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Prozam (Alprazolam)

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Prozam is used to treat anxiety and panic disorders. It belongs to a class of medications called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body (GABA). Prozam is mostly used to treat anxiety disorders, panic disorders, and nausea due to chemotherapy. Prozam may also be indicated for the treatment of generalized anxiety disorder, as well as for the treatment of anxiety conditions with co-morbid depression. The FDA label advises that the physician should periodically reassess the usefulness of the drug.

Other names for this medication:
Alpracon, Alprawin, Alprazan, Altok, Alzopam, Alzot, Ambusyn, Anxigon, Axizox, Besquil, Coolam, Dizeral, Elzopam, Endolam, Flumusa, Jolistar, Kaprolam, Notence, Ozolam, Paxor, Procalm, Prosanti, Rezolam, Selam, Sertakem, Setlan, Sowel, Tenzorid, Texidep, Zeprax, Ziety, Zotin

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Antabuse, Abilify, Zyvox, Cenforce, Trileptal, Eldepryl, Cialis, Nimotop, Glyburide

Also known as: Alprazolam


Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Prozam XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of alprazolam can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Prozam XR dosage information

Side effects

The most common side effects associated with Prozam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not use Prozam XR if you have:

narrow-angle glaucoma; if you are also taking itraconazole (Sporanox) or ketoconazole (Nizoral); or if you are allergic to alprazolam or to other benzodiazepines, such as chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

Before taking Prozam XR, tell your doctor if you are allergic to any drugs, or if you have:

asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems; glaucoma; kidney or liver disease (especially alcoholic liver disease); a history of depression or suicidal thoughts or behavior; or a history of drug or alcohol addiction.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

It is dangerous to try and purchase Prozam XR on the Internet or from vendors outside of the United States. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of alprazolam purchased on the Internet have been found to contain haloperidol (Haldol), a potent antipsychotic drug with dangerous side effects. For more information, contact the U.S. Food and Drug Administration (FDA) or visit

FDA pregnancy category D. Prozam XR can cause birth defects in an unborn baby. Do not use Prozam XR without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. Alprazolam can pass into breast milk and may harm a nursing baby. Do not use Prozam XR without telling your doctor if you are breast-feeding a baby.

The sedative effects of Prozam XR may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking Prozam XR. Do not give this medication to anyone under 18 years old.

Prozam XR pregnancy and breastfeeding warnings (more detail)

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Internet-based cognitive behavior therapy for obsessive compulsive disorder: a pilot study. The effects of oxidative stress on damage and repair can be examined separately, and it appears that, while light can damage PS II directly, oxidative stress acts primarily by inhibiting the repair of PS II. These results indicate that ACAN effectively inhibits melanin biosynthesis through down-regulation of MITF and thus could be useful as a new skin-whitening agent. It was thought previously to be an endogenous agonist, producing the several actions previously attributed to CRF. The result of author keywords analysis reveals that Molecular Dynamics, MEMS, Hard Disk and Diamond like Carbon are major research topics. Our algorithm mimics a parallel process as it evaluates concurrent folding possibilities by pattern recognition. MMT patients had generally poorer performance, as indicated by longer RTs, that were related to clinical OCD, drug abuse, poor cognitive state, and older age. Interestingly, HO-2WT- and HO-2H45A-overexpressing cells were both protected against H2O2-induced oxidative stress and had less oxidatively modified proteins as compared to control cells. This hypothesis has gained enormous attention among patients and physicians but has been questioned since. This report reviews a work in progress evaluating the use of postarthrography computed tomography (CT) of the wrist in assessing triangular fibrocartilage complex abnormalities.

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It is proposed that new and highly precise group velocity data constrain the solutions and imply a thickness near 70 km. In 2013, a key theme of research in renal transplantation was the diagnosis of rejection. Identification of grapevine cultivars by using microsatellite DNA markers has mostly become a routine. Using a modified Delphi method over a series of teleconferences, the group reached consensus for the Standard Set. Extra-adrenal and metastatic pheochromocytoma: the role of 131I meta-iodobenzylguanidine (131I MIBG) in localization and management. But on internal examination of abdomen, it was noticed that the left hemi-diaphragm was torn and the stomach and intestines were found displaced into the left thoracic cavity. Because of the risk of misinterpreting such patterns, routine assessment of each detector element is recommended for multi-detector row CT scanners that are routinely used in the axial scanning mode. Identification of filarial larvae in vectors by DNA hybridization. Elementary structural building blocks encountered in silicon surface reconstructions.

