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Piozulin (Pioglitazone)

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Piozulin is a member of the family of medications known as thiazolidinediones. It is used to lower high blood sugar associated with type 2 diabetes. Thiazolidinediones such as Piozulin help insulin to work more effectively.

Other names for this medication:
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Also known as: Pioglitazone


You should take Piozulin according to your doctor’s or healthcare provider’s instructions.

Piozulin comes as a tablet that you swallow.

When to take

You’ll take Piozulin once a day. Try to take this medication at about the same time each day.

Don’t take more than one dose in a day.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Taking Piozulin with food

You can take Piozulin tablets with or without food.

Can Piozulin be crushed, split, or chewed?

No, you shouldn’t break, crush, split, or chew Piozulin tablets. Broken tablets haven’t been studied, so it’s not known if it’s safe to take a tablet that’s broken.

If you’re having trouble swallowing your Piozulin tablets, talk with your doctor. They may be able to suggest ways to help you take your medication or recommend other drugs that may be easier for you to take.


The Piozulin dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Piozulin to treat
  • other medical conditions you may have, such as congestive heart failure (CHF)*
  • other medications that you’re taking to treat your type 2 diabetes
Typically, your doctor will start you on a low dosage. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

* <em>Piozulin</em> has a<em> boxed warning</em> for CHF. This is the most serious warning from the FDA. For more information, see “FDA warning: Congestive heart failure” at the beginning of this article.

Drug forms and strengths

Piozulin comes as a tablet that you swallow, and you’ll usually take it once a day. Piozulin is available in three strengths: 15 mg, 30 mg, and 45 mg.

Dosage for type 2 diabetes

Your doctor will likely have you start taking either a 15-mg or 30-mg dose of Piozulin once a day. If needed, they may increase the dose by 15 mg for extra control of your blood sugar. The maximum dose of Piozulin is 45 mg a day.

Your starting dose will depend on if you have other health conditions, such as CHF.* And the dose will be increased over time based on how your body responds.

And in some situations where your body may be very stressed, your doctor may need to change your dose or have you stop taking Piozulin. So tell your doctor right away if you:

  • have a fever
  • have an infection
  • have had an accident
  • have just had or will have surgery
Never change your dosage of Piozulin without first talking with your doctor. And before you start taking Piozulin, be sure to tell them about any medical conditions you have or any other medications that you take. Your doctor will determine what the best dosage is for you.

* Piozulin has a boxed warning for CHF. This is the most serious warning from the Food and Drug Administration (FDA). For more information, see “FDA warning: Congestive heart failure” at the beginning of this article.

What if I miss a dose?

If you miss your dose, wait and take Piozulin when your next dose is due. Never take two doses in 1 day. If you have questions on when to take your next dose of Piozulin after you’ve missed a dose, talk with your doctor or pharmacist.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

Piozulin is meant to be used as a long-term treatment. If you and your doctor determine that Piozulin is safe and effective for you, you’ll likely take it long term.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Piozulin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Piozulin if you are allergic to pioglitazone, or if you have:

severe or uncontrolled heart failure; or diabetic ketoacidosis (call your doctor for treatment).

This medication may increase your risk of developing bladder cancer. Talk with your doctor about your specific risk.

To make sure Piozulin is safe for you, tell your doctor if you have ever had:

congestive heart failure or heart disease; a heart attack or stroke; eye problems caused by diabetes; bladder cancer; or liver disease.

Piozulin may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Follow your doctor's instructions about using Piozulin if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

Pioglitazone may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

Women may be more likely to have a broken bone while using Piozulin. Talk with your doctor about ways to keep your bones healthy.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Piozulin is not approved for use by anyone younger than 18 years old.

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Usefulness of early exercise testing and clinical risk score for prognostic evaluation in chest pain units without preexisting evidence of myocardial ischemia. The properties that were examined for 10 field isolates of each inoculant type were symbiotic phenotype, phage type, intrinsic antibiotic resistance, maximum growth temperature, lipopolysaccharide and total soluble protein patterns, immunological properties, DNA restriction profiles, and DNA hybridization patterns, which were determined by using nifHDK and recA sequences as probes. Plasmablasts but not mature plasma cells are attracted by the ligands for the chemokine receptors CXCR4 and CXCR3. Fibula autograft survival following resection of osteoclastoma of radius. The continuing search for the cause and prevention of dental caries. The present study supports the idea that the selection of the relevant reference range for haemoglobin in boys should depend on the state of physical developments as expressed by serum testosterone. Extracellular single-unit recordings were performed in halothane-anesthetized, immobilized, artificially ventilated cats.

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Dental hygiene students in community dentistry: an extramural program at the University of Michigan. Conscientious objection in medicine: the ethics of responding to bird flu. For statistical inference, methods for obtaining the overall adjusted p-value, point estimate and confidence intervals are developed. Reliability and normal variations of computer analysis of Frank electrocardiogram by Smith-Hyde program (1968 version). The arterial approach is particularly useful for studying immediate results of the arterial angioplasty. Sturge-Weber syndrome is a rare phacomatoses which may present with ocular complications such as glaucoma. N167A (motif VI) and R202A (motif VIII) have normal AdoMet and DNA binding but reduced catalytic activity. Therefore, its supplementation could provide a new approach for the reduction in hepatic complication due to Mn poisoning. A defined medium that supports the growth of a range of Campylobacter strains and suitable for proteomic analysis was developed. Working memory task performance and memory fields of prefrontal delay units are degraded by extreme elevation or depletion of tonic DA levels.

