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Assoral (Roxithromycin)

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Assoral is an antibiotic that is used to treat infections such as infections of the chest, tonsils, skin or genitals. It works by killing or stopping the growth of bacteria (bugs). Like all antibiotics, Assoral is not effective against infections caused by viruses.

Other names for this medication:
Acevor, Aristomycin, Asmetic, Assoral, Azuril, Bazuctril, Biaxsig, Bicofen, Cadithro, Crolix, Delos, Dorolid, Elrox, Floxid, Ladlid, Macrosil, Overal, Pedrox, Redotrin, Remora, Renicin, Ritosin, Rokilide, Roksolit, Rolicyn, Rolid, Romac, Romyk, Rossitrol, Rotramin, Roxacine, Roxithromycin, Roxithromycine, Roxithromycinum, Roxitromicina, Rulid

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Also known as: Roxithromycin


Assoral is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Assoral is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Assoral is available under several brandnames. Assoral is not available in the United States. Assoral is available in Australia, Israel and New Zealand. Assoral has also been tested to possess antimalarial activity.

Assoral prevents bacteria from growing, by interfering with their protein synthesis. Assoral binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Assoral has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.


Assoral is typically prescribed for a period of 7 to 14 days and patients should take the medication for as long as it has been prescribed to prevent the infection from returning even if they become asymptomatic. Patients should not however, take doses larger than has been prescribed as this can result in an overdose. Overdosing requires immediate medical intervention and may present with symptoms which include abdominal pain, nausea, diarrhea, vomiting, and a general and prolonged feeling of illness.


Symptomatic treatment should be provided as required. There is no specific antidote.


Keep the tablets in the foil until it is time to take them.

Keep the tablets/in a cool dry place where the temperature stays below 30 degrees C.

Do not store Assoral or any other medicine in the bathroom or near a sink.

Do not leave it in the car on hot days or on window sills.

Heat and dampness can destroy some medicines.

Keep it where children cannot reach it.

A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Assoral are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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The Nambiar Technique encompassed using a 2-in left minithoracotomy incision through which the BITAs were conveniently harvested in a skeletonized manner under direct vision without robotic or thoracoscopic assistance. We show that the phenotypes in control mice fluctuate unexpectedly between batches and this can cause the false positive rate of phenotype calls to be inflated when only a small number of batches are tested, when the effect of knockout becomes confounded with temporal fluctuations in control mice. Thirty-three SNP markers linked to the Sen loci permitted the dissection of Sen alleles that increased or decreased resistance to wart. DNA fragmentation, caspase 3 and prostate-specific antigen genes expression induced by arsenic, cadmium, and chromium on nontumorigenic human prostate cells. Risk factors for melanoma include white race, sun sensitivity, family history of melanoma, and melanocytic nevi. Measurement of in-vivo force response of intra-abdominal soft tissues for surgical simulation. Three patients who were admitted for their sternal injuries had spine fractures which were not recognized during the hospitalization. The number of Helicobacter pylori clones infecting a single host has been discussed in numerous reports. Significant intrafamily correlation of the concentration of 90Sr was revealed. A study of the monoclonal antibody OC 125 to diagnose malignant ovarian tumors.

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INCIDENTAL to investigations of chemical oncogenesis, we have observed that 3-methylcholanthrene (3-MC)-induced subcutaneous sarcogenesis occurred more rapidly in the axillary than in the inguinal region of the mouse. The aim of this research was to exploit differences in epigenetic reprogramming that occur during SCNT and fertilization in the early embryo. CDI is more frequent in children with comorbidity and recent contact with the health-care system, presenting a mostly oligosymptomatic clinical course. Cardiovascular stress responses in young adulthood associated with family-of-origin relationship experiences. miletus and chigger mites were analyzed by using ecological statistic method. Because there is a large body of evidence for adverse effects of in-utero TSP as well as ETS exposure on respiratory health in children, we are in dire need of studies to elucidate when TSP exposure causes most damage, the mechanisms that underlie this damage, and how we can prevent unnecessary harm to the respiratory system in the vulnerable child. Significant predictors of hyperperfusion phenomenon after carotid angioplasty and stent placement included patient age, pretreatment CVR, and pretreatment asymmetry index. Lesions more than cerebellum in a puerpera of acute cerebellitis: concurrent encephalitis, not a subtype of ADEM. Computerized image analysis of calibrated photographic images taken under polarized light were used to measure the lesions.

