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Calcigard (Nifedipine)
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Calcigard

Calcigard is used to treat high blood pressure or angina (chest pain). For high blood pressure: Calcigard works by relaxing and expanding the blood vessels. This makes the blood flow more easily and lowers blood pressure. Lower blood pressure reduces the strain on your heart. For angina: Calcigard works by relaxing and expanding the arteries supplying the heart. This allows more blood and oxygen to reach the heart and decreases the strain on it. Your angina attacks will be less severe and less frequent if there is less strain on the heart.

Other names for this medication:
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Also known as: Nifedipine

Description

Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Calcigard PA 10. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Calcigard and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Calcigard are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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Increased secretion of leukemia inhibitory factor by immature airway smooth muscle cells enhances intracellular signaling and airway contractility. The hepatocyte-sinusoidal structures of the amphibian livers were classified into three different types: (I) several-cell-thick plate type, (II) two-cell-thick plate type, and (III) one-cell-thick plate type, depending on the percentage extension of sinusoidal areas per unit area, measured by morphometry. The findings suggest that cytotoxic activity in vivo may well contribute to the establishment of an initial injury in visceral tissues, and the action of CCWC could increase the chances of survival for an invading F. Overall, postbottling oxygen had a stronger influence than MOX on the evolution of VSCs. Tacrolimus versus cyclosporine after HTX: comparison of long-term effects. Efferent supraspinal influences, in turn, determine the activity of interneurons by releasing a variety of neurotransmitter substances, thus resulting in a high degree of modulation of nociception within the dorsal horn. Results of prognathism operations in the Westdeutsche Kieferklinik (West German Jaw Clinic). Densitometry was conducted on the femoral bone in order to compare the bone mineral density (BMD) of different research groups.

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Active vision and receptive field development in evolutionary robots. Crossover from fluvastatin to other lipid-lowering drugs, withdrawal from fluvastatin, and the use of lipid-lowering drugs in the control group were included. The animals received immunosuppression for either 6 or 3 weeks or no immunosuppression. The place preference produced by CGS 15943A (1.0mg/kg) was attenuated by CPA and CGS 21680, at agonist doses that failed to produce place conditioning when administered alone. The word work schedule can be created in only 90 seconds by the program and allows for individual nursing staff requests for particular work assignments. Several clinical and biological phenotypes define complex diseases such as inflammatory bowel disease (IBD). To describe the clinical and epidemiologic profiles of the disease and to compare the findings with those generated from the previous hospital-based studies. The WFH organizes regular educational workshops on key aspects of hemophilia care. Isolation and properties of inorganic pyrophosphatases from cockroach thoracic muscle mitochondria. These data suggest that the 4G/5G polymorphism has no significant influence on PAI-1 concentrations in dengue virus infected patients and is not associated with the risk of death from dengue.

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The n-6 polyunsaturated fatty acid gamma-linolenic acid is the precursor of di-homo-gamma-linolenic acid. Of the 2 false positive cases, one showed muscle enhancement because of a previous biopsy, and the other was incorrectly interpreted as showing muscle enhancement. Transcript levels of two JA-related genes (LOX, AOS) and a developmentally regulated transcription factor (bZIP) were also affected, suggesting a shift ahead of the ripening process. The regulation of wall stress in the abdominal aorta (AA) of humans might be of specific interest, because the AA is the most common site for aneurysm formation in which wall stress seems to be an important pathophysiological factor. Induction of local protective immunity to Eimeria acervulina by a Lactobacillus-based probiotic. Freeze-Recovery Physiology of Nitrogenase Activity in Terrestrial Nostoc sp.

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Data regarding the association of recent substance use and injury type and frequency in children and young adults are not available. Differential effects of phenobarbital and pentobarbital on stimulus train-induced bursting in the hippocampal slice. On the one hand, non-reciprocal contact-inhibition of locomotion may permit the spreading of epithelia over mesenchymal cells, thus generating or restoring an epithelial bounding membrane. Functional heterogeneity within stem and progenitor cells has been shown to influence cell fate decisions. Transcranial Doppler (TCD) is the key test in determining the need for prophylactic blood transfusion to prevent stroke in children with sickle cell disease (SCD). A bench-scale aeration study using batch reactors on swine manure stabilization to control odour in post treatment storage. To investigate the effects of low-level laser therapy applied to the serosal surface of the rat jejunum following ischemia and reperfusion. Daily patient volumes, complaint categories, and admission rates were measured during the study period and compared with a control population that included average daily patient volumes, complaint categories, and admission rates at the same facilities for six months before landfall. Immunostaining of serial sections showed co-localization of AM2/IMD-like immunoreactivity and vasopressin in the paraventricular nucleus. Role of diagnostic and surgical laparoscopy in treating female sterility.

