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Capecitabine is used to help treat patients with Dukes' C colon cancer (colon cancer that has spread to lymph nodes in the area close to the colon), after having surgery. This medicine is also used to treat metastatic colorectal cancer (cancer of the colon or rectum that has spread to other parts of the body).

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Alprostadil, Motrin, Ativan, Mellaril, Strattera, Fasigyn, Sovaldi, Dramamine


{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).


Usual Adult Dose of Capecitabine for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Capecitabine for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Capecitabine dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Capecitabine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Capecitabine if you are allergic to capecitabine or fluorouracil, or if you have:

severe kidney disease.

To make sure Capecitabine is safe for you, tell your doctor if you have ever had:

a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency; liver or kidney disease; heart problems; or if you use a blood thinner and you have routine "INR" or prothrombin time tests.

Capecitabine can harm an unborn baby if the mother or the father is using Capecitabine .

If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using Capecitabine and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using Capecitabine, and for at least 2 weeks after your last dose.

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Synthesis of 3-amino-4-methyl-2-pentenamide, 2-amino-1-cyclohexene-1-carboxamide and 3-amino-2,4-diphenyl-2-butenamide and synthesis of 4(3H)-pyrimidone derivatives from them. Studies with very long follow-up are scarce in patients with cryptogenic stroke and patent foramen ovale (PFO). In investigating possible mechanisms by which PA promotes neutrophil exocytosis, we demonstrated that exocytosis can only be restored in R59022-treated cells through simultaneous modulation of membrane fusion and increasing cytosolic calcium. Carnosic acid, which is one of extract components of rosemary, has anti-inflammatory, anti-oxidant, and anti-cancer effects. Their performances were evaluated by characterizing their properties such as structure, permeability and protein adsorption. Thrombosed external hemorrhoids: outcome after conservative or surgical management. Perinuclear intermediate filaments and filaments in cytoplasmic processes reacted positively for vimentin. Because of neighborhood crime problems, the Johns Hopkins Medical Institutions decided to undertake security improvement projects aimed at enhancing security/safety at the campus. Neither could any increased HLA-antigen sharing in sub-groups of aborting couples with and without autoimmunity be demonstrated.

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High throughput, high resolution enzymatic lithography process: effect of crystallite size, moisture, and enzyme concentration. This study offers a versatile approach for deposition of biopolymer on GO and provides a way for enzyme immobilization. Influence of fasting and of a high-protein diet on the activity of rat liver gamma-glutamyl transferase. Extensive surgical debridement and parenteral antibiotic therapy proved effective in treating the septicaemia and the large soft tissue abscesses in the buttock and thigh. Human bone marrow stromal cells lose immunosuppressive and anti-inflammatory properties upon oncogenic transformation. Our results show how the post-transcriptional network is intertwined with the transcriptional network to regulate gene expression in a coordinated way and that the integration of heterogeneous genome-wide datasets allows to relate structure to function in regulatory networks at a system level. Irradiation of tumors was performed in either of 5 moments: 4 h or immediately before SH, in-between SH and HT, 30 min. The incorporation of the surfactants into the lipid membranes is also accompanied by partial dissolution of the lipids from the model SC lipid membranes as confirmed by Fourier-transform infrared (FT-IR) spectroscopy.

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Citridones, new potentiators of antifungal miconazole activity, produced by Penicillium sp. CYP1A1 is overexpressed upon incubation of breast cancer cells with a polyphenolic cocoa extract. Taken together, these changes may be responsible for the observed decrease in NF-kappaB DNA binding activity. Very small embryonic-like (VSEL) stem cells are a rare cell population present in bone marrow, cord blood and other tissues that displays a distinct small cell size and the ability to give rise to cells of the three germ layers. Influence of near null magnetic field on in vitro growth of potato and wild Solanum species. Latin American consensus on hypertension in patients with diabetes type 2 and metabolic syndrome. Co-speech gestures traditionally have been considered communicative, but they may also serve other functions.

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To objectively define criteria for intracranial optic nerve (ON) size in ON hypoplasia (ONH) on magnetic resonance imaging (MRI) scans. In spite of the many pharmacological and physicochemical differences the drugs appeared to have a hypotensive effect of approximately equal magnitude. Repeated presentations of TS or LS were both capable of inducing habituation. The novel environments were the elevated plus-maze, the hole-board and the circular corridor. Video-assisted thoracic surgery (VATS) lung resection is a new alternative surgical approach to thoracotomy for patients with early lung cancer. Human chorionic gonadotropin (HCG) is routinely used for final oocyte maturation triggering in in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) cycles, but the use of HCG for this purpose may have drawbacks.

