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Apcical (Calcitriol)

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Apcical is a man made form of vitamin D. It helps your body keep the proper levels of calcium and phosphorus and maintain healthy bones and teeth. Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed.

Other names for this medication:
Alfabond, Alfacal, Aristrol, Biocal, Biocitral, Bonestat, Bonetuf, Calbec, Calbovic, Calcirol, Calcit, Caldix, Calosto, Calsure, Caltin, Caltop, Devita, Dmcal, Duracal, Ikmag, Koncal, Kurecal, Ostriol, Qpcal, Ritoca, Roical, Solbiocal

Similar Products:
Tricor, Avelox, Nuvigil, Lasix, Zetia

Also known as: Calcitriol


Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are available in the foods that you eat. Vitamin D is necessary for strong bones and teeth.

Lack of vitamin D may lead to a condition called rickets, especially in children, in which bones and teeth are weak. In adults it may cause a condition called osteomalacia, in which calcium is lost from bones so that they become weak. Your doctor may treat these problems by prescribing vitamin D for you. Vitamin D is also sometimes used to treat other diseases in which calcium is not used properly by the body.

Ergocalciferol is the form of vitamin D used in vitamin supplements.

Some conditions may increase your need for vitamin D. These include:

Alcoholism Intestine diseases Kidney disease Liver disease Overactivity of the parathyroid glands with kidney failure Pancreas disease Surgical removal of stomach

In addition, individuals and breast-fed infants who lack exposure to sunlight, as well as dark-skinned individuals, may be more likely to have a vitamin D deficiency. Increased need for vitamin D should be determined by your health care professional.

Alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are forms of vitamin D used to treat hypocalcemia (not enough calcium in the blood). Alfacalcidol, calcifediol, and calcitriol are also used to treat certain types of bone disease that may occur with kidney disease in patients who are undergoing kidney dialysis.

Claims that vitamin D is effective for treatment of arthritis and prevention of nearsightedness or nerve problems have not been proven. Some psoriasis patients may benefit from vitamin D supplements; however, controlled studies have not been performed.

Injectable vitamin D is given by or under the supervision of a health care professional. Some strengths of ergocalciferol and all strengths of alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are available only with your doctor's prescription. Other strengths of ergocalciferol are available without a prescription. However, it may be a good idea to check with your health care professional before taking vitamin D on your own. Taking large amounts over long periods may cause serious unwanted effects.


This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Apcical. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.


If you overdose Generic Apcical and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Apcical are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Problems in children have not been reported with intake of normal daily recommended amounts. Some studies have shown that infants who are totally breast-fed, especially with dark-skinned mothers, and have little exposure to sunlight may be at risk of vitamin D deficiency. Your health care professional may prescribe a vitamin/mineral supplement that contains vitamin D. Some infants may be sensitive to even small amounts of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol. Also, children may show slowed growth when receiving large doses of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol for a long time.

Studies on doxercalciferol or paricalcitol have been done only in adult patients, and there is no specific information comparing the use of doxercalciferol or paricalcitol in children with use in other age groups.

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These data may have important implications for reducing cognitive impairment in irritable bowel syndrome. In this study, the pubertal growth spurt in a number of morphological characteristics of female rhesus monkeys is related to serum endocrine status of insulin-like growth factor-I (IGF-I) and its binding protein, insulin-like growth factor binding protein-3 (IGFBP-3), to test the hypothesis that elevations in IGF-I and IGFBP-3 coincide with the time of greatest growth rate of different morphological characteristics. A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations. Detection of brain death onset using the bispectral index in severely comatose patients. Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice. We combined low-dose fractionated whole abdominal radiation (LDFWAR) with escalating doses of veliparib (ABT-888), a small-molecule PARP inhibitor, in patients with peritoneal carcinomatosis from advanced solid tumor malignancies.

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It was hypothesized that cochlear implant children follow a similar pattern of tone perception development, as do normal children. Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro. Seroprevalence of HCV infection in our population of pregnant women was relatively high. In female alates, the major sex-specific compound was identified as (5E)-2,6,10-trimethylundeca-5,9-dienal, a compound previously identified as the female sex pheromone of the termite Zootermopsis nevadensis. Acoustic properties and perception of stop consonant release transients. Twenty AD patients with high PEN scores, and 20 age- and sex-matched AD patients with low PEN scores were selected. Alternatively, RNA sequencing has provided some useful information about wheat genes.

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The left ventricular region was divided into anterior (A) and inferior (I) segments. Serotype and PCR-fingerprints of clinical and environmental isolates of Cryptococcus neoformans in Chiang Mai, Thailand. We report an extended family in which two brothers with a fragile X chromosome are mentally retarded while a third brother with the fragile site is both phenotypically and mentally normal. Unlike the Nd:YAG, the CO2 laser produces well circumscribed tissue removal with little unwanted damage because of its high absorption coefficient relative to tissue water. In addition, the relationships between service quality and satisfaction are also clarified.

