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Catapres (Clonidine)
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Catapres

Catapres lowers blood pressure, but isn't a first choice for treating high blood pressure (hypertension) due to side effects and risk of withdrawal. Catapres is an alpha agonist medication that lowers blood pressure by telling the brain to reduce the activity of stress hormones. Fewer stress hormones leads to more relaxed blood vessels.

Other names for this medication:
Arkamin, Clodict, Clonidine, Jenloga

Similar Products:
Crestor, Detrol, Albenza, Dulcolax, Xenical, Plavix, Vantin, Lipitor, Actos

Also known as: Clonidine

Description

Clonidine transdermal is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk for heart attacks. These problems may be less likely to occur if the blood pressure is controlled.

Clonidine belongs to the class of medicines called antihypertensives. It works in the brain to change some of the nerve impulses. As a result, the blood vessels relax and blood passes through them more easily, which lowers blood pressure. When the blood pressure is lowered, the amount of blood and oxygen going to the heart is increased.

This medicine will not cure your high blood pressure, but it does help control it. Therefore, you must continue to use it as directed if you expect to lower your blood pressure and keep it down. You might have to take high blood pressure medicine for the rest of your life.

This medicine is available only with your doctor's prescription.

Dosage

Usual Adult Dose for Hypertension:

Oral: -Initial dose: 0.1 mg orally 2 times a day (morning and bedtime) -Titration: Increments of 0.1 mg orally per day may be made at weekly intervals to desired response -Maintenance dose: 0.2 to 0.6 mg orally per day in divided doses -Maximum dose: 2.4 mg orally per day in divided doses Comments: -Taking the larger portion of the oral daily dose at bedtime may minimize transient adjustment effects of dry mouth and drowsiness Transdermal patches: -Initial dose: 0.1 mg/24 hr patch applied every 7 days -Maintenance dose: If, after 1 to 2 weeks the desired reduction in blood pressure is not achieved, increase the dosage by adding another 0.1 mg/24 hr patch or changing to a larger system -Maximum dose: Doses above two 0.3 mg/24 hr patches applied every 7 days is usually not associated with additional efficacy Comments: -The transdermal patch should be applied to a hairless area of intact skin on the upper outer arm or chest. -Each new patch should be applied on a different skin site from the previous location. -If the patch loosens during 7-day wearing, the adhesive cover should be applied directly over the system to ensure good adhesion. -There have been rare reports of the need for patch changes prior to 7 days to maintain blood pressure control. -When substituting patches for the oral formulation or for other antihypertensive drugs, physicians should be aware that the antihypertensive effect of the patches may not commence until 2 to 3 days after initial application; therefore, gradual reduction of prior drug dosage is advised. Some or all previous antihypertensive treatment may have to be continued, particularly in patients with more severe forms of hypertension. Use: For hypertension, alone or in combination with other antihypertensive agents

Detailed Catapres dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include feeling cold, irritable, weak, drowsy, or light-headed, or having weak reflexes, pinpoint pupils, slow heartbeats, shallow breathing, or a seizure.

Storage

Store the patches at room temperature in a closed container, away from heat, moisture, and direct light.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

After removing a used patch, fold the patch in half with the sticky sides together. Make sure to dispose of it out of the reach of children and pets.

Detailed Catapres-TTS dosage information

Side effects

The most common side effects associated with Catapres are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Catapres if you are allergic to clonidine.

To make sure Catapres is safe for you, tell your doctor if you have:

heart disease or severe coronary artery disease; a heart rhythm disorder, slow heartbeats; high or low blood pressure, or a history of fainting spells; a heart attack or stroke; pheochromocytoma (tumor of the adrenal gland); kidney disease; or if you have ever had an allergic reaction to a Catapres TTS patch.

It is not known if clonidine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of clonidine on the baby.

Clonidine may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using this medicine.

If you are breastfeeding, tell your doctor if you notice somnolence, tiredness, rapid breathing, and poor feeding in the nursing baby.

Catapres is not approved for use by anyone younger than 18 years old.

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When assessing the activity in vivo, it appears to be highly dependent on associated serum factors. To this end a library of HIC gels (Seph-C4 to Seph-C6) of different immobilized alkyl residue concentrations was synthesized and tested with purified bovine fibrinogen. By dephosphorylating PtdIns-3,4,5-P3, PTEN acts in opposition to phosphatidylinositol 3-kinase (PI3K), which has a pivotal role in the creation of PtdIns-3,4,5-P3. Especially when a pseudocyst is located in close contact with the posterior wall of the stomach, it is best drained by a pseudocyst gastrostomy, which can also be done with the use of an intragastric operative technique. For selected scenarios of true exposure-disease associations and selected patterns of misclassification, we illustrate the inconsistency in naive Poisson regression coefficients and show that it can be difficult to intuitively characterize the nature of the bias. However, in patients with mutations within codons 1445-1580, it may be advisable to postpone elective colectomy because desmoids may arise through surgical intervention. Sample pretreatment consisted of the acidification of whole saliva by phosphate buffer. Intubation offers definitive control of the airway but is not without risk, especially in an environment where experience and resources for pediatric intubation may be limited. The findings of this study support the belief that the PDSN, as a member of the multidisciplinary paediatric diabetes team, has a key role in the education of children with diabetes and their parents/carers.

