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Coolam (Alprazolam)

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Coolam is commonly used to treat anxiety and panic disorders. It falls into a category of medications called benzodiazepines. They are known to affect the central nervous system components and produce a calming effect, thus decreasing brain activity.

Other names for this medication:
Alflux, Alzin, Alzoft, Alzolam, Alzoset, Ambusyn, Anlzium, Anzilum, Belfa, Calmtec, Coolam, Cooltime, Endep, Endolam, Enxolam, Esteem, Imprax, Kurelam, Omelam, Plxna, Resto, Silam, Suzilam, Tensyl, Viprax, Zodia, Zolent, Zoloid, Zolyde

Similar Products:
Aurogra, Parlodel, Tricor, Tofranil, Nexium, Hytrin, Zyvox

Also known as: Alprazolam


Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Coolam XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of alprazolam can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Coolam XR dosage information

Side effects

The most common side effects associated with Coolam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

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A limitation of DBS is that additional considerations are required for analysis method development and validation. MCC is very prevalent in the MHS population, increases with age, and except for children is more prevalent in lower socioeconomic classes, possibly due to the a combination of the structure of the Israeli universal insurance and requirements of the ministry of education for exemptions and benefits. The presence of pure and mixed populations representing all three genetic clusters in North America demonstrates that H. In 12 patients, femoropopliteal reconstruction was performed with a contralateral great saphenous vein graft. Magnetic resonance imaging findings of T2 hyperintensities measuring more than 3 mm in diameter and fulfilling at least three out of four Barkhof criteria, with or without gadolinium-enhancing lesions, were considered to be suggestive of MS. (iii) Its ability to output the acquired data in a number of modes, including screen display, hardcopy plot, or disk file that may be transferred to a central treatment planning computer). Many of these situations occur in patients with large stones, and stones associated with obstruction and other problems. Sources of method bias in social science research and recommendations on how to control it. GnRH evokes localized subplasmalemmal calcium signaling in gonadotropes. Appearance of multidisperse low density lipoprotein and altered lipoprotein composition in non-insulin-dependent diabetes with type IIa hyperlipoproteinemia.

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With the same irradiation schedule, the optimal dose of radiation for induction of osteosarcomas was much lower than that for induction of skin tumors. Case illustrations of successful resections of lesions with each module are presented and discussed. 74 patients who met consensus criteria for FTD were evaluated at a two year follow up. It is necessary to understand these effects because controlling them will be a key technology that will very likely be used in future nanometer-scale fabrication processes. In our study we analyzed a group of patients treated with Heimox system during the period August 1996 to December 2000.

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Social and psychological problems of surveys on health and illness. Fractional derivative or fractional calculus plays a significant role in theoretical modeling of scientific and engineering problems. A total of 81 women with BN, BED and healthy controls (HC) took part in an in sensu exposure to idiosyncratic stress. In this study, we show that Nar2 is the main Nar enzyme active in mycelium and could characterize the conditions governing its synthesis. The SERS signal displays a clear polarization-dependent effect when the nanowires are arranged in a row. Changes in polyol, sugar and free amino acid (FAA) body contents were investigated in the aquatic, subterranean (i.e. Oxygen deprivation decreased adenine nucleotides leading to the efflux of nucleosides. This behavior of CYP2C19 was also observed with S-mephenytoin as the substrate. The pA2 values obtained did not differ significantly, indicating that the two agonists exert their effect on the same receptor. Atrial septal defect (ASD) is one of the most common congenital heart defects in adults.

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A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels. These results suggest that the linear amphipathic peptides in spider venoms and neuropeptides cooperate to capture insects efficiently. Screening has been recommended to reduce the prevalence and morbidity associated with genital chlamydia infection in the United Kingdom. The supposition that day hospitals would provide an acute service, while day centres would offer social support for a more chronic population has been contentious and there is little evidence of how they are currently used. It was established that it ensures a stable therapeutic effect in primary expiratory stenosis. In this study, 39 children admitted to our hospital with ischemic stroke were evaluated according to etiologic factors and treatment regimens with comparison to the literature. The aim of this study was to identify the risk factors for delayed hemorrhage after a colonoscopic polypectomy. However, the relationship between tumor MVD and the clinicopathological characteristics of rectal cancer are unclear.

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Jmjd2b and Nanog act through an interconnected regulatory loop, whereas Jmjd2c assists PRC2 in transcriptional repression. Most treatments have only been evaluated in 1 or 2 studies, which limits the generalizability of the findings. LS-OC-SVM extracts a hyperplane as an optimal description of training objects in a regularized least squares sense. Methanol and ethanol modulate responses to danger- and microbe-associated molecular patterns. Among the optimized parameters, SNR and CNR were dependent on TP, and inflow artifacts were reduced by increasing NR. The repeat DGA rate was cause for concern as was the quality of referrals. XLOS-observed mutations of MID1 Bbox1 domain cause domain unfolding.

