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Sildenafilo (Sildenafil)

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Sildenafilo is used to treat men who have erectile dysfunction (also called sexual impotence). Sildenafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly. The penis is one of the areas where this enzyme works. Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. When a man is sexually stimulated, his body's normal response is to increase blood flow to his penis to produce an erection. By controlling the enzyme, sildenafil helps to maintain an erection after the penis is stroked. Without physical action to the penis, such as that occurring during sexual intercourse, sildenafil will not work to cause an erection.

Other names for this medication:
Caverta, Intagra, Kamagra, Penegra, Revatio, Silagra, Sildenafil, Sildenafila, Sildenafilo, Sildenafilum, Sildigra, Suhagra, Veega, Zenegra

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Also known as: Sildenafil


Sildenafilo is approved to treat erectile dysfunction (ED) in men. With ED, you have trouble getting and keeping an erection that’s firm enough to allow you to have sex.

What causes an erection?

When you’re sexually aroused, either through sexual thoughts or touch, your brain sends messages to your penis. These messages cause certain chemicals to be released in your penis.

One of these chemicals, called cyclic GMP, relaxes and widens certain blood vessels in your penis. Cyclic GMP also relaxes the muscles around the erectile tissue in your penis that’s called the corpus cavernosum. These actions allow blood to flow into the corpus cavernosum, which causes your penis to get hard and become erect.

What happens with ED?

ED can occur if you have certain problems that affect your body’s ability to have an erection. The condition can result from problems with messages being sent from your brain. ED can also result from problems with blood flow into your penis.

What does Sildenafilo do for ED?

Sildenafilo works to treat ED by helping you have and maintain an erection. The drug does this by improving blood flow into your penis when you’re sexually aroused.

Sildenafilo is a type of drug called a phosphodiesterase type 5 (PDE5) inhibitor. It works by inhibiting (blocking) the action of an enzyme called PDE5. (An enzyme is a protein that helps chemical reactions to happen inside your body.)

Normally, an erection goes away when PDE5 breaks down the cyclic GMP in your penis. But Sildenafilo blocks the action of PDE5, so it allows cyclic GMP to keep working for a longer period of time than usual. This action improves blood flow to your penis and helps you to have and keep an erection.

Does Sildenafilo increase a man’s sex drive?

No, Sildenafilo doesn’t directly increase your sex drive. And it doesn’t make you sexually aroused. However, some men find that if Sildenafilo works to treat their erectile problem, it also increases their sexual confidence. And this may lead to an increased sex drive.

How can I tell if Sildenafilo’s not working?

Sildenafilo may not work for everyone, and it may not work every time you take it.

If you’re sexually aroused, Sildenafilo should work to help you have or keep an erection within 30 minutes to 2 hours. But if you don’t get an erection within 4 hours after taking a dose, Sildenafilo didn’t work for you this time.

If the drug doesn’t work for you, you shouldn’t take another dose until at least 24 hours later. And talk with your doctor if you feel Sildenafilo isn’t helping to treat your ED. They may recommend that you try a different medication for your ED.

How can I get Sildenafilo to work?

It’s important to remember that Sildenafilo only works if you’re already sexually aroused. Arousal may involve having sexual thoughts, looking at sexual images, masturbating, or engaging in foreplay.

But if you feel anxious, nervous, depressed, or stressed, your body may not respond well to sexual stimulation. If this is the case, try to relax, make yourself comfortable, and take your time. In addition, it’s best to avoid drinking a lot of alcohol. This is because consuming large amounts of alcohol can make it more difficult for you to get an erection.

If you’re having trouble getting an erection, even while using Sildenafilo, talk with your doctor.

Is Sildenafilo a blood thinner?

No, Sildenafilo isn’t a blood thinner. Instead, it belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. (A class of drugs describes a group of medications that work in a similar way.) Sildenafilo works by inhibiting (blocking) the action of a certain enzyme in your body.

Since Sildenafilo has been released onto the market, there have been a few reports of bleeding in people who’ve taken the drug. However, there’s no evidence that Sildenafilo caused these bleeding problems.

It’s not known if Sildenafilo is safe for use by people with a bleeding problem. If you have any bleeding problems, talk with your doctor about whether Sildenafilo is safe for you.


The starting dose is 50 mg. According to research, most men decide that 100 mg is a more effective dose if you are in a good state of health. Sildenafilo (Pfizer) should be taken once a day, 30 minutes to 1 hour before sex. You can take Sildenafilo (Pfizer) with or without food or alcohol. But if you want to get the quickest result you should avoid fat meals (fries or cheeseburgers) 2 hours before taking Sildenafilo (Pfizer).


