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Zofran (Ondansetron)

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Zofran blocks the actions of chemicals in the body that can trigger nausea and vomiting. Zofran is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.

Other names for this medication:
Acidom, Domar, Donrid, Doran, Emeset, Emitus, Emtop, Lupisetron, Naucid, Odanse, Omcet, Ondansetron, Ondar, Ondeo, Ondet, Ondon, Onsett, Ontron, Onzil, Osetron, Pantorex, Periset, Rancet, Ranidom, Ranivir, Ranon, Renol, Renty, Sanron, Supracetron, Tiron, Vomicare, Vomigo, Vomikind, Vomipra, Vomiven, Vomiz, Vomizen, Vorast, Voset, Xondmet, Zonda, Zondan, Zonde

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Also known as: Ondansetron


Generic Zofran is used for preventing nausea and vomiting due to cancer chemotherapy or surgery. It may also be used for other conditions. Generic Zofran is a serotonin 5-HT3 receptor blocker. It works by blocking a chemical thought to be a cause of nausea and vomiting in certain situations (e.g., chemotherapy). Zofran is also known as Ondansetron, Vomiof, Danzetron, Ondaz. Generic name of Generic Zofran is Ondansetron. Brand name of Generic Zofran is Zofran.


Take Zofran exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Zofran can be taken with or without food.

The first dose is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Follow your doctor's dosing instructions very carefully.

Take the regular tablet with a full glass of water.

To take the orally disintegrating tablet (Zofran ODT):

Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet. Use dry hands to remove the tablet and place it in your mouth. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Store at room temperature away from moisture, heat, and light. Store liquid medicine in an upright position.

Detailed Zofran dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting.


Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the unused soluble film in the foil pouch until you ready to use it.

Detailed Zofran dosage information

Side effects

The most common side effects associated with Zofran are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Zofran may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

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