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Atipam (Lorazepam)

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Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication. It is used to treat anxiety disorders, trouble sleeping, active seizures including status epilepticus, alcohol withdrawal, and chemotherapy induced nausea and vomiting, as well as for surgery to interfere with memory formation and to sedate those who are being mechanically ventilated. While it can be used for severe agitation, midazolam is usually preferred. It is also used, along with other treatments, for acute coronary syndrome due to cocaine use. It can be given by mouth or as an injection into a muscle or vein. When given by injection onset of effects is between one and thirty minutes and effects last for up to a day.

Other names for this medication:
Almazine, Anxilor, Anxionil, Anxipose, Atipam, Biokalm, Biolar, Calmese, Dulozep, Larosh, Larpose, Lopam, Lopez, Loracalm, Lorakar, Loralite, Lorazam, Lorazepam, Lorazine, Loricon, Loripam, Lorivan, Lorpam, Lorvin, Lotweet, Nexlor, Norpose, Olraz, Trapex, Urpam, Zelor, Zepatrac, Zepnap

Similar Products:
Cymbalta, Cardura, Benicar, Imdur, Antivert, Aurogra, Theolair

Also known as: Lorazepam


Lorazepam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen) that is used to treat a seizure emergency called status epilepticus. Lorazepam injection is also used as a sedative to help you relax before having surgery.


When given intramuscularly, Atipam Injection, undiluted, should be injected deep in the muscle mass.

Injectable Atipam can be used with atropine sulfate, narcotic analgesics, other parenterally used analgesics, commonly used anesthetics, and muscle relaxants.

Immediately prior to intravenous use, Atipam Injection must be diluted with an equal volume of compatible solution. Contents should be mixed thoroughly by gently inverting the container repeatedly until a homogenous solution results. Do not shake vigorously, as this will result in air entrapment. When properly diluted, the drug may be injected directly into a vein or into the tubing of an existing intravenous infusion. The rate of injection should not exceed 2.0 mg per minute.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if solution is discolored or contains a precipitate.

Atipam Injection is compatible for dilution purposes with the following solutions: Sterile Water for Injection, USP; Sodium Chloride Injection, USP; 5% Dextrose Injection, USP.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Atipam can be fatal. Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, fainting, or coma.


Store Ativan at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Atipam is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Atipam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


The additive central-nervous-system effects of other drugs, such as phenothiazines, narcotic analgesics, barbiturates, antidepressants, scopolamine, and monoamine-oxidase inhibitors, should be borne in mind when these other drugs are used concomitantly with or during the period of recovery from Atipam Injection.

Extreme caution must be used when administering Atipam Injection to elderly patients, very ill patients, or to patients with limited pulmonary reserve because of the possibility that hypoventilation and/or hypoxic cardiac arrest may occur. Resuscitative equipment for ventilatory support should be readily available.

When Atipam injection is used IV as the premedicant prior to regional or local anesthesia, the possibility of excessive sleepiness or drowsiness may interfere with patient cooperation in determining levels of anesthesia. This is most likely to occur when greater than 0.05 mg/kg is given and when narcotic analgesics are used concomitantly with the recommended dose.

As with all benzodiazepines, paradoxical reactions may occur in rare instances and in an unpredictable fashion. In these instances, further use of the drug in these patients should be considered with caution.

There have been reports of possible propylene glycol toxicity (e.g., lactic acidosis, hyperosmolality, hypotension) and possible polyethylene glycol toxicity (e.g., acute tubular necrosis) during administration of Atipam Injection at higher than recommended doses. Symptoms may be more likely to develop in patients with renal impairment.

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In all patients, a fast imaging sequence, fast spin echo sequence was employed, together with short time inversion recovery sequence and contrast enhancement scanning by intravenous injection of Gd-DTPA. Molecular evolutionary investigations suggest that codon bias is manifested as a result of balance between mutational and translational selection of such genes and that this phenomenon is widespread across species and may contribute to genome evolution in a significant manner. There was a linear correlation between cell death and enzyme expression for treatments with polyenes, detergents, some organic solvents which did not denature the enzyme, and various freeze-thaw regimens in graded amounts of glycerol. This base acts as a sensitive trigger for the response mechanism to UV exposure, providing protection against its damaging effects. Recombinant production of the human aquaporins in the yeast Pichia pastoris (Invited Review). The relation between the absorbance and K(Z), the degree of titration and the degree of overlapping of the basic and the acid ionization constant is given. The validated methods were proved effective for the simultaneous study of a large number of metabolites which are commonly present in urine samples and are used for detecting IEM.

