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Hydrea (Hydroxyurea)

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Hydrea is used in the treatment of some kinds of cancer and to prevent painful episodes associated with sickle cell anemia. It may be also used to treat some other conditions. It is sometimes used with certain other medicines as part of combination chemotherapy.

Other names for this medication:
Cytodrox, Droxia, Droxiget, Durea, Gindrea, Hondrea, Hydab, Hydroxyurea, Hytas, Myelostat, Neodrea, Oxyrea, Riborea, Urdox

Similar Products:
Vantin, Micardis, Abilify, Zovirax, Kemadrin

Also known as: Hydroxyurea


{name} is used to treat chronic myeloid leukemia, ovarian cancer, and certain types of skin cancer (squamous cell cancer of the head and neck).

{name} is also used to reduce pain episodes and the need for blood transfusions in people with sickle cell anemia. This medicine will not cure sickle cell anemia.


Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Hydrea is usually taken once per day at the same time of day, with or without food. Swallow the pill whole with a glass of water.

Wash your hands before and after you handle Hydrea or the bottle that contains the pills. For best protection, wear disposable gloves when handling the pills.

Do not open the Hydrea capsule or crush or chew a tablet. Do not use a broken pill. The medicine from a crushed or broken pill can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If this occurs, wash your skin with soap and water or rinse your eyes with water.

If any powder from a broken pill is spilled, wipe it up at once with a damp paper towel and throw the towel away in a sealed plastic bag where children and pets cannot get to it.

Your doctor may also want you to take a folic acid supplement. Follow dosing instructions very carefully.

Hydrea can lower your blood cell counts. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Hydrea.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Detailed Hydrea dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include drowsiness, mouth sores, and swelling with pain and purple discoloration in your hands and feet.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Hydrea are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Using Hydrea may increase your risk of developing skin cancer. Avoid exposure to sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Do not receive a "live" vaccine while using Hydrea, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Do not handle Hydrea pills or the medicine bottle without skin protection (disposable gloves).

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Lateral dose profiles were measured at depths of 2, 5, 10, and 15 cm in phantom with a Farmer chamber. Inconsistencies between guidelines might lead to physicians being unintentionally noncompliant with guideline recommendations. sp., an interesting commensal of African termites (Trombiculidae: Acarina). Using three-dimensional reconstructions of carnivoran and dasyuromorph tooth rows, we compared statistical models of the relationship between tooth row shape and the opposing tooth row, a static feature, as well as measures of mandibular motion during chewing (occlusion), which are kinetic features. We described the clinicopathological features of an example arising in the cochlear-vestibular portion of the VIIIth nerve with extension into the cerebellopontine angle. This technique can be useful for the differentiation and quantitation of HCMV and HHV-6 for monitoring transplant patients. Although granulocyte colony-stimulating factor (G-CSF) is reported to have a beneficial affect on postinfarction cardiac remodeling and dysfunction when administered before the onset of or at the acute stage of myocardial infarction (MI), its effect on established heart failure is unknown.

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In the present study, we characterize Vitis vinifera salt- and drought-induced RING finger 1 (VvSDIR1) a homologue of the Arabidopsis SDIR1 gene obtained from V. Pharmacology and cerebrospinal fluid penetration of moxalactam in children and dosage recommendations. One hundred twenty-seven patients with COPD recruited from the outpatient clinic of a single institution were followed up for a mean period of 16.2 months. Clinically, partial foot amputees display significant wasting of the triceps surae musculature, strongly indicative of disuse. Transplant coronary artery disease in pediatrics: favorable outcome with medical therapy. In the group of 40 children with neither hydrocephalus nor brain tumor, CAT more reliably showed ventricular enlargement in patients with neurologic impairment. We show that endogenous heat shock elements perform better than artificial heat shock elements derived from vertebrates. The pubertal growth spurt is influenced by a number of factors such as hormones, nutrition, physical activity and general health, acting mostly in concert in order to modify a genetic potential for growth. Knowledge about coronary stents, associated clinical outcomes, and current guidelines with regard to surgical management of antecedent antiplatelet therapy in Central Eastern Turkey is inconsistent, and heavily dependent on the location of dental practice. This valued and well-known drug mainly prescribed by dermatologists is now experiencing a renaissance far beyond dermatologic applications.

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Glandular inclusions of the pelvic lymph nodes in cervix carcinoma. The cause of iodine-induced hyperthyroidism is unclear, but it is probably more common in patients with goiters containing previously existing areas of autonomous function or iodine-poor thyroglobulin. More importantly, yeast two-hybrid and bimolecular fluorescence complementation analyses confirmed that MaNAC1/2 physically interacted with a downstream component of ethylene signalling, ethylene insensitive 3 (EIN3)-like protein, termed MaEIL5, which was downregulated during ripening. Consensus was achieved on 24 of 25 prepared statements for early initiation of fixed ICS/LABA combination treatment. We recently demonstrated that TRB3 was cleaved by caspase-3 (CASP3) in vitro and also in apoptosis-induced cells. Evaluation of transfer of radioactive albumin from subarachnoid space to plasma. X-ray inactivation of human cells in tissue culture under aerobic and extremely hypoxic conditions in the presence and absence of TMPN.

