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Cardizem (Diltiazem)

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Cardizem is a calcium channel blocker. It relaxes your blood vessels and decreases the amount of work the heart has to do. It treats and/or prevents chest pain (also called angina). Cardizem is taken four times a day. The total amount in a day typically ranges from 180–360 mg.

Other names for this medication:
Altiazem, Angizem, Cardem, Cardiorex, Cartia, Coriem, Dicard, Dilacor, Dilcardia, Dilcontin, Dilcor, Dilgard, Dilocor, Dilter, Diltia, Diltiaz, Diltiazem, Dilticard, Diltime, Diltp, Dilzem, Heartil, Icidil, Ionozem, Kaizem, Masdil, Onzem, Taztia, Tiamate, Tiazac

Similar Products:
Valium, Viagra, Differin, Altace, Lozol, Paxil, Moduretic

Also known as: Diltiazem


{name} (diltiazem) is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels.

{name} is used to treat hypertension (high blood pressure). It may be used alone or in combination with other high blood pressure medications.

{name} is also used to treat chronic stable angina (chest pain) and angina due to coronary artery spasm.


This section provides information on the proper use of a number of products that contain diltiazem. It may not be specific to Cardizem LA. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended-release tablet, extended-release capsule, or tablet whole. Do not open, crush, or chew it. It is best to take the extended-release capsule on an empty stomach.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For chest pain: For oral dosage form (extended-release capsules): Adults—At first, 120 milligrams (mg) once a day in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 180 milligrams (mg) once a day, either in the morning or evening. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 30 milligrams (mg) four times a day before meals and at bedtime. Your doctor may increase your dose if needed. Children—Use and dose must be determined by your doctor.

For high blood pressure: For oral dosage form (extended-release capsules): Adults—At first, 180 to 240 milligrams (mg) once a day in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 180 to 240 milligrams (mg) once a day, either in the morning or at bedtime. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of diltiazem can be fatal.

Overdose symptoms may include slow heartbeat, weakness, chest pain, shortness of breath, or fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Cardizem LA dosage information

Side effects

The most common side effects associated with Cardizem are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Reduction of toxic hexavalent chromium by Ochrobactrum intermedium strain SDCr-5 stimulated by heavy metals. The effect of noxious inhalants in the working environment on the degree of airway reactivity in exposed workers. Ser 650 is proximal to the DNA binding domain that contains a nuclear export signal. The information given by these two parameters indicates a strong correlation between the two IF methods. Management of atrial fibrillation in rheumatic valvular heart disease. The actions of 16,16-dimethyl prostaglandin E2 (dmPGE2) were investigated on ion transport in in vitro rabbit fundic mucosa and rat isolated jejunal cells.

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MiMiR: a comprehensive solution for storage, annotation and exchange of microarray data. The patient had hereditary hemolytic anemia with unstable hemoglobin of the Christchurch type. A moderate dose of profadol (1.25 mg/kg) was ineffective as an antagonist of morphine (20 mg/kg). The knockdown resistance mutation and knockdown time in Anopheles gambiae collected from Mali evaluated through a bottle bioassay and a novel insecticide-treated net bioassay. Effect of end-stage renal disease on responsiveness to calmodulin and thyroid hormone of calcium-ATPase in human red blood cells. Besides, it was found that similarly to the picture in mammals there are in chickens granular pneumocytes containing osmiophilic bodies that are in fact globularly winded parallel lamellae. Effects of marcaine, a myotoxic drug, on macromolecular synthesis in muscle. Using an adjusting interval schedule, pigeons were trained to key peck at a relatively constant rate during 45 degrees line tilt presentations and at an extremely low rate in the presence of 0 degrees and 90 degrees line angles.

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Effectiveness of a hospital school mathematics literacy program. Aortic valve mechanics--Part I: material properties of natural porcine aortic valves. Intercept and slope replots were linear and gave a KA of 250 microM and a KB of 10 microM. There is no published data on the interstudy reproducibility of perfusion cardiovascular magnetic resonance which can be used to determine the significance of longitudinal changes in myocardial perfusion after pharmacologic or therapeutic interventions with defined sample sizes. The technique consists of placing water into transparent plastic or glass containers (normally 2L PET beverage bottles) which are then exposed to the sun. When we examined the haplotypes of the three polymorphisms we found significant evidence for biased transmission of one of the haplotypes containing the 480-bp VNTR allele. Estimating equations approach is used to obtain the estimators of regression coefficients and baseline rate function. On the basis of the linkage and biochemical data, it was proposed that the genes are spatially and functionally redundant. Recovery of cholinesterases in soman-injected superior cervical ganglion of the rat in the presence and absence of innervation. We describe six diabetic patients with superimposed immune complex glomerulonephritis.