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The angiotensin I-converting enzyme gene insertion/deletion polymorphism is linked to early gastric cancer. The method is designed to discriminate between aquatic organisms that utilize phenanthrene as the sole carbon and energy source and organisms that cometabolize phenanthrene. Many investigations have found deficits in visuospatial perception in children born preterm, however, it is not clear whether the deficits are specific to visuospatial perception or the consequences of deficits in other functional areas, which often accompany preterm birth. In this work, a novel processing technique has been developed to create three-dimensional biodegradable polymer scaffolds with well-controlled interconnected spherical pores. Myelography revealed concentric constriction of the lower thecal sac due to abundant fat, as shown by computerized tomography. Platelet tagging with tritium labeled diisopropylfluorophosphate.

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These kinases are thought to be activated by tumor necrosis factor receptor-associated factor 6 (TRAF6). In the stage of depressed ICP, the administration of isoproterenol and steroids is recommended in order to try to alleviate the secondary rise of ICP. Involvement of potD in Streptococcus pneumoniae polyamine transport and pathogenesis. The LBPL proved to be critically dependent on the ionic binding capacity of a given hydrogel. Daily systemic IL-6 levels and leukocyte counts (Lc) were measured in the acute phase in 11 patients with pmSAH and in 9 patients with non-pmSAH. MRI showed a heterogeneous mass, with hypointense signal on T1 and iso/hyperintense signal on T2-weighted images (WI) and gadolinium enhancement. After selected with G418, a recombinant CHO cell line, ATR-Fc-1D5, whose expression level was about 10 - 15 microg/(10(6) cells x d), was established. To address this issue, we compared the molecular profiles of healthy versus PAD proximal femoral arteries. The principal technique used in this study has been chronopotentiometric stripping.

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Experiments were performed to test in such mice the therapeutic effects of 24-norUrsodeoxycholic acid, a C(23) homologue of ursodeoxycholic acid with 1 fewer methylene group in its side chain. Methodological issues in the direct observation of parent-child interaction: do observational findings reflect the natural behavior of participants?. The sequelae of PID that cause infertility can be assessed with the judicious use of hysterosalpingography and laparoscopy. From 07/03 to 03/04 we analysed out of 71 peripheral arterial reconstructions 10 alloplastic grafts (PBP) and 10 autologous vein grafts (VBP) for femoropopliteal above-knee bypass through the process cost calculation. Emphasis has been placed on the apparent discrepancies and inconsistencies reported within the literature as well as major methodological differences which make the integration of the data presented by various researchers almost impossible. The fainting patient: value of the head-upright tilt-table test in adult patients with orthostatic intolerance. Changes in the concentration of naturally occuring polyamines in experimental tumors. Although the mutations occur at adjacent codons in exon 8 and result in reduced functional activity with normal antigen levels, the patterns of inheritance appear to be quite distinct. Antibodies were administered at 4 different dose levels (30 microg, 270 microg, 810 microg, 1,600 microg of each antibody) either by intratumoral or intralymphatic injection.

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Isolation and Characterization of a Catabolite Repression-Insensitive Mutant of a Methanol Yeast, Candida boidinii A5, Producing Alcohol Oxidase in Glucose-Containing Medium. Prevalence and risk factors for HEV infection in pregnant women. Pharmacokinetics and tolerability of a single dose of DN-101, a new formulation of calcitriol, in patients with cancer. This report evaluated whether acute phase reactants can predict the development of mitral regurgitation following percutaneous mitral valvotomy. Brief goal-limited homosexual couple therapy can provide a useful adjunct to individual therapy of homosexuals. Furthermore, demyelinating lesions caused by excitotoxins can be similar to those observed in multiple sclerosis. When ARVC has progressed to heart failure in the right or left ventricles, orthotopic heart transplantation is an effective therapeutic option. Optionally a fraction of the QSAR-prioritized library can be docked in order to find the true docking hits. A systematic search was performed of the literature from January 1980 to December 2004 by using MEDLINE and EMBASE. The risks and opportunities of the globalization of health care delivery.

