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Calcitriol

Calcitriol is a synthetic version of Vitamin D3 used to treat calcium deficiency with hypoparathyroidism (decreased functioning of the parathyroid glands) and metabolic bone disease in people with chronic kidney failure.

Other names for this medication:
Actical, Alcee, Alfacip, Arachitol, Arcium, Biocal, Bonestat, Calcirol, Calday, Caldikind, Caltop, Cholical, Coecoral, Devita, Dmcal, Duracal, Estovon, Ikmag, Koncal, Minroset, Ostonex, Politrol, Primacal, Refirm, Rical, Riecal, Romical, Septriol, Solbiocal, Statbone, Vezocal, Vitalpha

Similar Products:
Colcrys, Myambutol, Eulexin, Deltasone, Prometrium, Decadron

Description

Generic Calcitriol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Calcitriol are intestine and bone. Generic Calcitriol receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Calcitriol may also act on the kidney and the parathyroid glands. Generic Calcitriol is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Calcitriol has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Calcitriol, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Calcitriol in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Calcitriol produces other independent beneficial effects. Calcitriol is also known as Calcitriol. Generic Calcitriol treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Calcitriol is Calcitriol. Brand name of Generic Calcitriol is Calcitriol.

Dosage

This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Calcitriol. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Calcitriol and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Calcitriol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

It is especially important that you receive the right amounts of vitamins so that your baby will also get the vitamins needed to grow properly. Infants who are totally breast-fed and have little exposure to the sun may require vitamin D supplementation. However, taking large amounts of a dietary supplement while breast-feeding may be harmful to the mother and/or baby and should be avoided.

Only small amounts of alfacalcidol, calcifediol, calcitriol, or dihydrotachysterol pass into breast milk and these amounts have not been reported to cause problems in nursing babies.

It is not known whether doxercalciferol or paricalcitol passes into breast milk. Be sure you have discussed the risks and benefits of the supplement with your doctor.

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These results suggest that intracellular signals initiated by alpha4beta7 integrin involve the tyrosine phosphorylation of paxillin and p105(Cas-L), which are differentially regulated, at least in part, by mechanisms that are PMA-sensitive or -insensitive. In addition, BtrV mutants predicted to mimic a constitutively phosphorylated form of BtrV or to be nonphosphorylatable and BtrW mutants defective in serine kinase activity or the ability to bind BtrV were constructed and analyzed. The aging of the United States population means that treatment of hypertension in the elderly is becoming an increasingly important issue, and the pathophysiology, consequences, and benefits of treatment are quantitatively different in older and younger people. The prospective Comprehensive, Observational, Multicenter, Prostate Adenocarcinoma (COMPARE) registry was used to study a cohort of 484 men with biochemically recurrent prostate cancer after radical prostatectomy, external beam radiation or brachytherapy. Mapping nutrient resorption efficiencies of subarctic cryptogams and seed plants onto the Tree of Life. Primary aldosteronism (PA) is associated with an increase in left ventricular (LV) mass beyond the amount needed to compensate the hypertension-related workload. Effect of light quality on the accumulation of photosynthetic pigments, proteins and mycosporine-like amino acids in the red alga Porphyra leucosticta (Bangiales, Rhodophyta). Patterns of myocardial endothelin-1 expression and outcome after cardiac transplantation. The aim of this study is to examine differences in distress, problems and referral wish in cancer patients according to relationship status and life phase. Study 1 exposed children to dense neighbors versus non-neighbors before training sound production in evaluation of the priming hypothesis.

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Literature search was performed in Pubmed and Embase to identify studies regarding the usefulness of survivin to diagnose MPE. Necrotizing enterocolitis (NEC) is one of the most frequent causes of gastrointestinal perforation in premature neonates, only few case series and reports being described in adult patients. Increased spermidine and N8-acetylspermidine levels reflect increased uptake and metabolism likely due to accelerated proliferation and regeneration of CECs. To our knowledge, this is the 5th report of a rupture in the retroperitoneum of an arteriovenous fistula, and renal arteriovenous fistula with the pyelonephritis is very rare. PDP is a highly effective method for rapid regression of atherosclerosis. To expand the utility of quantitative proteomics for metabolic engineering, we validated and optimized targeted proteomics methods for over 400 proteins from more than 20 major pathways in E. In commonly used caging systems, once the caging compound is removed, protein expression cannot be stopped, due to the irreversibility of the uncaging reaction.

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Features of vaccination are discussed, including the long persistence of humoral antibodies and long duration of effective protection. Reply to Griffiths: The Relationship Between Gambling and Homelessness. Other studies have described intramembranal cleavage of p75 and the potential nuclear targeting of cleavage fragments or of the complete receptor after it has been internalized into a putative signalling endosome. Skin biopsies are easy to perform, can be done under direct visual control, allow precise clinico-pathological correlation, and, accordingly, the significance of skin biopsies is very high. Sequential Metastatic Breast Cancer Chemotherapy: Should the Median be the Message?. The healing mechanism of experimentally produced ruptures of the round window was histologically studied in guinea pigs. Several lines of evidence suggest that the neuropeptide vasopressin is involved in the regulation of the immune system. This disruption in the immune system permits opportunistic infection and thus the acquired immune deficiency syndrome.

