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Viagra

Viagra is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. Its effectiveness for treating sexual dysfunction in women has not been demonstrated. Pfizer scientists Andrew Bell, David Brown, and Nicholas Terrett originally discovered sildenafil as a treatment for various cardiovascular disorders. Since becoming available in 1998, sildenafil has been a common treatment for erectile dysfunction The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus.

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Also known as: Sildenafil

Description

Viagra is approved to treat erectile dysfunction (ED) in men. With ED, you have trouble getting and keeping an erection that’s firm enough to allow you to have sex.

What causes an erection?

When you’re sexually aroused, either through sexual thoughts or touch, your brain sends messages to your penis. These messages cause certain chemicals to be released in your penis.

One of these chemicals, called cyclic GMP, relaxes and widens certain blood vessels in your penis. Cyclic GMP also relaxes the muscles around the erectile tissue in your penis that’s called the corpus cavernosum. These actions allow blood to flow into the corpus cavernosum, which causes your penis to get hard and become erect.

What happens with ED?

ED can occur if you have certain problems that affect your body’s ability to have an erection. The condition can result from problems with messages being sent from your brain. ED can also result from problems with blood flow into your penis.

What does Viagra do for ED?

Viagra works to treat ED by helping you have and maintain an erection. The drug does this by improving blood flow into your penis when you’re sexually aroused.

Viagra is a type of drug called a phosphodiesterase type 5 (PDE5) inhibitor. It works by inhibiting (blocking) the action of an enzyme called PDE5. (An enzyme is a protein that helps chemical reactions to happen inside your body.)

Normally, an erection goes away when PDE5 breaks down the cyclic GMP in your penis. But Viagra blocks the action of PDE5, so it allows cyclic GMP to keep working for a longer period of time than usual. This action improves blood flow to your penis and helps you to have and keep an erection.

Does Viagra increase a man’s sex drive?

No, Viagra doesn’t directly increase your sex drive. And it doesn’t make you sexually aroused. However, some men find that if Viagra works to treat their erectile problem, it also increases their sexual confidence. And this may lead to an increased sex drive.

How can I tell if Viagra’s not working?

Viagra may not work for everyone, and it may not work every time you take it.

If you’re sexually aroused, Viagra should work to help you have or keep an erection within 30 minutes to 2 hours. But if you don’t get an erection within 4 hours after taking a dose, Viagra didn’t work for you this time.

If the drug doesn’t work for you, you shouldn’t take another dose until at least 24 hours later. And talk with your doctor if you feel Viagra isn’t helping to treat your ED. They may recommend that you try a different medication for your ED.

How can I get Viagra to work?

It’s important to remember that Viagra only works if you’re already sexually aroused. Arousal may involve having sexual thoughts, looking at sexual images, masturbating, or engaging in foreplay.

But if you feel anxious, nervous, depressed, or stressed, your body may not respond well to sexual stimulation. If this is the case, try to relax, make yourself comfortable, and take your time. In addition, it’s best to avoid drinking a lot of alcohol. This is because consuming large amounts of alcohol can make it more difficult for you to get an erection.

If you’re having trouble getting an erection, even while using Viagra, talk with your doctor.

Is Viagra a blood thinner?

No, Viagra isn’t a blood thinner. Instead, it belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. (A class of drugs describes a group of medications that work in a similar way.) Viagra works by inhibiting (blocking) the action of a certain enzyme in your body.

Since Viagra has been released onto the market, there have been a few reports of bleeding in people who’ve taken the drug. However, there’s no evidence that Viagra caused these bleeding problems.

It’s not known if Viagra is safe for use by people with a bleeding problem. If you have any bleeding problems, talk with your doctor about whether Viagra is safe for you.

Dosage

The starting dose is 50 mg. According to research, most men decide that 100 mg is a more effective dose if you are in a good state of health. Viagra (Pfizer) should be taken once a day, 30 minutes to 1 hour before sex. You can take Viagra (Pfizer) with or without food or alcohol. But if you want to get the quickest result you should avoid fat meals (fries or cheeseburgers) 2 hours before taking Viagra (Pfizer).

Overdose

If you overdose Viagra (Pfizer) and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep this medicine where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Keep Viagra in a cool, dry place where the temperature stays below 30°C. Do not store it or any other medicine in the bathroom or near a sink.

Do not leave it in the car or on windowsills. Heat and dampness can destroy some medicines.

Keep the tablets in their pack until it is time to take them. If you take your tablets out of the pack they will not keep as well.

Side effects

The most common side effects associated with Viagra are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Before taking sildenafil, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as heart attack or life-threatening irregular heartbeat in the past 6 months, chest pain/angina, heart failure), stroke in the past 6 months, kidney disease, liver disease, high or low blood pressure, a severe loss of body water (dehydration), penis conditions (such as angulation, fibrosis/scarring, Peyronie's disease), history of painful/prolonged erection (priapism), conditions that may increase the risk of priapism (such as sickle cell anemia, leukemia, multiple myeloma), eye problems (such as retinitis pigmentosa, sudden decreased vision, NAION).

