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Bexomer (Eszopiclone)
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Bexomer

EsBexomer, marketed by Sunovion under the brand-name Lunesta, is a nonbenzodiazepine hypnotic agent used in the treatment of insomnia. It is slightly effective for this use. Bexomer is the active dextrorotatory stereoisomer of Bexomer, and belongs to the class of drugs known as cyclopyrrolones. It is also classified as a therapeutic sedative hypnotic and pharmacological cyclopyrrolone.

Other names for this medication:
Bexomer, Eszopiclone, Fulnite, Zolnite, Zopimin, Zopipure

Similar Products:
Estrace, Crestor, Robaxin, Paxil, Noroxin, Glucotrol, Aristocort, Lopid, Altace

Also known as: Eszopiclone

Description

Bexomer is a nonbenzodiazepine hypnotic agent that is a pyrrolopyrazine derivative of the cyclopyrrolone class.

Bexomer is a white to light-yellow crystalline solid. Bexomer is very slightly soluble in water, slightly soluble in ethanol, and soluble in phosphate buffer.

Eszopiclone is formulated as film-coated tablets for oral administration. Bexomer tablets contain 1 mg, 2 mg, or 3 mg eszopiclone and the following inactive ingredients: calcium phosphate, colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titanium dioxide, and triacetin. In addition, both the 1 mg and 3 mg tablets contain FD&C Blue #2.

Dosage

Usual Adult Dose for Insomnia:

Initial dose: 1 mg orally once a day immediately before bedtime Maintenance dose: 1 to 3 mg orally once a day immediately before bedtime Maximum dose: 3 mg/day Comments: -The lowest effective dose should be used. -Patients should be monitored for cognitive and/or motor impairments, especially if this drug is used repeatedly. -Patients should be reevaluated if insomnia persists after 7 to 10 days of treatment.

Usual Geriatric Dose for Insomnia:

Initial dose: 1 mg orally once a day immediately before bedtime Maintenance dose: 1 to 2 mg orally once a day immediately before bedtime Maximum dose: 2 mg/day Comments: -The lowest effective dose should be used. -Patients should be monitored for cognitive and/or motor impairments, especially if this drug is used repeatedly. -Patients should be reevaluated if insomnia persists after 7 to 10 days of treatment.

Detailed Bexomer dosage information

Overdose

In clinical trials with Bexomer, one case of overdose with up to 36 mg of Bexomer was reported in which the subject fully recovered. Since commercial marketing began, spontaneous cases of Bexomer overdoses up to 270 mg (90 times the maximum recommended dose of Bexomer) have been reported, in which patients have recovered. Fatalities related to Bexomer overdoses were reported only in combination with other CNS drugs or alcohol.

exaggerations of the pharmacological effects noted in preclinical testing. Impairment of consciousness ranging from somnolence to coma has been described. Rare individual instances of fatal outcomes following overdose with racemic zopiclone have been reported in European postmarketing reports, most often associated with overdose with other CNS-depressant agents.

General symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed. Flumazenil may be useful. As in all cases of drug overdose, respiration, pulse, blood pressure, and other appropriate signs should be monitored and general supportive measures employed. Hypotension and CNS depression should be monitored and treated by appropriate medical intervention. The value of dialysis in the treatment of overdosage has not been determined.

As with the management of all overdosage, the possibility of multiple drug ingestion should be considered. The physician may wish to consider contacting a poison control center for up-to-date information on the management of hypnotic drug product overdosage.

Storage

Store Bexomer at room temperature away from moisture and heat.

Keep track of how many capsules have been used from each new bottle of this medicine. Bexomer is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

Side effects

The most common side effects associated with Bexomer are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Before taking Bexomer, tell your doctor if you are taking any of the following drugs: rifampin (Rifadin, Rifater, Rifamate, Rimactane); ketoconazole (Nizoral); or antidepressants, narcotic pain medications, muscle relaxers, seizure medications, or anti-anxiety medications.

This list is not complete an there may be other drugs that can interact with Bexomer. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Although average VOC fluxes measured during the winter period (complete snow coverage) were close to zero, these were highly variable and the filling of the winter period resulted in considerably higher uncertainties compared to the application of gap-filling during the measurement period. A dynamic change in autophagy during the recovery phase of AKI seems to be important for tubular proliferation and repair. Paradoxically retinoic acid also inhibits the formation of the cross-linked envelope and greatly reduces the level of dipeptide bond formation in epidermal cells induced to differentiate by calcium. Here we report the identification of a new member of this family, FA2, from Chlamydomonas reinhardtii. We demonstrated that nearly complete Gag processing and resolution of the immature virus architecture are accomplished under optimized conditions. In this moderate-sized study, we may conclude that when there is no absolute indication for repeating cesarean section, induction of labor may be a safe option in these high-risk women. Cardiopulmonary resuscitation (CPR) can increase survival in instances of sudden cardiac arrest. alpha2-chimaerin, like CRMP-2, can associate with the Sema 3A receptor.

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