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Klonopin (Clonazepam)

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Klonopin is one of the products that belong to the bensodiazepine group and have a strong sedative effect. It is widely used among people with severe panic attacks and anxiety caused by depression treatment. Thanks to its unique features, Klonopin helps to stop convulsions and epileptic seizures.

Other names for this medication:
Almac, Alrest, Azpax, Calmnir, Cleps, Cloam, Clonapax, Clonapik, Clonasig, Clonatrac, Clonax, Clonaxyl, Cloneepam, Clonopam, Clonzy, Clopam, Clotweet, Cozil, Dipwell, Easyfeel, Eminaz, Epicloz, Epitril, Epizam, Escitapax, Escitrac, Meloprax, Nazee, Norep, Nozim, Nupam, Onapil, Prasilex, Rivotril, Sezolep, Somnolex, Ubitpam, Xitzen, Zeptril, Zicam, Zolpidox, Zozep

Similar Products:
Dostinex, Acticin, Artane, Mysoline, Elocon, Bactrim, Eriacta

Also known as: Clonazepam


Klonopin is a benzodiazepine medication that was initially primarily used for the treatment of seizures occurring in epilepsy and for anxiety, specifically anxiety that occurs in panic disorder. Klonopin is available in tablet form (0.5 mg, 1 mg, 2 mg) and as disintegrating wafers that are taken orally.

While Klonopin is generally prescribed for the treatment of anxiety disorders, such as panic disorder, and seizure control, it is intended as a short-term treatment protocol as opposed to a long-term treatment solution due to issues with tolerance (see below). In addition to treating anxiety and seizures, Klonopin has also been used in the treatment of:

chizophrenia, especially when the individual with schizophrenia has a restless or irritable component and is not responding to antipsychotic medications.

The manic phase of bipolar disorder or for restlessness associated with depression in bipolar disorder.

Tic disorders, such as Tourette's syndrome, by acting as a muscle relaxant and producing sedation.

Restless leg syndrome.

Withdrawal from alcohol or treatment for other substance abuse or addiction issues.

Klonopin has a relatively slow onset of action (it takes a while for the drug to begin working) and a half-life of between 10 and 50 hours. As it has a relatively slow onset of action and is a longer-acting benzodiazepine, Klonopin is more suited for the treatment of anxiety, seizures, and other similar disorders as opposed to being a useful sleep aid, even though it is sometimes prescribed for that purpose. Sleep aids need to work quickly, whereas with Klonopin, a person takes the drug early in the day and doesn't have to worry about monitoring for signs of a seizure or panic attack as it stays in the system a relatively long time. Its effects last longer than those of shorter-acting benzodiazepines, such as Xanax.

As it is a Schedule IV controlled substance, Klonopin can only be legally acquired with a prescription from a physician.


This section provides information on the proper use of a number of products that contain clonazepam. It may not be specific to Klonopin Wafers. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence).

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Swallow the tablet whole with water.

If you are using the disintegrating tablet (wafer), make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil. Do not push the tablet through the foil. Do not break or split the tablet. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, you may take a sip of water.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (tablets or disintegrating tablets): For seizures: Adults and children 10 years and older—At first, 0.5 milligram (mg) 3 times per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 20 mg per day. Children up to 10 years or 30 kilograms (kg) of body weight—Dose is based on body weight and must be determined by your doctor. The dose is usually 0.01 to 0.03 mg per kg of body weight per day, given in 2 or 3 divided doses. However, the dose is usually not more than 0.05 mg per kg of body weight. Your doctor may adjust your dose as needed. For panic disorder: Adults—At first, 0.25 milligram (mg) 2 times per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 4 mg per day. Children—Use and dose must be determined by your doctor.


Treatment after Overdose. If a person accidentally overdoses on Xanax, Valium, or Klonopin due to interactions with prescription medications, this is unlikely a sign of addiction or abuse. However, if the overdose was the result of benzodiazepine abuse of any kind, help is needed.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Side effects

The most common side effects associated with Klonopin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Before taking Klonopin,

tell your doctor and pharmacist if you are allergic to Klonopin, other benzodiazepines such as alprazolam (Xanax), chlordiazepoxide (Librium, in Librax), clorazepate (Gen-Xene, Tranxene), diazepam (Diastat, Valium), estazolam, flurazepam, lorazepam (Ativan), midazolam (Versed), oxazepam, temazepam (Restoril), triazolam (Halcion), any other medications, or any of the ingredients in Klonopin tablets. Ask your pharmacist for a list of the ingredients.

tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Nexterone, Pacerone); certain antibiotics such as clarithromycin (Biaxin, in Prevpac), erythromycin (Erythrocin, E-mycin, others), and troleandomycin (TAO) (not available in the US); antidepressants; certain antifungal medications such as itraconazole (Onmel. Sporanox) and ketoconazole (Nizoral); antihistamines; certain calcium channel blockers such as diltiazem (Cardizem, Tiazac, others) and verapamil (Calan, Covera, Verelan, in Tarka); cimetidine (Tagamet); HIV protease inhibitors including indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); medications for anxiety, colds or allergies, or mental illness; other medications for seizures such as carbamazepine (Epitol, Tegretol, Teril), phenobarbital, phenytoin (Dilantin, Phenytek), or valproic acid (Depakene); muscle relaxants; nefazodone; rifampin (Rifadin, Rimactane); sedatives; certain selective serotonin reuptake inhibitors (SSRIs) such as fluvoxamine (Luvox); other sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor what herbal products you are taking, especially St. John's wort.

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Caspases are divided into two classes: initiator caspases, which include caspase-8 and -9 and possess long prodomains, and effector caspases, which include caspase-3 and -7 and possess short prodomains. Microinjections of cholinergic antagonists in the vicinity of the basolateral amygdaloid nucleus produced a marked reduction of amphetamine-induced hyperactivity when amphetamine was administered i.p. Non-B subtype is largely restricted to individuals infected outside of Europe and to their direct contacts and is generally acquired by the heterosexual route. The distribution of myocardial perfusion was determined by a continuous infusion of krypton-81m (half-life 13 sec) into the aortic sinuses. Images of frozen hydrated crystals were collected by cryo-electron microscopy and a projection structure of EmrE was calculated to 7 A resolution. An observer evaluated the paired images and count rates were calculated from the images. Renin release and renal sympathetic nerve activity following vertebral artery embolism. Eicosapentaenoic acid, but not oleic acid, stimulates beta-oxidation in adipocytes. Protection of the myocardium during ischaemic asystole with intracoronary administration of ATP. PSMA is not expressed in any significant amount in the prostates of mouse, beagle dog, or macaque monkeys in this study but is expressed in high levels by human prostate.

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Removal of catalytic activity by EDTA from antibody light chain. The mutant was obtained from a collection created earlier by means of insertion mutagenesis. As such, it defines what sexual harassment is, explains the prevalence of sexual harassment between the physician and the patient, describes some of the general studies conducted in medical settings, provides a case scenario of doctor-patient sexual harassment, and identifies some key consequences to doctors, patients, and society. He appeared to have Candida glabratarelated pyopneumopericarditis and a fungal infection in the gastric tube. Up to 1st July, 1977, 164 patients from 14 different countries had been entered into the trial. Purification of boron nitride nanotubes through polymer wrapping. In second place in order of frequency were the intertriginous inflammation of the toes, due to the high level of temperature and humidity prevalent in some areas of the plant, besides the use of inadequate shoes and socks. Reactions of blood pressure and body spaces to hemofiltration treatment.

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The availability of effective antiviral therapy and virological assays has transformed HBV treatment in the past two decades. Receptor activator of NF-kappaB ligand (RANKL) and macrophage colony-stimulating factor are the essential osteoclastogenic cytokines and are increased in inflammatory joint disease. Thirty-eight diabetic men, including 12 with type I and 26 with type II diabetes, were followed up regularly for 10 years after they began self-injecting for severe ED. administration of 1.0 ml of water solution (169.2 mg/200 g) NaHCO2, (NH4)2SO4, MgSO4, MnSO4, and ZnSO4 (in proportion: 35 : 5 : 2 : 0.15 : 0.15, resp.) or after 1-hour effect of increased hypercapnia and hypoxia without cooling. In the presence of CD14, TLR3-mediated signal transduction events are amplified. Concentrations of water-soluble high- and low-molecular-weight carbohydrates were determined in the intestinal contents of four human subjects who had died accidentally. The fourth baby having a congenital W-P-W-syndrome was born with severe hydrops fetalis and was asphyxiated. At Howard University Hospital, nine terminally ill cancer patients with chronic pain have been treated with continuous intrathecal infusion of morphine delivered by the implantable Infusaid pump. The intersection of law and medicine: the case for providing federal funding for embryonic stem cell research.