This drug may make you dizzy or cause vision problems. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

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In cardiac disease patients (dilatative cardiomyopathy, advanced coronary artery disease, decompensated hypertensive heart disease) cigarette smoking was associated with depression in the overall and regional contraction behavior of the left ventricular myocardium. UV- and Bax-induced apoptosis is abrogated in AR-positive cells that express small interference RNA (siRNA) of AR and is sensitized by reintroduction of AR into AR-negative cells. Cysteinyl leukotrienes have been found in the sputum of patients with CF at high concentrations sufficient to cause potent biological effects. Volunteers provide a crucial role in support of nonprofit rape crisis centers, and factors influencing their continued service are an important consideration for decision makers. In addition, a possible correlation of antimicrobial peptides of the beta-defensin family to TLRs was tested. In the present studies, the sexual behavior of stubby mice and their coisogenic, normal siblings was compared quantitatively. The potential value of red cell transketolase in the metabolic evaluation of disease. The results and consequences of these prescriptions are explored by application to three examples of patient data. Transjugular intrahepatic portosystemic shunt (TIPS) has been popularized for the treatment of refractory variceal bleeding. A simple and quantitative method is described which assesses the motor function of the rat tibial nerve by recording the twitch tension developed by the digital flexors.

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Antioxidants, oxidative stress, and pulmonary function moduretic dosage in individuals diagnosed with asthma or COPD. We reviewed the charts of 504 consecutive women who had synthetic mid urethral sling procedures (154 TO or 350 TA) performed by 24 different urologists for SUI at 8 institutions from 2002 to 2004. The capsule produced clear and recognizable images of lesions even without bowel preparation. These doses produced nearly equivalent shifts in isoproterenol-induced chronotropic dose-response curves, indicating equivalent degrees of beta adrenergic blockade. Iridic and retinal coloboma associated with prenatal methimazole exposure. Relationship between the temperature and endocrine changes induced by cholinesterase inhibitors.

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The sequential reagent dispensing and washing processes are controlled by the programmable sequencer. Women selected the combination of music and labor support as a helpful coping strategy during labor. To systematically review the literature to determine the characteristics and efficacy of early psychological interventions in children and adolescents after a single, potentially-traumatising event. The effect of sequential addition of the nitrosourea, chlorozotocin, to the FAM combination in advanced gastric cancer. Tumor necrosis factor alpha sensitizes low epidermal growth factor receptor (EGFR)-expressing carcinomas for anti-EGFR therapy. Preclinical evaluation of the anti-neoplastic activity of an insulin-like growth factor I receptor (IGF-IR) kinase inhibitor in ovarian cancer. The expression pattern of WDR10 and its glyburide dosage in pregnancy chromosomal location makes this novel gene a candidate gene for the hypogonadism associated with some forms of retinitis pigmentosa and the Moebius syndrome.

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thermophilus, allowing defining the molecular bases of adaptative responses or markers for the identification of strains with potential industrial applications. Using cats anaesthetized with chloralose and urethane, comparison was made of the abilities of several antihypertensive and sympatholytic drugs to lower systemic blood pressure, and to depress the compensatory cardiovascular responses to bilateral carotid occlusion and to 45 degrees head-up tilting. However, the receptor subtypes and sites of actions as well as underlying mechanism are not clarified rigorously. Clinicopathological significance of intratumoural variations in elastosis grades and the oestrogen receptor status of human breast carcinomas. Improvements of optical tactile sensors for robotic system by gold nanocomposite material. A longitudinal study of breath isoprene in healthy volunteers using selected ion flow tube mass spectrometry (SIFT-MS). It increases sodium excretion with urine and retains potassium in the organism, without causing hyperkaliemia. A marginal vitamin A status alters the distribution of vitamin A among parenchymal and stellate cells in rat liver.

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Three patients with dural arteriovenous malformations contiguous with the cavernous sinus had marked worsening of their neuro-ophthalmic symptoms. Outer and inner arm dyneins from flagella of Chlamydomonas reinhardtii. Specimens of 1m were used to investigate the effect of water quality parameters using the circulatory method. The control group encompassed the health newborns matched as to the age. The 22 isoforms of the Pcdhg gene cluster are diversified into A-, B-, and C-types, and the C-type isoforms differ from all other clustered Pcdhs in sequence and expression. The effect of D-Trp6-LRH upon secretion of gonadotrophin--a possible therapeutic application in anorexia nervosa. Social exclusion of the mentally ill -- a critical review and outlook of community psychiatry at the beginning of the 21st century. Immunological properties of a collagen- can i take 80 mg of protonix a day like synthetic polypeptide. Haemorrhage due to accidental opening of the catheter occurred in three occasions.

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A causal association can be evaluated only with a case-control study, where normal controls are compared to ESCC cases for the presence of HPV. The video-radiographic examination of swallowing was done in the early period (max. Within this region, the gene encoding nicotinamide nucleotide transhydrogenase (Nnt) was found to be defective in C57BL/ tofranil 25 mg tablet cost 6J mice, and no mature NNT protein could be detected. The same trends were observed for dissection worktables used during the boning process. The third group includes NS1 proteins of H3N2 human influenza viruses. Cases with a successful healing, as determined at the one-year follow-up, demonstrated a continuous decrease of the Periotest values over time, whereas one-year failures showed increasing Periotest values over the study period. In patients with permanent AF, the rhythm control strategy consisting of internal cardioversion, performed by means of the implanted cardioverter-defibrillator after 3 months of CRT, was associated with a high rate of sinus rhythm resumption on long-term follow-up and with a better echocardiographic response to CRT than that seen in patients treated according to a rate control strategy.

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