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Sildenafil

Sildenafil is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased cGMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH.

Other names for this medication:
Caverta, Intagra, Kamagra, Penegra, Revatio, Silagra, Sildenafil, Sildenafila, Sildenafilo, Sildenafilum, Sildigra, Suhagra, Veega, Zenegra

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Description

Sildenafil (Pfizer) has fast become on the most effective methods to treat erectile dysfunction. The drug has the ability to increase blood flow to the penis causing it to become hard. There are a number of reasons why men lose that ability to get an erection, like stress and various psychological factors. After taking the medication, men will experience an erection, but not immediately. An erection will usually last about four hours, after which the blood flow returns to normal and the erection is lost. Sildenafil (Pfizer) can improve your sexual activity by prolonging erection for 4 hours. Sildenafil (Pfizer) helps to improve erection. With Sildenafil (Pfizer) you can be satisfied with your sexual life. Sildenafil (Pfizer) works for 4 hours, when you are in sexual activity. After this activity erection goes away. Sildenafil (Pfizer) works from the first time but sometimes your organism need more time. So, don't hurry because erection can be improved with practice. Sildenafil (Pfizer) is also known as Sildenafil citrate, Aphrodil, Edegra, Erasmo, Penegra, Revatio, Supra, Silagra, Zwagra. Sildenafil (Pfizer) doesn't protect you and your partner from sexually transmitted diseases (including HIV) and from pregnancy. Men of all ages, men who suffer from high blood pressure, diabetes and depression can treat ED with Sildenafil (Pfizer).

Dosage

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Adults up to 65 years of age—50 milligrams (mg) as a single dose no more than once a day, 1 hour before sexual intercourse. Alternatively, the medicine may be taken 30 minutes to 4 hours before sexual intercourse. Your doctor may adjust your dose if needed.

Adults 65 years of age and older—25 mg as a single dose no more than once a day, 1 hour before sexual intercourse. Alternatively, the medicine may be taken 30 minutes to 4 hours before sexual intercourse. Your doctor may adjust your dose if needed.

Overdose

In studies with healthy volunteers of single doses up to 800 mg, adverse reactions were similar to those seen at lower doses but incidence rates and severities were increased.

In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and it is not eliminated in the urine.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Sildenafil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Patients should be reminded that sildenafil, when used for erectile dysfunction, offers no protection against sexually transmitted disease. Counseling of patients about protective measures, including the prevention of transmission of human immunodeficiency virus (HIV) infection, should be considered.

Sildenafil has no effect on bleeding time when taken alone or with aspirin. In vitro studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside (a nitric oxide donor). There is no safety information on the administration of sildenafil to patients with a coagulopathy or active peptic ulcer disease. Therefore, sildenafil should be administered with caution to these patients.

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Post-transcriptional regulation of hepatic NADPH-cytochrome P450 reductase by thyroid hormone: independent effects on poly(A) tail length and mRNA stability. The patient was born in the UK but she and her family were African and of Kenyan origin. Despite their benefits, use of these therapies varies largely by physician preferences in part because of the concern for SIP. Differential diagnosis of perinatal OCD including pregnancy psychosis and post-partum depression is often difficult. The parents needed skilled staff who could relieve them of medical responsibility, but they wanted to be involved in the care and in the decisions taken. Implicit and explicit ethnocentrism: revisiting the ideologies of prejudice. Improved knowledge of gene expression changes and functional pathways associated with these clinical phenotypes may lead to new treatment targets, markers for early detection and a better understanding of disease progression. The difference between cultural (folk) and medical definitions of body size terms may serve as a barrier to effective communication between patients and providers about health effects of excess adiposity. In zithromax dose pid conclusion, these findings suggest that TXNL1 was a feasible modulator and potential chemotherapeutic target for the cisplatin resistant phenotype of human gastric cancer cells. One decade of improving palliative care of metastatic renal cell carcinoma by antiangiogenic therapies: time to move toward RCC cure.

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