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Calmnir (Clonazepam)

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Clonazepam, sold under the brand name Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class. It is taken by mouth. It begins having an effect within an hour and lasts between six and 12 hours. Calmnir was initially patented in 1964 and went on sale in the United States in 1975. It is available as a generic medication.

Other names for this medication:
Adnil, Anxrea, Clonapax, Clonark, Clonopam, Clonzy, Closis, Clotas, Ection, Epcon, Epitril, Escimax, Escitrac, Esitor, Estalonix, Ezinite, Jbcloz, Klopam, Lonipax, Meloprax, Norep, Prasilex, Prasilife, Somnolex, Somnotril, Xenotril, Xitzen, Zeptril

Similar Products:
Clozaril, Celexa, Adalat, Requip, Noroxin, Zyloprim, Dostinex

Also known as: Clonazepam


Calmnir is a benzodiazepine medication that was initially primarily used for the treatment of seizures occurring in epilepsy and for anxiety, specifically anxiety that occurs in panic disorder. Calmnir is available in tablet form (0.5 mg, 1 mg, 2 mg) and as disintegrating wafers that are taken orally.

While Calmnir is generally prescribed for the treatment of anxiety disorders, such as panic disorder, and seizure control, it is intended as a short-term treatment protocol as opposed to a long-term treatment solution due to issues with tolerance (see below). In addition to treating anxiety and seizures, Calmnir has also been used in the treatment of:

chizophrenia, especially when the individual with schizophrenia has a restless or irritable component and is not responding to antipsychotic medications.

The manic phase of bipolar disorder or for restlessness associated with depression in bipolar disorder.

Tic disorders, such as Tourette's syndrome, by acting as a muscle relaxant and producing sedation.

Restless leg syndrome.

Withdrawal from alcohol or treatment for other substance abuse or addiction issues.

Calmnir has a relatively slow onset of action (it takes a while for the drug to begin working) and a half-life of between 10 and 50 hours. As it has a relatively slow onset of action and is a longer-acting benzodiazepine, Calmnir is more suited for the treatment of anxiety, seizures, and other similar disorders as opposed to being a useful sleep aid, even though it is sometimes prescribed for that purpose. Sleep aids need to work quickly, whereas with Calmnir, a person takes the drug early in the day and doesn't have to worry about monitoring for signs of a seizure or panic attack as it stays in the system a relatively long time. Its effects last longer than those of shorter-acting benzodiazepines, such as Xanax.

As it is a Schedule IV controlled substance, Calmnir can only be legally acquired with a prescription from a physician.


Calmnir is indicated for the treatment of panic disorder, with or without agoraphobia, as defined in DSM-V. Panic disorder is characterized by the occurrence of unexpected panic attacks and associated concern about having additional attacks, worry about the implications or consequences of the attacks, and/or a significant change in behavior related to the attacks.

The efficacy of Calmnir was established in two 6-to 9-week trials in panic disorder patients whose diagnoses corresponded to the DSM-IIIR category of panic disorder.

Panic disorder (DSM-V) is characterized by recurrent unexpected panic attacks, ie, a discrete period of intense fear or discomfort in which four (or more) of the following symptoms develop abruptly and reach a peak within 10 minutes: palpitations, pounding heart or accelerated heart rate; sweating; trembling or shaking; sensations of shortness of breath or smothering; feeling of choking; chest pain or discomfort; nausea or abdominal distress; feeling dizzy, unsteady, lightheaded or faint; derealization (feelings of unreality) or depersonalization (being detached from oneself); fear of losing control; fear of dying; paresthesias (numbness or tingling sensations); chills or hot flushes.

The effectiveness of Calmnir in long-term use, that is, for more than 9 weeks, has not been systematically studied in controlled clinical trials. The physician who elects to use Calmnir for extended periods should periodically reevaluate the long-term usefulness of the drug for the individual patient.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, or coma.


Tablets should be kept at room temperature, between 15 C and 30 C (59 F and 86 F).

Side effects

The most common side effects associated with Calmnir are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as seizures, mental/mood changes, shaking, stomach/muscle cramps) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

If you have several different types of seizure disorders, you may experience a worsening of seizures when you first start using Calmnir. Consult your doctor right away if this happens. Your doctor may need to add or adjust the dose of your other medications to control the seizures.

