), N2 and contingent negative variation (CNV) event-related potential (ERP) components. Two models are proposed to relate maladaptive emotion regulation strategies and alcohol-related problems for women with a history of childhood sexual assault (CSA). Nitrofuran derivatives of isoxazole and their antitrichomonas activity. Here, we characterize the protein:DNA complex formed by a cooperative interaction between XGRAF, GR, and the DNA. An electron spin resonance (ESR) signal that changed with time suggested free radical production in HNE cells exposed to O(3). We studied the levels of ET-1 and the effect of postmenopausal hormonal therapy on ET-1 levels in postmenopausal women.

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We presented a clinical vignette of a woman at high risk for breast cancer and asked if they would encourage her enrollment into a breast cancer chemoprevention trial (yes/no). It is essential to include measures of psychosocial morbidity when assessing psoriasis severity and treatment efficacy because of the substantial role that psychosocial burden plays in patient perception of disease severity, quality of life, and disease course. This study represents a significant step toward the development of CPO as a practical catalyst for large-scale organic syntheses. Effect of condensate of food waste (CFW) on nutrient removal and behaviours of intercellular materials in a vertical submerged membrane bioreactor (VSMBR). Receptor-mediated interrelationships between progesterone and estradiol action on the anterior pituitary-hypothalamic axis of the ovariectomized immature rat. Acetaminophen overdose: incidence, diagnosis, and management in 416 patients.

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Analysis of the binding data indicates the enhanced avidity is due to increases in cross-linking of TCR on activated T cells. Whether ifosfamide is specifically transported by erythrocytes and which activated ifosfamide metabolites play a key role in this transport is currently being debated. Multiple logistic regression was used to study the relationship between these variables and student performance (above versus at or below average). A retrospective search was performed to find symptomatic patients with negative work up for paradoxical emboli whose chest CT or MR angiography by left arm contrast injection showed a visible right to left shunt through the LSICV/LVV collateral pathway (symptomatic group). Gallium scans are done frequently in paraplegics, quadriplegics, and comatose patients to look for occult infection. DNA microarrays have become synonymous with this kind of study and, in many cases, are the obvious platform to achieve this aim. Retinopathy of prematurity occurs almost exclusively in small premature babies, but the demographic characteristics of these babies vary depending on where they are born. Use of extratransference interpretation in psychoanalytic psychotherapy. In a pattern of segments of contours comprising only the regions containing the maxima and minima of the sine waves, a set of surfaces is perceived, each of which tends to be seen as convex, and which possesses an illusory slant which is different for columns of contour segments containing maxima as compared with columns containing minima.

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In patients with oestrogen-positive tumors, and/or progesteron-positive tumors, a rise was noted in the amount of circulating oestradiol, an increased contents of cytosolic oestradiol, especially in the tumoral cells as compared with the normal ones in the same breast. Interferon production and prevention of viral infections in mice by components of a mixed bacterial vaccine. FDG biodistribution was similar between early and advanced-stage. Experiments were conducted in the presence of running water (hydrodynamic noise) to further explore the sensory capabilities of the lateral line with special focus on the morphological sub-modalities. However, there has been no study analyzing the downstream genes of the rhBMP-2 induced intracellular signal transduction pathway. It is still unclear if the survival time can be extended through local ablative procedures. As a means of examining the role of dopamine in chemotransduction, we examined the spike interval pattern from single carotid body chemoreceptors before and following dopamine antagonism. Anti-meningococcal vaccines: diversity of vaccination policies and recommendations. Gait analysis disclosed a significant improvement by levodopa/benserazide in walking speed, stride length and the range of motion of hip, knee and ankle joints. Electron detachment dissociation of underivatized chloride-adducted oligosaccharides.

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For simplicity an additive model, comprising effects due to a single QTL, residual additive genetic factors, and individual-specific random environmental variation, is considered. DUMPS (Deficiency of Uridine Monophosphate Synthase) is a hereditary recessive disorder in Holstein cattle causing early embryo mortality during its implantation in the uterus. Effects of carbon monoxide on cochlear electrophysiology and blood flow. In this review we will discuss their potential safe use in humans following recent advances in their use in animals, including non-human primates. Lung cancer is a malignant disease with high incidence and mortality, and its prognosis is to large degree determined by early diagnosis and treatment. Cortical slices in a recording chamber were stimulated with a 473 nm blue laser via either a laser scanning photostimulation setup or by direct guidance of a fiber optic.

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Determination of high-energy phosphate compounds prevacid drug study and inorganic phosphate by reversed-phase high-performance liquid chromatography: evaluation of myocardial metabolic status in aerobically perfused and hypoxic mouse heart. The immunoglobulins are essentially free of transferrin and albumin, as determined by SDS-polyacrylamide gel electrophoresis. The CS mouse is a mutant strain which displays spontaneous splitting in the circadian locomotor rhythm under continuous darkness. This study was to explore the inhibitory effects of Scutellaria barbatae D. For diaphyseal fractures, healing is long and difficult, partly because of the insufficient mechanical properties of external fixation. In this study, energy dispersive X-ray microanalysis and an iron staining method were used to determine the localization of Fe in cells of the equine superficial digital flexor tendon. Inhibition of AIF-1 expression by constitutive siRNA expression reduces macrophage migration, proliferation, and signal transduction initiated by atherogenic stimuli. World at work: health hazards among foot massage workers in China.

