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Armotraz (Anastrozole)
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Armotraz

Armotraz is one of the first choice options for breast cancer that helps improve survival rates, but it is used only in women who've already reached menopause. It can cause hot flashes, night sweats, and headaches.

Other names for this medication:
Altraz, Altrol, Anabrez, Anastrocare, Anastrozole, Anatero, Anazol, Armilon, Armotraz, Femistra, Femitraz, Qubol, Redest, Rimidex, Stazonex, Xenosoul

Similar Products:
Ilosone, Loxitane, Tofranil, Hytrin, Fosamax, Lasix, Antabuse, Zovirax

Also known as: Anastrozole

Description

Armotraz is approved to treat certain types of breast cancer in women who’ve gone through menopause.

What breast cancer is

Breast cancer develops when cells in your breast start to grow and multiply (make more cells) more quickly than usual. With most breast cancers, the abnormal cells are encouraged to grow by the hormone estrogen.

If your breast cancer is stimulated by hormones, such as estrogen, certain tests will show that the cancer cells have receptors (attachment sites) for those hormones. This type of breast cancer is called hormone receptor-positive (HR+).

HR+ cancers can be treated with hormone therapies that lower the estrogen level in your body. And because most breast cancer is HR+, hormone therapies are also sometimes used to treat breast cancer whose receptor status isn’t known.

What Armotraz does

Armotraz is a hormone therapy that’s used to treat certain forms of breast cancer. It’s a type of drug called an aromatase inhibitor. Armotraz works by stopping (inhibiting) the action of an enzyme called aromatase. (Enzymes are certain proteins that help chemical reactions to happen inside your body.)

The aromatase enzyme makes estrogen out of steroid hormones in your body, such as testosterone. Aromatase is found in various tissues, including your brain, fat, and skin.

Before menopause, estrogen is mainly produced by your ovaries. And just a small amount is made by the aromatase enzyme. But after menopause, your ovaries stop producing estrogen. At that point, the aromatase enzyme is the main way that your body makes estrogen. (And in men, estrogen is also mainly produced by the aromatase enzyme.)

By stopping aromatase from working, Armotraz lowers the amount of estrogen in your body. This helps to stop estrogen from encouraging breast cancer to grow and spread.

How long does it take to work?

Armotraz will start working soon after you begin taking it. But you won’t be able to notice this. Your doctor may order different kinds of tests during your treatment to check and see if the drug is working for you.

Dosage

Usual Adult Dose for Breast Cancer:

Initial dose: 1 mg orally taken once a day Duration of therapy: Until tumor progression (treatment of advanced breast cancer); unknown (adjuvant treatment of early breast cancer) Uses: -Adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer; -First-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer; -Second-line treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy.

Detailed Armotraz dosage information

Overdose

If you overdose Generic Armotraz and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Armotraz are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

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We report two children who had CTs obtained at the onset of seizures and prior to the occurrence of intellectual deterioration or retinal pigmentary changes. The conversion of ribothymidine to thymine was assumed to be catalyzed by uridine phosphorylase, suggesting that ribose 1-phosphate was coproduced and served as a ribose donor for 5-FU. The application of these methods to the diagnosis of Tay-Sachs disease is discussed. Personnel health elements of infection control in the dental health care setting--a review. TB even at a higher dose produced little significant effect on the pancreatic and biliary secretion of rats. MIDD and a recently identified entity named proliferative glomerulonephritis (GN) with monoclonal IgG deposits are both characterized by non-organized granular electrondense deposits. In the analysis of real-time reverse transcription-polymerase chain reaction, an increase in the mRNAs for alpha(1b), alpha(2a), alpha(2d), and beta(2) adrenergic receptors was found with the ipsilateral DRGs after sciatic nerve injury. Oral antibiotics are regarded as a suitable therapeutic alternative. In hypertensive rabbits, resetting of the blood pressure-heart rate curves to higher pressures was associated with reduced reflex sensitivity, increased lower heart rate plateau, and operating pressures significantly greater than the region of maximum reflex sensitivity, resulting in substantial attenuation of reflex bradycardia in response to hypertension.

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Methodical aspects of using furylacryloylphenylalanylglycineglycine for photometric determination of the activity of angiotensin-converting enzyme. Malathion A and B esterases of mouse liver--III: In vivo effect of parathion and related PNP-containing insecticides on esterase inhibition and potentiation of malathion toxicity. We briefly report those designed for the superficial and medium depth peelings. The study also aimed to evaluate the cost-effectiveness of the intervention over 6 months, and to assess qualitatively the extent to which collaborative care was implemented in the intervention general practices. The relative rate of hemolysis, which is well known to be a parameter accounting for the fluidity of erythrocyte membrane, decreases with increasing drug concentration, indicating a decrease in membrane fluidity.

