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Xeloda (Capecitabine)
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Xeloda

Xeloda is in a class of medications called antimetabolites. It works by stopping or slowing the growth of cancer cells. Xeloda is used in combination with other medications to treat breast cancer that has come back after treatment with other medications.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Clarinex, Zithromax, Furadantin, Altace, Lopressor, Prandin, Imitrex, Tenormin, Ditropan, Strattera

Also known as: Capecitabine

Description

{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Xeloda for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Xeloda for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Xeloda dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Xeloda dosage information

Side effects

The most common side effects associated with Xeloda are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

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Pyrogenicity/antigenicity was evaluated in vivo by injecting autoclaved GO-CAT into New Zealand white rabbits. The present retrospective study is aimed to evaluate the pitfalls of DUS and the role of carotid angiography before carotid stenting in evaluating ICAD in patients with AVS. Is posttraumatic stress disorder associated with specific deficits in episodic memory?. A new challenge is treating patients according to radiation safety issues to avoid the risk of stochastic late effects, such as radiation-induced secondary tumors. Tidally induced fluctuations and transports of microfungi were investigated. The availability of particulate phosphofructokinase to complex inactivating antibodies specifically allows a separation of activating and inactivating antibodies from each other by a simple extraction procedure. The assist system has been evaluated for long-term circulatory assistance in a series of ten calves. The study implies that even in summer, after we sweat excessively, lipid products should be applied locally in order to maintain stability of the barrier function of the SC. Body weight of the spontaneously hypertensive rat during the suckling and weanling periods.

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Variants within the optineurin gene (OPTN) are recognized as causative mutations for primary open angle glaucoma. The hardening stresses in wall-to-wall bonded composites were measured and related to calculated values obtained from freely shrinking materials. The secondary objective was to test the suitability of the research method as a model for a wider study. Here, we report the relationship between the reorganization of AFs and vacuolar fusion revealed in pharmacological experiments, and characterizing stomatal opening in actin-related protein 2 (arp2) and arp3 mutants. We suggest that it is crucial to take both a theoretical and empirical approach to selecting a scoring method. In this study, the importance of different domains of the fibrinogen molecule in the binding and assembly of a surface plasminogen (plgn) activator has been analyzed. Here we explore the theoretical and practical considerations that arise when employing the general class of linear dynamical systems (LDS) as a model for sensorimotor learning. Two groups (Good Coping and Support Compensation) had significantly better health than expected in spite of severe abuse.

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Identifying function-specific therapeutics for SCA2 is problematic due to the limited knowledge of ATXN2 function. The X-linked macrosatellite DXZ4 is a large homogenous tandem repeat that in females adopts an alternative chromatin organization on the primate X chromosome in response to X-chromosome inactivation. The effect of Lewis lung tumor growth in mice on the induction of primary immune response to SRBC, was investigated by PFC assay for measuring antibody activity and by footpad test as a correlate for delayed type hypersensitivity reactions. Structure and stability of Co(n)(pyridine)(m)- clusters: absence of metal inserted structures. Monotic and dichotic ANL, monotic PRN, contralateral suppression of transient evoked otoacoustic emissions, and ipsilateral and contralateral acoustic reflex thresholds were measured in 31 adults with normal hearing. TS-1 was administered postoperatively, and recurrence or progression has not been detected for 3 years 4 months. During mediastinoscopy, the definition of the limit between station 2 and station 4 is arbitrary. Taken together, the encoding and recall results are consistent with the view that extracting passage gist under difficult listening conditions is especially vulnerable for patients with right hemisphere strokes. Program in pathology and postdoctoral programs must emphasize clinical and laboratory experience so that communication can be improved.

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Fibrinolytic activity, thrombin inhibitor and kinetics of clot formation in premature infants with respiratory distress syndrome. Binding of ciprofloxacin labelled with technetium Tc 99m versus 99mTc-pertechnetate to a live and killed equine isolate of Escherichia coil. Hematopoietic stem cell (HSC) division leads to self-renewal, differentiation, or death of HSCs, and adequate balance of this process results in sustained, lifelong, high-throughput hematopoiesis. The authors studied the rat brain after prolonged (up to 18 months) alcohol intoxication as well as the progeny of female rats after alcohol consumption for 4 months. Methamphetamine-HCl (0.1, 0.5 and 1 mg/kg, i.p.) increased motor activity of both the shocked and non-shocked rats, in a dose-related manner. Mycophenolate mofetil is currently studied with 48 months follow-up time.

