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Glucotrol (Glipizide)
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Glucotrol

Glucotrol is in a drug class known as sulfonylureas. Sulfonylureas work by telling your pancreas to release insulin, which lowers your blood sugar. Glucotrol tells your pancreas to increase the amount of insulin it produces in your body. Insulin works to lower your blood sugar.

Other names for this medication:
Actizide, Diabizide, Diaglip, Dibimet, Glibetic, Glicept, Glipicon, Glipicontin, Glipid, Glipimet, Glipiriv, Glipitis, Glipized, Glipizide, Glipmet, Glucolip, Gluconil, Glumin, Glycind, Glydal, Glylin, Glynase, Glysar, Glysin, Glytop, Glyzip, Gpzide, Libiz, Metglib, Swiglip, Tranase, Zidmin

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Also known as: Glipizide

Description

{name} (glipizide) is an oral diabetes medicine that helps control blood sugar levels by helping your pancreas produce insulin.

{name} is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

{name} is not for treating type 1 diabetes.

Dosage

Usual Adult Dose of Glucotrol for Diabetes Type 2:

Immediate release: Initial dose: 5 mg orally once a day, 30 minutes before breakfast Maintenance dose: Up to 40 mg in divided doses 30 minutes before a meal of adequate caloric content. Doses may be increased in intervals of 2.5 to 5 mg a day according to blood glucose response. Maximum single dose: 15 mg Maximum daily dose: 40 mg Comments: -At least several days should elapse between titration steps. -If response to a single dose is not satisfactory, dividing that dose may prove effective. Extended Release: Initial dose: 5 mg orally once a day, 30 minutes before breakfast Maintenance dose: 5 to 10 mg orally once a day Maximum daily dose: 20 mg Patients receiving immediate release may be switched safely to extended release tablets once-a-day at the nearest equivalent total daily dose, or titrate to the appropriate extended release dose starting with 5 mg once daily. Combination use: -When adding other blood-glucose-lowering agents to the extended release tablets, the agent should be initiated at the lowest recommended dose. Observe for hypoglycemia. -When adding extended release tablets to other blood-glucose-lowering agents, Glucotrol XL extended release can be initiated at 5 mg. Start at a lower dose in patients that are more sensitive to hypoglycemia. When transferring patients from insulin to glipizide, the following general guidelines should be considered: -For patients with daily insulin doses of 20 units or less: Discontinue insulin and begin glipizide at usual dosages. -For patients with daily insulin doses greater than 20 units: Insulin dose should be reduced by 50% and glipizide therapy may begin at usual dosages. Comments: -Several days should elapse between titration steps. -Subsequent reductions in insulin dosage should depend on individual patient response. -During the insulin withdrawal period, the patient should test urine samples for sugar and ketone bodies at least three times daily. -Some patients receiving greater than 40 units of insulin daily may need to consider hospitalization during the transition period. Patients Receiving Other Oral Hypoglycemic Agents: -When transferring from longer half-life sulfonylureas: Observe for 1 to 2 weeks for hypoglycemia. -Glucotrol XL extended release coadministered with colesevelam: Glipizide should be administered at least 4 hours prior to colesevelam. Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose of Glucotrol for Diabetes Type 2:

Initial dose: 2.5 mg orally once a day 30 minutes before breakfast Comments: -Maintenance dosing should be conservative to avoid hypoglycemic reactions. -Doses can be adjusted with caution taking into account the degree of hepatic, renal, or cardiac function, and the concomitant disease or other drug therapy. Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Detailed Glucotrol dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glipizide overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

Storage

Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Glucotrol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of glipizide in the elderly. However, elderly patients are more likely to have age-related heart, liver, or kidney problems which may require caution in patients receiving glipizide.

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Cytokine responses to EHV-1 infection in immune and non-immune ponies. Twelve rare copy number variants segregate with talipes equinovarus in multiplex pedigrees, and contain the developmentally expressed transcription factors and transcriptional regulators PITX1, TBX4, HOXC13, UTX, CHD (chromodomain protein)1, and RIPPLY2. Patients with gastroesophageal reflux disease (GERD) usually suffer from acid reflux and duodenogastroesophageal reflux (DGER) simultaneously. Guidance cues that regulate this decision, particularly those directing the midline crossing of contralateral axons, are still not well understood. Gastrointestinal bleeding is a rare but potentially life-threatening complication of pancreatitis. The mean number varied from forty-four (quadriceps) to eighty-two (anterior tibial). We isolated 8 strains of NP-degrading bacteria: 6 strains from the S. An examination of the available data in 1976 and the decision to vaccinate, as well as lessons learned from the HIV/AIDS epidemic in the early 1980s, may help shape an appropriate public health response to future threats from avian influenza or other infectious diseases. A total of 1,782 laboratory technicians were interviewed from major public sector hospitals and a few private hospital laboratories throughout Pakistan.

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Large-scale identification of human biliary proteins from a cholesterol stone patient using a proteomic approach. Steric tuning of N-aryl groups of homologous amidinate ligands affords discrete dimeric and tetrameric copper(I) clusters in solid state, but they undergo dynamic dimer-dimer and tetramer-dimer interconversion in solution. Comparison of portable CdTe(Cl) detectors with stationary NaI(Tl) detectors for subcutaneous 133Xe disappearance measurements. PD was deposited onto gold NRs, and antibodies were bound to PD-coated NRs. Linking inflammation and atherogenesis: Soluble markers identified for the detection of risk factors and for early risk assessment. Weight variations in the prophylactic therapy of primary headaches: 6-month follow-up. However, in clinical practice all antidepressants are used in adolescents. This cross-sectional study was conducted in January 2010 in Hamadan City, west of Iran. This suggests that UGT1A9 poor metabolizer genotype(s) may be a predisposing factor for COMT inhibitor-induced hepatotoxicity. Sulfhydryl group reactivity as a probe of transient protein conformational changes during rhodopsin photolysis.

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