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Dolodol (Tramadol)

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Dolodol is an opioid (narcotic) pain reliever. It works by binding to mu-opiate receptors in the brain and changes how you feel and respond to pain. Dolodol is usually started at 25 mg per day. After slowly raising the dose over several days, a typical dose would be 50 to 100 mg by mouth every 4 to 6 hours as needed for pain.

Other names for this medication:
Antram, Axedol, Cradol, Decotram, Doleira, Dolfre, Dolomed, Doltel, Haledol, Jpdol, Meridol, Midol, Novadol, Opidol, Oshdol, Postadol, Ramax, Ramcet, Relidol, Servodol, Simol, Tacil, Tradol, Tragesic, Tramacip, Tramafen, Tramaflam, Tramagesic, Tramatas, Tramataur, Tramex, Tranzat, Tremtec

Similar Products:
Crestor, Mestinon, Zebeta, Provera, Sovaldi

Also known as: Tramadol


{name} (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

{name} is used to treat moderate to severe pain in adults.

The extended-release form of tramadol ({name} ER) is for around-the-clock treatment of pain. {name} ER is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Dolodol: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Dolodol is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Dolodol dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Flammable: Keep away from fire or flame.

Detailed Dolodol dosage information

Side effects

The most common side effects associated with Dolodol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Dolodol if you are allergic to tramadol, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Dolodol should not be given to a child younger than 12 years old. Dolodol ER should not be given to anyone younger than 18 years old.

Do not give Dolodol to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Dolodol. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

To make sure Dolodol is safe for you, tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use tramadol during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using tramadol if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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In current practice, inferior vena cava (IVC) filters are commonly used in the prevention of pulmonary embolism. These findings demonstrate that short-term adipocyte exposure to palmitate disturbs neither the lipolytic action of epinephrine nor the antilipolytic action of insulin. Influence of crown thioether ligands in the structures and of perhalophenyl groups in the optical properties of complexes with argentoaurophilic interactions. Together with previous NMR data, the results of this study have allowed a biologically relevant model of the ESAT-6.CFP-10 complex to be constructed that is critical for understanding the structure-function relationship in tuberculosis pathogenesis. Effect of sericin on diabetic hippocampal growth hormone/insulin-like growth factor 1 axis. While the perspectives offered here only span a small part of this rapidly evolving field, we trust that they might provide the interested reader with a taste for this new class of non-equilibrium systems and their rich behaviour. Agent orange herbicides, organophosphate and triazinic pesticides analysis in olive oil and industrial oil mill waste effluents using new organic phase immunosensors. As the incidence of bariatric surgery increases, so will the demand for plastic surgery.

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Management of traumatic bone cyst in a 3-year-old child: a rare case report. JNK signaling and its downstream component Cdc42 cooperate with Ras signaling to induce upregulation of a secreted growth factor Upd (an IL-6 homolog) through inactivation of the Hippo pathway. Whereas a direct role of copper to facilitate angiogenesis has been evident two decades ago, the specific targets of copper action remained unclear. All patients were treated with immunosuppressive drug combination therapy (IDCT). Post-operatively, the histologic results of the intraoperatively excised nodes SN1-3 were compared to the histologies of the neck dissection specimen. To evaluate treatment outcomes with mycophenolate mofetil in patients with inflammatory eye disease. To characterize experimentally induced spondylarthropathy (SpA) in arthritis-susceptible inbred mice and in their F(1) and F(2) hybrid generations of susceptible and resistant mouse strains.

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The second MRA obtained 90 minutes after resolution of the symptoms showed nearly complete recanalization of the left middle cerebral artery, suggesting that the TIA was embolic mechanism. These findings may lead to a new understanding of membrane-microfilament interactions. Objective : Laparoendoscopic single-site surgery (LESS) is the latest innovation in minimally invasive surgery with unconfirmed advantages. This paper describes a new estimation method of the number of road injuries in The Netherlands. Eight strains showed concurrent palladium precipitation and biohydrogen production. With the use of antiserum raised against synthetic corticotropin-releasing factor (CRF), immunoreactive perikarya were observed in the nucleus praeopticus and the nucleus praeopticus periventricularis. Future study is warranted to examine the efficacy of this novel therapy. However, the oxygen balance was similar when either agent was used. Integration of the priming effect (PE) in ecosystem models is crucial to better predict the consequences of global change on ecosystem carbon (C) dynamics and its feedbacks on climate. Mitochondria have their own double-stranded DNA genome which is distinct from nuclear genome.

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Characterization of the peroxidase system at low H2O2 concentrations in isolated neonatal rat islets. Data were extracted from a database established in 2000 to prospectively gather data on DS-associated leukaemias and their outcomes following polychemotherapy. Clinical vigilance is indicated during scalp infiltration with ropivacaine. were studied for their antinociceptive property in chemical and thermal models of nociception in mice. The combined free partial vastus lateralis with anterolateral thigh perforator flap reconstruction of extensive composite defects. To understand a mechanism for the difference in clinical manifestations of congenital cytomegalovirus (CMV) infection between dizygotic twins, the placentas of the dizygotic twins were evaluated for the number of the cells infected with CMV by immunohistochemical and in situ hybridization studies. The purified and renatured V3 envelope protein was found to bind to receptors for JEV on red blood cells. The odds ratio for late neck metastasis in relation to HMGB1 was estimated. Between 1986 and 2012, a total of 32 patients with RET mutations underwent prophylactic thyroidectomy. Four daily injections of pergolide, an ergoline dopamine agonist, made male rats tolerant to the corticosterone-elevating effects of an acute injection of pergolide on the fifth day.