If you take an overdose of Sildenafilo, you should seek emergency medical attention or contact your healthcare provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Sildenafilo are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Sildenafilo if you are allergic to sildenafil, or:

if you take other medicines to treat pulmonary arterial hypertension, such as riociguat (Adempas). if you take nitrates.

Do not take Sildenafilo if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.

To make sure Sildenafilo is safe for you, tell your doctor if you have ever had:

heart disease or heart rhythm problems, coronary artery disease; a heart attack, stroke, or congestive heart failure; high or low blood pressure; liver or kidney disease; a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia; a bleeding disorder such as hemophilia; a stomach ulcer; retinitis pigmentosa (an inherited condition of the eye); a physical deformity of the penis (such as Peyronie's disease); or if you have been told you should not have sexual intercourse for health reasons.

Sildenafilo can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people taking sildenafil, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoked or were over 50 years old. It is not clear whether sildenafil is the actual cause of vision loss.

Sildenafilo is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether sildenafil passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Do not give this medicine to anyone under 18 years old without medical advice.

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miR-31 regulated the proliferation of colon cancer cells by targeting E2F2. The detection of cytomegalovirus (CMV) antigens in malignant cells has suggested that treatment strategies based on immunological intervention, such as adoptive transfer of antiviral T cells or vaccination with viral epitopes, could be exploited as cancer therapy. Inhibition of acetaminophen sulfation by 2,6-dichloro-4-nitrophenol in the perfused rat liver preparation. Research advances on DNA extraction methods from peripheral blood mononuclear cells. Peculiar surface-interface properties of nanocrystalline ceria-cobalt oxides were evidenced by X-ray diffraction, transmission electron microscopy and X-ray absorption spectroscopy. However, the molecular mechanisms underlying its interactions with these malignancies are largely unknown. Ultrasonographic follow-up and magnetic resonance imaging of the ovaries were employed in order to avoid exploratory laparotomy and rule out ovarian carcinoma. Longer procedure times result in higher radiation dose, to both patient and surgeon. In the third group, hesperidin was orally administered at the dose of 50 mg/kg day(-1) for 14 days. Here we show that Bchl synthesis also affects the expression of the bchC gene, which codes for a subunit of bacteriochlorophyll synthase, suggesting an autoregulatory mechanism for the Bchl biosynthetic pathway.

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Here, we demonstrated that Mycobacteria, Shigella, and Listeria but not Klebsiella, Staphylococcus, and Escherichia inhibit IFNG-induced autophagy in macrophages by evoking selective and robust activation of WNT and SHH pathways via MTOR. Of the core Field functions, identification and assembly of relevant trials into a specialized register would be among the most important. Kinetic analyses of the OJIP chlorophyll fluorescence rise in thylakoid membranes. However, the long-term consequences of mismanagement can be devastating. Genotyping of A1330V and V667M polymorphisms was performed by real-time polymerase chain reaction. When a standardized protocol is used, the reproducibility of maximal gait speed measurements is excellent. Concerning health of Nurses, an expert gives advice about how even nurses can stay in top physical condition.

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The proportion of lymphocytic inflammation with CD123-positive cells in lupus erythematous profundus predict a clinical response to treatment. By employing assemblies of magnetic nanoparticles as kernels against FMSNPs, both the saturation of magnetization and the magnetic resonance (MR) signal intensity were significantly enhanced. Incomplete longitudinal fractures and fatigue injury of the proximopalmar medial aspect of the McIII may occur in horses of many types and sports disciplines, and are not confined to immature performance horses. Combining CA inhibition with NO-donating moieties in the same compound offers an excellent approach for the management of glaucoma. Current approaches associate these measures to finite single values within an observation window, thus not being able to characterize the system evolution at each moment in time. Our results provide the first evidence that As2O3 enhances the anion transport activity of band 3 and the action is related with the C-terminal 16 residues of the protein. In this situation, the beam-tracking technique purely based on the received signal is not effective because both behavioral changes (rotation, displacement) and environmental changes (blockage) result in power loss in the received signal. Both the ubiquitin ligase activity of c-Cbl and the UIM of Eps15 were necessary for plasma membrane recruitment of Eps15 and entry of ligand-bound EGFR into coated pits and vesicles containing Eps15. The elevated serum resistin in human diabetes is often associated with a pro-inflammatory milieu.