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In 3 of the 5 cases of renal stones, variable amounts of glafenine were found in the zone of nucleation. Induction of DNA damage signaling genes in benzidine-treated HepG2 cells. In addition, PYR41, an inhibitor of ubiquitin activating enzyme E1, blocked the fenretinide-mediated decrease in SCD. The database is designed for researchers who require information on how to make best use of valuable biospecimens from biobanks and other sample collections, focusing on the choice of analytical techniques and the demands they make on the type of samples, pre-analytical sample preparation and amounts needed. Leptin, 16kDa product of obese gene, is adipocytokine playing critical role in regulation of body weight. Since TXNIP is induced by HG in most cells, its effects are not restricted to a particular cell type in DR. Normal skin and keloid fibroblasts derived from human donors were compared. Adverse side-effects mined from and were found to match the Adverse Drug Reactions on the Drug Package Labels of several drugs. When the tissues were contracted with PGF2 alpha in the presence of pyrilamine, histamine produced the relaxation of the circular muscle but not longitudinal muscle.

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Behaviour of several enzymes of fetal chick intestine in tissue culture. Topotecan efflux was inhibited and accumulation was partially restored in CL1/Tpt and MCF7/TPT cells when cells were incubated simultaneously with gefitinib. Some members of the scientific community in the United States and Europe have suggested the use of PM1 instead of PM2.5 as the fine particle measurement standard. Based on these results, we concluded that the closely related Arf GAPs, AGAP1 and AGAP2, distinguish between these related heterotetrameric adaptor protein complexes to specifically regulate AP-3 endosomes and AP-1 recycling endosomes. These results indicate that protracted seizure susceptibility following peripheral APR is associated with a robust polygenic response in the hippocampus. If participants were unable to answer by themselves due to physical condition, public health nurses read out each item and wrote in their answers. The cultures in the first region, low feed rates (0.5 and 1.0 d(-1)) combined with low bleed rates (0.05 and 0.10 d(-1)), were nutrient-limited, as an increase in the feed rate resulted in an increase in the viable-cell density. Risk of breast cancer and family history of other cancers in first-degree relatives in Chinese women: a case control study.

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Is atherosclerosis a multifactorial disease or is it induced by a sequence of lipid peroxidation reactions?. Spatio-temporal dipole source modeling of electrophysiological data revealed a significant difference between standard and deviant gap stimuli, with mismatch negativity responses that were comparable in amplitude and latency for within- and between-channel conditions. Use of pet food-grade poultry by-product meal as an alternate protein source in weanling pig diets. No differences were found between groups on smoking in the presence of negative affect or coffee, although heavier smokers smoked a greater proportion of cigarettes when experiencing low energy positive affect (e.g., calm). Preparation of human tissue for antigen labelling with monoclonal antibodies. Marital differences in blood pressure and the risk of hypertension among Polish men. The authors retrospectively reviewed 743 consecutive patients hospitalized at a tertiary referral center with a diagnosis of PE based on multi-detector row CT scan. In addition, their overall sleep architecture and, more importantly, parameters that quantify the time-varying sleep spindle morphology were affected.

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Patients with cancer have identified sexuality issues as being of equal importance to other quality-of-life issues. We observed a significantly reduced myelopathy rate at an intermediate radiation dose level and a longer time to myelopathy at a high-dose level. The scoring system provides a measure that discriminates between abused and non-abused children, which should be straightforward to implement, though the results must be interpreted carefully. In addition to an increasingly westernised diet, the traditional Chinese diet also plays a part, with the quantity and quality of rice intake linked to the risk of type 2 diabetes. Host immunological response and factors associated with clinical outcome in patients with the novel influenza A H7N9 infection. These findings suggest that speech motor control matures beyond young adulthood and that linguistic complexity in a repetitive task does not appear to have a consistent effect on measures of speech movement. The impact of postmastectomy radiotherapy on two-stage implant breast reconstruction: an analysis of long-term surgical outcomes, aesthetic results, and satisfaction over 13 years. Polyethylene glycol (PEG) polymers attached to biotherapeutic molecules enhance in vivo delivery and stability of these large molecular weight drugs.

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The sensitivity of this assay is better than another LC-MS/MS GLP-1 assay previously reported and many commercially available immunoassays. Taste function in xerostomia before and after treatment with a saliva substitute containing carboxymethylcellulose. This paper comments on the development history of the health education for parasitic disease prevention and control, current intervention modes and the effect of the health education for parasitic diseases in rural area. Progress in myambutol the epidemiologic study of variant Creutzfeldt-Jakob disease. Challenges in evaluating all-cause hospital readmission measures for use as national consensus standards. All these results suggest that the enhanced anti-opioid system may contribute to the development of morphine tolerance and dependence, and their contribution could be brain locus specific.