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Adjustment for age, performance status, and stage, however, attenuated the relation to Type 1, leaving only Type 5 as a significantly related personality factor. However, the corresponding PTV analyses revealed no significant differences between any of the overlap volumes of any of the PTVs with the bladder, rectum, and penile bulb, but did reveal a significant difference between the PTV(RIS) and PTV(post) overlap volumes with the symphysis compared with PTV(pre) overlap volumes with the symphysis. A decline of potassium concentration in the red cells of one animal and of transferrin type in another also continued. The frequency of large granular lymphocytes among peripheral blood lymphocytes (PBL), however, remained unchanged during the first 24 h of IFN treatment. A complex role for prostaglandins (PGs) in adipogenesis is suggested.

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Utilizing the microdevice, we analyzed the stress induced proteins. This method works on various types of scans (low dose and regular dose, normal subjects and diseased subjects) without the need for the user to manually adjust any parameters. In the livers of knockout mice, markedly increased caspase-3 activity was already evident at the 1-h time point following LPS administration, while in the wild type animals this increase was delayed. These observations ascribe to GHS a novel therapy possible for aging, AIDS, and transplant individuals, whose immune functions are compromised. Benign intraductal papilloma is a rare lesion in the male breast. RILP is recruited onto late endosomal/lysosomal membranes by Rab7-GTP where it induces the recruitment of the dynein-dynactin motor complexes. Mice blood glucose was monitored and ouabain-sensitive NKA activity was determined. Diabetic EPCs have phenotypic differences involving thrombospondin-1 expression compared with nondiabetic EPCs, revealing potential novel mechanistic insights and therapeutic targets to improve reendothelialization and reduce restenosis in diabetes. A single intratracheal (i.t.) instillation of 3H-BaP (2.5 mg/kg) cleared rapidly from the lung with a half life of approximately 8 h. The study of protein aggregation saw a renaissance in the last decade, when it was discovered that aggregation is the cause of several human diseases, making this field of research one of the most exciting frontiers in science today.

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Phylogenetic analysis of PbCTS1 and other chitinases suggests the existence of paralogs of several chitinases to be grouped based on specialized functions, which may reflect the multiple and diverse roles played by fungi chitinases. After controlling for age, race, and sex, more favorable HRV profiles were associated with more MVPA, better CVF, and less visceral and subcutaneous adiposity. Other therapeutic techniques can be deployed in association with those already mentioned, including photodynamic therapy and brachytherapy using low doses of radiation applied locally. Meeting the educational needs of adolescents from ethnic minorities: a study in alienation in the modern world. Relationship of HQ-275 to biliary excretion and portal blood flow in dogs. Pharmacy-based computer system for monitoring and reporting drug interactions. The selective N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 (3 micromol/kg, i.p.) blocked the ET-1 induced responses, and both the nitric oxide synthase (NOS) inhibitor L-NAME (N-nitro-L-arginine methylester 1 mmol/rat) and the nitric oxide (NO) scavenger hemoglobin (15 nmol/rat) had similar effects in reducing the ET-1 (10 pmol/rat)-induced behavioral changes and ABP elevation. Consequently, the difference in parasite dissemination was not attributable to an impaired proinflammatory immune response in the IgM-/- mice. Unresponsiveness is manifest by a failure of antigen-stimulated cells to incorporate thymidine or to produce lymphokines after antigenic challenge. We used an alternative marker system, 10 highly polymorphic microsatellites, to compare levels of genetic diversity between four native and five introduced house finch populations.

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To describe the treatment of juxtapapillary capillary angioma by pars plana vitrectomy (PPV) and tumor excision. Impact of substance abuse on the course and treatment of bipolar disorder. The score pattern found in men with asd is consistent with the clinical picture of asd and corresponds to earlier results of research done in Sweden. Exocytosis in PC12 cells and telencephalon cells occurs at the periphery or the interface between dividing cells, and the duration of single secretion events varies considerably. This technique is now being routinely used for objective functional evaluation on the patients with abnormal hip, knee and ankle joints as well as lower extremity amputees fitted with artificial limbs. The questionnaire battery included the Medical Outcomes Study Short Form 36, the Activities of Daily Vision Scale, the National Eye Institute Visual Function Questionnaire, and the Hospital Anxiety and Depression Scale.

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NO(x) serum levels were higher after biofeedback than those measured before starting treatment. Interestingly, the number of subpopulations has minor influence on genetic load except for the case of both very slightly deleterious mutations and small subpopulations. Neither the comprehensiveness of information nor the timeliness was achieved in a related project using a controlled trial approach. The very small incisions make it possible to install the prosthesis within an isometric, and therefore reliable, framework. Based on these results, the key roles of orientation and lateral diffusion on the kinetics of protein interactions in plane of the membrane are discussed.