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Two authors independently reviewed and extracted data from selected studies. Experiments performed with indicator cells revealed that HIV-1 is recycled and transcytosed. Gonadal steroids and body composition, strength, and sexual function in men. Isolated pre-arteriolar vessels of female Sprague-Dawley rats were prepared from the mesenteric arcade and the mesometrium. After treatment of hyperthyroidism there was complete resolution of the right heart failure, tricuspid regurgitation, and the pulmonary hypertension. The remaining 2 patients still had mild drooling, which was managed successfully with a second stair-step flap. MicroRNAs: The Missing Link in the Biology of Graft-Versus-Host Disease?. The induction of ERF gene expression in most cases preceded the mRNA accumulation of a basic chitinase gene, a potential downstream target for one or more of these ERFs. Damage to the lateral amygdala impaired acquisition of the CCP task but not the win-shift or win-stay tasks.

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This population of neurones is also critically involved in hyperalgesia. Also, hypoxia pathway analysis was applied to find statistically significant genes. In particular, we identified 4 primary networks representing the functional spectrum of the cingulate: somatomotor, attention-orienting, executive, and limbic. Placentae of women with GDM showed several changes that may be associated with impaired functioning, leading to bad perinatal outcome. Consequently, NaCl triggers stabilization of Aux/IAA repressors leading to down-regulation of auxin signaling.

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These results show that a lysosomal enzyme acquired by direct transfer during cell-to-cell contact follows a similar intracellular route and has a similar distribution to that of enzymes taken up via cell-surface receptors. Transesophageal echocardiography during operation revealed a localized, thin-walled saccular structure in the anterior leaflet that bulged into the left atrium, and severe mitral and aortic regurgitation. These were analyzed descriptively and with respect to predominant themes. We conclude that the 4-ABAH free radical metabolites which were bound to MP-11 were involved in the catalytic inhibition and were scavenged by DMPO. O-(triazolyl)methyl carbamates as a novel and potent class of fatty acid amide hydrolase (FAAH) inhibitors. Electron tomography of vitrified but otherwise unaltered cells emerges as a central method for three-dimensional reconstruction of cellular architecture at a resolution of 2-6 nm. A previously developed decision analysis model for NBSCF was fed with model parameters mainly based on a study evaluating two novel screening strategies among 145,499 newborns in The Netherlands.

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It is proved that IS-CE method determines acidity constants of sparingly soluble drugs in aqueous media (compounds with logS down to around -6), whereas other reference methods require the use of aqueous-organic solvent buffers and extrapolation procedures to obtain the aqueous pKa for the same compounds. In mouse plasmacytoma (MPC) S194, the rearranged c-myc gene was much more sensitive to DNase I digestion than the nonrearranged gene. The purpose of this study was to evaluate whether individuals consider their HCV infection to be a potentially traumatic experience. We report a patient with extensive skin necrosis on the infusion site of the right forearm and hand, which developed after the use terlipressin used to treat bleeding oesophageal varices in a 65-year-old man with cirrhosis. Cytoplasmic Ig alpha serine/threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation. Antidepressant drugs are indicated for prolonged depression accompanied by the typical physiologic dysfunctions. The primary aim of this survey was to record the preferred fixed retainer designs and retention protocols amongst general dentists and orthodontists in Switzerland. The importance of coronary heart disease risk factors may differ for individuals, the community, and by sex and age. Changes in the levels of endogenous antioxidants in the liver of mice with experimental endotoxemia and the protective effects of the antioxidants. To what extent do protein interactions act as constraints during evolution of the protein sequence?.

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Historically, vascular and vasal anastomosis have formed the foundation of genitourinary microsurgery. Molsidomine enhances the protective activity of valproate against pentylenetetrazole-induced seizures in mice. Some fetal risk, however, seems to remain despite of the use of these methods. ESMO Clinical Practice Guidelines for the management of refractory symptoms at the end of life and the use of palliative sedation. Conversely, the calcium rise during trains of action potentials was enhanced during muscarinic stimulation. This indicates that Bak is not sufficient to mediate cross-sensitization and synergism between 5-FU and TRAIL. We review the clinical presentation, workup of paraganglioma, as well as the surgical approaches to the clivus. To study the quantitative measurement of the extent of malrotation after interlocking intramedullary nailing of femoral shaft fracture. The role of positive emotion and contributions of positive psychology in depression treatment: systematic review.