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The diagnosis of involvement of the laryngeal cartilages presents some problems, which are discussed. Effect of cannabinoids on the turnover rate of acetylcholine in rat hippocampus, striatum and cortex. A clinical aspect of beta2-adrenoceptor pharmacology in recent years has been the recognition of genetic polymorphism of the receptor and how this affects responses to and tolerance to beta2-adrenoceptor agonists. It is revealed that the optical interference plays important role in the performance of the device and the optimal device performance is achieved when the thicknesses of the rubrene and C70 are set as 33 and 28 nm. Recent reports have shown that FVIIa binding to TF can influence a number of biological functions, such as angiogenesis and cancer metastasis. Diagnosis by imaging and cytological study after aspiration puncture. Laboratory measurement of cumulative food intake in humans: results on reliability. To assess whether simple, limited section analysis can replace detailed volumetric assessment of synovitis in patients with osteoarthritis (OA) of the knee using contrast-enhanced magnetic resonance imaging (MRI).

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The validity of ancient medicine is now being evaluated critically in cell-free systems, animal models, and human populations. Following chemotherapy and radiation, the mass appeared more mobile and surgically resectable. Nitrates and molsidomine are followed by calcium channel blockers and--afterwards--by beta-blockers. Rhizobial lipopolysaccharide as the receptor in lectin-Rhizobium interaction. A random-bred strain (Q) was established and divided into six replicates. p53 tumor suppressor protein regulates the levels of huntingtin gene expression. Studies carried out during the past two decades showed that bullying can have immediate and late negative outcomes for children and adolescents who are directly or indirectly involved. Hippocampal slice cultures were also used in our studies on glutamate transporters reviewed in the last part of this paper. Corresponding results for lower RTIs were (1.00, 0.80) and (0.93, 0.91) respectively. The aim of this study was the early detection of neurophysiological patterns of brain activity that may predict the possibility of certain subjects to develop MCI.

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Solvent Production and Morphological Changes in Clostridium acetobutylicum. These studies suggested that there may have been asbestos hazard in this industry although exposure was not known to exist. Median follow-up time in the 2 groups was 2.7 years in the medically treated patients and 4.0 years in the surgically treated patients. We studied the degradation of pentachlorophenol (PCP) under methanogenic and sulfate-reducing conditions with an anaerobic mixed culture derived from sewage sludge. formosa density were positively correlated with changes in vegetative cover for the population with a history of lower density, but not for the population with a history of higher density.

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As judged by sequence analysis, the V01 region, which comprises the homologous region 1 (hr1), is the most variable genomic region among the genotypes present in the Spanish isolates. Computerized tomography in the classification of hypopharyngeal and laryngeal cancers. Indications for intraoperative sonography of the CNS are biopsy guidance, tumor resection, and drainage or removal of inflammatory masses. Surgical residents have significantly less formal training in mass casualties, triage, and chemical, biological, and nuclear exposures than residents in other specialties. Clinical trial enrollment decisions were noted and factors that prevented accrual were identified. Initially all anastomoses were of the proximal first type (to ensure that the flow was adequate). Pulmonary artery catheter monitoring of patients who undergo complex spinal fusion facilitates the identification of patients with pulmonary injury and is essential in the management of these patients in the postoperative period.

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Chronic exposure of the peritoneum to normal saline causes overgrowth of the connective tissue and formation of new blood vessels within that tissue. Effect of antibody to theta antigen on cell-mediated immunity induced in syngeneic mice by murine sarcoma virus. Spin lattice relaxation times from magic angle spinning 13C-NMR spectra of phospholipid dispersions of interest were used as a measure of motional rates. The right hip joint pain was attributed to avascular necrosis of the femoral head. The glycosaminoglycan-binding domain of decoy receptor 3 is essential for induction of monocyte adhesion.

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