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Vaginitis and sexually transmitted infections in a hospital based study. Signal crosstalk and induced resistance: straddling the line between cost and benefit. To analyse published cost-of-illness studies that had assessed the cost of prematurity according to gestational age at birth. Its large sensitive area also greatly simplifies setup alignment. Hospital urinary infections caused by Pseudomonas after the necessary preventive measures have been taken. A dual modality SPECT-CT prototype system dedicated to uncompressed breast imaging (mammotomography) has been developed. Family-based psychosocial support and education as part of pulmonary rehabilitation in COPD: a randomized controlled trial. Experimental observation on nerve regeneration after reconstructive surgery of the facial nerve.

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Hypoadiponectinemia predicts the development of diabetes and hypertension, both being potent atherosclerotic risk factors. The molluscan neurosecretory peptide FMRFamide: comparative pharmacology and relationship to the enkephalins. Fibrodysplasia ossificans progressiva is a rare genetic disease in which heterotopic ossifications appear in early childhood and are accompanied by feet and spine defects. The unique strategies used in this process include leveraging the penetration of water between hydrophobic MoS2 films and hydrophilic growth substrates to lift off the films and dry transferring the film after the lift off. We assessed the administration of weekly Paclitaxel as second-line chemotherapy, or as first-line chemotherapy in unfit patients. There is an improved cosmetic outcome for patients, and the very small quantity of radioactivity used is safe for both patients and staff. Plasma levels of phenylacetic acid, m- and p-hydroxyphenylacetic acid, and platelet monoamine oxidase activity in schizophrenic and other patients.

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Zinc sulfide clusters were synthesized and characterized at low micromolar concentrations to assess the effect of metal-sulfide ligands on metal toxicity to aquatic organisms in oxic environments. Assessing the benefit of radiation therapy after breast-conserving surgery for ductal carcinoma-in-situ. In contrast, incorporation into more caudal sites was much less efficient. The study aimed to assess the effect of upper airway reconstructive surgery for OSAHS based on polysomnography (PSG) after nasopharyngeal tube insertion (NPT-PSG), and to evaluate the clinical value of NPT-PSG in localizing the obstructive sites. In a second step a pump-dump scheme from the perylene ground state to the first excited electronic state and back to the ground state is discussed. This was primarily done in order to obtain more information on the events surrounding the death of this individual, but also to assess the usability of the published methods on cranial fractures. HARVEST displays patient information longitudinally using a timeline, a problem cloud as extracted from notes, and focused access to clinical documentation. Probable social factors include child rearing practices, personal expectations and lifestyles, and societal institutions.

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Morphological and immunohistochemical changes to thymic epithelial cells in the irradiated and recovering rat thymus. The use of the quality model of Parasuraman, Zeithaml and Berry in health services. Another theme is the existence of central molecular hubs, either as single proteins (e.g., Msn2/4, Flo11) or as multisubunit complexes (e.g., TORC1/2 prometrium 200 mg price ), which are controlled by numerous pathways and in turn determine the fate of the cell. In man, there is a transient increase of alveolar ventilation via an increase of total ventilation VE, tidal column Vt, and respiratory frequency f. Reduction of Fe(III) oxide by methanogens in the presence and absence of extracellular quinones. Here, we report our results of a survey of the genome of the two-spotted spider mite Tetranychus urticae, using a set of 294 Drosophila orthologs of genes that function in signal transduction. The model does not provide an efficient description in that the number of hidden variables grows exponentially with the number of nuclear spins. Increased serum DHEAS may be a component of the pathophysiology of NAFLD. Schizophrenia-like and other psychotic disorders, followed by seizure disorders, were the most prevalent, while the least prevalent included autism spectrum disorders, enuresis, adolescent postpartum psychosis, and adjustment disorders, among others. In general, clearance efficiency for albumin bound substances is relatively low in all systems currently available.

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Treatment of (E)-1-(methoxymethylene)-1,2,3,4-tetrahydronaphthalene with styryl diazoacetates in the presence of catalytic amounts of the dirhodium complex Rh2(S-DOSP)4 provides a highly enantioenriched hexacyclic product with 10 new stereogenic centers. Bacteriophages provide additional information for the evaluation of microbial elimination in some treatment plants. The helical content of the peptides depends on the nature of the membrane-mimetic environment. The patients and a group of healthy controls were subjected to a standard LH-RH provocation test. In vivo demonstration of a late depolarizing postsynaptic potential in CA1 pyramidal neurons. Probes were delivered in brief trains, but only the first response exhibited this pattern. These results suggest major differences in bactrim drug drug interactions DNA repair between the two species and highlight the presence of error-prone repair functions on CAM-OCT.

