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Biokalm (Lorazepam)
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Biokalm

Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication. It is used to treat anxiety disorders, trouble sleeping, active seizures including status epilepticus, alcohol withdrawal, and chemotherapy induced nausea and vomiting, as well as for surgery to interfere with memory formation and to sedate those who are being mechanically ventilated. While it can be used for severe agitation, midazolam is usually preferred. It is also used, along with other treatments, for acute coronary syndrome due to cocaine use. It can be given by mouth or as an injection into a muscle or vein. When given by injection onset of effects is between one and thirty minutes and effects last for up to a day.

Other names for this medication:
Almazine, Anxilor, Anxionil, Anxipose, Atipam, Biokalm, Biolar, Calmese, Dulozep, Larosh, Larpose, Lopam, Lopez, Loracalm, Lorakar, Loralite, Lorazam, Lorazepam, Lorazine, Loricon, Lorivan, Lorpam, Lorvin, Lotweet, Nexlor, Norpose, Olraz, Trapex, Urpam, Zelor, Zepatrac, Zepnap

Similar Products:
Zanaflex, Cordarone, Estrace, Aldactone, Amethopterin, Motrin

Also known as: Lorazepam

Description

Biokalm, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or intravenous routes of administration.

Biokalm is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Biokalm affects chemicals in the brain that may become unbalanced and cause anxiety. Biokalm is used to treat anxiety disorders.

Biokalm may be habit-forming and should be used only by the person it was prescribed for. Biokalm should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

Dosage

When given intramuscularly, Biokalm Injection, undiluted, should be injected deep in the muscle mass.

Injectable Biokalm can be used with atropine sulfate, narcotic analgesics, other parenterally used analgesics, commonly used anesthetics, and muscle relaxants.

Immediately prior to intravenous use, Biokalm Injection must be diluted with an equal volume of compatible solution. Contents should be mixed thoroughly by gently inverting the container repeatedly until a homogenous solution results. Do not shake vigorously, as this will result in air entrapment. When properly diluted, the drug may be injected directly into a vein or into the tubing of an existing intravenous infusion. The rate of injection should not exceed 2.0 mg per minute.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if solution is discolored or contains a precipitate.

Biokalm Injection is compatible for dilution purposes with the following solutions: Sterile Water for Injection, USP; Sodium Chloride Injection, USP; 5% Dextrose Injection, USP.

Overdose

In cases of a suspected Biokalm overdose, it is important to establish whether the patient is a regular user of Biokalm or other benzodiazepines, since regular use causes tolerance to develop. Also, one must ascertain whether other substances were also ingested.

Signs of overdose range through mental confusion, dysarthria, paradoxical reactions, drowsiness, hypotonia, ataxia, hypotension, hypnotic state, coma, cardiovascular depression, respiratory depression, and death.

Early management of alert patients includes emetics, gastric lavage, and activated charcoal. Otherwise, management is by observation, including of vital signs, support and, only if necessary, considering the hazards of doing so, giving intravenous flumazenil.

Patients are ideally nursed in a kind, nonfrustrating environment, since, when given or taken in high doses, benzodiazepines are more likely to cause paradoxical reactions. If shown sympathy, even quite crudely feigned, patients may respond solicitously, but they may respond with disproportionate aggression to frustrating cues. Opportunistic counseling has limited value here, as the patient is unlikely to recall this later, owing to drug-induced anterograde amnesia.

Storage

Store Ativan at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Biokalm is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Biokalm are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use this medication if you have narrow-angle glaucoma, or if you are allergic to Biokalm or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), or oxazepam (Serax).

Before taking Biokalm, tell your doctor if you are allergic to any drugs, or if you have:

glaucoma;

asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;

kidney or liver disease;

a history of depression or suicidal thoughts or behavior; or

a history of drug or alcohol addiction.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

Biokalm can cause birth defects in an unborn baby. Do not use Biokalm without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. It is not known whether Biokalm passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

The sedative effects of Biokalm may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking Biokalm. Do not give this medication to a child younger than 12 years old.