Tell your doctor if your condition persists or worsens.

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Patients were followed monthly for safety and efficacy over 12 months. Pain can lead to increased pelvic blood flow, which dissipates the energy delivered, limiting the amount of heat delivered to the prostate. Behavioral and economic impact of a familial history of cancers. The asynergic score, defined as the number of asynergic segments, was assessed by echocardiography before and 1 month later. Optical recording of synaptic potentials from processes of single neurons using intracellular potentiometric dyes. In verified fungal NRPSs that produce macrocyclic peptides, each megasynthetase terminates with a condensation-like (C(T)) domain that may perform the macrocyclization reaction. Streptococci appeared to be a major component of the polymicrobial intracellular flora, being present at a level from one to two logs greater than the next most common species (G. In non-diabetic hypertensive patients, MAU as well as TPU increases the incidence of cardiovascular events. The type of changes differs according to the studied sperm species and follows the course of AR.

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Distribution of delayed-action sulfonamide sulfadimethoxine in human organism. The IgA content in each sample was analyzed by enzyme-linked immunosorbent assay (ELISA). Moreover, local topology has been shown to be disturbed on the boundary between proliferating and quiescent cells, where cells have fewer sides than natural proliferating epithelia. Remarkably, quantitative decreases in AvrPtoB anti-PCD activity are correlated with decreases in AvrPtoB ubiquitination and E3 Ub ligase activity. At histological examination, the mass was unencapsulated and composed by lobules of fat cells and scattered isles of cartilaginous tissue. Given the early and presumably devastating consequences of cell cycle re-entry, we have made a concerted effort to elucidate the initiating factor that drives aberrant mitotic re-entry in AD. Report from the XV-th Congress of Czechoslovak Morphologists, Brno 25-29.IX.1972. Intestinal absorption of food antigens and immune responses are mutually dependent, and luminal (environmental) and serosal (intrinsic) factors synergize to maintain a self-perpetuating cycle in which antigens penetrate the mucosa and induce allergic inflammation.

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One patient required surgical revision and 1 required stomal dilation for stomal stenosis. This paper explores how the contractile force generated at the sarcomeres within an individual muscle fiber is transferred through the connective tissue to move the bones. Acceptability was assessed with a 5-point response scale (eight items). 16S rRNA gene molecular analysis elucidated the spatiotemporal distribution of bacterial biofilm communities along a water quality gradient. Basic knowledge about the current status of the new reimbursement system, the German coding guidelines in psychiatry/psychosomatic medicine and the use of ICD-10-GM/OPS.

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Right-side ovarian and tubal incarceration through strangulation in pregnancy. Unlike the case for the pyrolysis of pure 2-chlorophenol, 4,6-DCDF was observed, but the analogous 4,6-DBDF remained undetected similar to the individual results with 2-MBP. They also gave themselves significantly lower ratings on some of the self-esteem and sociability items. Despite efforts to define the events at Fort Dix, many questions remain unanswered, including the following: Where did A/New Jersey come from?. Between 1996 and 2003 we examined 684 patients with Glasgow Coma Scales (GCS) between 2 and 15, median 7.2, using computed tomography (CT). Investigations into the blood plasma profiles of electrolytes, 17 beta-oestradiol and progesterone in sheep suffering from vaginal inversion and prolapse ante partum. To evaluate the acceptability, tolerance and efficacy of Urgotul wound dressing in the management of epidermolysis bullosa (EB) skin lesions. Among which the heart rate (HR) and the circadian rhythm are most important since they may interfere with the drug effect and need to be taken into account in the data analysis.

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PsV encapsidating a secreted alkaline phosphatase (SEAP) reporter plasmid were used to develop a high-throughput in vitro neutralization assay in a 96-well plate format. We suggest that these features may be related to the known ability of this parasite to rapidly develop drug resistance. GAP-43 was continuously expressed through adulthood in neuropil of the gray matter, the pyramidal tract, and the dorsal portion of the lateral funiculus that was identified as serotonergic by confocal laser scanning microscopic studies. sphaeroides harbors both a cbb3-Cox and an aa3-type cyt c oxidase (aa3-Cox), we examined whether R. The involvement of superoxide anion (O2-) and hydrogen peroxide (H2O2) in the antibacterial action of ciprofloxacin was analyzed using superoxide dismutase, catalase, and alkyl hydroperoxide reductase knockout strains of E. Many different functions have been assigned to SMN, including assembly of ribonucleoproteins (RNPs), splicing, transcription and axonal mRNA transport. We report the first known case in the English literature of an epidural hemorrhage complicating extracorporeal life support in a neonate with respiratory failure. In contrast, the bactericidal activity of most antibiotics was severely compromised when adherent bacterial biofilms were used as inocula. Amygdala-prefrontal cortical circuitry regulates effort-based decision making.