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The key features of this ideal trial include (1) a prospective definition of early onset of action, (2) increased frequency of assessment, (3) a data-analytic approach capable of capturing the dynamic nature of symptomatic change, and (4) various strategies to minimize bias and heterogeneity of response. Using a new algorithm to prepare the CNL data for chemometrics, discrimination of control and postdose samples could be performed using PCA and PLS-DA. The results indicate that the NKC of placental mammals is highly heterogeneous in terms of the gene content and rates of birth and death of different gene lineages, but the NKC is also remarkably conserved in its gene organization and persistence of orthologous gene lineages. Treprostinil was compared to epoprostenol for the economic impact of treating IPAH patients who failed or were not candidates for bosentan. Primary structure of an alpha-tubulin gene of Physarum polycephalum. Rate of change in carotid intima-media thickness and vascular events: meta-analyses can not solve all the issues. Examination of serial semithin (0.5 micron) methacrylate and paraffin (8 micron) sections of the rat kidney 6, 12, 24 and 48 hours after subcutaneous injection of sublimate in a dose of 0.6 mg/100 g bw has demonstrated that the damage to the different parts of the tubular component of nephron is heterogeneous in nature.

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A 12-yr-old captive intact male maned wolf (Chrysocyon brachyurus) was diagnosed with a fibrosarcoma of the incisive bones. Integration--a key to success in the genetic dissection of complex diseases?. Fifty-five out of 116 patients with childhood OCD classified according to DSM-IV criteria were interviewed personally using structured interviews. Leucine (10 mM) plus glutamine (10 mM), however, were still able to evoke an islet respiratory response after alloxan exposure. Their structures were characterized as polyhydroxyoleanene pentacyclic triterpenoid saponins by spectroscopic and chemical analyses. Analysis of pharmacological behaviours observed with several compounds within these classes, shows that broad-spectrum antibacterial activity, including relevant resistant strains and in vivo efficacy without toxicity are achievable. The results show random or aggregative distributions and variable susceptibilities according to the species. This study examines the association between mitochondrial genotypes and PTD and related outcomes. Oxygen electrode measurements in animal experiments have demonstrated a strong correlation between low tumor pO(2) and excess (60)Cu-ATSM accumulation.

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Bis(adamantan-1-aminium) hydrogen phosphate fumaric acid sesquisolvate. FDA issued guidance for industry regarding pharmarcogenomic data submission this year. We present here a critical review summarising the formation of dynamic polymeric networks through specific non-covalent interactions, with a particular emphasis on those systems based on host-guest complex formation, as well as the characterisation of their physical characteristics. However, the development of reliable, valid, and convincing tests that will distinguish such individuals remains a fascinating medico-legal challenge. The angle of rice leaf inclination is an important agronomic trait and closely related to the yields and architecture of crops.

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The lightspot operated typewriter: a communication aid for severely bodily handicapped patients. Lectin studies to classify the variety of polyagglutination demonstrated the simultaneous exposure of two latent membrane receptors, Tk and VA. Determination of fenpropimorph in citrus fruit by reversed-phase high-performance liquid chromatography. A significant enhancement on the decay rate of ATZ was resulted exclusively by adding the surfactant. Increased knowledge of the etiology of ureteroscope damage should aid urologists in prolonging the lives of these delicate instruments. These geographical differences could be related to immunogenetic factors as the allele HLA-DR6 has been found to be significantly expressed in Italian patients with OLP and HCV infection.

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An examination of the prevalence of and risk factors for shedding of Cryptosporidium spp. In thoracotomy, original tumor and mediastinal lymph node were resected. In vivo and in vitro effects of tumour specific antibodies with chlorambucil. A novel incentive called and Advance Market Commitment could help spur private sector investment in AIDS vaccine research and development. To better define outcome and prognostic factors in primary pineal tumors. Cucumarioside A9 (3), having an uncommon 18-hydroxy group, is the second representative of the unique metabolically active glycosides that are regarded as intermediates of glycoside biosynthesis in sea cucumbers.

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The effect of inhibition of lipolysis on blood concentrations of 3-hydroxybutyrate and acetoacetate. The computerized tomograms and angiograms were correlated with the clinical taking tylenol and motrin while breastfeeding course. The immunomodulating effect of TP5 and indomethacin in burn-induced hypoimmunity. Response to breast health screening program at a not-for-profit clinic for working poor, uninsured, ethnically diverse women. Jaw-closing muscles of kangaroos express alpha-cardiac myosin heavy chain.

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