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Then a useful method was found to study the similar effects under the microscopic observations of a single neuron instead of stereotaxic insertion of the microelectrode. Clinical use of the membrane lung oxygenator for acute respiratory insufficiency. Topical antimicrobial therapy: the efficacy of clioquinol- and tribromphenolbismuth- zinc oxide preparations. The separation between the abiotrophic dementia group and the arteriopathic dementia group was made after the trial, on the basis of clinical criteria (Hachinski ischemic score), and a scan when applicable. Immunolocalization and expression of endogenous nicastrin (NCT) and presenilin 1 (PS1) fragments during postnatal development of rat cerebellum were investigated with fragment-specific antibodies. The broader adoption of several strategies, including antimicrobial and catheter related interventions, has been advocated to prevent or reduce the risk of peritonitis in peritoneal dialysis.

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Unexpected formation of higher polythionates in the oxidation of thiosulfate by hypochlorous acid in a slightly acidic medium. The aim of this study was to investigate the effects of a human urine preparation on the differentiation of tumor cells. Pineoblastoma with spontaneous intra and extracranial metastasis. Cataract and corneal diseases were the leading causes of bilateral blindness and unilateral blindness respectively. wg and hh are also necessary for the development of their own expression domains, anal pads, and rectum, respectively.

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The half-time of the decrease in serum TSH concentration between 30 and 90 min was 77 min, a value slightly greater than the half-time of disappearance of radioiodinated TSH measured in adults. This technique was applied to a study of relief of back pain by lumbar corsets when it was found that there was significantly greater relief of back pain by a corset with a lumbar support than one without a spinal support. Formation of mixed micelles between gemini surfactant and membrane phospholipids at reduced pH may therefore provide a method of endosome rupture and subsequent escape of entrapped DNA, thus discarding the need for extra fusogenic or endosomolytic agents. If consumers consume the recommended quantities from each food group and subgroup, but fail to choose foods in low-fat, no-added-sugars, and low-sodium forms, they will not meet the USDA Food Patterns moderation goals or the 2010 Dietary Guidelines for Americans. They raise the question of whether myelination is an overlooked mechanism of activity-dependent plasticity, extending in humans until at least age 30. The aim of this study was to investigate the epidemiological and clinical features of botulism-infected patients admitted to a general hospital in Porto, Portugal. The development of an Australasian cardiac surgical database and performance indicators will enable benchmarking and comparison with international standards which should lead to performance improvements.

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The kidneys are nearly always visible on a routine radionuclide bone scan. Here we report the cloning of cecropin A (Pi-cecA), lebocin (Pi-leb) and lysozyme (Pi-lys) homologs from the moth Pseudoplusia includens. Commentary: selective treatment of external carotid artery stenosis. An immunohistochemical characterization of the inflammatory infiltrate in a group of 41 placentas from women living in a Plasmodium falciparum-hyperendemic area in Tanzania revealed a marked increase in the number of monocytes and macrophages and cytotoxic T cells in the intervillous space of placentas with active malaria infection, compared with noninfected placentas, placentas from women with past infection, and a control group of placentas from Spain. Patient/partner acceptance, use, and satisfaction rates of penile pros-theses are better than for many other alternatives including pharmacologic injections. 2 types of the clinical picture were noted: cholangitis phenomena and acute cholelithic ileus. Here, we show that a caveolin-1 (Cav-1) deficiency leads to an amplification of the adult mammary stem cell population, both in vivo and in vitro. Differences in contractility found between urethra and bladder may be ascribed to the presence of striated muscle in the proximal urethra. Paired-pulse TMS were applied to the M1 of both the hemisphere ipsilateral (IH) and contralateral (CH) to the epileptic focus before and immediately after real/sham exposure to the GSM-EMFs (45 min).

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The flow rate decreased with increasing volume of filtered blood with all the microfilters (p less than 0.01). Dosimetry with 111In-octreotide was performed in 24 patients, and the number of disintegrations (ND) were calculated for 177Lu. Therefore, familiarity with the implications of hyperglycemia and with its treatment are essential for clinicians practicing in hospital settings. Anomalous reversal of C-H and C-D quenching efficiencies in luminescent praseodymium cryptates. Serial clinical and echocardiographic data were collected out to 1 year. Multiple adjuvant aromatase inhibitor trials have been completed and published or presented. Our purpose is not to present a new class of procedures but rather to introduce the necessary rigorous framework that supports this interpretation. The data suggest that vascularized tissue flaps will promote wound healing by providing sufficient sources of growth factors in the wound environment.

