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Apalene (Adapalene)

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Apalene is used to treat acne. Apalene is in a class of medications called retinoid-like compounds. It works by stopping pimples from forming under the surface of the skin. Apalene has the unique ability to inhibit keratinocyte differentiation and decrease keratin deposition.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Xalatan, Strattera, Benemid, Compazine, Benicar, Prometrium, Levothroid

Also known as: Adapalene


Adapalene is used to treat acne. It works partly by keeping skin pores clear.

Adapalene is available only with your doctor's prescription.


Follow the directions for using this medicine provided by your doctor. Use Apalene exactly as directed. Apalene is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Apalene. Apalene should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Apalene. Continue using Apalene until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Apalene promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Apalene are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Apalene if you are allergic to Apalene components. It is not known whether Apalene will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant or breast-feeding. Do not get Apalene in your eyes or on the inside of your nose or mouth. For the first 2 to 3 weeks of treatment, your skin condition may appear to worsen. This is expected. Do not stop using the medicine during this time. Do not use other medicines on your skin without first discussing it with your doctor. While you are using Apalene, you may use cosmetics. After using cosmetics, thoroughly wash and dry the affected area before applying this medicine. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Apalene. Use a sunscreen if you must be outside. Do not apply it to sunburned skin. Do not stop taking Apalene suddenly.

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Radio frequency leakage current from unipolar laparoscopic electrocoagulators. Visual, anatomic, and fluorescein angiographic changes were documented. Accumulation and distribution of neutral lipid droplets is non-uniform in ovine blastocysts produced in vitro in either the presence or absence of serum. Influence of switching to travoprost on intraocular pressure of uncontrolled chronic open-angle glaucoma patients compliant to previously-used topical medication. Hypoglycaemia is the commonest diabetic emergency and is associated with considerable morbidity and mortality. Pathogenic mutations in the desmoglein 1 gene (DSG1) have recently been identified in a subset of patients with the striate type of PPK. Comparative in vitro activities of teichomycin and vancomycin alone and in combination with rifampin and aminoglycosides against staphylococci and enterococci. Hirsutism and menstrual patterns in women exposed to diethylstilbestrol in utero.

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Does ligation of the hypogastric artery at the time of radical hysterectomy and lymphadenectomy decrease blood loss?. Stimuli-responsive y-shaped polymer brushes based on junction-point-reactive block copolymers. Data are presented to show that human chorionic gonadotropin (hCG) in urine can be detected early in pregnancy by simple immunoassays performed prior to or around the time of the expected but missed menstrual period. Weighted mean percentages were calculated for the prevalence of overall periapical radiolucency, root canal treatment, and apical radiolucency in both treated and untreated teeth. His recovery was complicated by a sciatic nerve palsy, which we believe was caused by direct involvement of the nerve at the level of the sciatic notch.

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The results showed the importance of adapting or improving upon performance management strategies to influence staff motivation. Analysis of IL-12 p40 responses of both macrophage types to Lp-V infection assessed by reverse transcriptase/polymerase chain reaction revealed induction of increased message levels, but significant levels were induced only slowly. Renal failure frequently occurs in males who have the disease at a young age. Instead of being a blind alley, the meaning of parasitism for dimorphic pathogenic fungi should be considered as an open two-way avenue, in which the fungus may return to the environment, therefore contributing to preserve its teleomorphic (sexual) and anamorphic (asexual) forms in a defined and protected natural habitat. Assessment of benzophenone-4 reactivity with free chlorine by liquid chromatography quadrupole time-of-flight mass spectrometry. The present study describes ultrasonographic data of 158 spontaneously ovulating, infertile patients.

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Iron-deficiency had no impact on 109Cd distribution, neither during growth nor in adult animals. Derivation and characterization of induced pluripotent stem cells from equine fibroblasts. During the past few years CT has emerged as an unsurpassed diagnostic modality in cerebrovascular disease. Here we identify the defect of an interesting temperature-sensitive ftsZ mutant (ts1) of Bacillus subtilis. Besides QRS width, the presence of echographic systolic asynchrony has been used to identify future responders. Echocardiography revealed that transgenic heart was functionally normal. The predicted size can you buy zovirax tablets over the counter of the GHRH-R protein (48.9 kDa) was confirmed by binding of (125)I-GHRH to chicken pituitary membranes and SDS-PAGE. Problems are presented that are associated with adolescent developmental capacities, adolescent developmental change and stability, gender and ethnicity.