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Furthermore, epidemiological data suggest higher risk of cardiac, abdominal wall and orofacial defects of evaluated drugs. Heparin-neutralizing activity in the plasma of women with gynecologic malignancy: the effect of tumor stage on heparin concentration and fibrin generation after low-dose heparin. Individuals with repaired cleft lip and/or palate can have the same VSC levels as subjects without clefts. Furthermore, hassles correlated strongly with validated indicators of health status. Children with ADHD and comorbid learning disability tended to respond more poorly to MPH. These data showed that this protocol induced split tolerance in rat liver transplantation and, furthermore, the mechanism of split tolerance was not due to T helper 2 deviation. Insulin-stimulated interaction between endogenous IRS-2 and 14-3-3 was observed in rat hepatoma cells and in mice liver after an acute insulin stimulus and refeeding. The essential role of phosphoinositide 3-kinases (PI3Ks) in regulating pro-inflammatory responses and the progression of cancer. We successfully performed simultaneous pectus repair using sternal elevation without any prosthetic support and total correction of TOF after a prior modified Blalock-Taussig shunt. After 63 days of composting, the ratio of total organic carbon and soluble organic carbon decreased to a satisfactory low level and the solid and soluble C/N ratios decreased rapidly for the first 35 days before attaining a constant value, indicating compost maturity.

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Increased recurrence rates in perioperatively transfused colorectal malignancy patients. This study presents a new method for measuring axial rotation of vertebra. Lipid composition and temperature adaptation of the nervous system of the leech Hirudo medicinalis L. These results suggest that serum miR-10b may be a useful biomarker for the identification of bone metastatic breast cancer. Synthesis and biological evaluation of novel amides of polyunsaturated fatty acids with dopamine. The role of indirect recognition of donor MHC class II peptides in cardiac transplantation in miniature swine. By modifying the conditions of the fluorolytic sol-gel synthesis of aluminium fluorides transparent sols with low viscosities were obtained. Using RNA blot hybridization analysis, the gene was identified initially as a region 9-23 kilobases upstream of the gene for the related inhibitor ovomucoid. In this protocol, we describe in detail how to perform a genetic cross, isolate the endosperm tissue from seed, determine the imprinting status of a gene, and analyze DNA methylation of imprinted genes by bisulfite sequencing in Arabidopsis.

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Early death and late morbidity after blood transfusion of injured children: a pilot study. In eight severe sepsis was found and had to be treated by arthrodesis. Disulfide Tethering was applied to the active site of human caspase-1, resulting in the discovery of a novel, tricyclic molecular fragment that selectively binds in S4. In connection with our observations of three patients with giant-cell tumors of the sacrum a description of this disease is given reviewing the 51 cases which have been published world-wide. Many different applications/variations of multicolor staining were developed for flow- or slide-based cytometric analysis of suspensions and sections to whole animal analysis.

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Seasonal histomorphological alterations of adrenals and thyroid in normal and pinealectomized domestic pigeons Columba livia. Cancer patients as a group had significantly higher DNA damage when compared with controls. Fetal pulmonary valvuloplasty is feasible and may hytrin classification drug change the natural history of the disease in fetuses with critical PS-IVS. The direct application of radioactive materials (brachytherapy) in this setting has been employed for over 10 years. When administered alone, dexamethasone consistently increased isoform levels.

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It has been found that a minor change in the chemical structures of these fluorinated amphiphiles, such as a hydrogen substituted at the omega-position of the hydrophobic fluorocarbon tails instead of a fluorine as well as hydrophilic vinyl ester groups inserted between acrylates and methacrylates, induces a drastic change in the isotherms for the monolayers, suggesting different molecular orientation and packing in the films. However, the special role of methionine in preventing virtually all metabolic and pathologic effects plavix type of medication of ethionine, including liver cancer, places ethionine in a special position. However, rats fed the sucrose diet with chromium in drinking water had serum cholesterol concentrations similar to those of rats fed the starch diet without chromium in drinking water. Intracerebral inoculation of neonatal mice with the Edmonston strain of measles virus produced an acute, lethal encephalitis and thymic dysplasia in susceptible mice. The aim of this work was to evaluate the expression pattern of ADAMs and ADAMTS in non small cell lung carcinomas (NSCLC) and to investigate the possible correlation between their expression and cancer progression.

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Function of pat-4/integrin-linked kinase (ILK) and unc-112/Mig-2 was examined using RNA-mediated interference (RNAi). Complications of corticosteroid therapy in rheumatological practice. A similar arrangement has been described for representatives of each zithromax medication of the remaining five orders within Afrotheria. Biliary obstruction changes the spectrum of lipoproteins, which are now known to bind and neutralize endotoxin. Factors that facilitate or constrain the use of continuous sedation at the end of life by physicians and nurses in Belgium: results from a focus group study.