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According to these observations, BSA has undergone conformational changes that prevent further adsorption to a greater extent than the others. By 8 h the progression of the lesions had subsided and by 24 h there were signs of resolution. Determination of the conversion of air oxidation of penicillin derivatives by high performance liquid chromatography. The results of the clinical use of Bencyclane in cases of ureteric colic are described and discussed. The series included 72 patients with total knee replacement (unilateral 32 patients, bilateral 40 patients). The simple procedure can be completed within 30 min after isoelectric focusing, can detect extremely low levels of pectate lyase (6.4 x 10 mumol of product per min), and is sufficiently sensitive to determine the pectate lyase isozyme profile of a single bacterial colony with a diameter of 4 mm. Shortening of F-actin by gelsolin did not affect this decrease, suggesting that the elastic response of the filaments underlies the osmotically nonideal behavior. The effect of factor Va on lipid dynamics in mixed phospholipid vesicles as detected by steady-state and time-resolved fluorescence depolarization of diphenylhexatriene. A disposable skin stapler (Elite: Auto Suture UK Ltd) and Nylon vertical mattress sutures have been used for skin closure. We discuss our 3-year experience with the small-group format, comprising more than 25 sessions as either learners or facilitators.

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Our model integrates the roles of selenoproteins and specific Se metabolites to account for cancer risk reduction or enhancement. Proceedings: Histochemical mapping of monoamine neurons in the dog brain. Administrated FGF-2-modified MSCs strongly expressed the FGF-2 protein, which was proven by ELISA. The lesion showed early strong enhancement with rim enhancement on dynamic contrast-enhanced MR images, and internal portions of the lesion showed washout on delayed MR images. Repeat right ventricular outflow tract reconstruction using the Medtronic Freestyle porcine aortic root. Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients. Based on this approach, a new quantitative method for DNA assay is presented in this paper. Tension-free hernioplasty versus conventional hernioplasty for inguinal hernia repair. Early onset of puberty: tracking genetic and environmental factors. Using the in-gel activity staining method we have previously shown decreased activity of complex V (F(1)F(0)-ATPase) in male-sterile sunflowers (Sabar et al., 2003).

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Comparison of the degradation rates revealed that the strain degraded TAP most effectively when TAP was used as a sole nitrogen source. protophormiae endo-beta-N-acetylglucosaminidase was very similar to that of Endo-C(II) from Clostridium perfringens. In contrast, the non-conserved C-terminal fragment lacking the typical DNA binding motif, exhibited non-specific DNA binding behaviour. We present our favorable experience with this technique and identify its shortcomings coupled with recommendations to address future technical modifications. Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes.

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A review of retrospective studies of dose-intensity and phase I/II high dose chemotherapy trials, and an analysis of the EBMT registry data is used as evidence to support the case for dose-intensification in ovarian cancer. Because of these techniques, disorders of the globe, structures within the bony orbit, surrounding structures of the eye, and optic pathways can now be diagnosed with much more certainty than before. Nonetheless, we found that cortico-accumbens synapses unexpectedly express normal long-term depression because of a reversible switch in its underlying mechanisms. In addition, the divalent cation copper modulates the conformations of rPrP(c) and rPrP(8OR) differently. The technic is simple, and yet invaluable especially when the tumor locates in the mediastinum escaping from radiological detection. A molecular explanation for the long-term suppression of circadian rhythms by a single light pulse. We recorded age, gender, race/ethnicity, primary language, insurance carrier, age at vesicoureteral reflux diagnosis, initial presentation and vesicoureteral reflux severity. Several compounds under investigation which inhibit conformational change of HA under low pH, endonuclease activity to provide cap of m-RNA, antisense oligonucleotide stable for digestion by endonuclease, artificially synthesized Zn-finger motif peptide etc were reviewed.

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Comparative analysis of methods for calculating the average inhalational exposure loads in the assessment of health risk. Overexpression of JHDM1 reduced the level of dimethyl-H3-K36 (H3K36me2) in vivo. A major component of the conversion factor is the sustainable growth rate. Sigmoidal equations, including logistic and Gompertz equations, are widely used to describe bacterial growth. The mechanism by which EFS causes C1 secretion remains to be determined. The M-receptor antagonism of a new cholinolytic compounds TBBB in comparison with hyocine bromide (HBB) and atropine.

