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Anreb (Losartan)
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Anreb

Anreb belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body which binds to receptors in blood vessels, causing them to tighten. This results in an increase in blood pressure. Anreb prevents the binding of angiotensin-II to these receptors, causing the blood vessels to relax which in turn lowers the blood pressure. Anreb slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes.

Other names for this medication:
Acetensa, Cardon, Corodin, Corus, Cosart, Cozzar, Hilos, Hypozar, Klosartan, Loctenk, Lopress, Losacor, Losadel, Losan, Losapres, Losarb, Losargamma, Losartax, Losartic, Losartil, Losatrix, Lostad, Lostan, Lotar, Lotim, Lozar, Lyosan, Ocsaar, Osartil, Prelow, Sarvas, Sarvastan, Sarve, Satoren, Tanlozid, Tensiohess

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Also known as: Losartan

Description

Anreb (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Anreb is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Anreb is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Anreb 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Anreb 25 mg, Anreb 50 mg, and Anreb 100 mg may also contain carnauba wax.

Dosage

Take Anreb tablets orally with or without food. Do not crush or chew it. Take Anreb once or twice a day at the same time. If you want to achieve most effective results do not stop taking Anreb suddenly.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Anreb are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Anreb as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Anreb. Correct volume or salt depletion prior to administration of Anreb.

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MC4R oligomerizes independently of extracellular cysteine residues. Tn501 insertion caused three types of mutant phenotypes: isoleucine auxotrophy, lysine auxotrophy, and a reduced ability to oxidize reduced sulfur compounds and to fix CO(2). Catalase activity in Candida albicans exposed to antineoplastic drugs. Many dogs with CPV-associated enteritis had persistent vomiting despite antiemetic administration. Implication of an unfavorable residue (Thr346) in intrinsic flexibility of firefly luciferase. This follow-up study uses additional data collected when girls were 9 and 11 years old to examine whether girls from obesigenic families continued to show greater increases in BMI over time and reported unhealthy dietary and activity patterns. To test whether the sequence homology and structural similarity are indicative of functional conservation, we expressed GmCOI1 in the Arabidopsis coil-1 mutant. Change in the masticatory function in children with palatine position of the frontal teeth during orthodontic treatment. Patients were evaluated at 7-10 days, 1 month, and 3 months after completion of tumor treatment.

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The role of pudendal nerve block in anesthesia for obstetric surgery. The main finding of the present study is the favorable 1-year outcome for patients with psychotic depression after response to ECT with a trend toward the same result at 4 months. A total of 390 women completed self-report measures of pain, anxiety depression, and QOL prior to surgery. Effects of exogenous silicon on active oxygen scavenging systems in chloroplasts of cucumber (Cucumis sativus L.) seedlings under salt stress. Advances in our understanding of the mechanism responsible for AF have led to exciting new therapies that may soon provide a definitive cure.

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Central as well as peripheral negative feedback inhibition may be altered in PTSD. We report a case of LDLLT, in which pulmonary arterioplasties with autopericardial patch were performed on both a donor and a recipient. Intermittent tone periods of 7 s were then introduced, the last 5 s of which the drinking tube was electrified. The occurrence of problem drinking among indigenous adolescents was 2.98-fold higher than among Hans, indicating a diversity of biological factors, social norms, and expectation for alcohol drinking between these two ethnic groups. The responsible mutation was recently revealed to be an eleven base pair deletion, leading to a frame shift, in the gene encoding the potassium channel Kv1.1. We present the 26 A resolution three-dimensional structure of the DnaB hexamer in complex with its loading partner, DnaC, obtained from cryo-electron microscopy. Absorption spectra of riboflavin, lumiflavin, and lumichrome in organic solvents. All patients had some residual airway obstruction as measured during forced expirations. In order to differentiate non-neoplastic colons from colorectal neoplasms (adenoma and carcinoma), the values for CYP1B1, AhR, nuclear beta-catenin, p53 and bcl-2 expressions were subjected to discrimination analysis, then the cross-validation, sensitivity and specificity of these models were calculated. This study describes the concentration-dependent induction of dysmorphogenesis in whole embryo culture by three mixed chloro/bromo-HAAs and demonstrates the ability of the HAA QSAR to predict relative potencies within this family of xenobiotics.