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Vhl gene inactivation rapidly resulted in a marked splenomegaly and skin erythema, accompanied by renal and hepatic induction of the erythropoietin (Epo) gene, indicative of the in vivo activation of the oxygen sensing HIF pathway. The nondispersive component of surface free energy of most silica fillers was larger than the dispersive component and the acidic component was much larger than the basic one, which indicated that the surfaces of most silica fillers were rather acidic. Genetic control for these silencing pathways varies greatly between tissues of the gonad. Randomized controlled trials reporting on SM interventions delivered during hospitalization for an AECOPD or within 1 month of hospital discharge were included. Computerized texture features were extracted from regions-of-interest to assess the mammographic parenchymal patterns in the images. route may inhibit the stress-induced increase in adrenomedullary Ad secretion by an action on the central alpha 1-adrenoceptor. A novel D-pi-A system in which tetrathiafulvalene (TTF) and pi-extended TTFs as strong electron donors are covalently connected to a tricarbonyl (eta(6)-arene)chromium complex as the acceptor moiety through a systematically increased conjugated bridge of vinylene units (12a-c, 16a-c) have been synthesized by Wittig-Horner olefination reaction. C-S bond formation reaction between a phenolate and disulfide-bridged dicopper(I) complexes. The encoded protein included amino acid sequence motifs that are conserved with four homologous serine proteases from other insects.

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Oral KW3110 administration in the mouse allergy model directed the Th1/Th2 balance toward Th1 through the maturation of APCs and inhibition of serum IgE elevation. Research suggestions are recommended, including study design, risk factors, medication effects, and measurement strategies. Public health nutrition practice in Australia, the UK, Canada and the USA. Sexually transmitted infections in pregnancy: prevalence, impact on pregnancy outcomes, and approach to treatment in developing countries. Analytical Solutions Using Integral Formulations and Their Coupling with Numerical Approaches. Teaching medical students to use simple language when talking with patients.

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Compressibility and structural stability of nanocrystalline TiO2 anatase synthesized from freeze-dried precursors. Chromophore conformational analysis in phycocyanin and in related chromopeptides by surface enhanced Raman spectroscopy. Considerable insight into the biology of optimal switching (between corner controls) is extracted from numerical results for cases with nonconvex death rates. In contrast, charcoal particles as the control did not affect the expression of these molecules. Evaluation of secondary causes, especially hypogonadism, is important, as they can play a significant role in the development of osteoporosis in men. Patients in the study group received significantly less (P less than 0.03) morphine (0.32 h-1) and had significantly lower pain scores than did patients in the control group (0.71 h-1).

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Here we report that the general MPP (mitochondrial processing peptidase) plays an essential role in processing of the polyprotein. Generalized vaccinia, progressive vaccinia, and eczema vaccinatum are rare following smallpox (vaccinia) vaccination: United States surveillance, 2003. Effect of cadmium on the absorption and excitation energy transfer in cyanobacterium Nostoc muscorum. The association between PA and MFQ scores was modelled using ordinal regression. The vascularization of a scaffold is a complex process, and is modulated by the presence of transplanted cells, exogenous and endogenous signaling proteins, and the host tissue reaction, among other influencing factors. Glyceraldehyde-3-phosphate dehydrogenase as a target for small-molecule disease-modifying therapies in human neurodegenerative disorders. The haematoma resolved initially but recurred twice within a week after conservative treatment. Suitable chemical methods for preparation of graphene oxide, graphene and surface functionalized graphene nanosheets. The most associated condition in spontaneous SCH was hypertension. The effect of L-aspartic acid, alanine and L-glutamic acid on calcium oxalate precipitation has been tested.

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Management of cancer-related anemia with erythropoietic agents: doubts, certainties, and concerns. Using spectral and beamforming analyses to investigate the neural activity preceding the responses, we found a desynchronization in the beta band (15-25 Hz), which originated 900 ms prior to the onset of speech and was localized to motor and somatosensory regions in the cortex and cerebellum, as well as right inferior frontal gyrus. Our aim has been to assess the frequency of the diverse etiologies of goiter in adult patients aged 55 years and older, and evaluate the relationships between etiology and age, sex, and goiter features. Because heavily myelinated proprioceptive axons project to the ventral spinal cord, proprioceptive axons and their associated oligodendrocytes avoid the superficial dorsal horn. The treatment of an ovarian cyst relies on its nature, and accurate preoperative discrimination of benign and malignant cysts is therefore of crucial importance. After a complete and accurate diagnostic study, a rhinoplasty was performed with a good result and without complications during a 2-year follow-up period. However, when TMS was applied to the left motor cortex, MEPs were larger while observing right hand actions.