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To test the hypothesis that capitation payment to physicians reduces the length of physician-patient encounters but increases use of preventive and health counseling services. Humoral recognition of lipopolysaccharide core antigens of gram-negative bacteria in neonatal swine. CypA also inhibits the activity of guanylate cyclase-C (GC-c), the catalytic domain of GC-A, indicating that CypA interacts with the catalytic domain of GC-A. In addition, the topographic images showed that low-NaCl-concentration bilayers recover more easily due to the low cohesion between phospholipid molecules. Prefrontal cortex volume reductions and tic inhibition are unrelated in uncomplicated GTS adults.

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To overcome these shortcomings, the partial- or whole-embryo culture method was used. In an initial step, pooled urine was extracted and Acm and its metabolites were concentrated in n-butanol with a horizontal flow-through coil planet centrifuge. There may be marching to involve the head and limbs, ending with a generalized tonic-clonic seizure. Chronic obstructive pulmonary disease readmissions at minority-serving institutions. Fewer than half of the studies used solely professional musicians as their subjects (13 studies). Lack of association of immune cell function test with rejection in kidney transplantation. A syndrome of spontaneous dilantin drug screen orofacial dyskinesia was identified in groups of rats treated for 6 months with a wide range of neuroleptic drugs. The relief of pain and the restoration of functional activities are the main outcomes of primary total knee arthroplasty for the treatment of osteoarthritis. We also describe methods for characterizing the tF-AuNP complex as well as templating NP growth within the protein cavity. Transversely-inset great toe hemi-pulp flap transfer for the reconstruction of a thumb-tip defect.

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Dulploannulati and the limits of the section were investigated by analysis of sequence data from the ribosomal DNA ITS. These models were derived and tested with data for inhibition of digoxin transport, calcein accumulation, vinblastine accumulation, and vinblastine binding. Healthy diet in primary care: views of general practitioners and nurses from Europe. This study aims to improve our understanding of retirement by examining the impact of midlife educational, work, health, and family experiences on early retirement intentions and behavior. Arg (Para rubber tree) is does differin gel unclog pores a tropical tree species of Amazonian origin widely cultivated in several parts of the world for natural rubber, a highly priced commodity inevitable for the world rubber industry.

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Heart rates were significantly higher during ketamine-midazolam anesthesia. 5 mg/kg/day) or normal saline for the first 3 days, then treatment was crossed over for the next 3 days. Agnogenic myeloid metaplasia associated with Klinefelter syndrome: a case report. Precise and fast video assisted thoracoscopic bronchial sleeve resection. The present technique included snorkeling of the celiac trunk to preserve antegrade flow in the celiac artery and to maintain future options for reintervention. Branchial arch defects and 19p13.12 microdeletion: defining the critical region into a 0.8 M base interval. Renal lymphatics directly joining the thoracic duct without traversing any lymph nodes have been described in cadaver studies, yet to date, this has never been visualized using functional imaging in vivo. Evidence of Haplorchis taichui infection as pathogenic parasite: three case reports. Mutagenesis of the murine hepatitis virus nsp1-coding region identifies residues important for protein processing, viral RNA synthesis, and viral replication.

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Many different yeast species can take part in spontaneous fermentations, but the species of the genus Saccharomyces, including Saccharomyces cerevisiae in particular, play a leading role in the production of fermented beverages and food. Two months after transplantation, the average length of the colonies was 1.3 mm. Recognition and processing of a nuclear-encoded polyprotein precursor by mitochondrial processing peptidase. The authors conducted a systematic search of several electronic databases (MEDLINE, EMBASE, PubMed, Scopus, CINAHL, Evidence Based Medicine Reviews, LILACS) with the assistance of a senior librarian specialized in Health Sciences lodine 400 medication database searches through 25 August 2013, as well as a limited grey-literature search (Google Scholar). Mgat5 also promoted cytokine-mediated leukocyte signaling, phagocytosis, and extravasation in vivo. High-throughput quantitative proteomics, specifically label-free LC-MS/MS, allows rapid measurement of thousands of proteins, enabling large-scale studies of various biological systems.

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Surgical management of hyperinsulinemic hypoglycemia in children. Potential impact of nutritional strategy on noninvasive diflucan syrup measurements of hormones in birds. To report the ophthalmic findings and response to treatment in a patient with glutamic-acid decarboxylase antibodies. The hallmark of neuronopathic Gaucher disease (GD) is oculomotor abnormalities, but ophthalmological assessment is difficult in uncooperative patients. Here we report a child with recurrent pancreatitis attacks and N29I mutation. Patients with thoracic, abdominal, pelvic, retroperitoneal, and deep truncal STS undergoing resection and implantation of permanent (125)I mesh BRT at our institution were reviewed. Univariate and multivariate logistic regression were used to evaluate whether the time to intervention significantly affected the study endpoint. This study laid a solid foundation for further investigation of the physiological characteristics of liver cancer in a rat model, and was an important supplement to and reference for conventional contrast-enhanced CT scans. However, he was rehospitalized on PD 26 with severe abdominal pain.

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