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Bonestat (Calcitriol)

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Bonestat is a synthetic physiologically-active analog of vitamin D, specifically the vitamin D3 form. Bonestat regulates calcium in vivo by promoting absorption in the intestine, reabsorption in the kidneys, and, along with parathyroid hormone, regulation of bone growth. Bonestat receptor-binding protein appears to exist in the mucosa of human intestine.

Other names for this medication:
Actical, Admax, Alcee, Alfabond, Alfacalcirol, Apcical, Arcium, Aristrol, Biocal, Biocitral, Calbec, Calcicare, Calcigra, Calcikind, Calcimet, Calcitriol, Calday, Caldikind, Calfa, Calgel, Calotec, Calsonic, Caltive, Caltop, Calvical, Calzem, Carcal, Cholical, Devita, Dmcal, Duracal, Fovit, Kurecal, Laretol, Lctrol, Osteobel, Politrol, Refirm, Rockbon, Roical, Rolsical, Solbiocal, Statbone, Sunmic, Tobalt, Trolec

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Diflucan, Ventolin, Casodex, Tricor, Starlix, Floxin

Also known as: Calcitriol


Generic Bonestat is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Bonestat are intestine and bone. Generic Bonestat receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Bonestat may also act on the kidney and the parathyroid glands. Generic Bonestat is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Bonestat has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Bonestat, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Bonestat in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Bonestat produces other independent beneficial effects. Bonestat is also known as Calcitriol. Generic Bonestat treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Bonestat is Calcitriol. Brand name of Generic Bonestat is Bonestat.


Generic Bonestat is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Bonestat suddenly.


If you overdose Generic Bonestat and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Bonestat are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Problems in children have not been reported with intake of normal daily recommended amounts. Some studies have shown that infants who are totally breast-fed, especially with dark-skinned mothers, and have little exposure to sunlight may be at risk of vitamin D deficiency. Your health care professional may prescribe a vitamin/mineral supplement that contains vitamin D. Some infants may be sensitive to even small amounts of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol. Also, children may show slowed growth when receiving large doses of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol for a long time.

Studies on doxercalciferol or paricalcitol have been done only in adult patients, and there is no specific information comparing the use of doxercalciferol or paricalcitol in children with use in other age groups.

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Anti-hyperlipidemic and anti-oxidative effects of gelsemine in high-fat-diet-fed rabbits. Surgicel Nu-Knit hemostat for bleeding control of fragile sternum. Irregular particles adhere to indentations on the surface of the carrier particles and form stable ordered mixtures. The aim of this study was to evaluate the role of rs10757278 and rs1333049 in determining genetic susceptibility to AAA. They were administrative secretaries and computer technicians working mainly with office computers. Colonization of Dormant Walnut Buds by Xanthomonas arboricola pv. For 12 months, patients prospectively recorded events of severe hypoglycaemia (SH).

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Effect of wine addition on microbiological characteristics, volatile molecule profiles and biogenic amine contents in fermented sausages. This article examines the process of oxidative stress and the pathways by which it relates to many chronic diseases. Reduction in MAS and VAS and improvement of ROM during and after rESWT treatments were prominent compared to baseline. The level of PAR-1 mRNA differed up to 25 fold between the respective pancreatic cancer cell lines. Adrenocortical function related to thiopental-nitrous oxide-oxygen anesthesia and surgery in man. Unit costs for colposcopy are similar among the provinces reviewed, but substantial difference exists for certain treatment services. The impact of a multimodal Summer Camp Training on neuropsychological functioning in children and adolescents with ADHD: an exploratory study.

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The HSV-2-induced dUTPase differed from the host dUTPase activity in its molecular weight (53000 versus 46000) and isoelectric point (pI 5 X 9 versus 6 X 4). Influence of folic acid on noradrenaline stimulation of rat brain synaptosomes. To study the clinicopathologic characteristics, immunophenotypes and differential diagnosis of primitive myxoid mesenchymal tumor of infancy (PMMTI). The electronic transmission properties can be explained from the energy spectrum of the system. CSCW--a paradigm for an efficient management of the healthcare organizations. A larger orbital PFC volume was related to a worse working memory performance and a larger superior PFC volume was related to worse conditional association learning. The first wave propagates only in the region of newly inserted membrane along the cleavage furrow. adalat la 30 mg uses Berberine exerted anti-cancer effect in various cancer cell lines, and was also implied in the treatment of metabolic related diseases. Parasite prevalence is a summary statistic familiar to biologists.

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The distribution of WAVE1, PKA RII and RAC1 is conserved in mature mouse, bull, baboon and human sperm. The phenomenon of retrograde ejaculation and its correction after the therapy were clearly demonstrated by color Doppler ultrasonography. Previous strategies to reduce complement-induced IRI required systemic administration of agents, which can lead to increased susceptibility to infections/immune diseases. The four extracellular domains (ECDs) of DARC are essential for its interaction with chemokines, whilst the first (ECD1) is sufficient for the interaction with malaria erythrocyte-binding protein. In male homozygous animals the differences in the dynorphin (1-17) and leucine-enkephalin levels were small whereas the concentrations of alpha-neo-endorphin and dynorphin (1-8) showed a significant decrease compared to the male heterozygous controls. Peloruside induced apoptosis in a dose-dependent manner in murine (32D) and human (HL-60) myeloid cell lines, revealed by DNA laddering in agarose gels and flow cytometric analysis of annexin-V- and propidium iodide-stained cells. The honeybee Apis mellifera represents a valuable model for studying the neural segregation and integration of visual information. Synthesized N,O-dimethyl, N-methyl, or N-Benzyl hydroxylamine derivatives of sodium alginate were subsequently complexed with zinc to form beads.

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An official multi-society statement: ventilator-associated events: the new definition. The severity of acute pancreatitis was determined by hyperamylasemia, neutrophil sequestration in the pancreas (pancreatic MPO activity), and pancreatic acinar cell injury/necrosis on histological examination of pancreas sections. Risk of right bundle-branch block and complete heart block during pulmonary artery catheterization. To investigate the effect of topical keratinocyte growth factor (KGF) on wound healing after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK). Maternal factors associated with three phenotypes: spontaneous preterm labour, preterm pre-labour rupture of membranes and medically indicated preterm birth. Recurrent malignancy at esophagojejunal anastomosis represents an incurable stage of disease. Tissue-cultured skin autografts may be an alternative for the treatment of full-thickness wounds and wounds that cover large combivent respimat inhaler cost areas of the body surface. We therefore investigated the relationship between abdominal muscle, body size and the amplitude of nearby tailflip potentials in the freshwater crayfish (Cherax destructor). Differences in the kinetic behavior of the levodopa and benserazide hydrochloride were exploited by using principal component analysis, an artificial neural network (PC-ANN) to resolve concentration of analytes in their mixture. Photodegradation of the herbicide EPTC and the safener dichlormid, alone and in combination.

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