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Bolodol (Tramadol)

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Bolodol is a strong painkiller used to treat moderate to severe pain. It is generally used when non-opioid painkillers don't work as well to control the pain anymore. Bolodol may cause drowsiness. You shouldn't drive or use heavy machinery or perform dangerous activities until you know how this drug affects you.

Other names for this medication:
Acuvin, Axedol, Bludol, Cosdol, Decotram, Dolfre, Dolmeri, Domaspas, Esgiypyrin, Kamadol, Moludol, Neutram, Ospidol, Pentazen, Postadol, Servodol, Stemadol, Tandam, Taxidol, Tramagesic, Tramdop, Tramoflex, Trasic, Tridol, Urogendo

Similar Products:
Klonopin, Celexa, Tofranil, Lipitor, Soma

Also known as: Tramadol


{name} ER is an pain medicine similar to an opioid. This medicine is used to treat moderate to severe pain.

The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain.


Follow the directions on your prescription label and read all medication guides. Never use Bolodol ER in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of Bolodol ER.

Never share Bolodol ER with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Stop taking all other opioid medications when you start taking Bolodol ER.

Bolodol ER can be taken with or without food, but take it the same way each time.

Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Never crush or break a Bolodol ER pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.

You may have withdrawal symptoms if you stop using Bolodol ER suddenly. Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover Bolodol ER. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash.

Detailed Bolodol ER dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the foam can or spray bottle at room temperature, away from heat, flames, smoke, and direct light. Do not keep this medicine inside a car where it could be exposed to extreme heat. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.

Store the Bolodol® E cream at room temperature, away from heat, moisture, and direct light. Do not refrigerate. Keep Bolodol® E cream and Impoyz™cream from freezing.

Detailed Bolodol E dosage information

Side effects

The most common side effects associated with Bolodol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Bolodol ER if you are allergic to it, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Bolodol ER should not be given to a child younger than 12 years old. Bolodol ER should not be given to anyone younger than 18 years old.

Do not give Bolodol ER to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Bolodol ER. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

Tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use Bolodol ER during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using Bolodol ER if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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Progesterone but not testosterone restored the preovulatory LH surge and ovulation in hydroxyflutamide-treated rats. Direct screening of G-quadruplex ligands from Kalopanax septemlobus (Thunb.) Koidz extract by high performance liquid chromatography. Specimens were examined consecutively with the use of flat-panel CT and MDCT. We studied the influence of experimental H pylori infection on gastric mucosal injury induced by aspirin. The ethylenediamine triacetic acid (ED3A) group in 3NaHED3A can chelate many kinds of metal ions, which indicates a promising application prospect in many fields including metal anticorrosion, corrosion control agent, additives in electroplating solution, and ore selection and solid surface treatment. There is proven therapeutic benefit in bariatric surgery for obese patients.

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Molecular analysis of Cryptosporidium species isolated from HIV-infected patients in Thailand. After transformation by this plasmid, both Escherichia coli and Salmonella typhimurium were shown to express fimbriae which reacted with Klebsiella fimbrial antiserum. Likewise, we observed no distortion or infections, including pin infections during the entire healing period. These results support the view that PSE represents a rich source of growth inhibition and anti-IL 6 production. This curvature is then applied to the finite element model of a closed lipid bilayer in order to find the energetically favorable membrane configuration. In situ 125I-labelling of endosome proteins with lactoperoxidase conjugates. The objective of this study was to critically examine the relationship between benign meningeal tumors and dAVFs. 43 COPD patients and 20 healthy controls performed incremental cardiopulmonary exercise testing with cycle ergometer.


A Japanese woman living with cervical uterine cancer: a case study with the social phenomenology approach. Here, we use a modified method to analyze the function of secreted beta-1,4, endoglucanases of the potato cyst nematode Globodera rostochiensis, the first in vivo functional analysis of a pathogenicity protein of a plant-parasitic nematode. This decade had long-term consequences resulting in more TB deaths in later years than would have occurred had there been no flattening of the trend. Few cases of malignant melanoma (MM) arising in tattoos have been reported in the literature. Such high levels of MMP-9 expression are found in tumor cells and in stromal components. Health professionals, including district nurses, need to be aware of the health protection powers.

