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Angioten (Losartan)
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Angioten

Angioten slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes. to treat patients with high blood pressure (hypertension) in adults and in children and adolescents 6 - 18 years of age.

Other names for this medication:
Angioten, Asart, Corodin, Corus, Eklips, Faxiven, Fortzaar, Hizaar, Hypozar, Insaar, Lohyp, Loplac, Losadel, Losamet, Losartan, Losazid, Losium, Lostan, Lostankal, Lozar, Lyosan, Maxartan, Medzar, Niten, Omnitan, Prelow, Psycholanz, Sartaxal, Sartens, Sarve, Sortal, Tensaar, Zaart

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Also known as: Losartan

Description

Angioten (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Angioten is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Angioten is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Angioten 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Angioten 25 mg, Angioten 50 mg, and Angioten 100 mg may also contain carnauba wax.

Dosage

Usual Adult Dose for Diabetic Nephropathy:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Adult Dose for Hypertension:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Pediatric Dose for Hypertension:

6 Years or Older: Initial dose: 0.7 mg/kg orally once a day (up to 50 mg total) Comments: -May be given as a tablet or suspension. -Doses above 1.4 mg/kg (or 100 mg) daily have not been studied in pediatric patients.

Detailed Angioten dosage information

Overdose

If you overdose Angioten and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Angioten overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Angioten are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Angioten if you are allergic to Angioten components. Do not take Angioten if you're pregnant or you plan to have a baby, or you are a nursing mother. Angioten can harm your baby. Do not use Angioten if you are taking salt substitutes or potassium supplements, other blood pressure medicine, diuretic (water pill). It can be dangerous to use Angioten if you suffer from or have a history of liver disease, kidney disease, heart failure. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Avoid machine driving. Do not stop taking Angioten suddenly.

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Transplantation of cultured human spinal cord cells into the rat motor cortex: use of Phaseolus vulgaris leucoagglutinin as a cell marker. The megadiverse bivalve superfamily Galeommatoidea represents a promising study system to address this issue. The lower mediastinal dissection and the gastric tube construction are done in the laparoscopic part of the operation. Riluzole prodrugs for melanoma and ALS: design, synthesis, and in vitro metabolic profiling. An investigation with special reference to the fetlock joint, using high-speed cinematography and thermography. An experimental study of a splenic inhibitory factor influencing hepatic regeneration.

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The poor image quality of conventional metal screen-film portal imaging system has long been of concern, and various methods have been investigated in an attempt to enhance the quality of portal images. In vitro tuberisation experiments with auxin applications support the role of auxin during tuber initiation. Furthermore, endopolyploidy levels vary to some degree between individuals of one species in response to periactin medication different environmental conditions. The mechanisms used by Paracoccidioides brasiliensis to survive into phagocytic cells are not clear. Sixteen percent of patients showed a radiographic partial response. ochraceorivulosa with disjunct distributions in continental Africa and Madagascar. In contrast, susceptible strains display sustained IL-4 expression characteristic of a Th2 response.

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The sedative, anxiolytic, antipsychotic, antidyskinetic and neuroendocrine effects of low dose dopamine agonists in man will be described. Heat shock protein 60 of filarial parasite Brugia malayi: cDNA cloning, expression, purification and in silico modeling and analysis of its ATP binding site. This delay is exclusively found in insects and myriapods, but not in chelicerates, crustaceans and onychophorans. Equilibrium between depakote to depakene dose conversion intake and excretion of sodium and potassium was also achieved throughout, and serum electrolytes were unchanged. Enzymatic synthesis of chondroitin 4-sulfate with well-defined structure. Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene are thought to be associated with a varying risk of cervical dysplasia. By centrifugation of protoplasts homogenized in the presence of taxol, a MT-stabilizing reagent, in a density gradient of Percoll, we obtained membranous vesicles to which MTs forming a sheet-like bundle were attached. The study of such causal associations may provide insights that could lead to the development of strategies intended to prevent or treat dementia more effectively. Characterization of the arom gene in Rhizoctonia solani, and transcription patterns under stable and induced hypovirulence conditions.