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The hydrogen of the steroid is transferred by the enzyme to oxygen which is reduced to hydrogen peroxide. Adult patients at the Ahmanson/UCLA Adult Congenital Heart Disease Center with non-Fontan single-ventricle physiology who had undergone cardiac catheterization between 2005 and 2011 were included. The distinct permeability properties observed in different epithelia and endothelia seemingly result from the restricted tissue expression, variability of the homopolymer and heteropolymer assembly, regulated transcription and translation, and the subcellular localization of claudin family proteins. Rather, the apparent augmentation in Vno in such circumstances amoxil dose dental prophylaxis appears to be an arithmetic artifact. Stringent supervision of patients, after adequate ICI training, together with drug prescription, is essential.

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Comparative data on ecological differences in body fatness and fat distribution within Europe are sparse. Cells containing gpb1Delta gpb2Delta mutations also display increased phosphorylation of the PKA substrates Sfl1p and Msn2p, indicating that Gpb1p and Gpb2p are negative regulators of PKA substrate phosphorylation. The clinicohistologic features of seven urethral and four urinary bladder polyps with prostatic-type epithelium are described. The amp-ELISA was less sensitive in detecting toxins produced by nonproteolytic than proteolytic strains of type B and F organisms. Benzoctamine (10 mg), sodium hydroxybutyrate (2 g), fencamfamine (10 mg). nimotop tab uses The simplest paradigmatic problem would be a theory of helix-bundle folding. Although this culture model is clearly unsuitable for preparing germ cells for therapeutic purposes, it does represent a most valuable tool for testing the effects of biological and chemical agents on testicular tissue.

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Most patients also had a substantial reduction in urinary porphyrin and ferritin levels. Serotonin (5-hydroxytryptamine, 5-HT), a local transmitter substance released by activated platelets, has also recently been shown to induce the secretion of vWf. Consistent with the reported involvement coreg dose to metoprolol dose conversion of the latter in interaction with nucleic acids, the Dpb portion of the structure directly faces a single cleft in the Pol2 subunit that seems wide enough to accommodate double-stranded DNA. Regional expression of the histamine H(2) receptor in adult and developing rat brain. Prevalence of electrocardiographic left ventricular hypertrophy in human hypertension: an updated review.

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Three rescue workers used a protocol for triage and 15 for injury assessment. Extensive information on etanercept safety is available as this biological agent has been used for many years for other indications such as rheumatoid arthritis, and psoriatic arthritis. The purified OprF specifically reacted with rabbit serum, hyperimmune to P. Several polyanions, including unlabeled pyran, dextran sulfate, and poly(I)-poly(C), competed for acid-precipitable receptor molecules. However, this increased motion was not proportionately translated into rotation of the tibia through the subtalar joint. Mothers report that infants as young as 1-year-old can experience trauma symptoms as a result of hearing or witnessing IPV.

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We have developed an experimental animal model of diabetic autonomic neuropathy characterized by the regular occurrence of pathologically distinctive dystrophic axons in prevertebral sympathetic ganglia and ileal mesenteric nerves of rats with chronic streptozotocin (STZ)-induced diabetes. 100, whereas that of blind biopsies tended to increase with the degree of hazard involved, ranging from 49 p. Priority MICA uses data from birth and death certificates, hospital discharges, emergency departments, risk factors from the Behavioral Risk Factors Surveillance System, and eight epidemiologic measures to construct six priority criteria: size (the number of emergency department visits, hospitalizations, and deaths), severity (number of deaths of people younger than 65), urgency (trends in deaths and hospital morbidity), preventability (evidence-based score), community support (score of social support for preventive action), and racial-disparity (race comparison through death and morbidity rate ratio). Surgical myocardial revascularization without cardiopulmonary bypass (CPB) is not new, with the first consecutive series of patients appearing in the early eighties. Few transition metal complexes of tetradentate N(2)O(2) donor Schiff base ligands containing 2-hydroxybenzylidene-4-aminoantipyrine and amino acids (alanine/valine) abbreviated to KHL(1)/KHL(2) have been synthesized. This is a summary of the presentations and discussion of Session 1.5 on Health Policy and Coordination: A Critical Review of Experiences during the Conference, Health Aspects of the Tsunami Disaster in Asia, convened by the World Health Organization (WHO) in Phuket, Thailand, 04-06 May 2005.

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