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Study on the effects of two kinds of cactus polysaccharide on erythrocyte immune function of S180 mice. This study investigated the consequences of growth on gonadal transcriptome of European sea bass in: 1) 4-month-old sexually undifferentiated fish, comparing the gonads of fish with the highest vs. Based on prior biochemical studies and the phenotype in lrat(-/-) knockout mice, it has been assumed that LRAT is the sole or dominant retinyl-ester synthase in the retinal pigment epithelium. Strikingly, NirN uses an electron bifurcation mechanism for the two-electron oxidation reaction, during which one electron ends up on its heme c cofactor and the second electron reduces the substrate/product from the ferric to the ferrous state. We aimed to assess biatrial size and function, interactions on atrial and ventricular levels, and atrio-ventricular coupling in patients after tetralogy of Fallot repair. A novel in vivo lecithin-cholesterol acyltransferase (LCAT)-deficient mouse expressing predominantly LpX is associated with spontaneous glomerulopathy.

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SPCE immunoassays provide several advantages over other fluorescence-based methods. The objective of this randomized trial was to assess the antirestenotic effects of phosphorylcholine (PC)-coated stents as well as of abciximab in small coronary arteries when compared with percutaneous transluminal coronary angioplasty (PTCA) and placebo respectively. Human papillomavirus, a necessary cause of cervical cancer, induces COX-2 expression via E5, E6 and E7 oncoproteins, which leads to prostaglandin E2 increase and the loss of E-cadherin, promotes cell proliferation and production of vascular endothelial growth factor. The intracatheter 198Au grains, placed in an inner tube, were inserted into a percutaneous transhepatic catheter. Diffuse glomerulonephritis (prevention, treatment and nutrition). Anti-TNF but not corticosteroid therapy is associated with a significant reduction in diagnostic radiation exposure a year after treatment, which persisted after 3 years. The intent of this review is to provide a systemic evaluation of frequently overlooked conditions that can influence the distribution system and to offer a mnemonic to ensure an orderly sequence of inspection during clinical examination. This review addresses these issues related to treatment of hyperglycemia. In particular, we compare the natural measure obtained from a long trajectory on the chaotic saddle to that evaluated from unstable periodic orbits embedded in it. No significant difference in sensitivity of A1C by variant hemoglobin status was detected.

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Iterative CT Reconstruction using Models of Source and Detector Blur and Correlated Noise. A mechanistic understanding of how mitochondrial dysfunction contributes to cell growth and tumorigenesis is emerging beyond Warburg as an area of research that is under-explored in terms of its significance for clinical management of cancer. Last, adoptive transfer of splenocytes from WT, CII-immunized mice into naive WT and DPPI(-/-) mice led to development of arthritis in WT mice but not in DPPI(-/-) mice. Birds with large eyes can achieve greater pupil diameters and hence, all other things being equal, greater visual sensitivity and resolution than birds with small eyes. In a public lecture associated with the meeting, Larry Reid (Rensselaer Polytechnic Institute, Troy, NY, USA) reviewed the quite compelling evidence in favor of the effectiveness of naltrexone for preventing relapse in former alcoholics.

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Study on quality standard of extracts from Rhizoma Zingiberis by supercritical fluid extraction. Measuring trunk strength and function in persons with spinal cord injury (SCI) is difficult. In L(d) phase phospholipids, a model for 7-ketocholesterol indicates that the proximity of the 7-keto and 3beta-OH groups puts both polar moieties at the lipid-water interface to tilt the sterol nucleus to the plane of the bilayer. Ultrastructure of synapses with different transmitter-releasing characteristics on motor axon terminals of a crab, Hyas areneas. From January 2009 to September 2011, 174 patients with LSCS underwent CT-guided percutaneous IS implant in our department. Stimulation of H-REV107-1 expression was also observed in ovarian epithelial cells suggesting that IRF-1 is involved in H-REV107-1 regulation in human ovarian epithelium.