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Toll-like receptor 4 in bone marrow-derived cells contributes to the progression of diabetic retinopathy. Based on these findings, storage temperature appears to play an important role in the properties and hence clinical outcomes of MTA. Household food insecurity is associated with less physical activity among children and adults in the U.S. We report a case of a pregnant woman with an adrenal mass discovered serendipitously, who was followed-up during gestation and underwent adrenalectomy shortly after delivery. The results presented in this work indicate that purification of His-tagged protein using the Amicon Pro device is faster, easier, and provides better yields than other traditional methods (eg. Gaucher disease type III (GD III) is a rare form of GD characterized by neurological involvement and severe systemic disease. We have identified a new gene (paaP) that is most likely involved in a transport process.

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In this study, we compared three electrophysiological measures: compound muscle action potential (CMAP) amplitude, motor unit number estimate (MUNE), and electrical impedance myography (EIM) 50 kHz phase values in a mild mouse model of spinal muscular atrophy, the Smn1c/c mouse. Rice nitrate transporter OsNPF2.4 functions in low-affinity acquisition and long-distance transport. 1 Activity of short- and long-acting benzodiazepines is reviewed with reference to pharmacokinetics and residual sequelae, and to efficacy and adverse effects. Evaluation of cadmium-induced nephrotoxicity using urinary metabolomic profiles in sprague-dawley male rats. Results also suggest that healthy disc properties have a positive effect of loading on metabolic transport. CD spectra as a function of temperature show that P14 (2 microM) binds to the antisense strand of the GAT target in the mutated allele with a T(M) of 78 degrees C and to the antisense strand of the GGT target in the wild-type allele with a T(M) of 69 degrees C, in 50 mM Tris-HCl, pH 7.4, and 1 M NaCl. Bilateral angle closure glaucoma is a rare ocular emergency which can be a potentially blinding condition. Further randomised controlled trials with long follow-up are required. Arteriosclerosis, bone biology, and calciotropic hormone signaling: learning the ABCs of disease in the bone-vascular axis. These cell sheet transplantations have shown to ameliorate cardiac dysfunction and improve symptoms of heart failure.

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The extent of depletion of tyrosine hydroxylase activity from corpus striatum was used to monitor lesion efficiency. These data suggest that AST inhibits apoptosis in AECs-II cells through the ROS-dependent mitochondrial signalling pathway and may be of potential therapeutic value in lung fibrosis treatment. Nephrogenic fibrosing dermopathy (NFD) is a novel fibrosing disorder of the skin with characteristic histopathology. Environmental dsrAB sequences constituted at least 13 stable family-level lineages without any cultivated representatives, suggesting that major taxa of sulfite/sulfate-reducing microorganisms have not yet been identified. The remaining five patients are being followed by the craniofacial and orthodontic services and have not reached skeletal maturity. This paper reviews the history and current trends in laparoscopic surgery for UC. After the interviews, two physicians independently reviewed each VA questionnaire to determine a probable cause of death. FGF19 has been shown to have profound effects on glucose and lipid metabolism.

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Epidemiological survey on urinary incontinence in school population in Verona (Italy). Significant time and effort are required to determine and optimize many macromolecular structures because of the need for manual interpretation of complex numerical data, often using many different software packages, and the repeated use of interactive three-dimensional graphics. Deliveries occurred during a 25-year period, with a mean follow-up duration of 11.2 years. The American Pediatric Society and the Society for Pediatric Research. The results of Southern hybridization analysis were uninformative since all family members, including the probands and fetuses, had all four TaqI fragments. According to our observations, good sleep in SB patients is characterized by a low incidence of K-complexes or K-alphas and by the absence of any difference in other sleep microstructure variables or SWA. A novel perspective on seed yield of broad bean (Vicia faba L.): differences resulting from pod characteristics. Then, the data were entered into the SPSS statistical software (version 16) and analyzed using repeated measures ANOVA and post-hoc test (Scheffe).

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Fine needle aspiration enabled cytological identification of the algae in these 21 mammary glands, from which P. Jejunal preduodenal pouches provide a better QoL than Roux-en-Y reconstruction. Scaling dermatosis in three dogs associated with abnormal sebaceous gland differentiation. Prescription of benzodiazepines in general practice in the county of Arhus, Denmark. Results of radiotherapy for primary subglottic squamous cell carcinoma. Mild stromal edema was present during the first few days and disappeared afterward with mild haze around the tunnel site in all cases. Poliomyelitis in children can cause paralysis of shoulder girdle muscles leading to a flail shoulder. Operating time differed between groups, 87 versus 143 minutes for laparotomy and laparoscopy, respectively.

