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Detrol (Tolterodine)
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Detrol

Detrol can start working in 5 days but it might take 5 to 8 weeks for you to feel the full effects. It is important to continue taking this medication every day even if you do not see improvement in your OAB symptoms right away.

Other names for this medication:
Bapter, Concys, Detrusitol, Dezrolala, Flochek, Roliten, Terol, Tolter, Tolterodine, Uftol, Uridin, Urotel

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Also known as: Tolterodine

Description

{name} LA is used in adults to treat overactive bladder with symptoms of urinary frequency, urgency, and incontinence (urine leakage).

Dosage

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take with water.

Take Detrol LA with or without food, at the same times each day.

Swallow the capsule whole and do not crush, chew, break, or open it.

Store at room temperature away from moisture, heat, and light.

Detailed Detrol LA dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Detrol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Detrol LA if you are allergic to Detrol LA or fesoterodine (Toviaz), or if you have:

trouble emptying your bladder; a blockage in your stomach, slow digestion; or uncontrolled narrow-angle glaucoma.

Tell your doctor if you have ever had:

a stomach or intestinal disorder; problems with constipation; liver disease; kidney disease; myasthenia gravis; trouble emptying your bladder, or a weak stream of urine; glaucoma; or long QT syndrome (in you or a family member).

Tell your doctor if you are pregnant or breastfeeding.

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The etiology and pathophysiologic mechanism of their development is unknown, but there seems to be a close relationship to major surgery. The comprehension of the systemic mechanism of PBS and its comorbidities enable an understanding of the systemic etiologic factors associated with oral manifestations. Insurance reimbursement mechanisms for rehabilitation equipment and environmental modifications. The method was able to detect adenovirus infection in 31/43 conjunctival scrapings from patients with acute kerato conjunctivitis 10/40 nasopharyngeal aspirates from patients admitted to hospital with acute respiratory disease and 2/26 urine samples from patients with haemorrhagic cystitis with better sensitivity than cell culture or rapid diagnosis by antigen detection by immunofluorescence (IF) in the case of respiratory specimens. This article reports results related to the effects of an AMIS on type of analgesia chosen by women in labor, and on rates of anesthesia--one aspect of the full study. Concentration of catecholamines among various nosological was affected by perfusion and hypoxia of myocardium as well as forms of hyperfunction of cardiac muscle. Pharmacological effect of phenyl-3-dibutylaminoethylamino-5 oxadiazole 1,2,4 (LA 1221), particularly on the peripheral vessels. Study on pulmonary, prostatic and renal (medulla and cortex) distribution of sagamicin at different time intervals.

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Relative potency of cellular and humoral immune responses induced by DNA vaccination. Parental and patient satisfaction scores were obtained at discharge and three to five days after the procedure, with the opportunity to report side effects encountered at home. The feasibility of physically mapping these fibers demonstrated in this study suggests that molecular combing may be used to identify the replication origin of the BhC4-1 amplicon. A total of 1520 men born between 1927 and 1956 with serial height and weight measurements from the age of 9 to 18, followed up in adulthood at a mean age of 63 years. Arg phosphorylates Tyr-161 differentially in vitro, and LK treatment does cause a down-regulation of Arg activity. It is therefore possible that polymorphisms of genes producing functional changes in xenobiotic metabolizing enzymes may be susceptible factors in cervical carcinogenesis. Decoherence: the view from the history and philosophy of science. Systolic and diastolic meridional wall stress was calculated from echocardiographic and hemodynamic data. Miller Class I, II, and III gingival recession defects and gingival perforation defects were treated.

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Hematologic reserve after radioimmunotherapy (RIT) is an important consideration when subsequent therapy is required. A microcalorimetric method has been developed for the identification of 9 representative strains of lactic acid bacteria used in the dairy industry. At present, however, in silico methods cannot replace existing preclinical in vitro and in vivo models. The effect of cigarette smoking on dental implants and related surgery. Subjects were then returned to baseline conditions before administration of higher nicotine yield smoke or air. Female basketball players are more likely to tear their anterior cruciate ligament than are their male counterparts. On prophylaxis, early recognition and early treatment of infected osteosyntheses.

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Autogenous reversed vein bypass for lower extremity ischemia in patients with absent or inadequate greater saphenous vein. We compared a simple complement-dependent lymphocytotoxicity test with a widely used indirect immunofluorescence procedure to enumerate total T, T helper, and T suppressor lymphocytes in normal blood samples. A sequential study of viral DNA in serum in experimental transmission of duck hepatitis B virus. Estrogen receptor beta, but not estrogen receptor alpha, is present in the vascular endothelium of the human and nonhuman primate endometrium. The research project will identify barriers to the implementation of a family centered Aboriginal oral health strategy, as well as the development of evidence to assist in the planning of a Phase III cluster randomized study. The joint analysis of these sequences with a large continent-wide database and previously published diversity patterns allowed us to discuss a new explanation for the population dynamics inside the Franco-Cantabrian area, based on range expansion theory. Transluminal coronary angioplasty and coronary bypass surgery do not alter the natural progression of coronary atherosclerosis, but coronary angioplasty provides a real chance at least to postpone bypass graft surgery if not to provide lasting relief of angina. Interleukin-10 (IL-10) is reported as a vital factor for the differentiation and survival of germinal center B cells and is also a negative prognostic factor in non-Hodgkin lymphoma (NHL). Differences between the effectiveness of strains were masked under conditions of soil N availability.

