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Cardzaar (Losartan)
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Cardzaar

Cardzaar belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body which binds to receptors in blood vessels, causing them to tighten. This results in an increase in blood pressure. Cardzaar prevents the binding of angiotensin-II to these receptors, causing the blood vessels to relax which in turn lowers the blood pressure. Cardzaar slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes.

Other names for this medication:
Acetensa, Cosart, Cozzar, Forzaar, Hilos, Lifezar, Loben, Lopernal, Losadel, Losalet, Losap, Losardil, Losartas, Losartax, Losartic, Losatan, Losavik, Lostan, Lostat, Myotan, Nefrotal, Niten, Rasoltan, Resilo, Rosatan, Sarlo, Satoren, Sedeten, Sortal, Sortiva, Tanlozid, Tiasar, Zaart

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Also known as: Losartan

Description

Cardzaar (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Cardzaar is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Cardzaar is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Cardzaar 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Cardzaar 25 mg, Cardzaar 50 mg, and Cardzaar 100 mg may also contain carnauba wax.

Dosage

Usual Adult Dose for Diabetic Nephropathy:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Adult Dose for Hypertension:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Pediatric Dose for Hypertension:

6 Years or Older: Initial dose: 0.7 mg/kg orally once a day (up to 50 mg total) Comments: -May be given as a tablet or suspension. -Doses above 1.4 mg/kg (or 100 mg) daily have not been studied in pediatric patients.

Detailed Cardzaar dosage information

Overdose

If you overdose Cardzaar and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Cardzaar overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Cardzaar are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Cardzaar if you are allergic to Cardzaar components. Do not take Cardzaar if you're pregnant or you plan to have a baby, or you are a nursing mother. Cardzaar can harm your baby. Do not use Cardzaar if you are taking salt substitutes or potassium supplements, other blood pressure medicine, diuretic (water pill). It can be dangerous to use Cardzaar if you suffer from or have a history of liver disease, kidney disease, heart failure. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Avoid machine driving. Do not stop taking Cardzaar suddenly.

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The stratification of social capital and its consequences for self-rated health in Taganrog, Russia. Methanogenesis in an Upflow Anaerobic Sludge Blanket Reactor at pH 6 on an Acetate-Propionate Mixture. We report the case of a 57-year-old gravida 5 para 4 woman with vulvar AA arising from the left labium majus, which recurred 20 years after initial surgery. An mRNA-rRNA base-pairing mechanism for translation initiation in eukaryotes. Transthoracic echocardiography and aortography showed a noncoronary cusp ASV with rupture into the right atrium but without VSD. Bacterial Growth Rates and Competition Affect Nodulation and Root Colonization by Rhizobium meliloti. There was a strong negative correlation (-0.85) between the Salmonella inactivation rate and the maturity of compost in non-sterilized compost. No cells expressing CD1a and S-100 were observed in the intima and media of normal saphenous veins.

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Brain natriuretic peptide plasma level is a reliable indicator of advanced diastolic dysfunction in patients with chronic heart failure. The assessment of right ventricular function and pulmonary artery hemodynamics in patients with pulmonary hypertension by 1.5T MRI. Further, our in vitro analyses demonstrate that in trout mononuclear phagocytes, LPS fails to induce antiviral genes, an event that occurs downstream of TLR4 and is required for the development of endotoxic shock. This peptide was truncated to 15 mer and this also demonstrated ability to inhibit HCV RNA-directed translation as well as replication. Observation of patients with vesicoureteral reflux off antibiotic prophylaxis: physician bias on patient selection and risk factors for where to buy protonix over the counter recurrent febrile urinary tract infection. In addition to increased epinephrine excretion, increased urinary excretion of N-methylepinephrine was found in three out of five patients with histologically proven pheochromocytoma. Accordingly, a whole new field of applications is opened for image guided interventions, where the registration is continuously performed to match the real-time x-ray.

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Differences in the DNA methylation pattern between the offspring of High and Low licking/grooming--arched-back mothers emerge over the first week of life, are reversed with cross-fostering, persist into adulthood and are associated with altered histone acetylation and transcription factor (NGFI-A) binding to the glucocorticoid receptor promoter. Blood flow to the ruminoreticular epithelium varies cyclically with feeding. Biphenylsulfonacetic acid inhibitors of the human papillomavirus type 6 E1 helicase inhibit ATP hydrolysis by an allosteric mechanism involving tyrosine 486. An evaluation of automated in silico ligand docking of amino acid ligands to Family C G-protein coupled receptors. Methanosarcina mazei S6 and LYC were used to study the structure and differentiation of the aggregating methanogens. Taking into consideration the consumption pattern of asbestos in recent decades, the incorporation of motrin dose chart by weight later cohorts will improve the estimation.

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We studied the roles of the ubiquitous inflammatory transcription factors, NF-kappaB and AP-1, in activation of the TGF-beta1 gene and histone acetylation at the TGF-beta1 promoter. The synthesis and biological activities of acidic, basic and neutral types of butyric acid (BA) prodrugs possessing increased aqueous solubility are described. New evolutionary lineages, unexpected diversity, and host specificity in the parabasalid genus Tetratrichomonas. Coevolutionary arms races between species can favor exaggeration of traits for attack and defense, but relentless escalation of these arms races does not necessarily occur in all populations. No significant elevations of the permeability-surface area products for either compound were detected in clinically affected experimental animals when compared to neurontin gabapentin pills controls. A hairpin-like secondary structure in the intercistronic region between genes J and F of bacteriophages, phi X174 and G4 has been postulated to act as a transcription termination signal. These results suggest that SNB warrants further multi-institutional studies.

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The uptake and disposition of dl-norepinephrine in perfused rat lung. The participants identified many issues that would not have been considered by the authors, issues that were used to form the content of three information booklets for patients having bowel surgery. It seems likely that oxidation of L-cysteine does not require the presence of several copper ions constituting the catalytic centre of the blue oxidase (Cp.). In individuals with a family history of diabetes, retinopathy signs predict subsequent risk of clinical diabetes. A comparative study of sperm production in two species of Australian arid zone rodents (Pseudomys australis, Notomys alexis) with marked differences in testis size. Moreover, each ganglion receives projections from a distinct set of spinal cord segments. As the long-term consequences of these observations are unknown, the safety of treatment interruption must be further studied. Our results demonstrate that the IR absorption spectra of glycosylated proteins show distinct absorption bands for the sugar moiety, the protein amide group, and water. Hematologic toxicity was assessed separately in non-tumor-bearing NIH Swiss mice. Characteristics, specificity, and efferent control of frog cutaneous cold receptors.

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