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The study of convergent evolution provides an exciting opportunity to gain further insights into the evolutionary processes leading to human-like forms of cooperation and communication. RFID uses radio-frequency tags attached to people or objects to provide identification, tracking, security, and other functions that fall under the general heading of automatic identification and data capture (AIDC). Are first trimester trophoblast volume (TV) and placental bed vascular volume (PBVV) different in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies?. A prospective monitoring was conducted among the perinatal infants born in 945 hospitals in 20 provinces/municipalities/autonomous regions in anafranil 75 mg teilbar China during the period from 1 October 1986 to 30 September 1987 to count up the numbers of twins and of twins with BD or NTD. In addition, the HNC cell preferentially kills the MA-160 target, the herpes simplex virus-1-infected MA-160 cell line, and the two human tumor cell lines HEp-2 and HF-2. This finding suggests that a treatment schedule based on this regimen would be suitable for post-exposure prophylaxis. Primary assessments included pre- and postsurgery penile curvature, erectile rigidity, stretched penile length, intraoperative time, and occurrence of adverse events.

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In fact, the MTM measure can be viewed as a generalization of the NCC for nonlinear mappings and actually reduces to NCC when mappings are restricted to be linear. The study also supports a previous suggestion based on analysis of partial sequences of the structural proteins that LV is more related to the genus of Parechovirus than to other picornaviruses, but also shows that the three LV strains used in the comparison constitute a distinct monophyletic group, clearly separated from the parechoviruses. Bcl-xL silencing induces alterations in hsa-miR-608 expression and subsequent cell death in A549 and SK-LU1 human lung adenocarcinoma cells. This interaction appears similar in its characteristics to that occurring in the non-nuclear membrane fraction which is thought to occur at the synaptic glycine receptor complex. This open-label, multi-institutional phase II trial evaluated activity and safety of rilotumumab (AMG 102), a monoclonal antibody that targets HGF (hepatocyte growth factor), the ligand for the MET receptor, in women with recurrent or persistent epithelial ovarian, fallopian tube or primary peritoneal cancer. Mind-body practices have encouraging results for patients with cardiac disease. Strong evidence now exists that AM is able to act as an autocrine, paracrine, or endocrine mediator in a number of biologically significant functions, including the endothelial regulation of blood pressure, protection against organ damage in sepsis or hypoxia, and the control of blood volume through the regulation of thirst. The PGI2-induced hyperthermia was not mediated by its stable metabolite 6-keto prostaglandin F1 alpha. Aldosterone also plays a crucial role on systemic and vascular insulin resistance, i.e. Modified energy settings are mandatory to minimize oesophageal injury using the novel multipolar irrigated radiofrequency ablation catheter for pulmonary vein isolation.

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Chronic infection of Toxoplasma gondii downregulates miR-132 expression in multiple brain regions in a sex-dependent manner. At admission, there were mild changes in the blood count, most of which, however, were reversible after weight gain. Oxamniquine is at present the only available alternative to praziquantel. The number of CNTF-ir ONs varied interindividually in rats and was lower in mice than in rats. The diagnosis of tick paralysis must be considered in any patient, particularly children, who present with either acute ataxia or acute ascending paralysis.

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The different particle sizes of microspheres prepared from the same drug to polymer ratio showed no significant difference in drug content, indicating that the ratio between theophylline and PMM remained practically constant regardless of the size of microspheres. Comparative DNA damage and repair in echinoderm coelomocytes exposed to genotoxicants. We describe an unusual adverse effect from clozapine treatment that has not been described elsewhere to our knowledge. Two polymer chains that occupy equal volumes when covalently linked together at one end self-assemble into an alternating lamellar morphology that has a characteristic period dictated by the molecular weight. Clinical characteristics of hypervagotonic sinus node dysfunction. The authors therefore evaluated whether a short-course of immunosuppression (IS) given in addition to co-stimulation blockade would facilitate chimerism induction and allow reduction of the minimally required number of BMC without cytoreduction. Effect of low oxygen gas inhalation on the renal circulation and electrolyte metabolism in patients with liver diseases. If the observer agreement is high, the method used in the classification of lesion would be reproducible. To assess perceptions about the value and impact of publicly reporting hospital performance measure data.

