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Azimycin (Azithromycin)
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Azimycin

Azimycin belongs to a group of Macrolide Antibiotics useful for treating numerous infections caused by bacteria like middle ear infections, traveler's diarrhea. Along with other medications, it is sometimes used for malaria. It is also used to treat a number of intestinal infections and sexually transmitted infections including gonorrhea and chlamydia. Administration of the medicine takes place either by mouth or intravenously with doses once per day.

Other names for this medication:
Azalid, Azicin, Azimakrol, Azimax, Azimex, Azimycin, Azinix, Aziphar, Azithromycinum, Azitrolit, Azitromicina, Azitrox, Azomac, Azyter, Bactexina, Cinalid, Goldamycin, Macrozit, Momicine, Rarpezit, Tremac, Tromic, Unizitro, Zentavion, Zetamax, Zicho, Zimax, Zitroken, Zitroneo, Zomax, Zycin, Zymycin

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Also known as: Azithromycin

Description

Azimycin (Azimycin tablets and Azimycin for oral suspension) contain the active ingredient azithromycin, a macrolide antibacterial drug, for oral administration. Azimycin has the chemical name (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl) oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one. Azimycin is derived from erythromycin; however, it differs chemically from erythromycin in that a methyl-substituted nitrogen atom is incorporated into the lactone ring. Its molecular formula is C38H72N2O12, and its molecular weight is 749.00.

Azimycin, as the dihydrate, is a white crystalline powder with a molecular formula of C38H72N2O12∙2H2O and a molecular weight of 785.0.

Azimycin is supplied as tablets containing azithromycin dihydrate equivalent to either 250 mg or 500 mg azithromycin and the following inactive ingredients: dibasic calcium phosphate anhydrous, pregelatinized starch, sodium croscarmellose, magnesium stearate, sodium lauryl sulfate, hypromellose, lactose, titanium dioxide, triacetin, and D&C Red #30 aluminum lake.

Azimycin for oral suspension is supplied in bottles containing azithromycin dihydrate powder equivalent to 300 mg, 600 mg, 900 mg, or 1200 mg azithromycin per bottle and the following inactive ingredients: sucrose; sodium phosphate, tribasic, anhydrous; hydroxypropyl cellulose; xanthan gum; FD&C Red #40; and spray dried artificial cherry, creme de vanilla, and banana flavors. After constitution, each 5 mL of suspension contains 100 mg or 200 mg of azithromycin.

Dosage

It is important that your child completes the course of antibiotic. This means that they must take the medicine for the number of days that the doctor has told you to, or until all the medicine has been taken. If you stop giving the antibiotic too soon, the troublesome bacteria that are left will start to multiply again, and may cause another infection. There is also a risk that these bacteria will be resistant to (no longer be killed by) the first antibiotic. This means that it might not work next time, and your child might need a different antibiotic, which might not work as well or cause more side-effects.

Children are sometimes sick (vomit) or get diarrhoea when taking antibiotics. Encourage them to drink water to replace the fluid they have lost. If it is severe or your child is drowsy, contact your doctor.

Do not give your child any medicine to stop the diarrhoea unless your doctor has told you to, as this can make things worse.

Try to give the medicine at about the same times each day, to help you remember, and to make sure that there is the right amount of medicine in your child’s body to kill the bacteria.

Only give this medicine to your child for their current infection.

Never save medicine for future illnesses. Give old or unused antibiotics to your pharmacist to dispose of.

Only give the antibiotic to the child for whom it was prescribed. Never give it to anyone else, even if their condition appears to be the same, as this could do harm.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Azimycin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Abnormal liver function, hepatitis, cholestatic jaundice, hepatic necrosis, and hepatic failure have been reported, some of which have resulted in death. Discontinue Azimycin immediately if signs and symptoms of hepatitis occur.

The presence of other medical problems may affect the use of Azimycin. Make sure you tell your doctor if you have any other medical problems, especially: allergy to any macrolide and ketolide antibiotic or liver disease with prior Azimycin use or bacteremia (blood infection) or cystic fibrosis or infections, nosocomial or hospital-acquired or weak immune system or bradycardia (slow heartbeat) or hypokalemia (low potassium in the blood) or hypomagnesemia (low magnesium in the blood)

Not recommended in patients with these conditions: congestive heart failure or diarrhea or heart disease or Heart rhythm problems (e.g., prolonged QT interval), history of or Myasthenia gravis (severe muscle weakness).

Use with caution. May make these conditions worse: kidney disease, severe or liver disease. The effects may be increased because of slower removal of the medicine from the body.

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Amino acid composition of cytoplasmic yeast pyruvate decarboxylase. Identification of somatostatin receptor type 5 gene polymorphisms associated with acromegaly. Prothrombin expression is increased in response to joint immobility. 99mTc-MDP whole-body bone scan was routinely performed within 1 week for comparison. Adapting to the new millennium: nursing licensure and home care. Microdosimetric quantities such as lineal energy are generally considered to be better indices than linear energy transfer (LET) for expressing the relative biological effectiveness (RBE) of high charge and energy particles. Phenindione interference in enzymatic creatinine assay - A case report. Synthesis, characterization, antitumor activity and safety testing of novel polyphosphoesters bearing anthracene-derived aminophosphonate units. In situ hybridization by scanning electron microscopy for painting, centromeric, and YAC localization. Based on four reported cases including the present case, 16p trisomic infants have remarkably similar features.

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Theoretical investigation of triphenylamine dye/titanium dioxide interface for dye-sensitized solar cells. COPD patients are earning approximately half of that of controls before diagnosis. Particle breakage as well as mechanical activation of the surface of the alumina particles contributes to the radical formation. Correlating BMI ratio before and after weight loss with the ratio of total LPC and individual LPC species revealed significant negative relationships of LPC ratios with BMI ratio. A retrospective multicentre study comparing myomectomy by laparoscopy and laparotomy in current surgical practice. The ability to provide good palliative care to patients is increasingly recognised as a core clinical skill that all doctors should possess. However, this requires genetic data from an exhaustive sample of candidate males.