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Chemically defined medium for cultivation of several epiphytic and phytopathogenic spiroplasmas. The delay observed with strain 32H1 could be eliminated by incubating the rhizobial suspension, before inoculation, for 4.5 h either in the cowpea rhizosphere/rhizoplane condition or in the root exudate of cowpea plants, grown without NH(4) in the rooting medium. Role for dopamine neurons of the rostral linear nucleus and periaqueductal gray in the rewarding and sensitizing properties of heroin. Individual serotypes have different temporal patterns of circulation and can be associated with different clinical manifestations. A total of 75 strains (including 5 reference strains) of Bacillus amyloliquefaciens, B. In adolescent patients on CCPD therapy, a continuous maintenance dose of intraperitoneal ceftazidime in the absence of a loading dose achieves serum and dialysate levels greater than the mean inhibitory concentration of sensitive organisms within 4 hours that persist for 24 hours. Reconstruction and management of posterior urethral and straddle injuries of the urethra. The orbital branch of the infraorbital artery is an important surgical landmark but is frequently omitted from texts that discuss orbital anatomy and surgical technique. The trial was terminated early after 6.8 years of follow-up (planned duration, 8.5 years). A glucose solution taken three hours prior to the exercise (G3) resulted in the lowest heart rates at each work rate.

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Inflammatory markers are increased in chronic obstructive pulmonary disease (COPD) and are hypothesised to play an important part in muscle dysfunction and sulfasalazine 500 mg reviews exercise intolerance. A network of tubular lysosomes extends through the cytoplasm of J774.2 macrophages and phorbol ester-treated mouse peritoneal macrophages. Toxocara canis is an uncommon parasite of man, who is not the normal host for the nematode. Radiographic evaluation of the fate of developing tooth buds on the fracture line of mandibular fractures. We propose that induction of inappropriate ICER levels lead to defects in the secretory process of pancreatic beta-cells possibly contributing, in conjunction with other known deleterious effects of hyperglycemia, to defective insulin release in type 2 diabetes. To define causes of dementia, we reviewed all diagnoses, imaging study results, laboratory test results, and clinical courses, as recorded historically in the patient dossier. The inferior vena cava was always ligated to prevent recurrences. Intestinal alkaline phosphatase (ALP) is more prevalent in individuals of blood group O or B, and increases after a meal, especially on a high-fat diet. Reaction time (RT) did not vary between patients and controls in the visual face-in-the-crowd task or on a measure of psychomotor speed.

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In this study oxidative stress initiated by 6-hydroxydopamine caused mitochondrial dysfunction, activation of caspases 3/7, nuclear fragmentation, and apoptosis. In vitro studies showed that BMP-2 and -7 stimulated cellular migration and invasion of prostate cancer cells in a dose-dependent fashion, although BMP-4 had no effect. The fact that about one in five males sampled in northwestern Ireland is likely a patrilineal descendent of a single early medieval ancestor is a powerful illustration of the potential link between prolificacy and power and of how Y-chromosome phylogeography can be influenced by social selection. Tyrosine, histidine and tryptophan residues in chymotrypsin in the presence of substrate and in diisopropylphosphorylchymotrypsin. Laboratory data revealed markedly elevated serum concentrations of aldolase and creatine phosphokinase, and the presence of pigment granular casts and myoglobin in the urine. It has been proven that the dye does not show bactericide and bacteriostatic properties against the bacteria which were tested. Sustained or enhanced MMP-9 secretion, however, has been demonstrated to contribute to the pathophysiology of numerous diseases, including arthritis and tumor progression, rendering this enzyme a major target for clinical interventions. The performances of the uncertain/mild cognitive impairment (MCI) patients on the Alzheimer Disease Assessment Scale-Cognitive (ADAS-Cog) subscale were compared with those of normal controls, Alzheimer disease patients with CDR 0.5, and Alzheimer disease patients with CDR 1.0. Perinatal care regionalization and acceptability by professionals in France.

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The specific radioactivity-time curves for cholesterol-(14)C and cholestanol-(14)C suggested a precursor product relationship and provided additional evidence for the transformation of cholesterol into cholestanol. High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism. Successful surgical correction of bilateral ureteral compression after aortofemoral bypass surgery. Effects of Cd contamination on paddy soil microbial biomass and enzyme activities and rice physiological indices. With the increase of long-term survivors following renal transplantation, aorto-iliac aneurysms requiring surgical management may be encountered more often. The results obtained firmly indicate that Sp1 binding molecules based on PNA-DNA-PNA chimeras are powerful decoys, as they efficiently inhibit the interactions between Sp1 and the uPAR promoter elements. The use of antibody microarrays continues to grow rapidly due to the recent advances in proteomics and automation and the opportunity this combination creates for high throughput multiplexed analysis of protein biomarkers. We report a 33-year-old trader with bilateral traumatic anterior hip dislocation following a road traffic accident. We found that the expression of dharma was upregulated or ectopically induced by misexpression of a Wnt protein and cytoplasmic components of the Wnt signaling pathway and downregulated by the expression of dominant-negative Tcf3.

