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Biaxsig (Roxithromycin)

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Biaxsig is part of the family of medications known as macrolide antibiotics and is commonly used in the treatment of bacterial infections. Biaxsig is generically prescribed as roxithromycin and can cause life threatening heart complications in patients who also take pimozide, astemizole, cisapride, ergot medications, and terfenadine. Biaxsig is an ineffective treatment option for patients suffering from infections caused by a virus or bacterium.

Other names for this medication:
Acevor, Aristomycin, Asmetic, Assoral, Azuril, Bazuctril, Biaxsig, Biostatik, Cadithro, Claramid, Crolix, Delos, Dorolid, Elrox, Erybros, Floxid, Infectoroxit, Klomicina, Ladlid, Macrosil, Makrodex, Monobac, Nirox, Odonticina, Overal, Pedilid, Pedrox, Ramivan, Redotrin, Remora, Renicin, Ritosin, Rokilide, Rokithrid, Roksimin, Roksolit, Rolexit, Rolicyn, Rolid, Romac, Rossitrol, Rotramin, Roxacine, Roxithromycin, Roxithromycine, Roxitromicina, Rulid

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Also known as: Roxithromycin


Each Biaxsig tablet contains either 150mg or 300mg of the active ingredient roxithromycin. Each tablet also contains: hydroxypropylcellulose, poloxamer, povidone, colloidal anhydrous silica, magnesium stearate (470), purified talc (553), maize starch, hypromellose, anhydrous glucose, titanium dioxide (171), propylene glycol (1520). Biaxsig does not contain gluten, sucrose, lactose, tartrazine or any other azo dyes.


Biaxsig is typically prescribed for a period of 7 to 14 days and patients should take the medication for as long as it has been prescribed to prevent the infection from returning even if they become asymptomatic. Patients should not however, take doses larger than has been prescribed as this can result in an overdose. Overdosing requires immediate medical intervention and may present with symptoms which include abdominal pain, nausea, diarrhea, vomiting, and a general and prolonged feeling of illness.


Immediately telephone your doctor or pharmacist. Do this even if there are no signs of discomfort or poisoning.


Keep the tablets in the foil until it is time to take them.

Keep the tablets/in a cool dry place where the temperature stays below 30 degrees C.

Do not store Biaxsig or any other medicine in the bathroom or near a sink.

Do not leave it in the car on hot days or on window sills.

Heat and dampness can destroy some medicines.

Keep it where children cannot reach it.

A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Biaxsig are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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Patients with functioning renal transplant who develop abdominal aortic aneurysm can safely be treated with endovascular repair. The study was designed to determine whether serum levels of RCAS1 are of clinical significance as a tumour marker for biliary tract tumour, in comparison to CA19-9. Awareness of the normal dentofacial pattern of each ethnic group will undoubtedly ensure better success of treatment to establish optimal facial harmony. Use of beta-blocking agents to reduce the stress of presentation at an international cardiology meeting: results of a survey. In recent years it has been possible to significantly optimize the therapeutic options for venous malformations. The term cerebral small vessel disease (SVD) refers to a group of pathological processes affecting the small arteries, arterioles, venules and capillaries of the brain, and encompasses both ischemic and hemorrhagic lesions. Subsequently, probes developed from adjacent genomic intervals more precisely delineated deletion breakage intervals involving genes, pseudogenes and duplicons in 15q11.2q13. This new method using a triangle template ensures proper placement of the pivot point and will enable practitioners to achieve superior outcomes.

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Structure and function of the heat-stable enterotoxin receptor/guanylyl cyclase C. The age-adjusted 8-year incidence of malignant lymphoma in the Netherlands was retrieved from the Central Bureau of Statistics. This investigation reveals that the simultaneous cleocin capsules approach for fabricating composite alloys is the optimum approach for producing InGa alloys with better control on composition for plasmonic applications such as plasmonic waveguides. The kappa B DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription. Ninety-three point five percent of the commercially available simulators are not known to be tested for validity. Distribution and depletion of flubendazole and its metabolites in edible tissues of guinea fowl. Measurement of plasma free and total GH may be of value in examining GH dynamics and their relation to the clinical effectiveness of GH treatment in patients with GH antibodies. In the second case series, 223 knee MRIs were consecutively analyzed to measure the vertical distance between tibial tuberosity and PCL footprint. Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals?. A subclass of peptidergic sensory nerves express GPCRs and TRP channels that detect noxious, irritant, and inflammatory stimuli.

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