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In cell culture and in transgenic mice this fusion protein co-assembles and co-distributes with the endogenous intermediate filament network. Vasomotion enhanced by normovolemic hemodilution in rat diaphragmatic microcirculation. To our knowledge, this kindred has the earliest reported onset of pathologically confirmed FAD and dementia with Lewy bodies. A powerful reinforcing effect was observed when pretraining was conducted with a wet lure across multiple pretraining trials, indicating the importance of this difference between groups. Use of transluminal coronary angioplasty in ischemic heart disease. While evaluation for stem cell transplantation (SCT) remains a part of the algorithm for management of the newly diagnosed patient, these drugs offer improved options for induction before, and possibly maintenance after, SCT. High-resolution axial and coronal computerized tomography revealed a parachiasmal density compatible with the clinical course.

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You must anticipate some resistance, questions, and possible first-round rejection--but persist and be helpful so that all patients may profit from affordable, reimbursable nutrition care services. Here, we found that exposure of A549 human lung carcinoma cells to vanadate led to extracellular signal-regulated kinase, c-Jun NH(2)-terminal protein kinases (JNKs), p38 mitogen-activated protein kinase (p38) activation, and COX-2 protein expression in a dose-dependent manner. The enhancement effect is due to the light coupling to surface plasmon excitation facilitated by a film periodicity. For the specific immunoactive fractions a dependence of leucocyte adherence inhibition test values on the clinical state of sample donators has been found. These B cells appear in the circulation 5 to 7 days after in vivo immunization and spontaneously secrete antibody during a 3-day in vitro culture. When no codec is placed between the deinterlacer and inverse process, the original video is perfectly reconstructed. Nine-membered diallylic cyclic amines and amides have remarkably stable planar chirality. Universal calibration concept was used to examine the abnormal size exclusion separation phenomenon of Polymer JR samples when using different mobile phases. The relationship between work and cognitive status in schizophrenia was not as strong as has been previously reported in this population.

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Immunoreactivity was found to be solely specific for infliximab. A comparative GC-MS investigation of the alkaloid patterns of three varieties of Datura stramonium vars. Vitiliginous skin-blister fluid bFGF levels and serum levels were significantly higher in vitiligo patients compared with healthy normal controls. The dec mutants had an enlarged shoot apical meristem with enhanced cell division activity. Properties of soluble cytochromes P-450 from bovine adrenocortical mitochondria. Initial steps in the degradation of phosphinothricin (glufosinate) by soil bacteria. The pattern of inheritance is autosomal dominant with a milder phenotype compared with families with pathogenic MLH1 or MSH2 mutations. However, pseudoword rhyming induced the largest change in cerebral blood flow and activated more voxels in the left posterior prefrontal regions and the left inferior occipital-temporal junction.

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A survey was conducted in Dianshan Lake to study the eutrophication indexes including total phosphorus (TP), total nitrogen (TN), pH, temperature, diaphaneity and chlorophyll-a level and dominant algae in seasons. Intracerebroventricular injection of hypertonic saline (10 microl of 230 mM NaCl) produced an increase in blood pressure in both 4-week-old and 15-16-week-old SHR, whereas it did not affect blood pressure in both age-matched WKY. Katonga Bay is a wetland lined bay that receives water from the Katonga river, while Bunjako Bay is an outer bay between Katonga Bay and Lake Victoria. Body composition and newborn birthweight in pregnancies of adolescent and mature women. Many elderly and many subjects with impairments have problems with transition from sitting to standing. Oral contraceptives--possible mediation of side effects via an estrogen receptor in liver.