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Doses of melatonin were varied, to verify its physiological and pharmacological effects. Our research focuses on the potential role of hypoxia-inducible factors (HIFs), vascular endothelial growth factor (VEGF), and platelet-derived growth factors as well as the extracellular signal-regulated kinase (ERK), phosphatidylinositide 3-kinase /protein Kinase B (PI3-K/AKT) pathway in hypoxia-mediated abilify maintena 300 mg pray intimal hyperplasia processes. Priority directions in theoretic and applied research are presented, main results are given. The rapid dissemination of the 2009 pandemic H1N1 influenza virus emphasizes the need for universal influenza vaccines that would broadly protect against multiple mutated strains. The association of complication type with mortality and prolonged stay after cardiac surgery with cardiopulmonary bypass. Dosages were: 0, 0.5, 1, 2, 4, 5, 6, and 7.4 mg of AFB1/kg of body weight. Risk communication is a key element in fracture prevention and should have greater focus on less well-known risk factors. Ultrasound study of anal fistulas with hydrogen peroxide enhancement. In Canada, until recently immunization against pertussis in public programmes has been restricted to children under the age of 7. There was low-quality evidence that women with fibromyalgia can safely perform moderate- to high-resistance training.

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Establishing an evidence base for frequency of monitoring glycated haemoglobin levels in patients with Type 2 diabetes: projections of effectiveness from a regression model. Anterior cruciate ligament (ACL) tears are commonly seen injuries. Various potential reasons for this zithromax 500 mg dose discrepancy are discussed with several proposals for improving distance perception in peripersonal virtual environments. Elevations of Yp levels are characteristic of the cell culture system and factors regulating Yp transcription in nodules and carcinomas may also be operative in cultured hepatocytes. The hypothesis was that renal and patient survival would be better in CA-AKI than in HA-AKI. In the present study, we searched for proteins that interact with the GTPase activating protein (GAP) domain region of AS160 by the yeast two-hybrid screen. The objectives of the paper are to depict the rationale for a Youth Multi-function Centre, to broadly conceptualise a Youth Multi-function Centre, and to report on the process and methodology followed in an attempt to actually establish such a centre in Thabong/Welkom. However, few large, multisite studies have directly compared the benefits and harms of these procedures. Young women often have access to fewer resources to make expected behavior changes during pregnancy. (2) What is the median duration of each sequential chemotherapy regimen and subsequent survival of women following each sequence of chemotherapy regimen in MBC?.

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These strains of Bacillus caused growth inhibition of several phytopathogenic fungi, including Fusarium spp., Aspergillus spp., and Bipolaris sorokiniana. Valganciclovir is a highly recognized substrate of the intestinal peptide transporter PEPT1, which underlies the tenfold higher bioavailability of ganciclovir after valganciclovir compared to oral ganciclovir administration. In white mice infected with influenza virus A/England 42/72 dipyridamole administered orally showed a protection rate of 62.5 per cent. Both a general hydroxamate inhibitor of MMP activity and anti-MMP-12 antibodies restored this SSc MVEC-induced impaired functioning. PS concentration, fluence rate and oxygenation were independently controlled and monitored during the treatment. In proximal colon, butyrate increased the frequency of full-length propagations, decreased short propagations, and had a biphasic effect on non-propagating contractions. Children with NHIF at diagnosis had significantly lower chance of abandoning treatment and higher chance of survival. Epinephrine enhanced net glycogenolysis during contractions most markedly in slow-twitch red fibers.

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We recently introduced a novel cytochemical approach to high-resolution cytochemistry of phospholipids in biological tissues. No evidence of parvovirus B19, Chlamydia pneumoniae or human herpes virus infection in temporal artery biopsies in patients with giant cell arteritis. In a population-based prospective cohort study, among 8482 pregnant women, we examined whether blood pressure in early pregnancy tracks to third trimester and whether this tracking is influenced by maternal characteristics and is associated with the risk of gestational hypertensive disorders. Many areas of chloroplast research require methods that can assess the quality and quantity of chloroplast DNA (cpDNA). Chlamydiaceae were demonstrated in epithelial cells and macrophages in association with pyogranulomatous pyelonephritis (8/11 kidneys), focal interstitial nephritis (3/21), and active inflammation and fibrosis of the entire upper female reproductive tract (10/10).

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The concentrations of indolamines in the cisternal CSF reveal that psychotomimetic indolamines like 5MeODMT, 5MeOT and DMT and the indolamines N-Met and Try are present in psychological and pathological states. Excipient-process interactions and their impact on tablet compaction and film coating. To do this we compared astrocytic basic fibroblast growth factor and glial fibrillary acid protein immunoreactivity in hypothalamic nuclei and the cingulate cortex, area 2 among groups of cycling, late pregnant and lactating rats as well as in ovariectomized and ovariectomized hormone-replaced females. About 20 thread-like nematodes, identified as Capillaria plica larvae and fragments of adult stages, were found in the urine sediment. The pulmonary artery and capillary pressures fell to a normal level after a few months. We exposed rat astrocytes to FB1 with the aim of evaluating the involvement of oxygen free radicals and albenza 200 mg price of some other biochemical pathways such as caspase-3 activity and DNA damage.

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