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Thirteen bacterial isolates were shown to inhibit spore germination. A long-term ward and a day care hospital for very old and dependent people, located in Poitiers (France). Prolactin and luteinizing hormone levels of prelaying, laying and postlaying turkey hens following central administration of serotonin and peripheral administration of quipazine maleate. For molecules with several conformations, the changes in the relative stability of the different conformers also lead to noticeable changes in the ROA spectra. They appear to be analogous to the i(s) mutations found in the regulatory genes of the Escherichia coli lactose and galactose systems.

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Skills for intrapartum monitoring and neonatal resuscitation were inadequate. Possible role of adiponectin and insulin sensitivity in mediating the favorable effects of lower body fat mass on blood lipids. Small lungs and suspect smooth muscle: congenital diaphragmatic hernia and the smooth muscle hypothesis. Identification and characterization of the first Spanish familial ligand-defective apolipoprotein B homozygote. The dental management of children with clefts of the lip and palate. Comparability of classifications is hampered by disparity of applied methods and inter-observer variability. Identifying acanthosis nigricans in childhood permits the safe and timely treatment of cardiometabolic disorders through careful monitoring and appropriate treatment. Coronary arteriography by the single catheter percutaneous femoral technique. Clinical ratings during the AP phase were contrasted against the preceding and following two-week periods on neuroleptic alone, and these changes were analysed for a total of 27 psychopathology dimensions and for clusters of seven positive and seven negative symptoms. Based on our findings from 1,000 clinical specimens, we do not see the need to re-establish a baseline value or apply a conversion factor when switching from one assay to the other.

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Identification of geometrical isomers and comparison of different isomeric samples of astaxanthin. Through the interactions with Lck and p80, HVS Tip modulates diverse T-cell functions, which leads to the downregulation of T-cell receptor (TCR) and CD4 coreceptor surface expression, the inhibition of TCR signal transduction, and the activation of STAT3 transcription factor. The following conclusions can be drawn from our investigations: We could not find out isolated ruptures of the supraspinatus tendon, which were caused exclusively by injury. Serial serum complement levels and circulating immune complex levels were consistent with an immunologically mediated reaction. There is a misconception that direct questioning of adolescents about suicidality is sufficient to evaluate suicide risk. Downregulation of the LAR protein tyrosine phosphatase receptor is associated with increased dentate gyrus neurogenesis and an increased number of granule cell layer neurons. The Lake Maggiore area shows evidence of a great nocturnal stability and frequent formation of Nocturnal Stable Layer. pneumoniae by substances in lake water varied with the season of the year, and the rate and extent of decline of both species were different in sterile samples of different lakes. Plasmid pAJ1106 and its deletion derivative, plasmid pAJ2074, conferred lactose-fermenting ability (Lac) and bacteriophage resistance (Hsp) at 30 degrees C to Lac proteinase (Prt)-negative Lactococcus lactis subsp. While this framework can incorporate the so-called semi-competing risks data structure, we also derive a fundamental non-identifiability result.

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Familial adenomatous polyposis: prevalence of adenomas in the ileal pouch after restorative proctocolectomy. We conducted a retrospective analysis of 250 patients who underwent rigid endoscopy for globus symptoms over a 12-month period. These results are consistent with the hypothesis that photochemically induced endothelial alterations stimulate platelet activation and implicate abnormal endothelial function as a primary event in the pathogenesis of photochemically induced cerebral infarction. This represents the first report of an organism that requires the Tat pathway for viability when grown under such conditions. The triphenyl ether moiety, which was isolated only as ester, allows the hypothesis that the corresponding amino acids are the same as those of the other glycopeptide antibiotics. Infection is the commonest cause of death in acute pancreatitis. In addition, one patient received fresh islets from a living donor. Dry swallows have little use in the current evaluation of esophageal peristalsis.