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The deletion of the CaVPS34 gene caused disturbance of normal nuclear migration, which suggests that in the Cavps34 mutant the cell-size mediated control process of cell division is affected. A lethal A2662C mutation is suppressed by a concomitant lethal A2531 mutation. However, a decrease in serum albumin from normal to low levels but within the normal range was a stronger determinant of future decline in functional status. Use of this anchoring balloon allowed consistent access to the biliary tree for performance of diagnostic and therapeutic DPOC distal to the biliary bifurcation. Furthermore, these low temperatures do not appear to contribute to graft failure when negative factors such as long preservation, the presence of hepatic steatosis, or advanced donor age are present. The defective induction of stress-induced senescent phenotype (SIPS) creates an insufficient number of senescent cells, diminishing the inhibitor effect, causing the uncontrolled hyperproliferation and keloid formation. The protein expressions of CDKN1A and BTG1 play an important role in inhibiting the proliferation of cancer cells. The defective ejaculation may be the influential factor at the stage.

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Studies on the lipids of plasma of rats infected with Plasmodium berghei. Glycosylation in the channel catfish, a premier model system for studying the immune system of teleosts, has significant differences from the glycosylation patterns characterized in mammalian systems, likely with functional implications. Stepwise kinetic equilibrium models of quantitative polymerase chain reaction. For comparison, BChl e-containing native chlorosomes of Chlorobium phaeobacteroides and chlorosomes in which the energy acceptor had been degraded by alkaline treatment were also studied. Tubulovesicles also were nifedipine 10 mg pregnancy side effects increased in size and number and the tiny microvilli in them were also increased. Co-cultivation on solid media for 72 h was optimal for generating transformants, but increasing the ratio of bacterial cells to conidia did not affect transformation efficiency. Metabolite identification was done by high performance liquid chromatography (HPLC) and whole cell protein was measured as the indicator for cell growth. NAG-1 (non-steroidal anti-inflammatory drug-activated gene-1) is induced by several dietary compounds and belongs to a TGF-beta superfamily gene associated with pro-apoptotic and anti-tumorigenic activities.

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To characterize the attenuation of the curing light in filled resin restorative materials (FRRMs) to aid understanding of curing depth. Histologic examination of the resected gonads showed cortical dysplasia indicative of incipient gonadoblastoma. Transposition of chromosome loci in bystander cells upon exposure to an adaptive dose of ionizing radiation. Infection, immune responses and the aetiology of childhood leukaemia. Junctional epidermolysis bullosa with pyloric atresia (JEB-PA) (MIM 226730) is an autosomal recessive disorder resulting from mutations in the genes encoding alpha 6 beta 4 integrin (ITGA6 and ITGB4). Enantiomeric composition studies in Lavandula species using supercritical fluids. In patients with acute cholecystitis who cannot undergo early laparoscopic cholecystectomy (within 72 hours), 6 weeks to 12 weeks after onset is widely considered the optimal timing for delayed laparoscopic cholecystectomy. If the loading on the pars interarticularis would be decreasing, the cracks close and the pars interarticularis can ossify. The PKC agonist bryostatin-1 inhibited the growth in vitro and in vivo of cells transformed with oncogenic K-Ras in a S181-dependent fashion.

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Renal osteodystrophy in children: the effect of hemodialysis and renal homotransplantation. Spontaneous (BAO) and pentagastrin stimulated acid as well as hormonally stimulated pancreatic enzyme secretion revealed normal in all subjects and tests. The incorporation of HRQL measures in patients with neurological illnesses is an increasing and valued practice by its specialists. We address the latter by physically separating signal detection from encoding of information with remote detection. Experimental study on immunological function of palatine tonsils. Prostate cancer cells are generally resistant to induction of apoptosis by anticancer agents and death ligands. Measurement of urinary oxalate: an enzymatic and an ion chromatographic method compared. If contaminated cell cultures were found, they acticin were discarded and replaced from a pleuropneumonia-like organism (PPLO)-free cell bank.

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The receptor for advanced glycation end products (RAGE) is a multiligand receptor that has been shown to contribute to the pathogenesis of diabetes, atherosclerosis, and neurodegeneration. NORE1A promoter methylation was assessed by the combined bisulfite restriction endonuclease assay. We performed studies on the dynamics of floc stability, the desorption of cells from the flocs, and the reflocculation of detached material. Postoperative disorders of the central nervous system remain a major problem in thoracic aortic surgery. Accuracy of B-type natriuretic peptide levels in the diagnosis of left ventricular dysfunction and heart failure: a systematic review. The conserved kinase NHK-1 is essential for mitotic progression and unifying acentrosomal meiotic spindles in Drosophila melanogaster. The building block Fmoc-alpha-(ah-Ac3GalNAc)-L-glutamate allowed access to the target compound YEEE(alpha-ah-GalNAc)(3), a structural mimic of YEE(ah-GalNAc)(3), via solid phase peptide synthesis (SPPS).

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