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The transient hyperammonemia of the neonate (THAN) occurs mostly in premature babies, and the prognosis is usually better than for urea cycle disorders. This article reviews the methods and the usefulness of mindfulness-based cognitive therapy (MBCT) as a treatment for the prevention of the reactivation of the suicidal mode. The cause of sudden cardiovascular collapse in the perioperative period can be elusive. The dose of paclitaxel was 25 mg/m2 in the first cohort and escalated by 5 mg/m2 per cohort. Common regulatory sites in the promoter region of genes whose expression was induced after stress were identified. Transdermal therapeutic systems are an excellent alternative to conventional pharmaceutical dosage forms. To clarify which neural substrates participate in nonpsychotic VH in PD, the authors evaluated regional cerebral blood flow (rCBF) changes in patients with PD and VH. Influence of inotropic alteration on the severity of myocardial ischemia after experimental coronary occlusion. Our findings suggest that LPC might activate the endothelial NADH/NADPH oxidase to enhance superoxide production, and it might, in turn, enhance MMP-2 induction. Proceedings: Effect of furosemide on the short-circuit current and chloride flux across frog (Rana temporaria) skin.

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lanceolatum), BfMT2 cDNA resulting from an alternative splicing event. This represents the first step to developing a quantitative plasma biomarker that could be used to monitor glioma status. A substantial proportion of health services for rural Australians is provided in rural health facilities by rurally based generalist health professionals. According to TUNEL analysis, both vitrification protocols showed better preservation of preantral follicles than the conventional freezing method. The electromotor system of the electric catfish (Malapterurus electricus): a fine-structural analysis. The antireproductive properties of the agonist are also of interest for treatment of tumors, gynecologic disorders such as endometriosis and polycystic ovarian disease, and precocious puberty. Characterization of oligosaccharides from the chondroitin sulfates.

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Children older than 8 years of age have a higher rate of open supracondylar humerus fractures, although nerve injury rates are similar. The allergy reactions were classified into types I, II, III and IV according to Gell and Coombs. No difference in surface morphology could be discerned between the CT and the remainder of the PR. To confirm that these genes contribute to the etiology of some human NASH, further investigations using human liver samples are needed. An optimal protocol is proposed for examination of compatibility donor-recipient in MLC reaction in patients with hematological malignancies.

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Through improvements in xenograft assay methods and in the identification of novel cell surface markers, significant progress has been made in our understanding of the human hematopoietic stem and progenitor hierarchy. We here studied the catalytic behaviour of bovine liver catalase at low fluxes of H(2)O(2) (relative to catalase concentration), adjusted by H(2)O(2)-generating systems. Encoding the results as scientific assertions that are both human and machine readable would greatly enhance the synergistic growth and dissemination of knowledge. An RF phased array applicator designed for hyperthermia breast cancer treatments. Patients are individuals and therefore different methods of debridement may make sense. To decrease smoking relapse among pregnant and postpartum women by adapting existing, validated relapse-prevention materials to meet the unique needs of pregnant and postpartum women. The antibiotic, obtained as a colorless amorphous powder having the molecular formula C48H77N7O16, is an antifungal antibiotic active against yeasts and filamentous fungi. Anxiety disorders and risk for suicidal ideation and suicide attempts: a population-based longitudinal study of adults.

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Person trade-off (PTO) elicitations yield different values than standard utility measures, such as time trade-off (TTO) elicitations. This study provides further insights into the complex scenario of migraine mechanisms. Using a dynamic clamp system to inject simulated conductances into pyramidal neurons in motor cortical slices, we mimicked in vivo-like activity by introducing a random background of excitatory and inhibitory inputs. Bilateral kidney enlargement and renal failure are described in a five-years-old girl with brucellosis. Mechanization of the work of the personnel of the sterilization service of therapeutic-preventive institutions. Therefore, a reliable automated method for the identification of disulfide bridges can serve as an important tool in the analysis of the tertiary structure of proteins of interest. To learn whether nicotinic cholinergic receptors modulate postnatal eye growth and influence the course of form-deprivation myopia. Renal biopsies, which were obtained successfully, except one case of macroscopic hematuria, showed no histological changes in the kidney.

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Taking advantage of the recent innovations in systemic delivery of short interfering RNA (siRNA) using lipid nanoparticles (LNPs), we developed a self-amplifying RNA vaccine. Many of the initial studies suggesting a link between dietary cholesterol, blood cholesterol levels and cholesterol lowering drugs were performed more than a decade ago. Two hundred and twenty-three consecutive patients with 343 coronary lesions underwent angioplasty with implantation of 220 rapamycin-eluting stents (Cypher) and 297 paclitaxel-eluting stents (Taxus). These results provide insights into the mechanisms behind microglial glutamate transporter expression during pathological conditions, and contribute to the debate about the beneficial or harmful effects of glucocorticoids. In severe liver diseases the demethylation of caffeine as well as the metabolism of metamizol is significantly reduced. Validation is performed using PF joint contact area and patellar orientation measured from upright, weight-bearing MRI.