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We present a case series of 5 patients with intractable pruritus associated with inflammatory skin diseases or systemic diseases who demonstrated rapid and marked improvement when treated with intranasal butorphanol. The initial osmolality and pH of each sample were measured with a vapor pressure osmometer and electronic pH meter. Human papillomavirus DNA detection in sperm using polymerase chain reaction. A retrospective review was conducted of the MR findings of 18 patients with microbiologically and/or pathologically proven EMT. Compliance with well-established standard reconstructive procedures is of elementary importance in the gastrointestinal tract. Mediastinal lymph node metastases were classified into single (12 patients) or multiple (54 patients) stations. Such differential sensitization may reflect a modulation of the hierarchy of expression of quinpirole-enhanced hyperactivity via a non-associative process.

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Glycocalicin, a predominant glycoprotein on the human platelet surface, has been purified from a platelet suspension by means of sonication, ammonium sulfate precipitation and acid treatment followed by chromatography on columns of wheat germ agglutinin-Sepharose and Mono Q. After 10 years of observation, survival of the 4 types of tooth-colored inlays was similar and considered clinically acceptable. Differentiation of embryonic stem cells into neuronal cells in vitro. However, genetic defects underlying cytokine transcription have not been associated with ET. APE was also capable of inducing morphological changes as evidenced by nuclear condensation. It may damage multiple organs and cause auditory injuries ranging from transient hearing loss and vertigo to complete disruption of the auditory system.

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Myocardial infarction and multi-vessel lesions are common in SLE patients with CAD. The subjects in this study included 18 adult family members known to have a 2-base pair deletion in the ELOVL4 gene. Mechanism of transformation in Pichia methanolica yeast: transforming and nontransforming genes. Patients with ovarian cancer with clear cell histology often have venous thromboembolism (VTE) even before surgery. The present study examined the effects of Krill phosphatidylserine (Krill-PS) on the learning and is zyrtec a anticholinergic drug memory function and the neural activity in the normal young rats. Enzymatic synthesis of biodiesel from palm oil assisted by microwave irradiation.

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The data of annual parasite incidence (API) and LUCC in the counties of Huaiyuan, Yongcheng and Tong ai in 1990-2006 were collected retrospectively. The lengths of TRF and activity of telomerase were observed in 17 early gastric carcinoma tissues and 89 advanced gastric carcinoma tissues, using hybridization of nucleic acids directly in agarose gels and telomere repeat amplification protocol (TRAP) assays, corresponding normal gastric mucosa were used as controls. A case of intracardiac rhabdomyoma in infancy with successful removal. Ischemia without congestion, e.g., during hemorrhagic hypotension or celiac artery occlusion, was associated with a reduction in the indexes of mucosal hemoglobin concentration and of oxygen saturation. The identified compounds are mainly aliphatic, terpenes and aromatic compounds. Recovery from potentially lethal damage following irradiation with X-rays or cyclotron neutrons--I. Effect of NGF and neurotrophin-3 treatment on experimental diabetic autonomic neuropathy. 552 cases protonix class of drug were selected and analyzed to calculate arithmetic mean, median, mode, and geometric mean of disability duration.

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We argue that explicit consideration of utilities leads to decision-making that is more transparent, and lays foundations for data monitoring of more complex trials. The most common PSA events associated with propofol are respiratory related and appear consistent across these three practice settings. Characterization of these peaks shows that they arise from harmonic vibrations of proteins relative to each other. This study was to evaluate the antitumor efficacy of implantable sustained Pingyangmycin (PYM) release system as a polymer based biocompatible implant administrated interstitially in tumors on tumor-bearing nude mice. A LC method has been developed to determinate both compounds and related impurities in one run. Antigen binding to the charged PLG microparticles was influenced by several factors including electrostatic and hydrophobic interactions. The core transcriptional response was characterized by a subset of genes that responded in a stereotypical manner to all of the stresses analyzed. Strain 19061/II was found to be motile, and AN6/II regained motility when the bacteria were grown in low-osmolarity medium. We analyzed the in vivo transcripts of both phages and mutants derived from them with modifications of this hairpin structure.

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Although its use in patients with low-gradient aortic stenosis is not established, we hypothesized that it might have beneficial effects on outcome after aortic valve replacement. This strategy has been developed in communities where TB is highly endemic and at a time when antiretroviral (ARV) treatment was not, or was rarely available. To investigate the role of gastric oxidative stress and nitric oxide (NO) in the formation of gastric hemorrhagic erosion and their protection by drugs in rats with ischemic brain. A correlation between progestogens that bind to steroid-binding sites on human spermatozoa and progestogens that inhibit sperm migration was established. Comparison of methods for inhibiting bacterial activity in sediment. Aneurysmal bone cysts occurring in the metacarpals: a report of three cases.