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Child neurology: Exaggerated dermal melanocytosis in a hypotonic infant: a harbinger of GM1 gangliosidosis. The in vitro biological activity of the Brazilian brown seaweed Dictyota mertensii against Leishmania amazonensis. These differences in spontaneous activity and thermosensitivity provide a neuronal basis to explain the elevation of core temperature observed in SH rats. Recent advances in diabetes care have facilitated the achievement and maintenance of excellent metabolic control. Modulating effect of the applied factors after in vitro treatment of PBL was evaluated by the cytotoxic assay using 51chromium. It was found that cytochrome c bound more tightly to the folded CH6A DNA-hemin complex than to the folded CH6A DNA alone.

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It was concluded that the problems that are seen in common obstetric and gynecological practices in patients with systemic sclerosis may be explained by these tissue abnormalities. Summary of: Models of practice organisation using dental therapists: English case studies. (1) A cylindrical model: seeds from the compared distribution were linked to the reference distribution of Day 28. Although 1 h exposure to bright light at 0130 hours combined with a 200-mg dose of caffeine maintains performance throughout the remainder of the night/early morning, a 1-h exposure to bright light without the caffeine may actually degrade performance. Nonetheless slow application of theophylline loading dose is recommended in preterm infants.

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Viruses enter host cells through interactions of viral ligands with cellular receptors. The overall objective of this study is to non-invasively image and assess tumor targeting and retention of directly labeled T-lymphocytes following their adoptive transfer in mice. In the last decade a certain number of new cyclobutane and cyclobutanone synthesis and functionalization protocols have been published. The literature study showed that SSRIs may influence the development of the ENS in two ways. Molecular dynamics simulation of the phase transition between calcite and CaCO(3)-II. In our study, we enrolled 18 consecutive Japanese patients who had developed DVT during pregnancy and postpartum. This technique makes possible the in vivo evaluation of therapeutic efficacy of new drugs that interfere with lymphocyte migration. This article outlines the history behind the development of the Injury ICE, brief descriptions of current and past projects, collaborations, and reflections on the value of collaboration. The 7mG (7-methylguanosine cap) formed on mRNA is fundamental to eukaryotic gene expression. Effect of alinidine (St 567) on sympathetic and vagal activities.

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Disordered eating in Japanese and Chinese female runners, rhythmic gymnasts and gymnasts. Clinical microbiology laboratory and 17 general practice clinics in Telemark County, Norway. Pressure measurements, including intraperitoneal pressure, were recorded at body angles ranging from 0 to 55 degrees and at valve settings ranging from 30 to 200 mm H(2)O. Comparison of the effects of omeprazole and rabeprazole on ticlopidine metabolism in vitro. We analyze a set of 10 M-step molecular dynamics (MD) data of low-temperature SPC/E model water with a phenomenological analytical model. All volunteers completed two questionnaires at baseline (T1) and at the end of the study (T3).

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and increase lung pathogenesis during pulmonary bacterial infection. Further, this approach also allows investigation of long-term behaviors emerging from biologically-relevant alterations to vesicle trafficking and metabolic state. The intracellular mediators of activation signals, and their antagonists, are only partially known so far. This implies a strong link between depth perception and fusion, but it is well established that stereoscopic depth percepts are also obtained from stimuli that produce double images. Optokinetic stimuli: motion sickness, visual acuity, and eye movements. The purpose of this study is to describe our experience with cases of false negative findings at conventional colonoscopy (CC) that were identified by CT colonography (CTC). A complex syndrome of left-right axis, central nervous system and axial skeleton defects in Zic3 mutant mice. Exposure of neonatal rats to maternal cafeteria feeding during suckling alters hepatic gene expression and DNA methylation in the insulin signalling pathway. She had persistent symptoms for a year that affected her grades and precluded athletic participation.

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While the longterm consequences of CAA are well recognized from clinical and pathologic studies, numerous questions remain unanswered regarding the progression of the disease. Intradermal skin testing before the start of HA filler therapy, and before each subsequent injection, may prevent legal implications for the plastic surgeon. Increasing the use of community-based programs is an important trend in improving dental education to meet the needs of students and the public. 5-Carb-oxy-2-isopropyl-1H-imidazol-3-ium-4-carboxyl-ate monohydrate. Mixed amido-/imido-/guanidinato niobium complexes: synthesis and the effect of ligands on insertion reactions. The optimal threshold depends on the attributes of prospective mates, which are likely to vary across generations or within the lifetime of searchers due to stochastic environmental events. These new product ions proved to be diagnostic and made it possible to establish the presence of random sequences of ester and amide bonds in the poly(ester amide)s samples.

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