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Permanent deficit of neurones in cerebral and cerebellar cortex following early mild undernutrition. A total of 338 arterial segments from the level of the iliac to the popliteal artery were studied and compared with the results of arteriography read independently by two radiologists who were unaware of the results with the scanner. Viruses with this less stable complex are more sensitive to neutralization by a soluble octameric form of the CD46 receptor, consistent with their increased fusogenicity. Highly enantioselective direct organocatalytic alpha-chlorination of ketones. The LED programme consisted of group therapy with dietary consultations and two periods of a low-calorie diet of 810 kcal/day during weeks 0-8 and weeks 32-36. Repeating such surveys on a regular basis will further allow for evaluation of ABC programme impact on population size and reproduction in the remaining unsterilised dog population. Our participant group consisted of adults over 18 years of age presenting with OHCA who were in VF or pulseless VT at the time of emergency medical service (EMS) paramedic arrival.

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Pre-clinical and clinical studies have demonstrated that PDT is capable of affecting both the innate and adaptive arms of the immune system. Ulnar collateral ligament injury in the overhead athlete: diagnosis and treatment. The platform included 12630 unique clones, including 9436 known genes. Effect of relative positions of segments on strength of the Mueller-Lyer illusion. Influences of experimental factors on spinal stretch reflex latency and amplitude in the human triceps surae. Complex borides based on AlLiB14 as high-temperature thermoelectric compounds. Determination of the level of antibodies to CD4 in serum of patients with malignant lymphomas and of HIV-infected individuals. The linoleic acid (18:2n6) content in adipose tissue of 28 men with previously unidentified CHD was significantly lower than that in the rest of the group. Magnetic behaviour of nickel-cyclam complexes in mesoporous silica: EPR investigations. After informed consent was obtained, an extensive cognitive tests battery was administered.

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Modification of nerve membrane sodium channels by the insecticide pyrethroids. Relaxation of the upper age limits for solid organ transplantation coupled with improvements in post-transplant survival have resulted in greater numbers of elderly patients receiving immunosuppressant drugs such as tacrolimus. The purpose of our study was to evaluate the role of heterogeneity of the tumor microenvironment in the variability of nanoparticle (NP) delivery and efficacy. For patients known to take novel oral anticoagulants, drug-specific coagulation tests before neurosurgical intervention are prudent. A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection. Each enzyme, acting last in a sequential reaction of either two or three reactions, was in excess activity over the preceding enzyme(s) in every case but one. We show that calcium induced slow calmodulin dissociation from the KCNQ2 channel subunit. The aim was to study role of FNAC in the diagnosis of cysticercosis. Experience with International Neuroblastoma Staging System and Pathology Classification. Should an awareness and knowledge of cholera be developed, it is the residents of developing nation that stand to benefit the most.

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Most wheelchair users are unable to determine on their own when adjustments are needed. 20 patients and 50 controls of Chinese origin were studied by polymerase chain reaction followed by Mnl I restriction zyrtec 30 tabs enzyme analysis. Six female adult Macaca mulatta monkeys were made dependent upon morphine sulfate and were implanted with a chronic indwelling needle in the lateral ventricle of the brain for sterile intraventricular injections. Using spectral variants of GFP on Sla1p (YFP) and on Abp1p (CFP) we show for the first time that these proteins can exist in discrete complexes at the cell cortex. We investigated atorvastatin reloading effects on endothelial progenitor cell (EPC) count and inflammatory cytokine expression after percutaneous coronary intervention (PCI) in patients with stable angina pectoris who had previously received long-term statin treatments. In the validation cohort part of the study, patients were included at day 7 if they presented a persistent moderate to severe ARDS. To describe the epidemiological features of peptic ulcer disease in Wuhan area during 1997-2002, to analyze the sex, age and occupation characteristics, as well as the geographic distribution of peptic ulcer disease, and to determine the effective methods of preventing and controlling peptic ulcer disease.