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Dynamics of (Cd,Zn)-metallothioneins in gills, liver and kidney of common carp Cyprinus carpio during cadmium exposure. Synergistic datasets composed of image data from multiple image sources are also being developed. Appropriate molecular models are put diovan hct generic forward for prospective Monte Carlo simulations of nucleic acids, but can be easily adapted to other biomolecular systems, such as proteins and lipid structures in biological membranes. The retroposon method is a powerful tool for identifying monophyletic groups. A 16 mm woven Dacron tube graft was inserted between the right ventricle (RV) and main pulmonary artery (PA) in 18 adult mongrel dogs followed by pulmonary artery occlusion with a Dacron tape. These are combined with the Jarzynski equality and its generalizations to explicitly relate mean (as opposed to transient) entropy dissipation to experimental or simulation observables. Electrophysiological study of the function of the proximal and distal tubules of the nephron in vertebrates.

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Gas-filled detectors have played an important role in experiments at synchrotron sources for many years. A total of 1218 women were enrolled into the initial 1-year study (13 cycles), and subsequently 531 of these received treatment for a further year (26 cycles). The occasions, position and relative concentration of LDH iso-enzymes in the blood tissues of the thoroughbred horse were determined. The typical CT appearances of intracranial germinomas are described in three cases. Impact of HIV/AIDS on quality of life of people living with HIV/AIDS in Chitradurga district, Karnataka. Anti-apoptotic Bcl-2 is strongly expressed, probably reflecting an adaptive response to obesity or alcohol-related stress. Prophylactic cholecystectomy may lead to gain or loss of life-years in patients with small stones, depending on incidence and mortality of pancreatitis. Esterases in the malaria vector mosquito, Anopheles culicifacies.

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Pharmacokinetic study of piperacillin in the field of obstetrics and gynecology. Whilst the deficits may be attributable wholly to myotonic dystrophy pathology, the co-existence of a form of semantic dementia is also possible. Fluorescein dye exclusion indicated zyrtec while breastfeeding the complete microvascular occlusion in the tumor and surrounding skin immediately after effective PDT treatments, while only a limited vascular occulation was observed after non-effective PDT treatment. Tricuspid valve repair in an infant with multiple obstructive Candida mycetomas. Bone marrow mesenchymal stem cells (BM-MSC) have the characteristics of self-renewal and multipotency.

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Pseudomigraine with temporary neurological symptoms and lymphocytic pleocytosis is a rare syndrome resolving within less than 3 months. Our results suggest LPA1 as the major receptor subtype mediating LPA-induced proliferation and contraction of NHLF. Mutations in the coding region of IKBKG are associated with EDA-ID, and stop codon mutations, with OL-EDA-ID. Global health priorities are explicated, with recommendations for the conduct of outcomes-focused research leading to the generation of cost-effective interventions that contribute to the health and well-being of individuals, families, communities, and nations throughout the world. In the presence of 0.1 nM E2, however, 6 exhibited some ER antagonist activity at the highest concentration tested (1 microM).

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Functional and radiographic evaluation of 214 aggressive benign bone lesions treated with curettage, cauterization, and cementation: 24 years of follow-up. Among these are positive family relations, effective communication about sexuality and safer sexual behaviors, enhancement and support of academic functioning, and monitoring of peer activities. Refolding often presents a bottleneck in the generation of recombinant protein expressed as inclusion bodies. A pronounced increase in the mean duration of the oestrous cycle mainly due to lengthening of dioestrus was noted already 6 weeks after treatment of females given per os 40 mg Cd/kg or exposed to a concentration of 1 mg Cd/m3. Computational reconstruction of the human skeletal muscle secretome. The double proton transfer reactions between carboxylic acids and pyrazole were studied by computational methods up to the coupled-cluster level. In addition, tolerance develops in the serotonergic neuronal system while supersensitivity develops in the dopaminergic neuronal system. Thirty-five days after inoculation, the remaining 3 calves in group 1 were given vehicle SC and the group 3 calves were given ivermectin at the dose rate of 200 micrograms/kg, SC. N-alkylating reagents employed for pyrrole are methyl iodide, ethyl bromide, benzyl bromide, as well as acrylonitrile allyl cyanide and methyl acrylate. Baicalein, geniposide, and berberine also ameliorated the symptoms and suppressed eicosanoid generation with varying efficacies.

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