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Lasix (Furosemide)
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Lasix

Lasix is a loop diuretic (water pill) that makes you urinate more. It works in the kidneys to get rid of extra water and electrolytes (like sodium and potassium), which helps with swelling and lowers blood pressure. Lasix can be taken once or twice a day for swelling. Adults typically start with 20 mg to 80 mg per dose. Some adults with really bad swelling problems may take up to 600 mg in a day.

Other names for this medication:
Aldalix, Anfuramide, Ansemid, Betasemid, Foliront, Frusemide, Frusenex, Furantral, Furesis, Furetic, Furide, Furocot, Furosemide, Furovet, Furoxem, Furozenol, Fursemid, Furtenk, Fusix, Inclens, Intermed, Jufurix, Lasilacton, Lasilactone, Lasiletten, Lasilix, Salix, Vesix

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Also known as: Furosemide

Description

Lasix is a potent diuretic. It inhibits sodium and chloride absorption in the ascending limb of Henle's loop and in both the proximal and distal tubules. The high degree of efficacy is due to this unique site of action. The action on the distal tubule is independent of any inhibitory effect on carbonic anhydrase or aldosterone.

Frusemide may promote diuresis in cases which have previously proved resistant to other diuretics.

Frusemide has no significant pharmacological effects other than on renal function.

Dosage

Adults. The usual initial daily dose is 20 to 80 mg given as a single dose. If the diuretic response to a single dose of 20 to 80 mg is not satisfactory, increase this dose by increments of 20 to 40 mg, not sooner than 6 to 8 hours after the previous dose, until the desired diuretic effect is obtained. This individually determined dose should be given once or twice (e.g. at 8 am and 2 pm) daily. The dose of Lasix may be carefully titrated up to 400 mg/day (except in advanced renal failure) in those patients with severe clinical oedematous states. The mobilisation of oedema may be most efficiently and safely accomplished by giving Lasix on 2 to 4 consecutive days each week.

When doses exceeding 80 mg/day are given for prolonged periods, careful clinical laboratory observations are particularly advisable.

Overdose

In case of a Lasix overdose visit your doctor or health care provider immediately. Symptoms of a Lasix overdose include fainting, tinnitus, confusion, weakness, lightheadedness, lack of appetite.

Storage

Keep this medicine in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away unused furosemide solution after 90 days. Throw away any medicine that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medicine.

Side effects

The most common side effects associated with Lasix are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Excessive diuresis may result in dehydration and reduction in blood volume with circulatory collapse and with the possibility of vascular thrombosis and embolism, particularly in elderly patients.

Excessive loss of potassium in patients receiving cardiac glycosides may precipitate digitalis toxicity.

In patients with hepatic cirrhosis and ascites, initiation of therapy with Lasix is best carried out in hospital. Sudden alterations of fluid and electrolyte balance in patients with cirrhosis may precipitate hepatic coma, therefore, strict observation is necessary during the period of diuresis.

Cases of reversible or irreversible tinnitus or hearing impairment have been reported. Usually, reports indicate that Lasix ototoxicity is associated with rapid injection or infusion, severe renal impairment, hypoproteinaemia, doses exceeding several times the usual recommended dose, or concomitant therapy with aminoglycoside antibiotics, ethacrynic acid, or other ototoxic drugs. In patients with hypoproteinaemia, e.g. associated with nephrotic syndrome, the effect of Lasix may be weakened and its ototoxicity potentiated. Cautious dose titration is required. If the physician elects to use high dose parenteral therapy, controlled intravenous infusion is advisable (for adults with normal renal function, an infusion rate not exceeding 4 mg Lasix per minute must be used; for adults with impaired renal function, an infusion rate of no greater than 2.5 mg per minute must be used).

Caution should be exercised when administering curare or its derivatives to patients undergoing frusemide therapy. It is also advisable to discontinue frusemide for one week prior to any elective surgery.

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Activity of the TNF-related apoptosis-inducing ligand gene expressed from the hTERT promoter on colon cancer cell line HT-29. Transformation of Escherichia coli K-12 with a high-copy plasmid encoding the green fluorescent protein reduces growth: implications for predictive microbiology. Budesonide (Entocort) is effective for the treatment of collagenous colitis. The normally quiescent cells were made to enter cell cycle by treatment with either irradiation or the phase specific drug cytosine arabinoside (Ara-C). A method for the quantitative recovery of this mixed polymer, called poly-beta-hydroxyalkanoate (PHA), with analysis by capillary gas-liquid chromatography, showed the presence of at least 11 short-chain beta-hydroxy acids in polymers extracted from marine sediments. Passive cutaneous anaphylaxis in the guinea pig toward the Nichols spirochete by means of the blood and parotid secretion of syphilitic patients. Hemorrheologic abnormalities in defined primary dyslipoproteinemias with both high and low atherosclerotic risks.

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