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Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes. Trace minerals in experimental subarachnoid haemorrhage: zinc, copper and manganese levels in rat brain tissue, blood and urine. While work has been undertaken to understand the biomechanics of gait in lower-limb amputees, little is known about how amputees negotiate stairs and steps. Changes in health status measures over 2 years were similar in SLE, RA, and healthy controls. Inhibition of monosodium urate crystal-induced inflammation by scopoletin is it safe to drink alcohol with claritin and underlying mechanisms. Temporally resolved interactions between antigen-stimulated IgE receptors and Lyn kinase on living cells. This study evaluated possible effects of smoking and gingival inflammation on salivary antioxidants in gingivitis patients. Prevention and control of chemotherapy-induced nausea and vomiting. Musician children outperformed nonmusician children in the detection of the weak incongruity in both music and language.

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Increased susceptibility to Yersinia enterocolitica Infection of Tff2 deficient mice. Diagnostic problems on the subject of pericarditis (clinical case). Whether the induction of suppressor cells is due to the intracisternal A particles themselves or a factor co-purified with them, remains to be established. The tactile hairs of the head were characterised by a round profile of the hair shaft, a cylindrical central medullar canal, and a thick cortex covered by cuticular scales that were arranged in a waved pattern and oriented transversally in relation to the longitudinal axis of the hair. The effect of plum juice on the prevention of struvite calculus formation in vitro. Microscopic examination of native bile and smears stained with the Gram procedure rapidly provided information on the presence of bactericholia and the necessity of antibacterial therapy prior to closing of the postoperative wound in accordance with the drug spectrum. In group 1 sildenafil drug class apical hypokinesia was a regular finding, reflected by a significantly reduced shortening of the left ventricular long axis (P less than or equal to 0.01). Cyclin D1 levels decreased, and cells were arrested in G0 and failed to enter S-phase because of hypophosphorylation of Rb and to traverse the G2M checkpoint because of degradation of cyclin B1.

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Diffuse intracranial calcification appearing during the follow up of acute lymphoblastic leukemia. Like cyanamide it has a rapid onset of action in vivo with the highest inhibition occurring after 2--24 hrs. Increased expression of vascular endothelial growth factor in cardiac structures of fetus with hydrops as compared to nonhydropic controls. A mutant of Escherichia coli that requires high concentrations of biotin. A man, with a dermatitis acquired while working in a factory producing a weed killer, showed sensitivity to 4-methylsulfonyl 2,6-dinitro-N,N-dipropylaniline (DNA-nitralin) and its precursor, 4-chloro 3,-5-dinitrophenylmethyl sulfone (DNC), and cross-sensitivity to dinitrochlorobenzene (DNCB). Annual Conference of the British Association of Sport and Exercise Sciences. The five-factor general colorectal cancer screening model provided excellent fit and was invariant across race-sex subgroups. Development of a genetic system for the transfer of DNA into Flavobacterium heparinum. In addition, both C8 and WY produced a sustained increase in serum estradiol concentrations that correlated with the potency of the 2 compounds to induce Leydig cell tumors (i.e., WY caused a more consistent sustained increase in serum estradiol throughout the entire study, and more specifically at the end of the study, than did C8). 69 patients with osteoporosis were interviewed regarding personal and family histories of osteoporosis and related fractures.

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Despite its being a relatively new antidepressant, the effects of zimeldine on psychomotor skills have already been extensively investigated. In the presence of equal quantities of protein, cholinesterase is slightly more active in glomerular than in tubular proteinuria. 796 Thai women who stopped using the long-acting injectable contraceptive depot medroxyprogesterone acetate (DMPA, Depo Povera), 437 women who stopped using oral contraceptives and 125 women who had an IUD removed to have a planned pregnancy, were followed up to ascertain the delay to conception after the end of contraception and to determine the proportion of women who did not conceive in the 4 years after discontinuation. Micro-coil NMR to monitor optimization of the reconstitution conditions for the integral membrane protein OmpW in detergent micelles. Convulsive status epilepticus after sinus injection of a contrast medium. The expression and activity of CYP3A, an enzyme responsible for active androgen clearance, was investigated in the rabbit lacrimal gland. Toward this end, we first compared the distribution of the presynaptic boutons of antennal lobe projection neurons (PNs), which transfer odor information from the antennal lobe to the MB calyx. Thirty-one patients who had underwent a potentially curative resection for Stage III and IV (M0) gastric cancer were enrolled. A threefold classification of aetiological factors in consultation is suggested, for use in day-to-day clinical general practice.

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