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Tolerance to dinitrofluorobenzene (DNFB) contact sensitivity (DNFB CS) appeared in C3H/HeN mice within 2 days after application of DNFB on Langerhans cell-deficient tail skin. The barriers to clinical coding in general practice: a literature review. Consecutive instances of gallstone ileus due to obstruction first at the ileum and then at the duodenum complicating a gallbladder carcinoma: a case report. Dynamic evaluation of the incidence of hereditary pathology by an accounting of spontaneous abortions and congenital developmental defects. Tunicamycin pretreatment of target cells inhibited their triggering capacity but not their NK binding function.

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Acid-shifted isoelectric point profiles of the proteins in a hypersaline microbial mat: an adaptation to life at high salt concentrations?. The expressed arresten protein showed evident biological activities. Proton NMR study of the cyanide metmyoglobin reconstituted with meso-tetraalkylhemins. Physical and psychosocial working conditions of nursing personnel should be improved. 14,015 female nurses aged 50 years and above who in 1993 completed a questionnaire on general health and lifestyle issues, reproductive history including information on HRT, and family history of osteoporosis and personal history ultram 15 mg of a wrist fracture. Platelet large cell ratio if properly utilised can be a good aid in the differential diagnosis of conditions associated with abnormal platelet counts.

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Recurrent inhibition of motoneurons during the silent period in man. Since the results coincide with some of the bioassays and chemical analysis performed previously, the changes in bacterial community structure are explained as an effect of antropogenic pollution on the lake ecosystem by waters of the river Moraca and the stream Plavnica. We found a significantly higher prevalence of MRI-defined WMH in patients with a clinical diagnosis of pseudoexfoliation with or without glaucoma versus control subjects. Many plant species can modify their root architecture to enable them to forage for heterogeneously distributed nutrients in the soil. The expression level of proteins such as MEKK3, phosphoglycerate mutase was increased, and nitric-oxide synthase, mineralocorticoid receptor were decreased in TNF-alpha stimulated HUVECs, while ginsenoside Rg1 could prevent this change or reverse to some degree. Electrical and electronic waste management in China: progress and the barriers to overcome. The application and future prospects of transformation technology to engineer the resistance against insect protonix pantoprazole sodium 40 mg pests (stem borer, leaf folder, brown plant hopper, gall midge), fungal diseases (blast, bakanae/foot, rot), bacterial diseases (bacterial leaf blight, sheath blight), abiotic stresses (salinity and drought) and improved nutritional quality (accumulation of provitamin A and essential amino acids in endosperm) in Basmati rice, have been addressed. In vitro antibacterial and cytotoxicity assay of multilayered polyelectrolyte-functionalized stainless steel.

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A strategic approach to developing e-learning capability for healthcare. The density functional theory calculated results were found to be in good agreement with the experimental data available in the literature and help to explain some of the observed variation in these types of cyclization reactions with various substitutions. In this study, we used quantitative real-time PCR, Northern blots, whole genome RNA sequencing, Western blots, and immunofluorescence microscopy to study ABCG2 expression in hESCs. A new poly(ortho ester)-based drug delivery system as an adjunct treatment urispas 200 mg dosage in filtering surgery. This study was conducted to investigate the predisposing factors and bacteriologic agents of acute rhinosinusitis in children. To evaluates the diagnostic accuracy of the SPECT-tracers 3-(123)I-alpha-methyl-L-tyrosine (IMT) and (99m)Tc(I)- hexakis(2-methoxyisobutylisonitrile) (MIBI) as well as the PET-tracer 2-(18)F-2-deoxyglucose (FDG) for detecting tumour progression in irradiated low grade astrocytomas (LGA). Binding of the most potent inhibitor, AP23464, results in the largest induced-fit movement, which can be directly linked to interactions of the hydrophenethyl N9 substituent with a region at the interface between the two lobes. Transcranial magnetic stimulation (TMS) affects the brain by non-invasively stimulating the cerebral cortex and inducing electrical currents in neurons. Systematic study of the 87Srclock transition in an optical lattice. Carpal tunnel syndrome--median nerve enlargement restricted to the distal carpal tunnel.