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From the course of the lymphatic vessels it is evident that the breast cannot be divided into functionally separate segments. Pichia pastoris Aft1--a novel transcription factor, enhancing recombinant protein secretion. The results suggest that the amide tracer structure can generally be used to improve the quality of estradiol antibodies suffering from bridge binding effects. Calcitonin-producing well-differentiated neuroendocrine carcinoma (carcinoid tumor) of the urinary bladder: case report. Modification of the spinal peak growth velocity as a possible treatment for adult scoliosis. Further, single-gene expression outcome prediction is limited for cancer evaluation since genes do not act in isolation, but rather interact with other genes in complex signaling or regulatory networks. The sera from eight patients and four rabbit antibodies were used in this study.

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Salience of self-identity roles in persons with dementia: differences in perceptions among elderly persons, family members and caregivers. Voxel-wise FA analysis found a group effect in white matter underlying the right motor cortex. The use of random biopsies should be replaced by chromoendoscopy for targeting biopsies towards areas with abnormal appearance. In sighted people, this task normally produces robust task-independent decreases relative to a baseline of quiet wakefulness with eyes closed. However, the evidence for this in human alcohol dependence is as yet inconclusive.

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Newer PET application with an old tracer: role of 18F-NaF skeletal PET/CT in oncologic practice. Development and validation of an LC-APCI-MS/MS method for the determination of phenethyl isothiocyanate in human plasma. Effect of three different time periods of irrigation with EDTA-T, EDTA, and citric acid on smear layer removal. Draft Genome Sequence of an Enterococcus faecalis Strain Isolated from a Neonatal Blood Sepsis Patient. The important issue for separating the responses of sensing materials from interference by other subcomponents in a FET transducer under global physical stimuli has not been completely resolved. They mediate a number of events that culminate in tolerance against excitotoxicity, hippocampal neurogenesis, synaptic remodeling, neuronal plasticity, cognitive and emotional processing.

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To identify cell proteins regulated by the Epstein-Barr virus (EBV) transcription factor EBNA-2, we analyzed a cell line with conditional EBNA-2 activity by using microarray expression profiling. Low femoral neck BMD found in cases may stress the need for supplementing calcium and treating vitamin D deficiency in this specific group. The experimental results support the validity of the ultrasound treatment for OC. After administration of the test substance, blood was drawn to measure bupropion, GH and PRL up to 240 minutes thereafter. It is designed to give the consensus view of College members in Australia and New Zealand on the nature and frequency of tests which should be performed on diagnostic x-ray equipment to maintain adequate quality control of imaging performance and radiation safety. A 36 year-old female patient with schizophrenia and Tourette syndrome is described. The goals were to ascertain whether stimulating the microbial cenosis only has a local effect on the rhizoplane, and to establish the importance of this stimulation for the water purification process in the root zone. In addition to conventional factors, which include staging factor and histological evaluation, the present study also performed univariate and multivariate analyses to consider claudin, a cell adhesion molecule, as a prognostic factor by immunohistochemical staining. The protein profile at 8, 24, and 48 h post infection revealed that UL84 tightly associated with IE2-p86, and more viral and cellular proteins came into association with IE2-p86 with the progression of virus infection. Prevalence estimates were adjusted via post-stratification weighting.

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Outcomes were assessed longitudinally using preintervention and follow-up surveys of program implementation and accelerometer measures of physical activity. This diagnostic modality can assist in management of select renal masses as treatment options are expanding. The OrganismTagger, including supporting tools, resources, training data and manual annotations, as well as end user and developer documentation, is freely available under an open-source license at http://www.semanticsoftware.info/organism-tagger. Flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), are two major coenzyme forms of dietary riboflavin. Chief among these benefits is a rapid, cost-effective response to requests for elective tracheostomy. Although prior studies have identified certain aspects of metal regulation in Cryptococcus species, little is known regarding the regulation of these elements in P. Finally, we emphasise four key areas where new research approaches will provide fertile opportunities to advance this field. PTC3 and PTC5 are tripartite Tc (toxin complex) toxins from Photorhabdus luminescens, which consist of the binding component TcdA1, the linker component TcdB2 and the enzyme components TccC3 and TccC5 respectively. The expression of VEGF mRNA in HepG2 cells after different treatments was detected by reverse transcriptase-polymerase chain reaction (RT-PCR).

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Abstract Venous thromboembolism (VTE) is a common and potentially fatal disease in postmenopausal women. Using both Specific Absorption Rate (SAR) and thermal damage limits as constraints, and 300 Kbps as the required capacity for telemetry streams 100 ms in duration, the model shows that conventional antennas smaller than 0.1 mm could not support human neuronal telemetry to a remote receiver (1 m away.) Reducing the antenna to 10 microns in size to enable the monitoring of single human neuron signals to a receiver at the surface of the head would require operating with a channel capacity of only 0.3 bps. Findings such as these suggest that inhibitory control is driven by two dissociable mechanisms, one that is flexible but deliberate and another that is automatic but inflexibly learned. The transcriptional regulatory network of Mycobacterium tuberculosis. The properties of units with a high sensitivity to stimulus intensity were similar to the properties of units that were highly sensitive to stimulus direction. This response was most pronounced in bacterial communities where the abundance of photosensitive amino acids was highest (amended treatments and autochthonous DOM) and least pronounced when the abundance of these amino acids was low (unamended and allochthonous DOM), likely because these bacteria already had these biosynthetic pathways functioning.

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