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The use of TENS had no impact on mother or child and no influence on labor. Likely, infliximab precipitated a pre-existing mycobacterial infection of the intestine. Our data suggest the need for a randomized comparison of the two treatment modalities for small HCCs. Gemcitabine and carboplatin combination chemotherapy is an effective and manageable treatment option in elderly advanced NSCLC patients with good performance status. Only one device did not raise pressure in response to central apnoeas with opened upper airways.

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Face-to-face appointment frequencies (visits/year) of each patient were calculated before and after the first message in a matched-pairs analysis. Model output is in a form suitable for integration with dispersion models, the predictions of which can in turn be used to indicate the probability of annoyance. The aim of this operation was to contain the residual mass after excision within a tight net against the force of gravity, thus limiting and preventing drooping or bulging of the facial soft tissue while preserving muscles and nerves associated with facial expression. The temporal aspects of life cycle characteristics, such as diapause development, are under strong selection in seasonal environments. Pelvic exenteration is an extensive surgical procedure performed for locally advanced cancers in the pelvis.

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Because of this difficulty, this paper proposed a decoupled scheme of the links involved in the working process of a sarcomere and established a semiphenomenological model integrating both linear and nonlinear frames of no higher than a second-order system. Currently, patients on insulin therapy for Cystic Fibrosis-Related Diabetes Mellitus (CFRD) at the All Wales Adult Cystic Fibrosis Service, UK are invited for annual screening. Does closure of acid-sensing ion channels reduce ischemia/reperfusion injury in the rat brain?. The birth of a premature or critically ill infant can result in debilitating parental responses. We show that this phenomenon is specifically generic levitra triggered by carbon source exhaustion but not by nitrogen starvation. Wing shape of four new bee fossils (Hymenoptera: Anthophila) provides insights to bee evolution. We consider a dynamical model of cancer growth including three interacting cell populations of tumor cells, healthy host cells and immune effector cells. Furthermore, the absolute structure of caprazamycin B (2) was established by NMR spectroscopy and X-ray crystallography of its degradation products and by total synthesis of the 5-amino-5-deoxy-D-ribose moiety. The test differentiated clearly between plasmids from unrelated incompatibility groups, whereas cross-reaction occurred with closely related groups such as FI and FII.

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Two potentially useful treatments for patients with chronic low back pain are called the McKenzie and Back School treatment programs. Intravenous self-administration of the indirect dopaminergic agonist amfonelic acid by zyrtec 10 mg cost rats. Two enlarged lymph nodes were detected--the middle thoracic paraesophageal lymph node in the mediastinum and the right cardiac lymph node. However, some cell bodies of GABAergic neurons in the cortex and hippocampus demonstrate an increased accumulation of reelin in the Golgi and endoplasmic reticulum. Combined thermal and mechanical loading significantly reduced the FPD fracture resistance from 1832N to 410N. Youth in the alcohol and marijuana use class were more likely to be older and depressed. CSF pharmacokinetic samples were obtained in a subset of patients. Gastric carcinoma is the most frequent Epstein-Barr virus-associated malignancy. Anti-oxidant studies and anti-microbial effect of Origanum vulgare Linn in combination with standard antibiotics. For IMRT and VMAT the application of metal artefact reduction significantly increases the agreement of dose calculations with film measurements.

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In vitro analysis of the effect of alkyl-chain length of anionic surfactants on the skin by using a reconstructed human epidermal model. Combined treatment with cyclosporine microemulsion preconcentrate (CyA MEPC) and steroids has been widely used for idiopathic membranous nephropathy (IMN) associated with steroid-resistant nephrotic syndrome (SRNS). Malaria epidemic trend and zantac 50 mg tablet characteristics at monitoring sites in Yunnan province in 2008. The transmission of medical information is currently a daily routine. Apigenin generated reactive oxygen species, a loss of mitochondrial Bcl-2 expression, mitochondrial permeability, cytochrome C release, and the cleavage of caspase 3, 7, 8, and 9 and the concomitant cleavage of the inhibitor of apoptosis protein, cIAP-2. A better understanding of the vitamin D(3) metabolism is required to evaluate its potential therapeutic value for cancers. 24 hours after transfection in K562 cells, the recombinant plasmid could down regulate the expression of the bcr/abl mRNA and bcr/abl protein(P210) in K562 cells. Especially, the strain YJ-17 which belonged to Phomopsis genus showed the best inhibitory effect on the targeting microbes.

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