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Sivelestat reduces inflammatory mediators and preserves neutrophil deformability during simulated extracorporeal circulation. Modular poly(ethylene glycol) matrices for the controlled 3D-localized osteogenic differentiation of mesenchymal stem cells. As the repair techniques for mitral valve disease evolved, so has the need for detailed and accurate imaging of the mitral valve prior to surgery in order to better define the mechanism of valve dysfunction and the severity of regurgitation. In this case report an unusual chain of late complications with a fatal outcome following conization is presented. HCMV is a common cause of opportunistic infection that causes severe and fatal disease in immune-compromised individuals. Tissue engineering of angiogenesis with autologous endothelial progenitor cells. Cutaneous manifestations may be the first clinical sign of chronic Hepatitis C infection. These results suggest that CD14, together with a TLR other than TLR2 or 4, is an essential coreceptor of the influenza A virus sensing recognition system. The cognitive basis of prosocial behavior has received considerable recent attention.

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Disruptive visions: surgeon responsibility during the era of change. Rarely is it possible to obtain absolute numbers in free-ranging populations and although various direct and indirect methods are used to estimate abundance, few are validated against populations of known size. Females are both the main victims as well as the main perpetrators. Monomeric C18 chromatographic method for the liquid xanax bar pill id chromatographic determination of lipophilic antioxidants in plants. We introduce a controller model possessing a potentially highly parallel implementation and offer an example with supporting neural firing rate data.

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Semen analysis in post-pubertal patients with posterior urethral valves: a pilot study. The high within-individual genetic variability observed in Ethiopian cattle represents an untapped opportunity for adaptation to changing environments and for implementation of what is protonix 40 mg within-breed genetic improvement schemes. The aim of this study was to evaluate how photochemical degradation of amino acids affects bacterial metabolism and whether or not photochemical degradation of DOM competes for amino acids with biological processes. Neuroimaging studies in traumatized children are in a relative state of infancy. We describe the case of a young man addicted to heroin with the clinical pattern of symmetrical brachial neuropathy, without other neurological involvement. This paper describes the protocol of a systematic review that will examine the effectiveness of financial incentive programs at company cafeterias in improving dietary habits, nutrient intake, and obesity prevention. A new approach for the fabrication of microscale lipid bilayers at glass pipets: application to quantitative passive permeation visualization.

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Histone H1 is an important constituent of chromatin, and is involved in regulation of its structure. Guidelines for the psychiatric referral of visually handicapped patients. To study the MRI features of proximal femur bone marrow edema syndrome for further improve the understanding of the disease. By correcting the AF misalignments, the joint angle differences caused by the difference in AF determination are eliminated and the remaining discrepancies are mainly from the measurement accuracy of the systems themselves. We tested whether alpha-based EEG indexes reflect self-scored sleepiness and objectively measured waking ability. This study was designed to determine whether olive leaf extract can inhibit lead-induced brain injury, and whether this effect is associated with antioxidant capacity.

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New definitions of ventilator-associated conditions involving worsening oxygenation have been recently proposed to make surveillance of events possibly linked to ventilator-associated pneumonia as objective as possible. Inheritance of lysosomal acid beta-galactosidase activity and gangliosides in crosses of DBA/2J and knockout mice. The patient was referred to partial surgical excision of the glans. Whatever factors are changed at the national or community levels during economic (and social) transition in South Africa appear not yet to have resulted in improved child physical growth. The subjects were asked to express their preferences regarding various hypothetical health states derived from combining different health states with time durations in order to compare observed utility values of the couples (health state, time) and calculated utility values using the QALY formula.