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Integrated understanding of urban land, groundwater, baseflow and surface-water quality--the City of Birmingham, UK. The model predicts how the amplitude and duration of the biochemical changes induced by critical pulses vary with this phase. Comparisons were made with perinatal stages of Caluromys philander and with adult specimens of other marsupials. Immunoreactive axons were located throughout the hypothalamus with the highest concentrations in the subependymal and internal zones of the median eminence, the interstitial nucleus of the stria terminalis, the medial preoptic area, and in the following nuclei: periventricular, suprachiasmatic, paraventricular, perifornical, median preoptic, and arcuate. Structural changes of starch during baking and staling of rye bread.

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Characteristics of the androgenic function of steroid-producing glands of baboons in the metapyrone test. Chronic infections have been demonstrated to be early factors of atherosclerosis and cardiovascular diseases, and their relevance increases when they are caused by agents with extremely broad spectrum of disease outcome such as Helicobacter pylori. The BODE index was calculated for each patient using variables obtained within 4 weeks of enrollment. Clinical cardiac MR imaging techniques generally require patients to hold their breath during the scanning process to minimize respiratory motion-related artifacts. Cell division of Escherichia coli BUG-6: effect of varying the temperature used as the nonpermissive growth condition. PAHs were accumulated in the oligochaete worm (Enchytraeus crypticus), and biota-soil accumulation factors exceeded those for the plants. The animals were sacrificed on the 7th, 12th and 17th day after irradiation. Combinations of toxic concentrations of cadmium and mercury show a synergistic lengthening of the lag period, but their cumulative influence on the growth rate is lower than the sum of the corresponding inhibition effects. Transporters are thus important as a determinant of the clearance in the body. Using confocal fluorescence scanning microscopy, we directly observe the 3D structure of colloidal phases assembled from these mixtures as a function of varying composition.

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Restriction endonuclease analysis of human globin genes in cellular DNA. For Pb and Cd a roughly three-fold increase of these limits was observed when the calibration method according to DIN 32 645 was applied. Photodynamic therapy (PDT) and photodynamic diagnostics (PDD) of cancer are based on the use of non-toxic dyes (photosensitisers) in combination with harmless visible light. Two participants awaiting a lung transplant dropped out of the study, and no adverse events occurred. A large number of practical problems still have to be solved before continuous monitoring in sewer networks will be successful.

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In epidemiological research, the most frequently adopted approach is to restrict the analysis to persons with narrow seroconversion intervals and to impute the midpoint of this interval as date of seroconversion. This pathway was therefore assumed to be absent from this organ. A new method for the determination of glycogen phosphorylase (1,4 alpha-D-glucose:orthophosphate alpha-glucosyltransferase, EC 2.4.1.1) in cultured cells is described. Splenocytes obtained from non-transplanted mice responded to specific alloantigen stimulation (primary response) at least 2 days later than the splenocytes from mice which had rejected skin grafts (effector/memory response). Disruption of the L1-CAM-ankyrin B complex with the calcium channel mimics transmitter-induced trafficking of the channels, reduces calcium influx, and decreases exocytosis. Within minutes all cats displayed tremors, increased muscle tone, fear response, repeated vocalization and salivation. We have previously shown the requirement of membrane cholesterol in the organization, dynamics and function of the serotonin(1A) receptor, a representative G-protein coupled receptor.

