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Sustiva

Sustiva is used along with other medications to treat human immunodeficiency virus (HIV) infection. Sustiva is in a class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). It works by decreasing the amount of HIV in the blood.

Other names for this medication:
Cytocom, Duovir, Efavir, Efavirenz, Efcure, Efferven, Emduo, Estiva, Evirenz, Lamivir, Lazid, Odivir, Retrodel, Revenz, Tenola, Trioday, Trustiva, Viraday, Viranz, Virocmb, Virolis, Vonavir, Zidolam

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Also known as: Efavirenz

Description

{name} (efavirenz) is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body.

{name} is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS).

{name} is for adults and children who are at least 3 months old and weigh at least 8 pounds. This medicine is not a cure for HIV or AIDS.

Dosage

Usual Adult Dose for HIV Infection:

600 mg orally once a day Comments: -This drug should be used with a protease inhibitor and/or NRTIs. Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Usual Adult Dose for Nonoccupational Exposure:

US CDC recommendations: 600 mg orally once a day Duration of therapy: 28 days Comments: -This drug should be used with (lamivudine or emtricitabine) plus (zidovudine or tenofovir); recommended as the preferred NNRTI-based regimen for nonoccupational postexposure prophylaxis of HIV infection. -Prophylaxis should be started as soon as possible, within 72 hours of exposure. -Not approved by US FDA.

Usual Adult Dose for Occupational Exposure:

US Public Health Service working group recommendations: 600 mg orally once a day Duration of therapy: 28 days, if tolerated Comments: -An alternative antiretroviral agent for use as HIV postexposure prophylaxis only with expert consultation -Prophylaxis should be started as soon as possible, preferably within hours after exposure. -The optimal duration of prophylaxis is unknown and may differ based on institution protocol. -The most current therapeutic guidelines should be consulted for more information. -Not approved by US FDA.

Usual Pediatric Dose for HIV Infection:

3 months or older: 3.5 to less than 5 kg: 100 mg orally once a day 5 to less than 7.5 kg: 150 mg orally once a day 7.5 to less than 15 kg: 200 mg orally once a day 15 to less than 20 kg: 250 mg orally once a day 20 to less than 25 kg: 300 mg orally once a day 25 to less than 32.5 kg: 350 mg orally once a day 32.5 to less than 40 kg: 400 mg orally once a day 40 kg or more: 600 mg orally once a day Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Detailed Sustiva dosage information

Overdose

If you overdose Sustiva and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Sustiva are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Sustiva if you are allergic to efavirenz, or if you also take elbasvir and grazoprevir (Zepatier) to treat hepatitis C.

Do not take with Atripla (combination efavirenz, emtricitabine, and tenofovir), unless your doctor tells you to.

Tell your doctor if you have ever had:

liver disease (including hepatitis B or C); long QT syndrome; a seizure; mental illness or psychosis; heart disease; or if you drink large amounts of alcohol or have a history of injection drug use.

Do not use Sustiva if you are pregnant. It could harm the unborn baby or cause birth defects. Use 2 forms of birth control, including a barrier form (condom, diaphragm, cervical cap, or contraceptive sponge) to prevent pregnancy while you are using this medicine and for at least 12 weeks after your last dose. Tell your doctor if you become pregnant during treatment.

Hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy while you are taking Sustiva.

HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

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Photo-assisted Fenton type processes for the degradation of phenol: a kinetic study. Unsuspected chronic pelvic inflammatory disease in the infertile female. Cardiomyopathic etiology and SERCA2a reverse remodeling during mechanical support of the failing human heart. Furthermore, hsp105 immunoreactivity in some cases of gastric, esophageal, and hepatocellular carcinoma was much stronger than that in normal corresponding tissues. Therefore, GLV-1h153 is a promising candidate for the noninvasive imaging of virotherapy and warrants further study into longterm monitoring of virotherapy and potential radiocombination therapies with this treatment and imaging modality. A low-resistance flow meter for wide-range ventilatory measurement. Results of a 4-year study on 15,447 medical abortions provided by privately practicing general practitioners and gynecologists in France. From February 2003 to May 2004, we have performed 220 surgical procedures for colorectal pathology: 63 were conducted by a laparoscopic approach with 10 patients who, converted to a laparotomic procedure in theatre, were not taken under consideration. For membranes composed of an arbitrary number of aligned, laterally unconnected thin layers, these are area expansivity and local and non-local bending.

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Host factors such as underlying disease and cell-mediated immunity play a decisive role in the clinical expression of C. Intraocular pressure changes secondary to reduction of orbito-zygomatic complex fractures. Sixty-four eyes of 51 patients with chronic macular oedema, refractory to conventional treatments, received an intravitreal injection of 4 danocrine tablet obat apa mg Kenacort (triamcinolone acetonide). Application of C-nuclear magnetic resonance to the observation of metabolic interactions in anaerobic digestors. With the demonstration of PgIB activity in vitro, fundamental questions surrounding the mechanism of N-linked glycosylation can now be addressed. Heterotopic pregnancy is a simultaneous occurrence of intra-uterine pregnancy and ectopic pregnancy. Perceptual flexibility in word recognition: strategies affect orthographic computation but not lexical access. Sodium butyrate treatment increased the transcriptional activity in all cell lines, but remained two- to fourfold higher in the HP75 and GH3 cell lines than in the TtT/GF cells. In the recently vaccinated racehorses in Newmarket the single radial haemolysis antibody levels in acute sera appeared to be adequate, and there did not appear to be significant antigenic differences between the infecting virus and A/eq/Newmarket/1/93, the representative of the American lineage virus present in the most widely used vaccine, to explain the vaccine failure. Twenty-two isolates of Anabaena azollae derived from seven Azolla species from various geographic and ecological sources were characterized by DNA-DNA hybridization.

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