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Distension of the vascularly isolated pulmocutaneous artery evoked falls in systemic blood pressure. An increasing pattern of alignment and outgrowth of neurites in the direction parallel the long axis of the packed filament bundles with decreasing filament diameters ranging from supracellular and beyond (500 to 100 mum), cellular (30 mum), down to subcellular size (5 mum) was observed. BD750 has the potential to be used as a lead compound for the design and development of new immunosuppressants for preventing graft rejection and treating autoimmune diseases. Revised criteria for the early diagnosis of diabetic nephropathy. Expression of a Lactose Transposon (Tn951) in Zymomonas mobilis. Heparin and heparin-derived components are widely applied anticoagulant drugs used for amongst other applications medical treatment of deep vein thrombosis and pulmonary embolism. The introduction of Computerized Tomography brought some improvements in understanding the ARDS lung, leading to a pulmonary model made up of three zones: 1) normally inflated, 2) recruitable and 3) consolidated.

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The level of mGSH determines the fate of hepatocytes to acidic sphingomyelinase activation by TNF and hence strategies aimed to replenish mGSH or to antagonize the generation of ceramide from acidic sphingomyelinase may be of therapeutic value for ALD. Protein expression of selected differentially expressed genes was analysed by radial immunodiffusion or immunohistochemistry. Cholinergic mechanism in the cerebral cortex--a further study with acetyl-beta-methylcholine (methacholine). If the tensile stress in the ligament reaches its strength and the ligament breaks, the pars interarticularis cracks through, the vertebra slips and the spondylolisthesis develops. The multivariate workload evaluation index, which integrates physiological parameters and one subjective parameter through Principle Components Analysis, was proposed to characterize task specific responses and individual differences in response patterns to mental tasks. The expression of Flt-1 and KDR/Flk-1 mRNA transcripts also peaked on day 3 and then returned to the basal levels observed in normal muscles on day 10. The resulting multilayer system can electrocatalyze the oxidation of NADH and offer potential applications in other fields such as biosenors and photovoltaic devices.

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Childhood multiple sclerosis: clinical features and demonstration of changes in T cell subsets with disease activity. Thiol groups were introduced to dermal bovine collagen (DBC) by the reaction with gamma-thiobutyrolactone. The test compounds were found to interact with alkyl radicals more effectively than with peroxyl radicals. In addition to grape varieties, GVA infects Nicotiana benthamiana plants and protoplasts. Psychological factors as a predictor of treatment response in patients with heartburn: a pooled analysis of clinical trials. Each patient initially underwent optimal cytoreductive surgery, however, developed recurrent disease and were treated with pegylated liposomal doxorubicin.

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Instruments included the Abuse Assessment Screen, Prenatal Psychosocial Profile, Perceived Stress Scale, and a questionnaire to collect data on demographic characteristics, complications during pregnancy, and lifestyle behaviors. The catalytic domain may be responsible for controlling the glycosylation of GspB, while other surrounding regions are functionally required for glycoprotein transport. During the past year, Eph receptors have been shown to associate with glutamate receptors in excitatory neurons, suggesting a role in synapse formation or function. Compound 25 behaved as a inverse agonist at CB1 receptors as assessed in the cyclic AMP functional assay. These polymorphic alleles did not cosegregate with the disease, and they were found in healthy individuals as well. According to their mechanism of action these preparations are subdivided into alkylantions, antimetabolites, antibiotics and substances of different efficacy. Promotion of lactate production by oligopeptides of partial hydrolysate of bovine serum albumin. The neurotoxic hazard of a dithiocarbamate is influenced by route of exposure and acid stability of the dithiocarbamate. A comparison of clindamycin and erythromycin in beta--hemolytic streptococcal infections. Innate and adaptive immunity and the pathophysiology of psoriasis.

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Systemic sclerosis is the most severe of all connective tissue diseases. Influence of calcite and dissolved calcium on uranium(VI) sorption to a hanford subsurface sediment. This paper evaluates the conformation of medieval pigs from about 140 pictures of various sources (books of hours, misericords, illustration of bibles text or proverbs, sculptures etc.). The objective was to uncover patterns of frequently occurring incidents that are in need of careful prospective investigation. We analyzed results using analysis of variance with repeated measures. Most of these patients will eventually develop hormone refractory disease which is incurable, and for whom gene therapy, if feasible may develop as an alternative treatment option. Preliminary three-day administration of curantil in a dose of 10 mg per kg body wt produced a marked protective effect on the isadrin damaged myocardium of pubertal rats. Trk proteins are also of interest in oncology, since Trk activation has been observed in several cancer types. As documented previously, limit dilution cultures of tolerant spleen cells in the presence of CAS showed a functional clonal deletion of hapten-specific CTL-P. The predominant theme which emerges, not surprisingly, is that the more deviant chromosome patterns are associated with other measures of increased biologic malignancy.