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Ormetoprim-sulfadimethoxine in cattle: pharmacokinetics, bioavailability, distribution to the tears, and in vitro activity against Moraxella bovis. The expression of COX-1, Ep1, Ep2, and Ep3 receptors decreased on day 14 of the culture, whereas the expression of COX-2 and Ep4 receptors increased significantly with the addition of LPS. Quantitative analysis of these products on Caenorhabditis elegans Affymetrix GeneChips shows that this amplification does not reduce overall sensitivity and has only minor effects on fidelity. For example, test-retest scores show that the PASAT is extremely susceptible to practice effects. Subcutaneous microdialysis for children - safe biochemical tissue monitoring based on a minimal traumatizing no touch insertion technique. Here, we present the analysis of HpaI REase, an ORFan with no detectable homologs, for which we detected a structural template by protein fold recognition, constructed a model using the FRankenstein monster approach and identified a number of residues important for the DNA binding and catalysis. The goal of this study was to determine, through a longitudinal follow-up, whether sex influences bone adaptation during simulated weightlessness.

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Ninety patients with TPP, 61 SPP, and 100 age and sex-matched healthy subjects were performed. Conversely, pretreatment with ketanserin blocked the central sympatholytic action of prazosin. A substantial proportion of obese patients without CHF or CKD have concentrations greater than the upper reference limit for NT-proBNP but not for simultaneously measured BNP. Food authentication of commercially-relevant shrimp and prawn species: from classical protonix dr 40 mg side effects methods to Foodomics. Lateral displacement of the diaphragmatic crus and interposition of fluid between the crus and vertebral column indicate an intrapleural component. Staffing of anaesthesiology departments must take into account the possibility of sudden medical emergencies. Girls described themselves as significantly more go d than boys. Circulating factors affect 6-phosphofructokinase activity in human adipose tissue.

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Further investigations over a broader geographic area are urgently needed for better understanding the clinical and epidemiological characteristics of HIV infection in small Brazilian municipalities and rural areas. Dose verification in highly conformal radiation therapy such as IMRT or proton therapy can benefit from the high spatial resolution offered by radio-chromic films such as Gafchromic EBT or EBT2. After cross-linking with glutaraldehyde, lysozyme protein crystal tips image gold nanoparticles and grating standards with a resolution comparable to that of conventional tips. Cystic fibrosis transmembrane conductance regulator (CFTR) is an ion channel employing the ABC transporter structural motif. In the familial nonkinesigenic form, the movements are of longer duration, occur less frequently, and rarely respond to anticonvulsants.

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In revisions, non-cemented rectangular revision stem were used for 27 cases and two-stage surgery were used for 4 infection cases. Synthesis and evolution of PbS nanocrystals through a surfactant-assisted solvothermal route. In contrast, for nonmatching pairs, a second representation was activated over right parietal areas. It is defined as the difference between nucleophilic and electrophilic condensed philicity functions. A systemic lupus erythematosus-like syndrome induced by procainamide.

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Evaluation included clinical assessment of spasticity (Ashworth scale), maximal Hoffmann reflex (H(max))/compound muscle action potential (M(max)) ratio measurement, gait analysis, and muscle stiffness evaluation performed before and 2 mos, 1 yr, and 2 yrs after the neurotomy. The two aerosol-related processes should be considered in the study of O3 formation because high aerosol concentration is a ubiquitous phenomenon that affects the urban- and regional air quality in China. Compaction of DNA by gemini surfactants: effects of surfactant architecture. Purification of a thermostable high molecular weight factor promoting tubulin polymerization. Direct vasodilatory action of nitroglycerin on vascular smooth muscle cells may predict the chronic antihypertensive effect of angiotensin II receptor antagonist. Heterogeneity of the hydrocortisone-resistant cell subpopulation in the mouse thymus. Microglia in the hypendyma of the rat subcommissural organ following brain lesion with serotonin neurotoxin. The effects of various nutritional supplements on the growth, migration and differentiation of Xenopus laevis neural crest cells in vitro.

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To our knowledge, this is the first report of endobronchial polypoid CMV disease in lung transplant recipients. No significant excess of nonmelanoma cancers was documented, suggesting that hereditary cutaneous malignant melanoma/dysplastic nevus syndrome is not pleiotropic for other tumor types. Preliminary studies with the sensitive cytochemical assay for parathyroid hormone. Editoral: Grounds for optimism in treating acute granulocytic leukemia. Randomised trial of clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid hemorrhage undergoing surgical clipping (CONSCIOUS-2). To use modern terminology, this method allows you to correct the serious but not fatal error you have made in letting a child program your lifetime computer.

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