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Phosphorylated EGFR expression may predict outcome of EGFR-TKIs therapy for the advanced NSCLC patients with wild-type EGFR. Understanding the role of the hypothalamus and other central stress-regulating structures could help us to further understand the neurobiological underpinnings of this complex disorder. Arterial dissection was the dominant injury type in chiropractic manipulation and diagnostic cerebral angiography. The testicle was suspended in the superficial inguinal pouch close to the scrotal neck using 2 methods: stitch and ball. In this study the authors investigated whether patterns of intracranial venous drainage in children with complex craniosynostosis associated with raised intracranial pressure (ICP) were abnormal and, thus, could support the theory that venous hypertension is a major contributor to raised ICP that can lead to impaired visual function or even blindness in these patients. Three patients per cohort received doses of .1, .3, 1.0, and 2.0 mg/kg. Loci for 5S and 18S-5.8S-25S rDNA were determined for the first time in six taxa, and previously unreported rDNA constellations were described in an additional 12 accessions. Cycloisomerization of 1,n-enynes and diynes is a powerful method in organic synthesis to access heterocyclic compounds and has drawn increasing attention from organic chemists.

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Myasthenia gravis: influence of thymic changes on clinical parameters. Arthroscopic treatment of multidirectional glenohumeral instability: 2- to 5-year follow-up. The changes of delta f0, delta R1, delta L1 and delta C0 suggest that the polymer film was compact and rigid. In multibacillary diseases with a high mycobacterial load, a positive Ziehl-Neelsen smear with a positive NAA test is diagnostic of active tuberculosis, whereas a positive Ziehl-Neelsen smear with a negative NAA test in the absence of inhibitors would indicate nontuberculous mycobacterial disease. In positive patterning, adhesive molecules, such as laminin or polyethylenimine (PEI) were patterned on polydimethylsiloxane (PDMS) substrates in a single spraying operation. D-values for these species were 72, 66, 48, 120, 30 and 660 s, respectively. Hearts with isomerism of the right atrial appendages - one of the worst forms of disease in 2005. The effect of extinction on previously established environment-specific sensitization of the locomotor activating effects of 1.0mg/kg d-amphetamine sulfate was studied in an attempt to investigate the relation between sensitization and conditioning of the drug effect. Retinal vein thrombosis with peripheral venous thrombosis and thrombocytopenia. Increasing influenza vaccination among high-risk elderly: a randomized controlled trial of a mail cue in an HMO setting.

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Expression of v-E10 induces hyperphosphorylation and redistribution of bcl-10 from the cytoplasm to the plasma membrane, a process which is dependent on the intactness of the v-E10 CARD motif. Firstly, we developed a real-time PCR assays based on the TaqMan technology targeted to a single copy gene. Solubilisation and reconstitution of acylcoenzyme A:estradiol-17 beta acyltransferase. Here we summarize a combination of evidence that the alcoholic rat CIE model demonstrates changes in GABAA receptor subunit levels, in receptor localization, and in physiology and pharmacology, leading to alterations in behavior that contribute to the hyperexcitable alcohol withdrawal state (anxiety, insomnia, seizure susceptibility) and alcohol dependence. This study will help to elucidate pathways to CVD involving autonomic dysfunction and lifestyle factors which might be responsible for the CVD epidemic in some populations. Photocatalytic demethylation of 2,4,6-trinitrotoluene (TNT) by porphyrins.

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Overexpression of wild-type NOD2 (WT-NOD2) gene induced NF-kappaB-dependent transcriptional activity and this activity was further increased by muramyl dipeptide (MDP). Furthermore, it is stable and folded, enabling us to unambiguously determine the initiating conformational changes for amyloid assembly at atomic resolution. In the present study, we report identification and purification of vitellogenin in the mosquitofish (Gambusia affinis). Urine samples from 10 infants with bilateral abnormal drainage from the kidneys were collected at the time of relief from obstruction, and after 2 and 4 weeks. Even with image co-registration, the spatial resolution of the seroquel dose in elderly molecular imaging modality is not improved. Therefore, the need to know exactly the different involvement either of the body of the esophagus or the LES for each case is underlined. Myocardial tissue velocities in the normal left and right ventricle: relationships and predictors.

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Ultrastructural study of mast cell degranulation from patients with allergic respiratory disease. Sixteen hours after cessation of repeated morphine administration, N-ethylmaleimide-sensitive factor mRNA level increased again to a level approximate to that of the single morphine injection group in the hippocampus, periaqueductal gray and cerebral cortex. These subjects had extensive periodontal and medical evaluations. Electrophoresis and chromatography were used to determine the radiochemical purity of each complex. Additional evidence of the existence of the putative cardiotropic factor is provided by the finding that the sera of rats with cardiac overload displaying digoxinlike immunoreactivity stimulate the multiplication of rat cardiac myocytes in the tissue culture.

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Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma. Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats. Excretory urography revealed a space-occupying lesion in the lower pole of the left kidney. The rp51 protein showed immunoreactivity with anti- mouse p51 antibodies. Phosphorus (P), an essential macronutrient required for plant growth and development, is often limiting in natural and agro-climatic environments. The color differences between different thicknesses of resin veneered over amalgam. Pyridoxamine lowers oxalate excretion and kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria.

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