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Benclamet (Glibenclamide)

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Benclamet is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying the absorption of sugar (glucose) from the intestines, and increasing the body's sensitivity to insulin.

Other names for this medication:
Afdiex, Benclamet, Benformin, Codica, Combidos, Daonil, Diabetnil, Diabnil, Diolin, Duotrol, Dutrol, Eumet, Glibenclamide, Glibet, Glibson, Glifil, Glime, Glimsug, Glitrac, Gluconil, Glucored, Glucosafe, Glucotrac, Glunil, Glutowin, Glybenclamide, Glybid, Glybonil, Glyboral, Glybovin, Glycurb, Glymep, Iscept, Melitus, Metclam, Metica, Pionorm, Sugatrol, Sugnil, Sycored, Triglycomet

Similar Products:
Urispas, Cialis, Casodex, Ceftin, Dramamine

Also known as: Glibenclamide


This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.


Usual Adult Dose for Diabetes Type 2:

Doses provided as Benclamet-metformin -As Initial Therapy in Patients with Inadequate Glycemic Control on Diet and Exercise Alone: Starting dose: 1.25 mg-250 mg orally once a day -Consider a starting dose of 1.25 mg-250 mg orally twice a day for patients with fasting blood glucose (FBG) greater than 200 mg/dL or HbA1c greater than 9% Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control Maximum Initial Dose: 10 mg-2000 mg per day -Patients with Inadequate Glycemic Control on a Benclamet (or another Sulfonylurea) and/or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Maximum Dose: 20 mg-2000 mg per day Comments: -Give with meals; 5 mg-500 mg dose should not be used as initial therapy due to an increased risk of hypoglycemia; initial doses should be conservative to avoid hypoglycemia largely due to Benclamet and gastrointestinal side effects largely due to metformin. -For patients who are switching to combination therapy, initial doses should not exceed the daily dose of Benclamet (or equivalent sulfonylurea) and metformin already being taken; the decision to switch to the nearest equivalent dose should be based on clinical judgement. -Addition of thiazolidinedione may be appropriate for patients not adequately controlled on Benclamet-metformin; in patients experiencing hypoglycemia, consider reducing the dose of the Benclamet component. -Monitor patients closely for signs and symptoms of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Detailed Benclamet/metformin dosage information


In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include hypoglycemia symptoms as well as the following:

  • seizures
  • loss of consciousness


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

Side effects

The most common side effects associated with Benclamet are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to Benclamet, micronized or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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TIMP-2 gene was transferred into human gastric cancer cell line SGC-7901 by lipofection technology. Such autologous sera inhibiting LMC contained increased IgG levels (P less than 0.01) when compared to those that failed to inhibit LMC. Structure of Escherichia coli ribonucleotide reductase R2 in space group P6122. A survey of mycobacteria isolated at a South London chest hospital. Evaluation of postoperative swallowing ability in thirty-eight patients having had partial laryngectomy indicates that there are marked differences in the degree of dysphagia among individuals with similar surgical defects. Inhibition of autophagy at therapeutic drug concentrations led to accumulation of dysfunctional mitochondria, increased ROS production, increased apoptosis, decreased proliferation and increased intracellular lipid accumulation. Developmental plasticity of bacterial colonies and consortia in germ-free and gnotobiotic settings.

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A genetic replacement system for selection-based engineering of essential proteins. Analysis of the data showed that the action of diazepam was mainly confined to alpha 1 and beta 2 frequencies whereas tramadol acted predominantly on the theta and alpha range. For most disease systems, prognostic variables that are related to the outcome are available and are called risk factors. The expression and activity of EGF receptors in endothelial cells are less well characterized. Our approaches to TSS prediction are based upon an ensemble of support vector machines (SVMs) employing a variant of the mismatch string kernel. The anomalous behaviour of dimethyl phosphates in the biochemical test for delayed neurotoxicity. This study underlines the important function of fibrinolysis in the spontaneous evolution of acute coronary syndrome. can you drink alcohol when taking lamictal Ischemic preconditioning of the rat brain as a method of endothelial protection from ischemic/repercussion injury. Entropy flow and entropy production are considered taking into account entropy calculation of incoming and outgoing radiant energy.

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