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This indicated that p18-deficiency synergizes, at least partially, with lpr-mediated pathology. These results demonstrate that the Np24 domain plays an important role in RNA packaging and is in agreement with evidence that suggests that correct intracellular targeting of Gag to the nuclear compartment is an fundamental step in the retroviral life cycle. A new macrocyclic DOTA-like ligand (BPAMD) for bone imaging and therapy containing a monoamide bis(phosphonic acid) bone-seeking group was designed and synthesized. The experimental results show that the (207)Pb chemical shifts are strongly influenced by the cost of lipitor generic local electronic structure. Lower cognitive performance in healthy G2019S LRRK2 mutation carriers.

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Iron-starved meningococci grown at either pH 7.2 or 6.6 were capable of removing and incorporating iron from human transferrin by a saturable, cell surface mechanism that specifically recognized transferrin rather than iron. CP-induced neuropathy was symmetrical, distal and predominantly sensory in character, though minor to moderate motor signs were only evident in severely affected patients. Fractures of the proximal fifth metatarsal, other than those involving the tuberosity, have a tendency to delayed union or even nonunion. Randomized trial of an information system with clustering at the practice level. In the case of the artery, an action potential was superimposed on the EJP. pneumophila pilD mutant lost the ability to cleave lysophosphatidylcholine. Studies in a variety of organisms as diverse as molluscs, insects, birds and mammals have shown that memories can exist in a variety of temporal domains ranging from short-term memories in the range of minutes to long-term memories lasting a lifetime. Irrespective of fiber type, there were significant differences between the groups with regard to muscle-fiber mitochondrial (runners greater than lifters greater than controls) and lipid content (runners greater than controls greater than lifters).

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Ultrastructural demonstration of retrovirus antigens with immuno-gold staining in prodromal acquired immune deficiency syndrome. NO-dependent osteoclast motility: reliance on cGMP-dependent protein kinase I and VASP. A specimen obtained at suprapubic exploration consisted of fatty tissue and tentative diagnosis was pelvic lipomatosis. Letter: Clofibrate-induced antinuclear factor and lupus-like syndrome. The current status of two difficult and controversial issues--confidentiality of preliminary results of clinical studies and is it safe to take tetracycline while breastfeeding compensation for research-related injuries--is outlined.

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Studies 3 and 4 explored the boundary conditions of this effect and found that perceived heartbeat had less influence on deception when people are mindful or approach the decision deliberatively. The detection of unusually cold-adapted EEA in environmental samples has ramifications not only to polar ecosystems and carbon cycling but also to protein evolution, biotechnology and bioremediation. In this report, tissue microarray analysis of 190 breast carcinomas from a nested case-control study shows that EZH2 is significantly associated with interval breast cancers. Data on early complications was available for all patients, while long-term follow-up data was available for 50 patients. We demonstrate that asbestos activates p53 promoter activity, mRNA levels, protein tofranil mg expression, and Bax and p53 mitochondrial translocation. A randomization test revealed significant changes in bacterial structure between samples, while canonical correspondence analysis (CCA) related each individual ARISA profile to linear combinations of the chemical variables (mineralogy, major element and heavy metal concentrations) revealing the geochemical factors that correlated with changes in the ARISA data. Invited lecture from the ASHT Annual Meeting, San Antonio, September 2005.

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Some of these mutants were found to accumulate indole-3-acetic acid (IAA) and tryptophan in culture. The highest rate of sulfurylation of delta 5P and D is found in the cytosol of the fetal zone (5 nmol min-1 mg protein-1). After a total dose of 30 mg was administered, she was hospitalized with disturbance of consciousness. A total of 121 patients with upper urinary tract calculi underwent SWL treatment. Eighty-one postmenopausal women with hemiplegia were admitted within 6 mo of their first cerebrovascular accident. Characteristics of the obesity syndrome in Zucker-Brown Norway (ZBN) hybrid rats.

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The technique is simple, allows serial or concurrent estimates of mitotic activity to be made in the same animal, and eliminates problems associated with intravenous colchicine administration. Purified lipopolysaccharide from Ap serotype 6 was used as antigen. The anorexia rat model was established by feeding special prepared forage for one week, and all the model rats were administrated with EBG by gavage for 3 weeks. Thus, TRH is absolutely required for both TSH and TH synthesis but is not necessary for thyrotroph cell development. The aim of this study was to carry out a preliminary trial evaluating the effectiveness of homeopathy in the treatment of attention-deficit/hyperactivity disorder (ADHD). We compared the clinical profiles of 69 seropositive type 1 AIP patients, 21 seronegative type 1 AIP patients and 22 type 2 AIP patients. Formate and hydrogen blocked the energetically unfavorable succinate oxidation to fumarate involved in propionate catabolism. Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter.

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