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Additionally, solid-oxide fuel cell anode samples prepared through the FIB/SEM technique underwent volume-independence studies for multiple properties such as volume fraction, average particle size, tortuosity and contiguity to observe the characteristics of FIB/SEM samples in X-ray nanotomography. Our data suggest that fatigue-induced activation of skeletal muscle afferents triggers an early increase in phosphorylated HSP25 in muscles and a delayed elevation of non-phosphorylated HSP25 and HSP70 in skeletal and respiratory muscles, kidney and brain. Functional criteria included renal transit time, differential renal function, and time-intensity curves when available. Local (intradermal) HPD (5-500 micrograms) in combination with red light or UVA produced a dose-dependent erythema and inhibition of epidermal DNA synthesis. This is an important finding in relation to the appearance of delayed myelosuppression of the nitrosoureas and in the design of dose schedules of these agents. Toxic epidermal necrolysis is a potentially fatal disease and the use of intravenous immunoglobulins for this condition has been reported as successful.

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The microbial community underlying oil slicks increased and danazol dose showed a population shift to a greater percentage of hydrocarbon-utilizing microorganisms. The wavelet expansion is thresholded before reconstruction to reduce the dimension of the computational problem. In an attempt to determine any difference in the anticonvulsant activity of the two forms a variety of adrenergic agents were used, viz. Data were collected on heart rate, blood pressure, haematocrit, resection volumes, blood loss and the efficacy of Omni-stat in haemostasis. A method for formation of high-electrical-resistance seals on the Neurospora crassa plasma membrane, allowing resolution of single-ion-channel activity by patch clamp electrophysiology, is reported. A combination of the full-length human estrogen receptor alpha with the nuclear receptor-binding domain of co-activator steroid receptor co-activator-1 (SRC-1) or transcriptional intermediate factor-2 (TIF-2) was most effective for estrogen-dependent induction of the chromosome-integrated UAS(GAL)-CYC1(p)-lacZ reporter construct among the two-hybrid systems so far tested. The phenomenological distinction between delusions and obsessions has been the subject of much debate in psychiatry.

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Injections limited to small areas of MD indicated that projection between MD and PFC shows precise topography and reciprocity. Graft infections were established in the back subcutaneous tissue of 120 adult male Wistar rats by implantation of 1-cm(2) Dacron/ePTFE prosthesis followed by topical inoculation with 2 x 10(7) CFU of clinical isolate of MRSE. The effect of iron deficiency anemia on the catecholamine levels and morphology of the heart was studied in young male Wistar rats. Neither ototoxicity nor nephrotoxicity occurred in any of the patients. Age-stratified, survey-weighted chi-square and logistic regression analyses were conducted. Assessment of cognitive function in the ocular motor system may provide insight into cerebral function, in health and disease, and may provide both diagnostic information and permit quantification of deficit in future. Whiplash in individuals with known pre-accident, clinical neck status. We conclude that a single injection of CD3xCD19 bispecific antibodies is capable to induce an activation of autologous T lymphocytes if simultaneous costimulatory motrin 400mg dosing signaling by CD28 antibodies is provided.

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To evaluate the efficacy and safety of zoledronic acid in preventing bone loss in patients with hormone-sensitive prostate cancer and bone metastases who were receiving androgen deprivation therapy. qPCR revealed there was an up-regulation of pro-apoptotic (Bax, casapase-9, caspase-8, apoptosis-inducing factor (AIF) and Endonuclease G (EndoG)) and cell-cycle arrest genes (p53 and p21) and down-regulation of anti-apoptotic (Bcl-2 and survivin) and Myc genes. Screening for chickenpox in the UK: evaluation of a pre-conceptual screening program. The temperature dependence of degradation was adequately modeled by Arrhenius equation. The virus was a thermostable paramyxovirus that was classified as a mesogenic Newcastle disease virus.

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Elemental distribution in selected Agaricus and Rhizina mushrooms in South Africa. It is concluded that the study of adaptation of muscle size requires an integrative approach taking into account fundamental mechanisms of adaptation, as well as effects of higher levels of organization. It is concluded that with proper precautions, extractions can be performed on these patients. Does assessment of signs and symptoms add to the predictive value of an algorithm to rule out pregnancy?. Vestibulospinal reflexes in differentiating between organic and functional (psychogenic) causes of vertigo. Effects of some divalent cations on the denervated skeletal muscle of the rat. Long-term corticosteroid replacement and bone mineral density in adult women with classical congenital adrenal hyperplasia.

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