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Cytoxan (Cyclophosphamide)
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Cytoxan

Cytoxan is in a class of medications called alkylating agents. When Cytoxan is used to treat cancer, it works by slowing or stopping the growth of cancer cells in your body. When Cytoxan is used to treat nephrotic syndrome, it works by suppressing your body's immune system.

Other names for this medication:
Cyclomet, Cyclophosphamide, Cycloxan, Cycram, Cycrame, Cydoxan, Cyphos, Eldamide, Endoxan, Ledoxan, Neophos, Neosar, Oncomide, Oncophos, Oncoxan

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Also known as: Cyclophosphamide

Description

Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin). It belongs to the group of cancer medicines called alkylating agents.

Cyclophosphamide is also used for some kinds of kidney disease.

Cyclophosphamide interferes with the growth of cancer cells, which are then destroyed by the body. Since the growth of normal body cells may also be affected by cyclophosphamide, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with cyclophosphamide, you and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain cyclophosphamide. It may not be specific to Cytoxan Lyophilized. Please read with care.

Take this medicine only as directed by your doctor. Do not take more or less of it, and do not take it more often than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Taking too much may increase the chance of side effects, while taking too little may not improve your condition.

Cyclophosphamide is sometimes given together with certain other medicines. If you are using a combination of medicines, make sure that you take each one at the proper time and do not mix them. Ask your doctor to help you plan a way to remember to take your medicines at the right times.

While you are using cyclophosphamide, it is important that you drink extra fluids so that you will pass more urine. Also, empty your bladder frequently, including at least once during the night. This will help prevent kidney and bladder problems and keep your kidneys working well. Cyclophosphamide passes from the body in the urine. If too much of it appears in the urine or if the urine stays in the bladder too long, it can cause dangerous irritation. Follow your doctor's instructions carefully about how much fluid to drink every day. Some patients may have to drink up to 7 to 12 cups (3 quarts) of fluid a day.

Usually it is best to take cyclophosphamide first thing in the morning, to reduce the risk of bladder problems. However, your doctor may want you to take it with food in smaller doses over the day, to lessen stomach upset or help the medicine work better. Follow your doctor's instructions carefully about when to take cyclophosphamide.

Cyclophosphamide often causes nausea, vomiting, and loss of appetite. However, it is very important that you continue to use the medicine even if you begin to feel ill. Do not stop taking this medicine without first checking with your doctor. Ask your doctor for ways to lessen these effects.

If you vomit shortly after taking a dose of cyclophosphamide, check with your doctor. You will be told whether to take the dose again or to wait until the next scheduled dose.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets): For the treatment of cancer: Adults—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 5 milligrams (mg) per kilogram (kg) of body weight per day. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 5 mg per kg of body weight per day.

Overdose

If you overdose Cytoxan and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature at or below 25 degrees C (77 degrees F) away from moisture and heat. This medicine can be stored at room temperatures of up to 30 degrees C (86 degrees F) for a short time. Protect from temperatures above 30 degrees C (86 degrees F). Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Cytoxan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Okadaic acid markedly increased the co-immunoprecipitation of both the catalytic and regulatory subunits of phosphatidylinositol 3-kinase and of Akt/protein kinase B with the adrenoceptor and only marginally increases receptor association with protein kinase C epsilon. Co-operativity in seminal ribonuclease function: binding studies. 99mTc-methylene diphosphonate bone scintigraphy showed bilateral abnormal activity extending from the acetabula to the trochanteric regions. Rheolytic thrombectomy shows potential for rapid, large-burden thrombus removal in cases of internal carotid artery thrombosis, allowing expedient access to the intracranial circulation for additional thrombolytic therapy. Pathogenesis of fibrous cortical defect and non-ossifying bone fibroma. IgG4 levels in polyvalent immunoglobulins and immunoglobulins prepared by precipitation with caprylic acid. Cardiac compliance and dimensions in carbon monoxide-induced cardiomegaly. The significance of various wound dressings in the treatment of leg ulcers with special reference to the wound textile Novalind. We undertook a Medline search in order to find predictive factors for risk of developing irreversible ischaemic complications in giant-cell arteritis. Deprivation status and educational attainment are weakly and inconsistently associated with short term fatality but seem not to influence one year prognosis of acute myocardial infarction.

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We report that the Fok I polymorphism at the VDR gene locus is associated with insulin sensitivity, but has no influence on beta cell function in healthy Caucasians. Structure, properties and reactivity of polyoxometalates: a theoretical perspective. Comparing the long and short forms of the student version of the Jenkins Activity Survey. Several laboratory tests that are currently used for the diagnosis of lead poisoning in man were evaluated for the detection of lead poisoning in sheep given 3 or 10 mg Pb/kg body weight/day for 7 weeks. The result was that by 1995/96 nearly 40 percent of inpatient days were used by people who died in hospital, compared to 9 percent in 1969. In this article, a case of brucellosis associated with the development of DIC, infective endocarditis and capillary leak syndrome is presented. The asterixis may be caused by the abnormal control of arm posture maintenance due to functional dysregulation of the brainstem-spinal tracts from the cerebello-brainstem-thalamo-frontal lobe system. The second effort was to divide the group of rare radionuclides among the independent participants in a manner that assured that each radionuclide naprosyn ec 250 mg 20 tablet would be redundantly and independently calculated, and the results subsequently be submitted for publication in a separate manuscript. Psychosomatic aspects seem to be an obligatory part of inpatient dermatological therapy.

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In this context the improvement of standards of care can shed light on the efficacy of different treatments. The chimpanzee as a model to test the side effects of human interferons. Early healing pattern of autogenous bone grafts with and without e-PTFE membranes: a histomorphometric study in rats. A 10-day old newborn with post-operative acute renal failure and in whom peritoneal dialysis was impossible was successfully treated by haemodialysis. Mixtures of volatile aldehydes prepared from linolenate hydroperoxide decomposed either thermally or with iron and ascorbate had the same activity as 2,4,7-decatrienal. Tissue fluid pressure was always maximal in subcutaneous tissue at mid-cuff. The K4 kringle region may be particularly involved in the plasmin-plasmin interaction that results in autolysis, since it significantly reduced degradation when incubated with Lys-plasmin.

cytoxan pill chemotherapy 2016-07-24

We conclude that abdominal muscle recruitment during inspiratory mechanical loading may facilitate inspiration by increasing diaphragmatic length. Here, we present three cases of solitary metastatic/secondary tumor of the kidney, and discuss the features of the lesions on FDG PET in comparison with their appearance on CT. Severe deficiency of natural killer activity in the peripheral blood of patients with hairy cell leukemia. The poor response rate in adenoid cystic carcinoma is consistent with prior reports in this chemoresistant histologic subtype. The human and mouse membrome datasets are available through the Membrome homepage (http://www.membrome.org/) and correspond to subsets of the SymAtlas content restricted to known membrane trafficking components. Because the unusual afferent neurons of the small intestine and colon make their synaptic connections outside the central nervous system, the neurons and the reflex centres that they affect are potential targets for non-central penetrant therapeutic compounds. A comparison of sister chromatid exchange frequencies in peripheral lymphocytes and bone marrow cells of Fischer 344 and Sprague-Dawley rats.

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