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Daklinza (Daclatasvir)
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Daklinza

Daklinza was approved by the FDA on July 24, 2015. It is an oral, once-daily, 12-week treatment option for use in combination with sofosbuvir. Daklinza is considered a direct-acting antiviral agent for HCV genotype 3. This medication binds to the N-terminus of nonstructural protein 5A (NS5A), which is a large polyprotein translated from the HCV genome. The result of this binding is a structural distortion and impaired function of NS5A, which inhibits viral RNA replication and virion production.

Other names for this medication:
Daclatasvir

Similar Products:
Zebeta, Clomid, Zithromax, Trileptal, Rulide

Also known as: Daclatasvir

Description

{name} (daclatasvir) is an antiviral medicine that prevents hepatitis C virus (HCV) from multiplying in your body.

{name} is used in combination with other medications to treat chronic hepatitis C in adults.

{name} treats specific genotypes of hepatitis C, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people.

{name} must be given in combination with other antiviral medications and should not be used alone. It is usually given with sofosbuvir, with or without ribavirin.

{name} is sometimes used in people who also have HIV. Daclatasvir is not a treatment for HIV or AIDS.

Dosage

Usual Adult Dose for Chronic Hepatitis C:

60 mg orally once a day Recommended Regimen and Duration of Therapy: Genotype 1: -Without cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Compensated (Child-Pugh A) cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Decompensated (Child-Pugh B or C) cirrhosis: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks -Posttransplant: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks Genotype 3: -Without cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Compensated (Child-Pugh A) or decompensated (Child-Pugh B or C) cirrhosis: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks -Posttransplant: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks Comments: -Dose recommendations also apply to HCV/HIV-1-coinfected patients. -Optimal duration of therapy has not been established for HCV genotype 3-infected patients with cirrhosis or for HCV genotype 1-infected patients with Child-Pugh C cirrhosis. -The manufacturer product information for sofosbuvir should be consulted regarding dosing. The manufacturer product information should be consulted regarding ribavirin dosing and dose adjustments (if applicable). Use: With sofosbuvir (with or without ribavirin), for the treatment chronic HCV genotype 1 or 3 infection

Detailed Daklinza dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Use the oral liquid within 15 days after opening the pouch. Keep the ampules in the pouch until you are ready to use them.

Detailed Daklinza dosage information

Side effects

The most common side effects associated with Daklinza are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Daklinza if you are allergic to daclatasvir.

When taking Daklinza with other medicine: To make sure all medicines are safe for you, tell your doctor about all your medical conditions, and if you are pregnant or breastfeeding.

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with daclatasvir. Your doctor may change your treatment plan if you also use:

rifampin; St. John's wort; or seizure medicine - carbamazepine, phenytoin.

To make sure Daklinza is safe for you, tell your doctor if you have ever had:

hepatitis B; liver problems other than hepatitis C; a liver transplant; diabetes; heart disease; if you have recently used a heart rhythm medicine called amiodarone; or if you use a blood thinner (warfarin, Coumadin, Jantoven) and you have routine "INR" or prothrombin time tests.

Daklinza is sometimes used in combination with ribavirin. Both men and women using ribavirin should use effective birth control to prevent pregnancy. Ribavirin can cause birth defects, miscarriage, or death to an unborn baby if the mother or father is using this medicine.

You should not take ribavirin if you are pregnant, or if you are a man and your sex partner is pregnant. Use effective birth control to prevent pregnancy. Keep using birth control for at least 6 months after your last dose of ribavirin.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is using ribavirin.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Daklinza is not approved for use by anyone younger than 18 years old.

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SLP76 and SLP65 are adaptor proteins that lack intrinsic enzymatic activity but contain multiple protein-binding domains. Laminectomy electrode placement, although more invasive than percutaneous placement, yields significantly better clinical results in patients with failed back surgery syndrome at mean 1.9 years follow-up. Based on enzyme cytochemical and immunocytological findings in conjunction with the course of the disease lymphomatoid papulosis is designated as pseudolymphoma of T-cell type. An intracanalicular scaffold (Hydrus microstent) designed to reduce intraocular pressure as a glaucoma treatment was tested in human anterior segments to determine changes in outflow facility (C). As a starting point for a phylogenetic study of self-incompatibility (SI) in crucifers and to elucidate the genetic basis of transitions between outcrossing and self-fertilizing mating systems in this family, we investigated the SI system of Arabidopsis lyrata. Indications and late results in the treatment of femur neck fractures with femur head arthroplasty.

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