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This study significantly expands previous reports on microbial abundances in is biaxin a sulfa drug sponge tissues and contributes to a better understanding of the HMA-LMA dichotomy in sponge-microbe symbioses. Grades chosen for this assessment included 1, 2, 3, 6, 7, 8, and 11. Extending these approaches, this study introduces a method, which defines the evolution of fractal dimensions of tablets as surrogate parameter for the available surface area. Regular TCP dishes and PPy polymerized on TCP by chemical polymerization without surfactant using 5 x 10(-3) M Py, were used as controls. Spatial constraints on visual-tactile cross-modal distractor congruency effects. Spatial contrast sensitivity demonstrated some lateralization, as the sensitivity to low spatial frequencies obtained through separate eyes showed significantly larger side-differences in migraine patients than in control subjects. A number of obstacles were encountered that would need to be tackled to achieve a consistency of thought across the profession. Analytical and preparative chromatographic procedures for obtaining pure cresyl violet and cresyl red from commercial cresyl violet.

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Early apoptosis induced by 4 h incubation with xanthoangelol was detected using flow cytometry after double-staining with annexin V and propidium iodide (PI). The characteristic glomerulopathy found in the present patient is considered to be an additional renal lesion, leading to the renal failure. Recent research indicates that BZs act by binding to free beta-tubulin in the cell and inhibiting the formation of microtubules. Clinicians should report as soon as possible to their insurance companies to get professional help. Report the de novo formation of an aneurysm after wingspan placement and describe the treatment modality. Interestingly, mutant strains having coreg 37.5 mg a deletion in type III secretion system 1 (TTSS1) failed to elicit DNA fragmentation in HCT116 cells. Inclusion of propranolol in the perfusion buffer blocked the isoproterenol-induced inhibition of HX-XO-stimulated TNF-alpha release and release of cyclic AMP into the coronary effluent. Risk factors and mortality among newborns with persistent pulmonary hypertension. This review centers upon defining basic biological characteristics of stem cells used for sustaining cardiac integrity during disease and maintenance of communication between the cardiac environment and stem cells.

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However, preincubation of mammary microsomes with both cytochrome b5 and terminal desaturase results in a 200-fold stimulation of overall desaturation. The aim of our study was to assess the possible relationship between event-related potentials (ERP) and serotonergic or noradrenergic activity in depression. Preoperative location of the pituitary bright spot in patients with pituitary macroadenomas. To exhaustively address the association of virus and glioblastoma, we developed and validated a robust metagenomic benicar max dosing approach to analyze patient biopsies via high-throughput sequencing, a sensitive tool for virus screening. Participants also had significantly higher life satisfaction scores after the program. Use rate (number of units used/number of units donated) and quality-adjusted life years were calculated.

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The acidic solutions were characterized by pH value and titratable acidity. Analysis of kinetic data of allosteric enzymes by a linear plot. Effect of bovine somatotropin and rumen-undegradable protein on mammary growth of prepubertal dairy heifers and subsequent milk production. Results of an orthopaedic survey in young patients with severe haemophilia in Spain. The most commonly used treatment modalities were assessed for the best results in terms of efficacy and tolerability. The study included patients admitted to the intensive care unit with septic shock at an 805-bed tertiary, academic center. The direct actions of transmembrane receptors within the nucleus remain enigmatic. No change of gene expression of AMPA receptor subunits other than GluR1 was observed.

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The administration of L-Trp also significantly increased plasma nitric oxide and serotonin levels. A reduced antiplatelet effect of name of claritin generic aspirin may be explained by an increased number of immature platelets. Integrating problem-based learning into teaching has many positive implications. The present study showed that microbial biomass-carbon was significantly higher in planted soils than in bulk soil, especially with wheat and corn, after several cropping cycles. Immunomodulatory antibody therapy of cancer: the closer, the better. These metabolites represent the end product of gene expression, thus metabolic profiling can give a broad view of the biochemical status or biochemical phenotype of a hairy root line that can be directly linked to gene function.

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Mortality in Cumberland during 1959-78 with reference to cancer in young people around Windscale. The physical measurement of image quality was conducted with an aluminum step-wedge. Isolated oral Kaposi sarcoma in an HIV-negative patient: a case report. The expression levels of hepatic miR-370 in male C57BL/6 mice subjected to hepatic IR injury or ischaemia preconditioning were assessed by quantitative real-time PCR. The role of the plexin-A2 receptor in Sema3A and Sema3B signal transduction. Mycophenolate mofetil-based salvage as acute GVHD prophylaxis after early discontinuation of tacrolimus and/or sirolimus.

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