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Splitting of the stomach wall as a method of layer-by-layer study of blood vessel topography. Temporary balloon occlusion may improve selection of patients for definitive operation. Intimidation: practitioners speak up about this unresolved problem. Role of nutrition in the development of functional shifts in the thyroid. Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues. Although the significant influence of American bioethics on the Japanese medicine and medical education it does not mention cost of tofranil however sufficiently on the psychiatric ethics, so we have to discuss once more what ethical issues stand in the area of clinical psychiatry. The effect of TPA was maximum at about 25 ng/ml, and half-maximum stimulation occurred at about 8 ng/ml TPA.

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The use of biofeedback relaxation techniques in the pre-competition period may significantly improve the performance of competitive athletes hampered by particularly high levels of pre-competition muscle tension can flagyl treat mouth infection . Spearmen product moment correlation and Cronbach alpha coefficient were used for reliability analysis. Chromatographic determination of riboflavin and flavin nucleotides in yeast. Broken-symmetry density functional theory investigation on bis-nitronyl nitroxide diradicals: influence of length and aromaticity of couplers. Who owns the discovery, the doctoral candidate or the professor?.

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These data support the presence of an aberrant cell-mediated immune response in children with recurrent respiratory papillomatosis. Three electrophoretically distinct acid proteases appear in culture filtrates of Neurospora crassa. Unlike both asymptotic formulations, the exact solution remains accurate regardless of the range of physical parameters. Hepatitis C virus core protein potentiates c-Jun N-terminal kinase activation through a signaling complex involving TRADD and TRAF2. In our sec8 null mutants, in which the sec8 gene is specifically deleted, Sec8 immunoreactivity at the NMJ is eliminated but immunoblots reveal substantial maternal contribution in the rest of the animal. Shear-horizontal vibration modes of an oblate elliptical cylinder and energy trapping in contoured acoustic wave resonators. Spike-generation in dendrites and synaptic inhibition in immature cerebral cortex.

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Transglutaminase activity was found to be present in highly purified non-synaptosomal rat brain mitochondria. A consistent pattern according to the site of the produced sound was seen. Two new species of black flies, Simulium (Comphostilbia) terengganuense sp. Emphasis should be placed on training physicians on a regular basis in documenting and classifying complications and providing feedback. Clinicians and policymakers need to be aware of these findings, and further research is required to delineate whether treatment of anxiety disorders reduces the risk of subsequent suicidal behavior. Disseminated lymphangiomatosis was diagnosed after an open-lung biopsy. Thirty-four patients undergoing elective open sigmoid resections for recurrent diverticulitis or cancer. A flexible endoscope, 0.56 mm in diameter, with a tenormin dosage range depth of field of 5 mm and a 3000 fiberoptic light source was used for the procedure.

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Their antiproliferative activities were tested against four cancer cell lines: A431, MCF-7, A549, and B16-F10. Intravenous infusion of adenosine but not inosine stimulates respiration in man. Using a fully automated optimization strategy, we derived promising conditions that were scale-up tenfold. The complexity and anatomical arrangement of the two valves system suggests that, despite the existence of a favorable Delta P(TD), in the physiological condition no fluid bulk flow takes place between the pleural and peritoneal cavity through the diaphragmatic lymphatic network. Combined administration of barbourin--albumin and hirudin--albumin fusion proteins limits fibrin(ogen) deposition on the rabbit balloon-injured aorta. Contribution to the diagnosis of benign and malignant lesions of soft parts of the extremity. A review of anaesthetic technique in 15 paediatric patients with temporomandibular joint ankylosis.

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Determination of adenosine and thymidine in Fritillaria bulbs by ultraviolet spectrophotometry. The effect of pentagastrin on the A 1 -cells of the pancreatic islets in guinea-pigs. Indeed, 1p/19q deletion has been correlated with chemosensitivity in oligodendrogliomas, and is becoming more and more widely used in clinical practice. Together, these data suggest that the hypothalamus regulates body weight by controlling energy expenditure, as well as energy intake. Healthy school environment: effectiveness of hand washing instruction in an elementary school setting. Computed tomography revealed a 13 x 9 cm presacral mass displacing the rectum. Functional morphology and classification of interneuronal synapses. Using anti-tobacco industry messages to prevent smoking among high-risk adolescents. Hemicentin tracks facilitate mechanosensory neuron anchorage to the epidermis, gliding of the developing gonad along epithelial basement membranes and germline cellularization. Therapeutic implications of silent myocardial ischemia during daily activity.

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