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While having worse prognostic factors compared with glycopeptide-based therapy, linezolid-based salvage therapy revealed a trend toward better outcomes than the comparator. The tympanic aperture of the auditory tube is bordered by the entotympanic. PTSD symptoms among men and women survivors of intimate partner violence: the role of risk and protective factors. CEA appears promising as an indicator of tumor presence in patients with carcinoma of the esophagus. The major terminal oxidases, cytochromes (cyt) aa(3) and o, were present in all strains of cultured cells. About one quarter of women with the diagnosis conceive after the diagnosis has been made, and patients and clinicians are concerned about the health of the foetus and the possible side effects of medical and surgical treatment. The results are useful for estimating the number of families required for detecting the familial aggregation of a continuous attribute. The aim of this study was to observe the effect of HHT on patients with high-risk PV and ET. This inhibition appeared to be caused mainly by blocking of the collagen receptors on platelets by Lens culinaris agglutinin. An overview of the physical processes giving rise to the generation of protons with multi-MeV energies, in well defined beams with excellent spatial quality, is presented.

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Hence, a pulsed x-ray facility has been built at SLAC mainly for testing the response of different radiation detection instruments to pulsed radiation fields. Stromal tumors of the small bowel causing unexplained melena: report of two cases. Costs were estimated using a generalized linear model, adjusting for age, sex, comorbidities, and disease severity. Rural immersion as an instructional method in northern community health. Several recent investigations have shown encouraging potential for the removal of arsenic (As) from groundwater by granular zerovalent iron (Fe0).

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The activation of the Smad cascade is well characterised, but little is known about how TAK1 is activated in response to TGFbeta, and no direct link between any MAPK kinase pathway and the TGFbeta receptors has yet been established. When Miracil is present from early times in infection, only a limited synthesis of both double- and single-stranded virus-specific RNA is observed. Together these results suggest that p38alpha, and not p38beta, is the major p38 isoform involved in the immune response and that it would not be necessary to retain activity against p38beta during the development of p38 inhibitors. Cost-effective reduction in stroke: lessons from the Japanese hypertension detection and control program. Intravenous MgSO4 alone and in combination with glucose, insulin and potassium (GIK) prolong the atrial cycle length in chronic atrial fibrillation.

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Patterns of contraceptive use are also consistent with this model. HIV-1 infection prevalence and incidence trends in areas of contrasting levels of infection in the Kagera region, Tanzania, 1987-2000. The pseudostratified epithelium is the most prominent feature of the maxillary organ. Type III procollagen N-terminal propeptide, soluble interleukin-2 receptor, and von Willebrand factor in systemic sclerosis. Pressure-diameter relations of capillaries and small blood vessels in frog lung. Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense. Effect of chronic hypoxia on purinergic synaptic transmission in rat carotid body. Past research has not fully ascertained the extent to which people with glaucoma have difficulties with reading. The findings provide evidence of the efficacy of CPP with this population and highlight the importance of a relationship focus in the treatment of traumatized preschoolers. It is suggested that the chelator differences in iron mobilization may be related to variations in the chelator molecular structure, the protein structure, iron forms and in the mechanism of iron release.

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The essential point of the paper is that disability is a dynamic rather than a fixed phenomenon which can best be understood through longitudinal studies of various types. In a Japanese trial, the combination of irinotecan and cisplatin had initially shown promise in treating patients with extensive-stage SCLC, but a confirmatory trial in the United States did not find a difference in overall survival with irinotecan/cisplatin versus etoposide/cisplatin. These findings are consistent with the hypothesis that in some patients with bipolar affective disorder, there may be a reduction of frontal cortical function which may be associated with affective as well as attentional processing deficits. Sagamicin is an aminoglycosidic basic antibiotic closely related to gentamicin and its penetration rate into lungs, kidney and prostate, together with its serum concentrations time-course, were investigated. The circular index of the ASD was defined as the ratio of the maximal diameter to the minimal diameter on the 3D-TEE image. Although diverse classes of proteins are transported via the Tat pathway, in most organisms it facilitates the secretion of a relatively small number of substrates compared to the Sec pathway. Many countries have developed, or are developing, national strategies aimed at reducing the harms associated with hepatitis C infection.