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This failure may preclude patients from receiving effective interventions for substance use disorders. Semaphorins provide crucial attractive and repulsive cues involved in axon guidance. Promoting instruments for stroke risk assessment in AF is a plausible but untested strategy to improve decision making in AF, and its impact on OAC prescribing and patient outcomes should be evaluated in pragmatic trials. The following ligamentous structures were identified on transverse CT images in all stifles: cranial cruciate ligament, caudal cruciate ligament, medial meniscus, lateral meniscus, and the medial and lateral collateral ligaments. It is very recommendable to refer such kind of patients to university-based and specialized advanced heart failure and cardiac transplant centers, in time. However, in the last few years, some approaches have been focused on utilizing organic metals in these devices, which have been fabricated by means of both evaporation and solution-processed techniques. Cardiopulmonary and gas-exchange responses during the six-minute walk test in patients with chronic obstructive pulmonary disease. Therefore this study aimed to evaluate the effect of plant substrates and inoculation with AMF on the production of neem seedlings. In April 2002 a new law regarding euthanasia came into effect in The Netherlands.

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There has been limited research about disordered eating in middle-aged women, and to date, few data exist about restrained eating behavior in postmenopausal women. These results suggest that adenosine action on tracheal smooth muscle cells may be mediated by direct action on cell surface receptors. Patient and physician interactions were more involved and in the case of physicians, more collaborative compared with routine dispensing. In this paper, we present a facile and robust approach to synthesize multifunctional organic/inorganic composite microspheres with chitosan-poly(methacrylic acid) (CS-PMAA) shells and cadmium tellurium/iron oxide nanoparticle cores. CPA is usually seen in patients with documented or suspected underlying lung diseases like cystic fibrosis, bronchiectasis, inactive tuberculosis, pulmonary fibrosis, enalapril hctz dose sarcoidosis, previous lung section, of these, previous pulmonary tubercurosis is the most associated condition. In SHR, elastase was also demonstrated in medial smooth muscle cells and particularly in the modified smooth muscle cells in areas of intimal thickening.

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The proteins that were less abundant belonged to various functional categories such as nucleic acid and protein biosynthesis, detoxification mechanisms, or cell division. New pigtail catheter for pleural drainage in pediatric patients. Liability issues are not a prominent concern of chiefs or officers. In this study, we developed a novel bioreactor to load hydrostatic pressure to promote chondrogenesis of prechondrogenic ATDC5 cells in as little as 3 days. Cell-free DNA in serum and plasma: comparison of ELISA and quantitative PCR. Relaxed selection on perch function due to increased selfing may explain the increased incidence of apical flowers in some populations.

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We herein report a case of laparoscopic high anterior resection with D3 lymph node dissection for rectosigmoid colon cancer with a horseshoe kidney. The results were estimated by Harris scale and showed significant advantages of operative methods over conservative ones. Safe and effective use of local anesthesia is essential in hair transplantation. Cultured ureteric bud cells express fibronectin and the origin of fibronectin at mesenchyme-ureteric bud interface is likely both the metanephric mesenchyme and ureteric bud epithelium. The patient had an episode of shingles involving the same dermatome 4 years earlier. This study focused on the structure of membrane-bound vesicles and their ability to promote invasion in cultured malignant ovarian epithelium. Nonoperative management is often successful in alleviating symptoms. Genomic DNA was isolated from the blood samples of 178 schizophrenia patients in Shanghai, including 82 chronic schizophrenics with a course of minipress xl 5mg tablet uses in hindi more than 10 years, and 88 healthy persons as controls.

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Forty-five villus samples from spontaneous abortion cases (with 33 maternal peripheral blood samples) and 44 villus samples from induced abortion (with 34 maternal peripheral blood samples) were examined with high-pressure liquid chromatography (HPLC) to measure the overall methylation level of the genomic DNA. Response of the right ventricle to progressive pressure loading in pigs. The use of renal cortical slices from the Fischer 344 rat as an in vitro model to evaluate nephrotoxicity. Brain imaging findings in elderly adults and years of life, healthy life, and able life over the ensuing 16 years: the Cardiovascular Health Study. Therefore, aneurysmal wall enhancement may be an indicator of the ruptured condition, which is useful information for managing patients with SAH. Organ-specific difference in the sugar chains of gamma-glutamyltranspeptidase. The regimens differed in the timing of the evening dose of hydrocortisone, 06.00-07.00 pm in regimen 1 and 09.00-10.00 pm in regimen 2.

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