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To determine whether the susceptible individual can be identified, ultrasound was used to measure the spinal canal diameters of 204 miners. In this study we characterized a series of naturally occurring variants of UpaH. Continuous Removal of Lactic Acid from Wastewater by Candida utilis. Well-resolved peaks and accurate mass-measured values were obtained using a 2-(4-hydroxyphenylazo)benzoic acid (HABA) matrix, but significant fragmentations took place in the absence of silver as a cationizing reagent. The role of estrogen receptor alpha in breast cancer cell proliferation lopressor 25mg tab mediated by progestins.

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To determine if this feature is conserved in the retroviral family, we cloned, expressed, purified, and solved the structure of a N-terminal 134 amino acid fragment (CA(134)) from the human T-cell leukemia virus type 1 (HTLV-I) using high resolution nuclear magnetic resonance (NMR) spectroscopy. Rhodamine 123 inhibits import of rat liver mitochondrial transhydrogenase. In this study, we examined whether in utero and lactational exposure to BPA alters thyroid status in rat F1 offspring. The aims of this study were to identify factors associated with birthweight, birth length and head circumference for triplets, and analyze these body size parameters at birth, especially head circumference, according to gestational age. Reduced cardiocirculatory complications with unrestrictive visiting policy in an intensive care unit: results from a pilot, randomized trial. Changes in the organs of the lesser pelvis in women employed in dairy cattle breeding farms in the light of the ergonomic evaluation of their work place. Presumably, hijacking the normal physiologic functions of GPCRs contributes to all biologic capabilities acquired during tumorigenesis. To assess the role of phosphatidylinositol-3 kinase (PI3K) inhibition in vascular permeability, angiogenesis, and vascular remodeling in tumor vessels and peritoneal lining in an athymic mouse model of i.p. Diagnosis of cysticercosis/echinococcosis is primarily based on imaging techniques.

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Raising the health education level of workers on dairy farm complexes. To prospectively determine the accuracy of combination positron emission tomography-computed tomography (PET/CT) in lymph node staging in patients with early-stage cervical cancer, with histopathologic results as the reference standard. The results of this study indicate that even though the USP Guidelines have been promoted strongly through basic and continuing education during the TIPPA Project, more than half of the respondents were not aware of the Guidelines. The aim of this study was to assess working memory (WM) in patients with major depressive disorder (MDD), using a robust parametric WM task (the n-back task). HCV appears to make use of the host lipid metabolism and one common feature of chronic hepatitis C is the steatosis, characterized by excessive accumulation of triglycerides and lipid content in the liver. To determine the in vitro kinetics of morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) formation and the inhibition potential by methadone enantiomers and structurally related opioids. Birth defects in infants born in 1998-2004 to men and women serving in the U.S. Perspective in the environmental health sciences: a meeting report.

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25-hydroxycholecalciferol treatment of early neonatal hypocalcemia in a department of resuscitation. Both the mithramycin and ethidium bromide gave falsely high values compared to the DABA method, which by subtraction after DNase digestion approached the DABA value. Dictyostelium transcriptional host cell response upon infection with Legionella. Importantly, the kinase-inactive IKK-i/IKKepsilon mutant reduced the endogenous levels of these genes as well as the ability of breast cancer cells to grow in soft agar or form invasive colonies in Matrigel. 230 consecutive patients with oral mucosal malignant melanoma were included in the study.

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A rat model for closed diffuse brain injury was successfully constructed by hit the parietal bone with a spring-driven steel stick. Clinico-morphological characteristics of intestinal diseases in staphylococcal sepsis in infants. Dose-response (DR) curves for pancreatic flow rate, bicarbonate and protein output to cholecystokinin (CCK) were determined by two techniques in six conscious dogs with gastric and duodenal Thomas fistulas. Resistance to sexual aggression: personality, attitudinal, and situational factors. Data on fatal injuries were obtained from the national forensic department. In summary, these data show that PPARalpha activation causes an increased nephrin expression by a dual action, on the one hand by stimulating nephrin promoter activity and on the other hand by reducing nephrin mRNA degradation. Cortisol levels remained stable in maternal blood and amniotic fluid, but increased before delivery in fetal blood. Prevention of clot formation during haemodialysis using the direct thrombin inhibitor melagatran in patients with chronic uraemia.

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