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In this work we present the fabrication and characterization of immunosensors based on polystyrene (PS)-multiwalled carbon nanotube (MWCNT) composites. We found no effect on plasma TGs, weight, and other cardiometabolic risks in the ITT analysis, although the intervention lowered plasma TGs and MetS prevalence among obese participants. In vivo and in vitro examination of the tendinous inscription of the human semitendinosus muscle. Action potential duration and effective refractory period were lengthened in both atrium and ventricle, the effects being long-lasting and persisting on wash-out of the drug when other measurements had returned to control values. We also describe the patterning of two aligned SAMs that resist the adsorption of proteins and a third region that does not resist the adsorption of proteins. Intracranial pressure measured in five patients through the reservoir showed the efficacy of the treatment, as well as the unreliability of clinical and ultrasonographic criteria in determining the amount of cerebrospinal fluid that should be aspirated daily. Stroke is the third leading cause of death and the leading cause of adult disability in the United States. Prevention of thromboembolism with low molecular weight heparin (Dalteparin-Na) in risk pregnancy. Application of free skin grafts is a standard procedure for reconstruction of anterior lamellar lid defects.

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Proprotein convertases (PCs) have been implicated in tumor cell invasion by processing a variety of substrates including matrix metalloproteinases (MMPs). FD-3 immobilized on iron(II, III) oxide poly (styrene-glycidyl methacrylate) magnetic porous microspheres: effects of inorganic compounds and kinetic study of effective diffusion in porous media. In response to IGF-1, but not to PDGF signaling, EGFP-p85alpha translocates to discrete foci in the cell. We have examined the structure of nuclear genes coding for ribosomal RNAs in maize and its wild relatives, the teosintes and Tripsacum. A constant level of FtsZ1 and FtsZ2 transcripts and proteins was observed in non-synchronized cell cultures. Biopsy specimens of each patient in both groups were taken from two lymph nodes with two needle aygestin 5 mg generic name passes per lymph node. Morphological and functional MRI studies after correction of aortic isthmus stenosis. Because of a lack of certified and experienced chemotherapy nurses in the ICU, oncology nurses may be pulled from their unit to administer chemotherapy.

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Naturally occurring peer support through social media: the experiences of individuals with severe mental illness using YouTube. This article explains AAA development and traditional repair, and introduces a new, less invasive method of repair: endovascular stenting. Contamination of coagulation factor concentrates with human parvovirus B19 genotype 1 and 2. In the oldest animals, the microcysts had spread to other central auditory structures, including the superior olivary complex, the nuclei of the lateral lemniscus, and the inferior colliculus. Studies with more rigorous designs are required before definitive conclusions can be made. Here, the overall performance of Si-doped WO(3) nanoparticles, made by flame spray pyrolysis, as portable acetone detectors is critically reviewed focusing on the requirements for medical diagnostics. Metabolic syndrome was defined with the National Cholesterol Education Program Adult Treatment Panel III (MetSNCEP) and World Health Organization (MetSWHO) definitions. Shielding requirements for constant-potential diagnostic x-ray beams determined by a Monte Carlo calculation. We also verify that robust statistics outperform t-statistics in identifying differentially expressed genes when there are few replicates.

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This model will be useful in examining the effect of joint inflammation on nociceptor sensitisation in both normal and transgenic mice. Fiber tracking in the same regions of interest (genu of the corpus callosum) was performed separately. Our results demonstrate that AhR is essential to the resistance against LM infection as it promotes macrophage survival and ROS production. Our results suggest that down-regulation of Skp2 appears to induce apoptosis in oral cancer cells, targeting this molecule could represent a promising new therapeutic approach for this type of cancer. As a result of progressing airway obstruction acute intubation was performed prior to completion imuran 100 mg tablet of tube thoracostomy resulting in immediate improvement of the condition. Thus a high cortisol value identified three major targets for treatment in type 1 diabetes. Multiple intracranial aneurysms: endovascular treatment and complications. The assessment of the prognosis of the schizophrenic illness by most patients and relatives appears quite realistic. The inhibitory effects of these three uraemic toxins on the interaction of three marker ligands sodium octanoate (for medium chain fatty acids), salicylic acid and phenol red (bilirubin site/site I) with albumin have been investigated by differential scanning microcalorimetry and flow microcalorimetry. Pharmacologic modification of the late allergic response is especially important because these reactions may be more severe and prolonged than immediate allergic reactions.

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