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Cyclic electron transport can be stimulated either by inhibiting Photosystem II activity or increasing the turnover of Photosystem I relative to Photosystem II. We reviewed the records of 72 patients treated with standard radical nephrectomy to determine the incidence of adrenal involvement and to determine if adrenal lesions were detectable by radiographic methods preoperatively. However, local variations in the occurrence of cells containing intracellular collagen fibrils may occur. Studies of immune functions of patients with systemic lupus erythematosus: antibodies to desialized, rather than intact, T cells preferentially bind to and eliminate suppressor effector T cells. Four wk after completion of the radiotherapy, patients received three additional cycles of FP every three wk. Moreover, myofibroblasts and cell-matrix interactions mediated by the CD44-OPN and CD44-HA receptor-ligand pairs may play important roles in the formation and progression of the crescents. Treatment of hypersensitive root surfaces with dental adhesive materials. Clinico-statistical review of 630 cases of surgically treated epitheliomas of the head.

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Virulence and immunogenicity of Salmonella typhimurium rough mutants. Individual differences in learning a motor task are rarely assessed even though they can potentially contribute to our understanding of the problem of motor redundancy-i.e., how individuals can exploit multiple different strategies to realize the task goal. Within each CDR, there are more variable positions that are directly involved in the interaction with antigen, i.e., specificity-determining residues (SDRs), whereas there are more conserved residues that maintain the conformations of CDRs loops. Although a free rotation around a single bond gives no mechanical output, it has let us imagine a molecular motor. However, this effect zithromax z-pak tablet of decrease in rosetting ability of PBL could be completely reversed by a second incubation of the cells for 30 minutes at 37 degrees C in IC-free medium. Collection of household waste is also a job which requires repeated heavy physical activity such as lifting, carrying, pulling, and pushing. Gamma aminobutyric acid metabolism in different areas of rat brain at the onset of soman-induced convulsions. Both the laughter and control interventions appeared to improve longer-term anxiety. Involvement of internal genitalia in female patients undergoing radical cystectomy for bladder cancer: a clinicopathologic study of 37 cases. Magnetic resonance imaging revealed the multiocular nature of the lesion into the humeral lumen with a cystic lesion involving the soft tissues of the upper arm.

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Adult plant and seedling resistance to powdery mildew in a Triticum aestivum x Triticum militinae hybrid line. The suppressor cells inhibit the proliferation of adult mouse spleen cells responding in vitro to an allogeneic stimulus. Complications following dermabrasion in the treatment of tattoos. Each compound was orally administered 1 h (SM-20302 and aspirin) or 3 h (ticlopidine) before the ADP/epinephrine infusion. Amino acid ionic liquid modified mesoporous carbon: a tailor-made nanostructure biosensing platform. Advances in technique and equipment have allowed urologists to perform percutaneous stone removal with increasing efficacy and decreasing complications. Records of 207 patients undergoing pancreatoduodenectomy (1998-2009) for periampullary adenocarcinoma were reviewed. Long-term outcomes in juvenile dermatomyositis: how did we get here and where are we going?. Many efforts to implement evidence-based programs do not reach their full potential or zithromax type of antibiotic class fail due to the variety of challenges inherent in dissemination and implementation.

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On the basis of the vectorial Rayleigh diffraction integrals and stationary-phase method, the analytic expression describing the vectorial field distribution of radially polarized Gaussian beams diffracted by an axicon is derived. Progestin inhibition of cell death in human breast cancer cell lines. Susceptibility of Neisseria gonorrhoeae isolates from Jakarta, Indonesia, to antibiotics. Audiometric data from 451 stapes operations were used to demonstrate the use of the Amsterdam Hearing Evaluation Plots. Progressive passive Heymann nephritis was produced in rats by simultaneous intravenous injections of heterologous antirat glomerular basement membrane antiserum and heterologous antirat kidney tubular fraction 3 antibody. Psychosocial vulnerabilities to depression after acute coronary syndrome: the pivotal role of rumination in predicting and maintaining depression. Immunosuppressive and antiinflammatory properties of cyclophosphamide, azathioprine and methotrexate.

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