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The purpose of this study was to determine the prevalence of diastolic dysfunction and its association with prognosis in asymptomatic patients after mediastinal irradiation. The clinical presentation of cyanide intoxication, its diagnosis, and subsequent treatment are discussed. Assessment of graduates and diplomates in practice in the UK--are we measuring the same level of competence?. Autotransfusion devices offer a practical and obviously economical option to wash banked RBCs intraoperatively to prevent hyperkalemia and other disturbances in massive transfusion or pediatric patients. Action of probenecid on the central nervous system of the rabbit. Bone marrow can be extracted from the large flat bones of the body with relative ease and safety, and it provides a rich source of adult stem cells as well as growth factors that facilitate osteogenesis.

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The indications for surgery were in relation to trauma in 17 cases or for progressive lower limb or spine deformity. Higher frequency and severity of symptoms, lower esophageal acid exposure and lower incidence of reflux-related complications have been observed in women. With the completion of the Human Genome Project (HGP), typing single nucleotide polymorphisms (SNP) has become one of the main tasks in the post-genome era. Moreover, Syk and Lck play differential roles in regulating Sp1 activation and expressions of melanoma cell adhesion molecule (MelCAM), urokinase-type plasminogen activator (uPA), matrix metalloproteinase-9 (MMP-9), and vascular endothelial growth factor (VEGF) in response to H/R. A total of 58,201 beneficiaries switched from an HMO to the FFS sector and were analyzed separately. HO modulations affected plasma lipid hydroperoxide (LPO) levels and nitrite/nitrate levels. Two are the anthocyanins, delphinidin and cyanidin 3-O-beta-D-galactosides, respectively. The two-echelon system, using adaptive exponential smoothing, was recommended.

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Estrogen activates rapid signaling in the brain: role of estrogen receptor alpha and estrogen receptor beta in neurons and glia. A 17-year old boy with hypertrophic obstructive cardiomyopathy (HOCM) developed repeated short runs of self terminating ventricular tachycardia 12 hours after starting oral verapamil, which was substituted for propranolol therapy. Telomeric repeat binding factor 1 (TRF1) is crucial for forming and maintaining the protective over the counter protonix dose telomeric structure. While interviewing with this purpose in mind, I was struck by the fact that a number of the people I spoke with gave me a sense of being extremely suitable for this sort of therapy, but that others seemed quite unsuitable. The same significant suppression of PFC was observed in adrenalectomized groups.

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Hematopoietic progenitor cells were served as target of MDR1 gene transferred by the mediation of retrovirus vector and engrafted into the BALB/c mice with 60Co-gamma ray exposure in advance. However, it is becoming clear that several semaphorins are crucially involved in the immune system. 30 nuclear proteins which were preferentially released by limited digestion with DNase I, but no proteins were released from sperm nuclei. The attenuation by chronic electroconvulsive treatment of hypothermia induced by histamine H2-receptor stimulants does zyrtec cure sinus infection in rats. The interaction of heparin with human plasmin was investigated measuring plasmin activity and enzyme inactivation in the presence of heparin. Determination of absolute values for the size of morphofunctional zones and number of cellular elements of a lymph node.

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The effectiveness of gamma-irradiated antileptospirosis vaccines and of vaccines dutasteride 0.5mg capsules killed with formol was compared in guineapigs. We excluded moribund patients with ICHs who died within 12 hours of hospital admission. Recent studies have provided a plausible disease mechanism for FSHD in which FSHD results from inappropriate expression of the germline transcription factor DUX4. Basal serum levels of AMH, E(2), inhibin B, FSH, and LH, as well as GnRH-stimulated levels of FSH and LH. Chronic experimental testing of a new formulated fish product--an analog of salmon based on isolated krill protein.