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An AFM determination of the effects on surface roughness caused by cleaning of fused silica and glass substrates in the process of optical biosensor preparation. This background conductance was suppressed by muscarinic agonists. The SMGs of 19 patients with severe keratoconjunctivitis were transferred to their temporal region by microsurgery. The haemorheological changes associated with strenuous exercise appear to be linked with enhanced oxidative stress and depletion of antioxidant capacity, and that may affect oxygen delivery and availability to the tissues. A comparison of the taking 4 flagyl pills at once steroidogenic acute regulatory protein-related lipid transfer (START) domain-containing 6 on the brain and testes between young and aged rats. However, childless women with disabilities who wanted and intended to have a child were more likely to report uncertainty about those intentions than were childless women without disabilities (odds ratio, 1.7). In spite of the fact, that most of the studies about mast cells are performed ex vivo on human tissues or cell cultures and rodents, this findings lead to recognize mechanisms by which mast cell can intervene in atherogenesis process. Combined with the understanding of when and where gene products are expressed in normal and diseased conditions, we create information that is essential for understanding the interplay of genes and proteins in the complex biological network. However, no known research has tested the incremental validity of personality traits as predictors of substance use beyond identified group-specific risk factors.

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When treatment was performed at 4 degrees C, the enhancing effect of huFN on parasite-cell interaction was greater than that observed at 37 degrees C. This ontogenetic memory is an immanent property of a chromosome and cis-regulation plays a key role in its maintenance. In order to provide the recommended international standard of care for TB patients, clinicians need to be aware of the impact of HIV on TB patients and programmes and the implications for the policies that provide the framework for this standard. Participants requested that hospital policy revisions address work assignments, pay/financial compensation, flexibility for extenuating circumstances, pet care, family sheltering, and provision of basic needs. In rats anesthetized with HVAs, we observed a greater than twofold increase of NO content in brain cortex as compared to the nonanesthetized animals. We present two cases of apical extrusion of non-setting, calcium hydroxide paste which had been placed as an interappointment root canal dressing during routine endodontic treatment resulting in tissue necrosis of a large part of the mandible.

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Endovascular therapy for intracranial dural arteriovenous fistulas. Development of a photoacoustic, ultrasound and fluorescence imaging catheter for the study of atherosclerotic plaque. Early feedings improve nutritional outcomes but may increase the risk of SIP. Immunofluorescent microscopy for the identification of human necrotic myocardium. No basal cell carcinomas had resolved but the keratoses were clinically clear and histologically less active.

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These findings conclude that the active principles responsible for the antihyperglycaemic effect might be concentrated in the ethyl acetate and dichloromethane fractions of the extract. Relatives, who care for male sufferers reported greater distress than those caring for females. Parvovirus infection presenting as severe hemophagocytosis is extremely rare. The aim of this study was to evaluate the secondhand can i drink alcohol while taking lamisil exposure to nicotine and other tobacco-related toxicants from e-cigarettes. Diastereoselective synthesis of the endo- and exo-spirotetronate subunits of the quartromicins. Our cohort included three patients, of which two were men (53 and 77 years old) and one a 28-year-old woman. Multivariate logistic regression models were implemented to predict 30-day mortality (AMI) or 48-hour surgery (HF), adjusting for demographic characteristics and comorbidities plus clinical data and drug prescription information.

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Here, we report that neurons in rat primary visual cortex (V1) exhibited shorter response latency in the desynchronized state than in the synchronized state. This study demonstrates that fasting had a stimulatory effect on dimethylation and trimethylation of histone 3 at lysine 27 (H3K27) in preoptic/anterior hypothalamus (PO/AH) of 3-day-old chicks. Beta desynchronization is often seen as an indicator of motor processing and thus reflects motor activity related to the hand movements that gestures add to speech. Experimental performance assessment of SPM for SPECT neuroactivation studies using a subresolution sandwich phantom design. Do patients need continuous passive motion for their post-surgery rehabilitation?. Regarding the cow: from time to time samples of feed and blood should be available for checking how much of the milk iodine has passed through the body and has contributed to the iodine status.

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Many transformations that take place over time can only occur in one temporal direction, and adults are highly sensitive to the differences between forward and backward presentations of such events. The use of such expandable cell lines, for chronic spinal delivery of opiates, could offer an attractive and safe alternative strategy based on ex vivo gene therapy for the control of opioid-sensitive chronic pain. This change was typically at low frequencies, 125 Hz at the beginning when cooled HPDs were placed. A significant reduction of urine output and urinary sodium excretion lasted for about 30 min after intravenous administration of antiserum. Canine awake head-out plethysmography (HOP): characterization of external resistive loading and spontaneous laryngeal paralysis. Rapid decline in eGFR before entering chronic RRT associates with increased mortality on RRT. The purpose of this study was to evaluate the significance of diabetes mellitus as a risk factor for postoperative major morbidity and mortality after surgery for critical lower limb ischemia (CLI). The survey was conducted with 434 nurses working in general hospitals in Seoul.

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The introduction of two-view mammography at incident screens is associated with a reduction in incidence of interval cancers. We review the literature surrounding disparities in gastric cancer and provide data pertaining to potential contributing factors. The positive longitudinal association between risk estimations and CIMT confirms the use of risk scores in assessing individuals and populations at risk. The complexes self-assembled under aqueous conditions to form vesicles with bilayer membranes containing palladium species. Adrenergic vasoconstriction as a cause of inadequate hypotensive response to beta-adrenergic blockade.

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