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In Xinjiang region, the infection rate of hepatitis B virus in Uygur and Kazak people is significantly lower than that in Han people. Morning and evening plasma cortisol, dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) were measured in ten women with hyperprolactinemia secondary to pituitary adenomas and in seven control subjects with cyclic menses and normal prolactin (PRL) levels. The 3D sphere developed its osteogenic potency in a time-dependent manner, containing approximately 10-fold higher mineralization, 5-fold higher protein content, and 4-fold greater ALP activity than those in the controls. Intimately admixed with tumor cells were spindle shaped fibroblastic cells. The oncogenic Vav1-induced apoptosis is associated with reduced expression of Bcl-2 and Bcl-xL proteins and effectively suppressed by transgenic overexpression of Bcl-2, suggesting Vav1-mediated signaling via Bcl-2 in apoptosis. Evidence that autobiographic memory retrieval does not become independent of the hippocampus: an fMRI study contrasting very recent with remote events. The present study investigated whether opticin interacts directly with the heparan sulfate (HS) proteoglycan type XVIII collagen. After geostatistical analysis of the datum of monitoring site, the values of evaluation indices were estimated in the whole research area. The data obtained indicated that adrenorecption of the rynecephalo-hypothalamic complex took part in the central regulation of the gonadotropic function of the hypophysis.

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On the use of a new derivative of benzodiazepines (Ro 4-5360) in the treatment of insomnia in pre-surgery patients. Vitamin and trace mineral metabolism in medroxyprogesterone acetate users. Alpha-Gal detectors in xenotransplantation research: a word of caution. Rad3-Cds1 mediates coupling of initiation of meiotic recombination with DNA replication. Identification of a conserved calmodulin-binding motif in the sequence of F0F1 ATPsynthase inhibitor protein. The purpose of this study was to investigate the effects of exercise, advice, and pelvic support belts on the management of symphysis pubis dysfunction during pregnancy. Absolute benefit is greater in men, in patients aged 70 years or more, and in those with previous cardiovascular complications or greater pulse pressure.

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Influence of Phosphate on the Growth and Nodulation Characteristics of Rhizobium trifolii. The results were correlated with clinical and molecular biomarkers. The last 20 years have seen a significant shift in location of death from the community to hospitals and care homes. Immunohistochemistry demonstrated that the beta1 subunit was localised in newly differentiated odontoblasts in the root and in mature odontoblasts in the crown, including their intradentinal cell processes. On the relationship between reflection-impulsivity and field-dependence--independence. We demonstrate that the formation of molecules can be used to measure the occupancy of the lattice and perform thermometry. On physical examination the patients complained of pain on both passive flexion and internal rotation of the hip, and when the thigh was pushed backwards at 90 degrees of flexion. Results indicate that zero retinal disparity is a strong stimulus for suppression in the central and peripheral visual field of patients with small angle strabismus.

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Xenogenic transplantation of human bladder- and renal-cell carcinoma into NMRI mice treated with cyclosporin A and into NMRI nu/nu mice. Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death. Six of the 10 items displayed were ambiguous items which might be seen as belonging to either set. We clarified the number of biopsies required to determine malignancy of the biliary tract on the basis of the type of bile duct tumor. - A method for the breeding value estimation of trotter stallions. Mitral and aortic valvular insufficiency in chronic relapsing polychondritis. Evaluation of adhesion reformation by early second-look laparoscopy following microlaser ovarian wedge resection. A method for determining the two components from calibration images of a grid phantom is presented. Microbial growth, predominantly Gram-negative aerobes, increased over time. The nicotinic acetylcholine receptor Dalpha7 is required for an escape behavior in Drosophila.

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Specific scenarios and other suggestions regarding payment policy, coding, and quality of care are provided. The American Spinal Injury Association (ASIA) impairment scale was used to assess neurological function. Clinical manifestations in this patient included failure to thrive, psychomotor retardation, mild facial dysmorphic features, and long and slender fingers and toes. In vitro analysis of milk derived from different transgenic lines revealed a linear correlation between antibody expression and virus-neutralizing activity, indicating that the recombinant antibody is the major determinant of MHV-JHM neutralization in murine milk. Patients and controls gave comparable probability estimates for all alternatives.

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SERMs bind the strogen receptor (ER) and modulated ER-mediated gene transcription. During the erythroblastic phase, blood transfusion resulted in a suppression of erythropoiesis as evidenced in both the peripheral blood and bone marrow. All fungi exhibited the capability to depolymerize pectin, xylan, and cellulose. There are several imaging techniques available to the clinician today. Long-term intubation caused stenosis and formation of a mucosal bridge in the trachea. Astrocytes overexpressing Cu,Zn superoxide dismutase have increased resistance to oxidative injury. Neuropeptide Y (NPY) produced a concentration-dependent decrease in the field stimulation induced release of NE from the perfused mesenteric artery. Radiotherapy may be offered as a short-term adjuvant treatment or a long-term course with the aim of downstaging. Our results indicate that the primary effect of the nb mutation is a deficiency of another erythrocyte membrane skeletal protein, ankyrin.

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