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The major influencing factors of pulmonary infection after transthoracic esophagectomy for esophageal cancer are PCEA, diabetes, general anesthesia plus epidural analgesia, other postoperative complications, OLV, transfusion volume of RBC, BMI and age. Platelet adenine nucleotide levels in patients with Dacron vascular prostheses. Biological reactions as basis for the diagnosis of the beginning cervix carcinoma. Aseptic loosening of implants in bone is the main reason of prosthesis failure. The BTAi 1 isolate can be differentiated from members of the family Rhodospirillaceae by several criteria. In addition to quantifying differences in total cerebral volume, specific areas of interest have been prefrontal regions, basal ganglia, the corpus callosum, and cerebellum. To compare a reduced (three-sequence) magnetic resonance (MR) imaging protocol with a full (eight- to 10-sequence) MR imaging protocol in adults suspected of having stroke. The second is the necessity for specific training on the local anaesthesia for anaesthetist nurses but also training to choose the anaesthesia best adapted to the surgery, the condition of the patient and the means available. The importance of utmost continuous supervision and care for both the vital functions: respiration and circulation, is stressed. With both methods globular particles of 8 to 9 min diameter could be demonstrated on the surface of these organelles.

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Study with radio-iodinated albumin in carriers of progressive systemic sclerosis. Further tests with the single components of the steroidal cream disclosed a specific hypersensitivity towards clobetasol-17-propionate in two cases, towards the preservative 4-chlor-m-kresol in the third case. Although it has been thought that chloroplast transcription is mediated by a basically cyanobacterium-derived system, due to the endosymbiotic origin of plastids, recent studies suggest the existence of a hybrid transcription machinery containing non-bacterial proteins that have been newly acquired during plant evolution. In this study, we focused on the change of microRNA (miRNA) profiles and Tyrosinase Related Proteins (TRPs) in MITF knocked down melanocytes. The SHARM-3D code performs simultaneous calculations for all specified incidence-view geometries and multiple wavelengths in one run. Ventral cutaneous flaps, measuring 8x4 cm, were designed in 20 Wistar rats based on the right cranial epigastric artery. In the investigations reported here, multivalent artificial glycoproteins bearing galactose moieties as pendant groups have been prepared via the coupling reaction of amine-functionalized galactose with the glutamic acid functional groups of the protein polymer.

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The effect of electrostatic force on the evolution of sand saltation cloud. The options available are determined by the magnitude and age at onset, risk profile of cancer in carriers (the penetrance function of the gene) and the different cancer sites involved. Recognized limits of permissible exposure to hazardous airborne substances adopted by different countries for industrial health protection may differ by a factor of 10. Selective COX-2 inhibition by rofecoxib failed to decrease mucosal PGE2 levels nor to affect mucosal integrity in both PSD and sleep undisturbed rats. The risk values for fatal cancer and severe hereditary disorders, respectively, associated with a typical CRT procedure were 273 per million and 0.2 per million treated patients. Moreover, the molecular changes in the vasculature parallel progression in tumor development, hence making the vessels in premalignant lesions distinguishable from normal vessels and from the vessels in malignant tumors of the same tissue. Those disorders are characterized clinically by predominant anterior tibial muscle weakness and atrophy, and pathologically by rimmed vacuoles on muscle biopsy. These novel autoregulatory plasmids display the requirements for gene therapy applications in chronic conditions which are remitting/relapsing such as rheumatoid arthritis or multiple sclerosis, where novel protein therapeutics and combination therapies are needed. It was found that expression of the late operon, assayed from a late-gene-lacZ gene fusion, was reduced by more than twofold when the only functional copy of gene 23 was present in trans.

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Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling. Worldwide, arboviral illnesses constitute the most important international infectious threat to human neurological health and welfare. The chromosomes in metaphase maps prepared using standard cytogenetic protocols, are usually covered by cellular debris, which obscures the structural details on the surface and limits analysis by techniques when using nanometric resolution. In particular, a conserved, transcription-factor-encoding ovo gene was expressed from the earliest stages of eye regeneration and was required for regeneration of all cell types of the eye. The abnormal vessels block light, cause corneal scarring, compromise visual acuity, and may lead to inflammation and edema.

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