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Exhaled breath temperature in patients with stable and exacerbated COPD. The rapid prediction of fluid viscosity, especially the fluid in heavy-oil petroleum reservoirs, is of great importance for oil exploration how long after stopping bactrim can i drink alcohol and transportation. Investigating the host response in the early stage of influenza A virus (IAV) infection is of considerable interest. Neuronal dysfunction and changes in cortical excitability occur in RTT individuals and Mecp2-deficient mice, including hippocampal network hyperactivity and higher frequency of spontaneous multiunit spikes in the CA3 cell body layer. Chemical structures of the TU-C and TU-C(red) products derived from E. Proliferative capacity and cytokine production by cells of HIV-infected and uninfected adults with different helminth infection phenotypes in South Africa.

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(2014) measure the contemporary response to natural selection across the genome in multiple cohorts of Atlantic salmon during their first year at sea. Despite new treatment modalities, cyclophosphamide (CYC) remains a cornerstone in the treatment of organ or life-threatening vasculitides and connective tissue disorders. Does advanced airway management improve outcomes in adult out-of-hospital cardiac arrest?. Omeprazole, a gastric proton pump inhibitor, inhibits melanogenesis by blocking ATP7A trafficking. A 2-mm grasper forceps was inserted directly without a trocar below the costal margin. glucophage xr 500mg tablets

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Functional biogeography of oceanic islands and the scaling of functional diversity in the Azores. Thus, we conclude that plakophilin 2 is important for the assembly of junctional proteins and represents an essential morphogenic factor and architectural component of the heart. Leydig cells of UC bulls produced greater (P less than .05) amounts of T in vitro, both without LH or in response to 75 ng LH, than did Leydig cells of IN bulls at 10 mo after gonadal manipulation. An evaluation of two indirect methods of blood pressure measurement in ill patients. One theory associates it with finer-grained attention in the lower field, an idea consistent with a change in relative efficacy with task difficulty. Identification and characterization of errors and incidents in a medical intensive care unit. Modified sagittal split technique for patients with a high lingula. In the intestine, TREM-1 is highly expressed by macrophages, contributing to inflammatory bowel disease (IBD) pathogenesis. Insertion of small pieces of foreign genetic material into somatic cells.

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To determine the risk factors for and relationship between diabetic retinopathy (DR) and diabetic nephropathy vantin dosage (DN), including microalbuminuria and overt nephropathy, in a population-based study of diabetes mellitus (DM) patients in Korea. venulosum, which normally affects sheep and wild ruminants, in cattle suggests aggressive recruitment within the genus. Using an adaptation of a commercially available high sensitivity enzyme-linked immunosorbent assay, the ubiquitous proinflammatory cytokine interleukin (IL)-6 was measured in the normal skin of six healthy volunteers after insertion of the microdialysis catheter. On the other hand, urban greenery systems which are under intense management and maintenance may contribute to the emission of carbon dioxide or other greenhouse gases. These results may provide information on the source of increased thrombin activity in various animal models and in clinical forms of arthritis. The Technical Working Group noted that (i) no strategy will prevent all cases of early-onset GBS infection, (ii) intrapartum antibiotics are associated with rare, but serious, adverse effects, (iii) concerns remain over developing antibiotic resistance, (iv) an economic analysis is required to help inform policy, (iv) reliable bedside diagnostic tests for GBS in early labour are not yet available and (iv) the most important determinant of effectiveness will be compliance with a single national prevention policy. NUP153 and CPSF6 have overlapping binding sites, but each makes unique CA interactions that, when mutated selectively, perturb cofactor dependency. Gemcitabine in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy: a phase II California cancer consortium trial. Apoptosis in glioma-bearing rats after neural stem cell transplantation.

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Monitoring pollution in Tunisian coasts: application of a classification scale based on biochemical markers. Silicon(111)-H surfaces were derivatized with omega-functionalized alkenes in UV-mediated and thermal hydrosilylation reactions to give Si-C linked monolayers. The internet provides abundant web-sites and resources for the practicing forensic toxicologist and those interested in the field of forensic toxicology. LMW-PTP, by means of dephosphorylation of EphA2 kinase, negatively regulates the ephrinA1-mediated repulsive response, cell proliferation, cell adhesion and spreading, and the formation of retraction fibers, thereby confirming the relevance of the net level of tyrosine phosphorylation of Eph receptors. To evaluate the association of intrapartum magnesium sulfate for fetal neuroprotection (MgSO4-FN) with the delivery room resuscitation and neonatal outcomes of preterm infants in an era of minimisation of invasive mechanical ventilation. The serum and urinary BA profiles were also not affected by age. The synthesis of emetine analogue NSC-134754, a potent inhibitor of the HIF pathway, has been accomplished and its structure reassigned. Altered mesenteric perfusion may be a contributor to the development of necrotising enterocolitis in patients with hypoplastic left heart syndrome. Microsatellite markers were developed to investigate genetic diversity and genetic structure of Euryale ferox, a vulnerable aquatic plant. Wuhu and its surrounding 6 counties are served by a single psychiatric hospital.

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