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The delicate balance between UPP-mediated degradation and refolding of denatured proteins is governed by relative levels of CHIP and other molecular chaperones. Tumor cell implantation following neodymium-YAG bladder injury: a comparison to electrocautery injury. Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel. The importance of glucose metabolism and insulin therapy during myocardial ischaemia is increasingly being albenza generic name investigated. Furthermore, we highlight the many parallels to the now well-established field of environmental bioremediation, and the vast potential to leverage emerging metagenomic tools to shed new light on these important microbial biotransformations. Demographics, presenting complaints, vital signs, tests ordered, medications administered, disposition, and discharge instructions were recorded, and associations were tested in bivariate analyses.

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Although it is not yet clear through which pathways such cerebellar nonsomatic functions are mediated, the direct bidirectional connections between the cerebellum and the hypothalamus, a high autonomic center, have recently been demonstrated in a series of neuroanatomical investigations on a variety of mammals and indicated to be potential pathways underlying the cerebellar autonomic modulation. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. The purpose of this study was to develop and to evaluate a health promotion program for elderly. Magnetic iron oxide nanoparticles have numerous applications in the biomedical field, some more mature, such as contrast agents in magnetic resonance imaging (MRI), and some emerging, such as heating agents in hyperthermia for cancer therapy. Tissue culture cells were treated with hematoporphyrin derivative (HPD) and analyzed for (1) HPD uptake, (2) HPD washout, and (3) fluorescence changes. While exercise resulted in improved fitness, body composition, and glycemic control, there were no changes in FMD or circulating endothelial biomarkers. The average TMH of the five techniques was similar, although OCT and SL-X tended to record lower and higher values, respectively. The first, biphasic with an early peak within 2 h and a delayed one after 24 h, was shown by T, its unconjugated precursors and DHT.

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Some biochemical findings in Burlington (Vt.) junior high school children. Treatment consisted of early administration of intravenous broad-spectrum antibiotics and debridement. The effects of ischaemia on the arterial wall were studied in fragments of common carotid artery taken downstream from the occlusion. It also causes postoperative and device-related infections and has been associated with a number of other conditions such as sarcoidosis and synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO), although its precise role as a causative agent remains to be determined. To estimate penetrance of the mutation, we consider a marginal likelihood approach that is computationally simple to implement, more flexible than the original analytic approach proposed by Wacholder et al. Proliferation of peroxisomes in pericentral hepatocytes of rat liver after administration of a new hypocholesterolemic agent (BM 15766). We used linear mixed-effects statistical modeling and found a gradual slowing of reach speed and a more rapid decrease of movement jerk with increasing age. Despite the improvement in the overall prognosis of HIV/AIDS does lodine show up on a drug test patients and the improvement of global ICU care, the prognosis of HIV/ADS patients hospitalized in ICU with severe sepsis remained poor. The EAT scores of female students from a northern and a southern Italian high school were compared. Ecdysteroid titers were low for low rankers, but were more than twice as high for both high rankers and alphas.

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Chromosomes of Onchocerca volvulus (Spirurida: Onchocercidae): a comparative study between Nigeria and Guatemala. The weak-link approach (WLA) to supramolecular assemblies allows for the design of multimetallic two- and three-dimensional arrays, host-guest architectures, sensors, catalysts, switches, and signal amplification devices. They had previously been shown to carry large deletions of the F8, but the precise gene abnormalities remain to be elucidated. Emphasis and perspectives of the situation in health and occupational policies. The prejunctional inhibitory effect of serotonin on adrenergic neurotransmission is mediated by receptors which have the same affinity for agonists as the 5-HT1 binding sites. in Response to the Presence of Anthoceros punctatus or Its Extracellular Products. PML-RAR alpha gene, as a molecular marker of APL, is possibly responsible for genesis of APL.

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Androgen receptor CAG and GGC polymorphisms in Mediterraneans: repeat dynamics and population relationships. Estimation of pulmonary/systemic resistance ratios from echocardiographic systolic time intervals in young patients with congenital or acquired heard disease. A list of agency resources serving the visually handicapped is provided. Ninety-four cutaneous melanoma patients with inferior extremity lesions were submitted to SNB according to a established protocol. Afibrinogenemia in man following the bite of a rattlesnake (Crotalus adamanteus).

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